肺部结节的诊疗新进展
摘要
国家癌症中心发布的2018年全国最新癌症报告中指出肺癌位居我国癌症发病首位,早期肺癌无明显临床症状,部分仅以肺部结节的形式呈现,而当患者出现不适就诊时多已处于中晚期,远期生存率大大降低。近几十年来,随着临床各项检查技术的更新和发展,尤其是低剂量螺旋计算机断层扫描(LDCT)在肺部体检筛查中的应用,使得越来越多的肺部小结节得以发现,但由于结节的表现各异,其良恶性的鉴定及恰当有效的治疗措施成为当今肺部结节的研究热点。本文就肺部结节诊断及治疗的最新进展进行综述。
引文
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[13]杨珂.孤立性肺结节体素内不相干运动扩散加权磁共振成像研究[J].现代肿瘤医学,2018,26(3):452-455.
[14]雷正文,史宏灿.孤立性肺结节良恶性评估的研究现状及进展[J].国际外科学杂志,2016,43(4):270-274.
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[19]李金龙,潘骄平.恶性孤立性肺结节诊断与治疗[J].临床与病理杂志,2017,37(6):1276-1281.
[20]王一北,陈宽冰,张洪岩,等.血清肿瘤标记物对肺部结节的诊断价值[J].临床肺科杂志,2017,22(4):598-601.
[21]Gillies RJ,Kinahan PE,Hricak H.Radiomics:images are more than pictures,they are data[J].Radiology,2016,278(2):563-577.
[22]杨春然,郭翌,汪源源.基于影像组学的肺结节恶性程度预测[J].肿瘤影像学,2017,26(2):97-101.
[23]郭翌,周世崇,余锦华,等.影像组学的前沿研究与未来挑战[J].肿瘤影像学,2017,26(2):81-90.
[24]Gevaert O,Echegaray S,Khuong A,et al.Predictive radiogenomics modeling of EGFR mutation status in lung cancer[J].Sci Rep,2017,31(7):41674.
[25]周舒畅,王玉锦,胡琼洁,等.2017RSNA胸部影像学[J].放射学实践,2018,33(3):229-237.
[26]刘凯,张荣国,涂文婷,等.深度学习技术对胸部X线平片亚实性结节的检测效能初探[J].中华放射学杂志,2017,51(12):918-921.
[27]Bendixen M,Jdrgensen OD,Kronborg C,et al.Postoperative pain and quality of life after lobectmy via video-assisted thoracoscopic surgery or anterolatera thoracotomy for early stage lung cancer:a randomised controlled tria[J].Lancet Oncol,2016,17(6):836-844.
[28]Tsutani Y,Miyata Y,Nakayama H,et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma:wedge resection or segmentectomy[J].Chest,2014,145(1):66-71.
[29]Huang HZ,Wang GZ,Xu LC,et al.CT-guided Hookwire localization before video-assisted thoracoscopic surgery for solitary ground-glass opacity dominant pulmonary nodules:radiologicpathologic analysis[J].Oncotarget,2017,8(64):108118.
[30]Jang HJ,Cho S,Kim K,et al.Effect of adjuvant chemotherapy after complete resection for pathologic stage Ib lung adenocarcinoma in high-risk patients as defined by a new recurrence risk scoring model[J].Cancer Res Treat,2017,49(4):898-905.
[31]王沁雪,曾晓宁,刘亚南,等.第三代表皮生长因子受体-酪氨酸激酶抑制剂研究进展[J].国际呼吸杂志,2016,36(1):51-55.
[32]倪莲芳,聂立功.第三代EGFR-TKIs耐药之初探[J].中国肺癌杂志,2018,21(2):110-115.
[33]郭佳,陈志营,谭平.肺癌免疫治疗进展[J].国际呼吸杂志,2018,38(4):290-296.
[34]王丽萍.肺癌免疫治疗现状及展望[J].中华实用诊断与治疗杂志,2017,31(2):105-110.
[35]支修益,石远凯,于金明.中国原发性肺癌诊疗规范[J].中华肿瘤杂志,2015,37(1):67-78.
[36]刘宝东,叶欣,范卫君,等.影像引导射频消融治疗肺部肿瘤专家共识(2018版)[J].中国肺癌杂志,2018,21(2):76-88.
[37]McDaniel JD,Racadio JM,Patel MN,et al.CT-guided localization of pulmonary nodules in children prior to video-assisted thoracoscopic surgical resection utilizing a combination of two previously described techniques[J].Pediatr Radiol,2018,48(5):626-631.
[2]周清华,范亚光,王颖,等.中国肺部结节分类、诊断与治疗指南[J].中国肺癌杂志,2016,19(12):793-798.
[3]Aberle DR,Adams AM,Berg CD,et al.Reduced lung-cancer mortality with low-dose computed tomographic screening[J].N Engl JMed,2011,365(5):395-409.
[4]陈亚男,陈武飞,滑炎卿.肺结节倍增时间的CT研究进展[J].中华解剖与临床杂志,2017,22(6):522-527.
[5]Mazzone PJ,Sears CR,Arenberg DA,et al.Evaluating molecular biomarkers for the early detection of lung cancer:when is a biomarker ready for clinical use?an official american thoracic society policy statement[J].Am J Respir Crit Care Med,2017,196(7):e15.
[6]周清华,范亚光,王颖,等.中国肺癌低剂量螺旋CT筛查指南(2018版)[J].中国肺癌杂志,2018,21(2):67-75.
[7]孙凯,王新文,张建伟,等.CT能谱成像对孤立性肺结节鉴别诊断的初步研究[J].中国药物与临床,2015,15(6):794-796.
