外周血血脂指标对妊娠期间胎儿先心病发生率的影响
|
摘要
目的观察外周血血脂指标对妊娠期间胎儿先心病发生率的影响。方法选取2017年5月～2018年5月在我院进行孕检及分娩的妊娠女性60例,其中25例胎儿存在先天性心脏病作为研究组,另外35例作为对照组,测定两组甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、空腹血糖(fastingplasmaglucose,FPG)及胰岛素抵抗指数(homeostasis model assessment-insulin resistance,HOMA-IR)的水平,采用Spearman相关性分析血脂及血糖指标与胎儿先天性心脏病的相关性。结果与对照组比较,研究组患者的低密度脂蛋白胆固醇显著升高,差异具有统计学意义(P<0.05);两组患者在空腹血糖和胰岛素抵抗指数上比较,差异无统计学意义(P>0.05);Spearman相关性分析结果显示,低密度脂蛋白胆固醇与胎儿先天性心脏病的发病呈显著正相关性。结论外周血低密度脂蛋白胆固醇与妊娠期间胎儿先天性心脏病的发病具有一定的正相关性。
Objective To investigate the effect of peripheral blood lipids on the incidence of fetal congenital heart disease during pregnancy. Methods 60 pregnant women who underwent pregnancy test and were delivered in our hospital from May 2017 to May 2018 were selected. Among them, 25 cases had congenital heart disease and were set as the study group and 35 cases were set as the control group. Triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), the levels of fasting plasma glucose(FPG) and homeostasis model assessment-insulin resistance(HOMA-IR) were detected. The correlation between blood lipids, blood glucose levels and fetal congenital heart disease was analyzed by Spearman. Results Compared with that of the control group, the low-density lipoprotein cholesterol in the study group was significantly increased, and the difference was statistically significant(P<0.05). There was no significant difference between the two groups in fasting blood glucose and insulin resistance index(P>0.05). Spearman correlation analysis showed that low-density lipoprotein cholesterol was significantly positively correlated with the incidence of fetal congenital heart disease. Conclusion Low-density lipoprotein cholesterol in peripheral blood has a positive correlation with the incidence of fetal congenital heart disease during pregnancy.
Objective To investigate the effect of peripheral blood lipids on the incidence of fetal congenital heart disease during pregnancy. Methods 60 pregnant women who underwent pregnancy test and were delivered in our hospital from May 2017 to May 2018 were selected. Among them, 25 cases had congenital heart disease and were set as the study group and 35 cases were set as the control group. Triglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), high-density lipoprotein cholesterol(HDL-C), the levels of fasting plasma glucose(FPG) and homeostasis model assessment-insulin resistance(HOMA-IR) were detected. The correlation between blood lipids, blood glucose levels and fetal congenital heart disease was analyzed by Spearman. Results Compared with that of the control group, the low-density lipoprotein cholesterol in the study group was significantly increased, and the difference was statistically significant(P<0.05). There was no significant difference between the two groups in fasting blood glucose and insulin resistance index(P>0.05). Spearman correlation analysis showed that low-density lipoprotein cholesterol was significantly positively correlated with the incidence of fetal congenital heart disease. Conclusion Low-density lipoprotein cholesterol in peripheral blood has a positive correlation with the incidence of fetal congenital heart disease during pregnancy.
引文
[1]Michelle Gurvitz,Kristin M.Burns,Ralph Brindis,et al.Emerging Research Directions in Adult Congenital Heart Disease:A Report from a National Heart,Lung,and Blood Institute/Adult Congenital Heart Association Working Group[J].J Am Coll Cardiol,2016,67(16):1956-1964.
[2]Michelle Gurvitz,Anne Marie Valente,Craig Broberg,et al.Prevalence and Predictors of Gaps in Care Among Adult Congenital Heart Disease Patients(The Health,Education and Access Research Trial:HEART-ACHD)[J].J Am Coll Cardiol,2013,61(21):2180-2184.
[3]Hannah Ferentzi,Constanze Pfitzer,Lisa-Maria Rosenthal,et al.Long-term early development research incongenital heart disease(LEADER-CHD):A study protocol for a prospective cohort observational study investigating the development of children after surgical correction forcongenitalheartdefects during the first 3 years of life[J].BMJ Open,2017,7(12):e018966.
