参黄降糖胶囊对气阴两虚证2型糖尿病糖脂代谢、胰岛β细胞功能、氧化应激指标的影响
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摘要
目的:探究参黄降糖胶囊对气阴两虚证2型糖尿病患者糖脂代谢、胰岛β细胞功能、氧化应激指标的影响。方法:300例气阴两虚证2型糖尿病患者随机分为对照组和观察组,各150例。对照组患者给予盐酸二甲双胍片内服,观察组患者则在此基础上加用参黄降糖胶囊内服,2周为疗程,连续用药6个疗程。通过评估主要中医证候积分变化评价临床效果,监测糖脂代谢、胰岛β细胞功能、氧化应激指标水平变化。结果:观察组患者有效率90.0%较对照组患者的74.7%显著升高(P<0.05);治疗后观察组的主要中医证候积分较对照组降低明显(P<0.05);糖脂代谢改善更为明显,血糖、血脂水平较对照组降低明显(P<0.05);胰岛β细胞功能指标HOMA-β、ISI水平显著高于对照组(P<0.05),而HOMA-IR、FINS水平则显著低于对照组(P<0.05);血清氧化应激指标SOD、GSH-PX水平显著高于对照组(P<0.05),而MDA、ROS水平则显著低于对照组(P<0.05)。结论:参黄降糖胶囊治疗气阴两虚证2型糖尿病患者疗效肯定,利于减轻临床症状,改善糖脂代谢及胰岛β细胞功能,减轻氧化应激损伤,值得临床推广应用。
Objective: To investigate the influence of Shenhuang Jiangtang Capsule on glucose lipid metabolism, islet beta cell function and oxidative stress indexes for treating deficiency of both vital Qi and Yin syndrome diabetes patients. Methods:A total of 300 cases of type 2 diabetes patients were randomly divided into a control group of 150 cases and an observation group of 150 cases. Patients in the control group were treated with metformin hydrochloride tablets while those in the observation group were treated with Shenhuang Jiangtang Capsule. Two weeks was a course and there were 6 courses for treatment. The paper focused on comparing the effectiveness, evaluating the main syndromes points, monitoring the changes of glucose lipid metabolism, islet beta cell function and oxidative stress indexes. Results: The efficiency of patients in the observation group was 90.0%, which was higher than the control group's 74.7%(P<0.05). The improvement of main clinical symptoms for the patients in the observation group was better than that for the patients in the control group, and the symptoms scores were shorter than that of the control group(P<0.05). The improvement of glucose and blood fat levels for the patients in the observation group was better than those for the patients in the control group, and the levels of FPG,2hPG,HbA1 C, TC, TG and LDL-C were lower than those of the control group(P<0.05). The islet beta cell function levels of HOMA-β and ISI for the patients in the observation group were higher than those for the patients in the control group, and the levels of HOMA-IR and FINS were lower than those of the control group(P<0.05). The oxidative stress indexes of SOD and GSH-PX were higher than those for the patients in the control group, and the levels of MDA and ROS were lower than those of the control group(P<0.05). Conclusion: The therapy has good hypoglycemic effect. It can improve the patients' clinical symptoms and reduce the oxidative stress injury, being good to improve the function of glucose lipid metabolism and islet beta cell and worthy of wide application in the clinical practice.
Objective: To investigate the influence of Shenhuang Jiangtang Capsule on glucose lipid metabolism, islet beta cell function and oxidative stress indexes for treating deficiency of both vital Qi and Yin syndrome diabetes patients. Methods:A total of 300 cases of type 2 diabetes patients were randomly divided into a control group of 150 cases and an observation group of 150 cases. Patients in the control group were treated with metformin hydrochloride tablets while those in the observation group were treated with Shenhuang Jiangtang Capsule. Two weeks was a course and there were 6 courses for treatment. The paper focused on comparing the effectiveness, evaluating the main syndromes points, monitoring the changes of glucose lipid metabolism, islet beta cell function and oxidative stress indexes. Results: The efficiency of patients in the observation group was 90.0%, which was higher than the control group's 74.7%(P<0.05). The improvement of main clinical symptoms for the patients in the observation group was better than that for the patients in the control group, and the symptoms scores were shorter than that of the control group(P<0.05). The improvement of glucose and blood fat levels for the patients in the observation group was better than those for the patients in the control group, and the levels of FPG,2hPG,HbA1 C, TC, TG and LDL-C were lower than those of the control group(P<0.05). The islet beta cell function levels of HOMA-β and ISI for the patients in the observation group were higher than those for the patients in the control group, and the levels of HOMA-IR and FINS were lower than those of the control group(P<0.05). The oxidative stress indexes of SOD and GSH-PX were higher than those for the patients in the control group, and the levels of MDA and ROS were lower than those of the control group(P<0.05). Conclusion: The therapy has good hypoglycemic effect. It can improve the patients' clinical symptoms and reduce the oxidative stress injury, being good to improve the function of glucose lipid metabolism and islet beta cell and worthy of wide application in the clinical practice.
引文
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[7] 王胜麟,肖武,张海峰. 葡多酚通过缓解内质网应激改善胰岛β细胞功能的机制[J]. 中国老年学杂志,2017,37(18):4432-4434.
[8] 周波,黄春,李青, 等.西洋参联合二甲双胍对糖尿病患者HbA1C、FPG、CRP的影响[J].中医药导报,2015,21(4):88-89.
