美罗培南对重症细菌感染新生儿血清PCT、CRP及PLT水平的影响
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摘要
目的探讨美罗培南对重症细菌感染新生儿血清相关指标的影响。方法选择2016年5月—2018年6月在商丘市妇幼保健院治疗的重症细菌感染新生儿100例,随机分为2组,各50例。参照组采用头孢他啶治疗,研究组采用美罗培南治疗,比较两组降钙素原(Procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)、血小板计数(Blood platelet,PLT)以及不良反应发生率。结果治疗前,两组PCT、CRP水平与PLT值对比,差异无统计学意义(P>0.05);治疗14 d后,研究组PCT、CRP水平低于参照组,PLT值高于参照组,差异有统计学意义(P<0.05);研究组不良反应发生率为2.00%,低于参照组的16.00%,差异有统计学意义(P<0.05)。结论重症细菌感染新生儿经美罗培南治疗,可有效控制病情,且不良反应相对较少,具有一定安全性。
Objective To investigate the effect of meropenem on serum indexes in neonatal severe bacterial infection.Methods Totally 100 cases of neonatal severe bacterial infection treated in the hospital from May 2016 to June 2018 were randomly divided into two groups, with 50 cases in each group. Reference group was given ceftazidime, while research group was treated with meropenem. The procalcitonin(PCT), C-reactive protein(CRP), blood platelet(PLT), incidence of adverse reactions were compared between the two groups.Results Before treatment, there was no statistical difference in the PCT, CRP and PLT between the two groups(P>0.05); After treatment for 14 d, the levels of PCT and CRP in research group were lower than those in reference group, while the PLT in research group was higher than that in reference group(P<0.05); The incidence of adverse reactions in research group(2.00%) was lower than that of the reference group(16.00%)(P<0.05).Conclusion Meropenem in treatment of neonatal severe bacterial infection can control the disease and have less adverse reactions, which has certain safety.
Objective To investigate the effect of meropenem on serum indexes in neonatal severe bacterial infection.Methods Totally 100 cases of neonatal severe bacterial infection treated in the hospital from May 2016 to June 2018 were randomly divided into two groups, with 50 cases in each group. Reference group was given ceftazidime, while research group was treated with meropenem. The procalcitonin(PCT), C-reactive protein(CRP), blood platelet(PLT), incidence of adverse reactions were compared between the two groups.Results Before treatment, there was no statistical difference in the PCT, CRP and PLT between the two groups(P>0.05); After treatment for 14 d, the levels of PCT and CRP in research group were lower than those in reference group, while the PLT in research group was higher than that in reference group(P<0.05); The incidence of adverse reactions in research group(2.00%) was lower than that of the reference group(16.00%)(P<0.05).Conclusion Meropenem in treatment of neonatal severe bacterial infection can control the disease and have less adverse reactions, which has certain safety.
引文
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[4] 李朝霞.降钙素原检测在儿童感染性疾病中的诊断价值[J].中国实用医刊,2015,42(7):60-61.
[5] 顾海红,黄烈平,王吉.美罗培南临床治疗早产儿重症细菌感染的疗效分析[J].中华医院感染学杂志,2015,25(1):86-87,107.
[6] 马雪,赵丽丽,赵佩,等.两种不同方法输注美罗培南治疗重症感染患者的效果比较[J].中国医药,2018,13(4):594-597.