[4]蒲红,邢绣荣,梁潇,等.超急性期脑梗死合并急性心肌缺血患者的早期评估及相关因素分析[J].中国急救复苏与灾害医学杂志,2017,12(9):831-834.
[5]陈厚爱,杨军平.60岁以上脑梗死患者血清Hcy、hsCRP、血糖、血脂水平及其相关性[J].实用中西医结合临床,2016,16(10):19-21.
[6]廖鑫龙,王瑞,由天辉.急性ST段抬高型心肌梗死患者PCI术后院内预后影响因素分析[J].齐齐哈尔医学院学报,2015,36(14):2087-2089.
[7]邹佳妮,樊光辉,丁世芳,等.冠心病患者血清胆红素、尿酸、血脂与冠状动脉病变程度的相关性[J].华南国防医学杂志,2010,24(4):244-247.
[8]颜志钦,易兴阳,虞君儒,等.瑞舒伐他汀强化降脂对缺血性脑卒中血脂及颈动脉粥样硬化斑块的影响[J].中国药物与临床,2013,13(11):1408-1410.
[9]Jackson Jamie L,Brian Misiti,Bridge Jeffrey A,et al.E-motional functioning of adolescents and adults withcongenital heart disease:A Meta-analysis[J].CongenitHeartDis,2015,10(1):2-12.
[10]Ivo Roca-Luque,Nuria Rivas-Gándara,Laura DosSubirà,et al.Predictors of acute failure ablation of intraatrial re-entrant tachycardia in patients with congenital heart disease:Cardiac disease,atypical flutter,and previous atrial fibrillation[J].J Am Heart Assoc,2018,7(7):e008063.
[11]Antonio Augusto Lopes,Barst Robyn J,Sheila Glennis Haworth,et al.Repair ofcongenital heart diseasewith associated pulmonary hypertension in children:What are the minimal investigative procedures?Consensus statement from the congenital heart diseaseand pediatric task forces,pulmonary vascular research institute(PVRI)[J].Pulm Circ,2014,4(2):330-341.
[12]Candice K Silversides,Erwin Oechslin,Markus Schwerzmann,et al.Canadian cardiovascular society 2009 consensus conference on the management of adults with congenital heart disease:Complex congenital cardiac lesions[J].Can J Cardiol,2010,26(3):e98-e117.
[13]唐萍,王立中,杨戎威,等.先天性心脏病胎儿母血同型半胱氨酸水平与血脂相关性研究[J].中国优生与遗传杂志,2018,26(8):114-116.
[14]Werner Budts,Jolien Roos-Hesselink,Tanja R覿dle-Hurst,et al.Treatment ofheartfailure in adultcongenital heart disease:A position paper of the working group of grownup congenital heart diseaseand the heart failure association of the European society of cardiology[J].Eur Heart J,2016,37(18):1419-1427.
[15]袁远,徐燕,高旭光.匹伐他汀与阿托伐他汀对缺血性脑卒中患者血脂调控的临床对比研究[J].中华老年心脑血管病杂志,2013,15(10):1024-1026.
[16]张素玲.阿托伐他汀联合阿司匹林对急性缺血性脑卒中患者血脂及神经功能缺损程度的影响[J].河南医学研究,2016,25(9):1626-1627.
[17]吴秋珏,吕佳琪,王恬.母体营养不良对子代发育影响研究进展[J].动物医学进展,2011,32(6):123-126.
[18]王箭.广东地区孕妇的膳食营养状况及其与孕期血脂水平的关系研究[D].南方医科大学,2014.
[19]巴宏军,王慧深,张兴,等.妊娠期血脂紊乱与胎儿先天性心脏病发病关系探讨[J].中国实用儿科杂志,2016,31(8):612-614.
[20]许艳芳,莫芳贵.血脂异常患者单项血脂及血脂比值与心血管疾病的相关性分析[J].实验与检验医学,2018,36(1):58-60.
[2]Michelle Gurvitz,Anne Marie Valente,Craig Broberg,et al.Prevalence and Predictors of Gaps in Care Among Adult Congenital Heart Disease Patients(The Health,Education and Access Research Trial:HEART-ACHD)[J].J Am Coll Cardiol,2013,61(21):2180-2184.