[8]贾玉琳,孙秋莲,肖喜刚,等.肺结节及肿块的能谱CT应用研究进展[J].中华放射学杂志,2017,51(8):630-632.
[9]潘江峰,应明亮,李惠民,等.肺结节的3T多b值磁共振扩散加权成像鉴别诊断[J].中国医学计算机成像杂志,2015,21(6):533-537.
[10]孙运国,刘烽,潘海静.MRI动态增强和弥散加权成像对肺结节鉴别诊断价值[J].中华医学研究,2017,15(21):59-61.
[11]童月钗,凌志宇.CT动态增强扫描与磁共振STIR-EPI序列在肺恶性与炎性结节鉴别诊断中的应用[J].浙江实用医学,2017,22(4):268-270.
[12]王金良,Sushant Kumar Das,张川.磁共振扩散峰度成像对肺结节恶性和良性鉴别诊断[J].中国CT和MRI杂志,2018,16(2):68-73.
[13]杨珂.孤立性肺结节体素内不相干运动扩散加权磁共振成像研究[J].现代肿瘤医学,2018,26(3):452-455.
[14]雷正文,史宏灿.孤立性肺结节良恶性评估的研究现状及进展[J].国际外科学杂志,2016,43(4):270-274.
[15]刘瑛,吴宁,郑容,等.良性肺结节在18 F-FDG PET-CT上的摄取特点[J].癌症进展,2015,13(2):213-217.
[16]李莹,谢继承,王琤.螺旋CT多层扫描结合99mTC-甲氧异丁基异腈亲肿瘤显像在孤立性肺结节病变诊断中的应用[J].中国基层医药,2016,23(20):3045-3048.
[17]朱海涛.CT引导下经皮肺内小结节穿刺活检23例分析[J].中国实用医刊,2013,40(1):120.
[18]陈众博,金燕平,邓在春,等.虚拟导航联合支气管超声在肺外周结节诊断中的价值[J].中华结核和呼吸杂志,2016,39(7):509-513.
[19]李金龙,潘骄平.恶性孤立性肺结节诊断与治疗[J].临床与病理杂志,2017,37(6):1276-1281.
[20]王一北,陈宽冰,张洪岩,等.血清肿瘤标记物对肺部结节的诊断价值[J].临床肺科杂志,2017,22(4):598-601.
[21]Gillies RJ,Kinahan PE,Hricak H.Radiomics:images are more than pictures,they are data[J].Radiology,2016,278(2):563-577.
[22]杨春然,郭翌,汪源源.基于影像组学的肺结节恶性程度预测[J].肿瘤影像学,2017,26(2):97-101.
[23]郭翌,周世崇,余锦华,等.影像组学的前沿研究与未来挑战[J].肿瘤影像学,2017,26(2):81-90.
[24]Gevaert O,Echegaray S,Khuong A,et al.Predictive radiogenomics modeling of EGFR mutation status in lung cancer[J].Sci Rep,2017,31(7):41674.
[25]周舒畅,王玉锦,胡琼洁,等.2017RSNA胸部影像学[J].放射学实践,2018,33(3):229-237.
[26]刘凯,张荣国,涂文婷,等.深度学习技术对胸部X线平片亚实性结节的检测效能初探[J].中华放射学杂志,2017,51(12):918-921.
[27]Bendixen M,Jdrgensen OD,Kronborg C,et al.Postoperative pain and quality of life after lobectmy via video-assisted thoracoscopic surgery or anterolatera thoracotomy for early stage lung cancer:a randomised controlled tria[J].Lancet Oncol,2016,17(6):836-844.
[28]Tsutani Y,Miyata Y,Nakayama H,et al.Appropriate sublobar resection choice for ground glass opacity-dominant clinical stage IA lung adenocarcinoma:wedge resection or segmentectomy[J].Chest,2014,145(1):66-71.
[29]Huang HZ,Wang GZ,Xu LC,et al.CT-guided Hookwire localization before video-assisted thoracoscopic surgery for solitary ground-glass opacity dominant pulmonary nodules:radiologicpathologic analysis[J].Oncotarget,2017,8(64):108118.
[30]Jang HJ,Cho S,Kim K,et al.Effect of adjuvant chemotherapy after complete resection for pathologic stage Ib lung adenocarcinoma in high-risk patients as defined by a new recurrence risk scoring model[J].Cancer Res Treat,2017,49(4):898-905.
[31]王沁雪,曾晓宁,刘亚南,等.第三代表皮生长因子受体-酪氨酸激酶抑制剂研究进展[J].国际呼吸杂志,2016,36(1):51-55.
[32]倪莲芳,聂立功.第三代EGFR-TKIs耐药之初探[J].中国肺癌杂志,2018,21(2):110-115.
[33]郭佳,陈志营,谭平.肺癌免疫治疗进展[J].国际呼吸杂志,2018,38(4):290-296.
[34]王丽萍.肺癌免疫治疗现状及展望[J].中华实用诊断与治疗杂志,2017,31(2):105-110.
[35]支修益,石远凯,于金明.中国原发性肺癌诊疗规范[J].中华肿瘤杂志,2015,37(1):67-78.
[36]刘宝东,叶欣,范卫君,等.影像引导射频消融治疗肺部肿瘤专家共识(2018版)[J].中国肺癌杂志,2018,21(2):76-88.
[37]McDaniel JD,Racadio JM,Patel MN,et al.CT-guided localization of pulmonary nodules in children prior to video-assisted thoracoscopic surgical resection utilizing a combination of two previously described techniques[J].Pediatr Radiol,2018,48(5):626-631.