热解吸-电晕放电电离-离子迁移谱法现场快速筛查化妆品中5种禁用组分
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摘要
采用热解吸-电晕放电电离技术结合离子迁移谱,研究建立了化妆品中5种禁用卡因类化合物的现场快速筛查方法。化妆品样品无需前处理步骤,样品轻轻蘸取、滴加或喷雾在采样拭纸上,置于离子源样品槽中,采用热解吸-电晕放电电离技术实现样品中待测物的热解吸和离子化,随后以离子迁移谱进行快速筛查分析。5种卡因类化合物的检出限为10～50 ng,离子迁移谱分析时间小于20 ms,整个样品分析周期不超过1 min。本方法简便、快速、成本低廉,适用于化妆品中卡因类禁用组分的现场快速筛查。
A rapid on-site analytical method is developed for screening lidocaine and four other types of prohibited ingredients in cosmetics using thermal desorption-corona discharge ionization together with ion mobility spectrometry. Performing no pretreatment, we dropped or sprayed cosmetic samples onto a Nomex sampling swab. The sampler was placed into a compartment for thermal desorption and corona discharge ionization; then, ion mobility spectrometry analysis was performed. The limits of detection(LODs) for the five analytes ranged from 10 to 50 ng. The instrumental analysis time for a single run was less than 20 ms, and the total sample analysis period was within 1 min. The proposed method is simple, fast, and has low cost, and could be used as an analytical tool for rapid on-site screening of prohibited ingredients in cosmetics.
A rapid on-site analytical method is developed for screening lidocaine and four other types of prohibited ingredients in cosmetics using thermal desorption-corona discharge ionization together with ion mobility spectrometry. Performing no pretreatment, we dropped or sprayed cosmetic samples onto a Nomex sampling swab. The sampler was placed into a compartment for thermal desorption and corona discharge ionization; then, ion mobility spectrometry analysis was performed. The limits of detection(LODs) for the five analytes ranged from 10 to 50 ng. The instrumental analysis time for a single run was less than 20 ms, and the total sample analysis period was within 1 min. The proposed method is simple, fast, and has low cost, and could be used as an analytical tool for rapid on-site screening of prohibited ingredients in cosmetics.
引文
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[2]Zhang Q S,Wang G L.Safety and Technical Standards for Cosmetics:Reading.Beijing:People’s Medical Publishing House,2017张庆生,王钢力.《化妆品安全技术规范》读本.北京:人民卫生出版社,2017
[3]China Food and Drug Administration.Safety and Technical Standards for Cosmetics.(2015-12-23)[2016-03-11].http://www.sda.gov.cn/directory/web/WS01/images/MjAxNcTqtdoyNji6xbmruOa4vbz+LnBkZg==.pdf国家食品药品监督管理局.化妆品安全技术规范.(2015-12-23)[2016-03-11].http://www.sda.gov.cn/directory/web/WS01/images/MjAxNcTqtdoyNji6xbmruOa4vbz+LnBkZg==.pdf
[4]Regulation(EC)No.1223/2009 of the European Parliament and of the Council of 20 November 2009 on Cosmetic Products.(2009-12-22).http://eur-lex.Europa.Eu/LexUriServ/LexUriServ.Do?Uri=OJ:L:2009:342:0059:0209:en:PDF
[5]SN/T 4147-2015
[6]Ma D J,Xu X,Lian W,et al.Chinese Journal of Analytical Chemistry,2009,37(11):1617马东杰,许旭,廉伟,等.分析化学,2009,37(11):1617
[7]Wang M Y,Shanxi Medical Journal,2017,46(11):1363王美云.山西医药杂志,2017,46(11):1363
[8]Liu X L,Yang L N,Ni X X,et al.Anhui Medical and Pharmaceutical Journal,2016,20(9):1658刘晓玲,杨丽娜,倪晓霞,等.安徽医药,2016,20(9):1658
[9]Liu X F,Huang K J,Lin C W,et al.Physical Testing and Chemical Analysis Part B:Chemical Analysis,2015,51(2):245刘晓峰,黄克建,林翠梧,等.理化检验-化学分册,2015,51(2):245
[10]Xie R F,Li Z,Li Y W,et al.World Latest Medicine Information,2016,16(77):172解润芳,李桢,李玉雯,等.世界最新医学信息文摘,2016,16(77):172
[11]Zhang L P,He H Y,Yu Z S,et al.Chinese Journal of Forensic Medicine,2014,29(4):360张蕾萍,何洪源,于忠山,等.中国法医学杂志,2014,29(4):360
[12]Zhou W H,Liu J,Ding J H,et al.Chinese Journal of Analytical Chemistry,1995,23(8):880周伟红,刘峻,丁建华,等.分析化学,1995,23(8):880
[13]Mans D J,Callahan R J,Dunn J D,et al.J Pharm Biomed Anal,2013,75:153
[14]Dussy F E,Berchtold C,Briellmann T A,et al.Forensic Sci Int,2008,177(2/3):105
[15]Najarro M,Morris M E D,Staymates M E,et al.Analyst,2012,137(11):2614
[16]Wang J F.[PhD Dissertation].Beijing:Beijing University of Chemical Technology,2012王建凤.[博士学位论文].北京:北京化工大学,2012
[17]Li D,Qiu J,Qian Y Z,et al.Quality and Safety of AgroProducts,2012(5):41李丹,邱静,钱永忠,等.农产品质量与安全,2012(5):41
[18]Lu Y T,Hu S,Lu P,et al.Journal of Food Safety and Quality,2014,5(4):1087陆娅婷,胡双,陆鹏,等.食品安全质量检测学报,2014,5(4):1087
[19]Liu X Y,Kong X H,Ji R D,et al.Journal of Atomic and Molecular Physics,2007,24(1):163刘宪云,孔祥和,季仁东,等.原子与分子物理学报,2007,24(1):163
[20]Jiang D D,Peng L Y,Wen M,et al.Anal Chem,2016,88(8):4391
[21]Najarro M,Morris M,Matthew M,et al.Analyst,2012,137(11):2614
[22]Contreras M,Jurado-Campos N,Callado C,et al.Sensor Actuat B-Chem,2018,273:1413
[23]Sisco E,Verkouteren J,Staymates J,et al.Forensic Chem,2017,4:108
[24]Guo C H,Cao S Y.Ion Mobility Spectrometry.Beijing:National Defense Industry Press,2010郭成海,曹树亚.离子迁移谱.北京:国防工业出版社,2010
[25]Commission Decision of 12 August 2002-Implementing Council Directive 96/23/EC Concerning the Performance of Analytical Methods and the Interpretation of Results(2002/657/EC).(2002-08-17).http://eur-lex.europa.edu/legalcontent/EN/TXT/?uri-CELEX:32002D0657
[26]Guo X Y,Ma Q,Meng X S,et al.Journal of Hygiene Research,2017,46(3):467郭项雨,马强,孟宪双,等.卫生研究,2017,46(3):467
[27]LüY G,Guo X Y,Ma Q,et al.Journal of Instrumental Analysis,2017,36(8):949吕悦广,郭项雨,马强,等.分析测试学报,2017,36(8):949
[28]Chen M,Guo X Y,Cao W,et al.Journal of Analytical Science,2018,34(3):342陈萌,郭项雨,操卫,等.分析科学学报,2018,34(3):342