[3]Hannah Ferentzi,Constanze Pfitzer,Lisa-Maria Rosenthal,et al.Long-term early development research incongenital heart disease(LEADER-CHD):A study protocol for a prospective cohort observational study investigating the development of children after surgical correction forcongenitalheartdefects during the first 3 years of life[J].BMJ Open,2017,7(12):e018966.
[4]蒲红,邢绣荣,梁潇,等.超急性期脑梗死合并急性心肌缺血患者的早期评估及相关因素分析[J].中国急救复苏与灾害医学杂志,2017,12(9):831-834.
[5]陈厚爱,杨军平.60岁以上脑梗死患者血清Hcy、hsCRP、血糖、血脂水平及其相关性[J].实用中西医结合临床,2016,16(10):19-21.
[6]廖鑫龙,王瑞,由天辉.急性ST段抬高型心肌梗死患者PCI术后院内预后影响因素分析[J].齐齐哈尔医学院学报,2015,36(14):2087-2089.
[7]邹佳妮,樊光辉,丁世芳,等.冠心病患者血清胆红素、尿酸、血脂与冠状动脉病变程度的相关性[J].华南国防医学杂志,2010,24(4):244-247.
[8]颜志钦,易兴阳,虞君儒,等.瑞舒伐他汀强化降脂对缺血性脑卒中血脂及颈动脉粥样硬化斑块的影响[J].中国药物与临床,2013,13(11):1408-1410.
[9]Jackson Jamie L,Brian Misiti,Bridge Jeffrey A,et al.E-motional functioning of adolescents and adults withcongenital heart disease:A Meta-analysis[J].CongenitHeartDis,2015,10(1):2-12.
[10]Ivo Roca-Luque,Nuria Rivas-Gándara,Laura DosSubirà,et al.Predictors of acute failure ablation of intraatrial re-entrant tachycardia in patients with congenital heart disease:Cardiac disease,atypical flutter,and previous atrial fibrillation[J].J Am Heart Assoc,2018,7(7):e008063.
[11]Antonio Augusto Lopes,Barst Robyn J,Sheila Glennis Haworth,et al.Repair ofcongenital heart diseasewith associated pulmonary hypertension in children:What are the minimal investigative procedures?Consensus statement from the congenital heart diseaseand pediatric task forces,pulmonary vascular research institute(PVRI)[J].Pulm Circ,2014,4(2):330-341.
[12]Candice K Silversides,Erwin Oechslin,Markus Schwerzmann,et al.Canadian cardiovascular society 2009 consensus conference on the management of adults with congenital heart disease:Complex congenital cardiac lesions[J].Can J Cardiol,2010,26(3):e98-e117.
[13]唐萍,王立中,杨戎威,等.先天性心脏病胎儿母血同型半胱氨酸水平与血脂相关性研究[J].中国优生与遗传杂志,2018,26(8):114-116.
[14]Werner Budts,Jolien Roos-Hesselink,Tanja R覿dle-Hurst,et al.Treatment ofheartfailure in adultcongenital heart disease:A position paper of the working group of grownup congenital heart diseaseand the heart failure association of the European society of cardiology[J].Eur Heart J,2016,37(18):1419-1427.
[15]袁远,徐燕,高旭光.匹伐他汀与阿托伐他汀对缺血性脑卒中患者血脂调控的临床对比研究[J].中华老年心脑血管病杂志,2013,15(10):1024-1026.
[16]张素玲.阿托伐他汀联合阿司匹林对急性缺血性脑卒中患者血脂及神经功能缺损程度的影响[J].河南医学研究,2016,25(9):1626-1627.
[17]吴秋珏,吕佳琪,王恬.母体营养不良对子代发育影响研究进展[J].动物医学进展,2011,32(6):123-126.
[18]王箭.广东地区孕妇的膳食营养状况及其与孕期血脂水平的关系研究[D].南方医科大学,2014.
[19]巴宏军,王慧深,张兴,等.妊娠期血脂紊乱与胎儿先天性心脏病发病关系探讨[J].中国实用儿科杂志,2016,31(8):612-614.
[20]许艳芳,莫芳贵.血脂异常患者单项血脂及血脂比值与心血管疾病的相关性分析[J].实验与检验医学,2018,36(1):58-60.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |