两色金鸡菊提取物对运动小鼠抗疲劳和耐缺氧作用的研究
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摘要
为研究两色金鸡菊提取物对小鼠的抗疲劳和耐缺氧作用,选择48只小鼠随机分为4组,即对照组,低、中、高剂量两色金鸡菊提取物组(每日5、10、20g/kg体重)。各组小鼠分别灌胃(每日0.20mL/10g)给予不同剂量的两色金鸡菊提取物,连续灌胃21d后,观察不同浓度的两色金鸡菊提取物对小鼠负重游泳时间及运动后小鼠血清尿素氮、血乳酸、肝糖原含量和小鼠常压耐缺氧存活时间、断头后呼吸维持时间的影响。结果表明,两色金鸡菊提取物能延长小鼠负重游泳时间,降低运动小鼠血清尿素氮、血乳酸含量,增加运动小鼠肝糖原含量,明显延长小鼠常压耐缺氧存活时间及断头后呼吸维持时间。结果提示,一定剂量的两色金鸡菊提取物具有抗疲劳作用和提高耐缺氧能力作用。
To study the effects of Coreopsis tinctoria extracts on anti-fatigue action and hypoxia tolerance action in mice,48 mice were randomly divided into control group,and high-dose,middle-dose,low-dose groups of Coreopsis tinctoria extracts,12 mice in each group,all mice were administered orally,once a day for 21 consecutive days,the effects of Coreopsis tinctoria extracts on the loaded-swimming time,the blood lactic acid,the serum urea nitrogen and the hepatic glycogen after exercise,the survival time under hypoxia and the maintenance time after decapitation were observed in mice.The results showed as follows:The Coreopsis tinctoria extracts could significantly prolong the loaded-swimming time,decrease the contents of blood lactic acid and serum urea nitrogen,increase the content of hepatic glycogen after exercise,significantly prolong the survival time under hypoxia and the maintenance time after decapitation comparing with the control group.The results suggested that the Coreopsis tinctoria extracts have the effects of anti-fatigue and hypoxia tolerance actions.
To study the effects of Coreopsis tinctoria extracts on anti-fatigue action and hypoxia tolerance action in mice,48 mice were randomly divided into control group,and high-dose,middle-dose,low-dose groups of Coreopsis tinctoria extracts,12 mice in each group,all mice were administered orally,once a day for 21 consecutive days,the effects of Coreopsis tinctoria extracts on the loaded-swimming time,the blood lactic acid,the serum urea nitrogen and the hepatic glycogen after exercise,the survival time under hypoxia and the maintenance time after decapitation were observed in mice.The results showed as follows:The Coreopsis tinctoria extracts could significantly prolong the loaded-swimming time,decrease the contents of blood lactic acid and serum urea nitrogen,increase the content of hepatic glycogen after exercise,significantly prolong the survival time under hypoxia and the maintenance time after decapitation comparing with the control group.The results suggested that the Coreopsis tinctoria extracts have the effects of anti-fatigue and hypoxia tolerance actions.
引文
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[12]王彦武,赵鹏,张洁宏,等.红景天功能饮料对小鼠抗疲劳和耐缺氧能力的影响[J].广西医学,2014,36(12):1772-1774.
[2] Li Y,Chen X,Xue J,et al.Flavonoids furomCoreopsis tinctoria adjust lipid metabolism in hyperlipidemia animals by downregulating adipose differentiation-related protein[J].Lipids Health Dis,2014,13:193-200.
[3] Yang Q,Sun Y H,Zhang L,et al.Antihypertensive effects of extract from flower buds of Coreopsis tinctoria on spontaneously hypertensive rats[J].Chinese Herbal Med,2014,6(2):103-109.
[4]沙爱龙,吴瑛,盛海燕,等.昆仑雪菊黄酮对衰老模型小鼠脑及脏器指数的影响[J].动物医学进展,2013,34(7):66-68.
[5]明婷,孙玉华,胡梦颖,等.金鸡菊提取物降压及体内抗氧化作用的研究[J].中国实验方剂学杂志,2012,18(10):249-252.
[6] Tan W,Yu K Q,Liu Y Y,et al.Anti-fatigue activity of polysaccharides extract from Radix Rehmanniae preparata[J].Int J Biol Macromol,2012,509(1):59-62.
[7]俞浩,张成孜,毛斌斌.滁菊多糖抗疲劳耐缺氧作用效果观察[J].食品工业科技,2014,35(12):365-372.
[8]韩咏梅,刘紅微,赵丽芹.土庄绣线菊水浸液对小鼠抗疲劳作用的试验研究[J].内蒙古农业大学学报,2014,35(2):9-12.
[9]刘晓辉,李沐灵,莫言,等.绣线菊叶水煎液对小鼠的抗疲劳和抗氧化作用[J].现代食品科技,2014,30(12):25-29.
[10]苏成虎,陈晓农,杨新波,等.水芹提取物抗运动性疲劳作用及初步机制分析[J].解放军药学学报,2011,7(2):103-106.
[11]梁寻杰,黄小夏,卢棉,等.茉莉花叶水提液影响小鼠抗疲劳及耐缺氧能力的研究[J].中国临床药理学杂志,2017,33(16):1575-1577.
[12]王彦武,赵鹏,张洁宏,等.红景天功能饮料对小鼠抗疲劳和耐缺氧能力的影响[J].广西医学,2014,36(12):1772-1774.