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[13] 吴群,郝丽丽,陶雯璇,等. 糖尿病型白内障患者血清和房水中部分抗氧化指标及血管内皮生长因子水平[J]. 贵州医科大学学报,2017,42(11):1-3.
[14] Wided K,Hassiba R,Mesbah L.Polyphenolic fraction of Algerian propolis reverses doxorubicin induced oxidative stress in liver cells and mitochondria[J].Pak J Pharm Sci,2014,27(6):1891-1897.
[15] 秦保锋,朱旭莹,翁伟力, 等. 黄芪桂枝五物汤对糖尿病周围神经病变患者血清谷胱甘肽过氧化物酶活性的影响[J]. 上海中医药大学学报,2017,31(2):36-39.
[16] 刘杰,孙冰,班博, 等. 糖尿病周围神经病变氧化应激等相关机制探讨[J]. 北京医学,2015,37(1):16-19.
[17] PATIL VS, PATIL VP, GOKHALE N, et al. Chronic periodontitis in type 2 diabetes mellitus: oxidative stress as a common factor in periodontal tissue injury[J]. Journal of Clinical and Diagnostic Research: JCDR,2016,10(4): 12-16.
[18] 李伟,郭伟,周密, 等. 降糖通脉片联合二甲双胍对2型糖尿病患者球后动脉血流动力学及氧化应激指标的影响[J]. 吉林中医药,2017,37(9):916-920.
[19] 林细炳,雷鸿耀,郭真, 等. 氧化应激与2型糖尿病患者并发脑梗死的相关性研究[J]. 现代医院,2017,17(10):1507-1509.
[20] 李凌鸥,刘东方. 胰岛β细胞衰老与糖尿病相关性研究进展[J]. 现代医药卫生,2017,33(21):3233-3235.
[2] Mogensen CE. Preventing microalbuminuria in type 2 Diabetes-NEJM[J]. New England Journal of Medicine, 2013, 19(21):589.
[3] Aronson R, Reznik Y, Conget I, et al. Sustained efficacy of insulin pump therapy compared with multiple daily injections in type 2 diabetes:12-month data from the OpT2mise randomized trial [J]. Diabetes Obes Metab, 2016, 18(5): 500-507.
[4] 李秋云,王彩宁,史丽萍,等.2型糖尿病及前期患者胰岛素抵抗与脂代谢紊乱的关系[J].中国全科医学,2014,14(8):2716-2717.
[5] Lv WS, Zhao WJ, Gong SL, et al. Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis[J]. Journal of endocrinological investigation, 2015, 38(5): 513-518.
[6] Sherr JL, Hermann JM, Campbell F, et al. Use of insulin pump therapy in children and adolescents with type 1 diabetes and its impact on metabolic control: comparison of results from three large, transatlantic paediatric registries[J]. Diabetologia, 2016, 59(1): 87-91.
[7] 王胜麟,肖武,张海峰. 葡多酚通过缓解内质网应激改善胰岛β细胞功能的机制[J]. 中国老年学杂志,2017,37(18):4432-4434.
[8] 周波,黄春,李青, 等.西洋参联合二甲双胍对糖尿病患者HbA1C、FPG、CRP的影响[J].中医药导报,2015,21(4):88-89.
[9] 韩旭亮,王晓雯,郑艳侠,等.2 型糖尿病的药物治疗进展[J].西北药学杂志,2012,27(6):616.
[10] 中华医学会糖尿病学分会.中国2型糖尿病防治指南[S].中华糖尿病杂志,2014,6(7):448.
[11] 国家中医药管理局.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:215.
[12] 华婷婷,孙志. 孙志教授泻胃补脾针法治疗2型糖尿病的经验[J]. 浙江中医药大学学报,2017,41(10):834-836.
[13] 吴群,郝丽丽,陶雯璇,等. 糖尿病型白内障患者血清和房水中部分抗氧化指标及血管内皮生长因子水平[J]. 贵州医科大学学报,2017,42(11):1-3.
[14] Wided K,Hassiba R,Mesbah L.Polyphenolic fraction of Algerian propolis reverses doxorubicin induced oxidative stress in liver cells and mitochondria[J].Pak J Pharm Sci,2014,27(6):1891-1897.
[15] 秦保锋,朱旭莹,翁伟力, 等. 黄芪桂枝五物汤对糖尿病周围神经病变患者血清谷胱甘肽过氧化物酶活性的影响[J]. 上海中医药大学学报,2017,31(2):36-39.
[16] 刘杰,孙冰,班博, 等. 糖尿病周围神经病变氧化应激等相关机制探讨[J]. 北京医学,2015,37(1):16-19.
[17] PATIL VS, PATIL VP, GOKHALE N, et al. Chronic periodontitis in type 2 diabetes mellitus: oxidative stress as a common factor in periodontal tissue injury[J]. Journal of Clinical and Diagnostic Research: JCDR,2016,10(4): 12-16.
[18] 李伟,郭伟,周密, 等. 降糖通脉片联合二甲双胍对2型糖尿病患者球后动脉血流动力学及氧化应激指标的影响[J]. 吉林中医药,2017,37(9):916-920.
[19] 林细炳,雷鸿耀,郭真, 等. 氧化应激与2型糖尿病患者并发脑梗死的相关性研究[J]. 现代医院,2017,17(10):1507-1509.
[20] 李凌鸥,刘东方. 胰岛β细胞衰老与糖尿病相关性研究进展[J]. 现代医药卫生,2017,33(21):3233-3235.