先天性心脏病危险因素和防治的研究进展
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摘要
先天性心脏病(先心病)发病率呈逐年上升趋势,已跃居我国出生缺陷的首位,成为影响婴幼儿和儿童身心健康及人口生存质量的重大公共卫生问题,给家庭和社会带来严重的精神和经济负担,因此通过研究先心病的病因和危险因素,开展人群筛查和防治措施,减少先心病的发生率,加强对先心病的救治,对提高我国人口素质具有战略意义。
Recently,the incidence of congenital heart disease is increasing year by which leapts to the top of Chinese birth defects.It has been a major public health problem that affecting physical and mental health of infants and the quality of life of the population,bringing serious mental and economic burdens to the family and society.Therefore,studing of etiology and risk factors of congenital heart disease will promote defect screening and prevention,as well as reduce the incidence of congenital heart disease,which is of strategic significance to improve the quality of the population.
Recently,the incidence of congenital heart disease is increasing year by which leapts to the top of Chinese birth defects.It has been a major public health problem that affecting physical and mental health of infants and the quality of life of the population,bringing serious mental and economic burdens to the family and society.Therefore,studing of etiology and risk factors of congenital heart disease will promote defect screening and prevention,as well as reduce the incidence of congenital heart disease,which is of strategic significance to improve the quality of the population.
引文
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[2]Krasuski RA,Bashore TM.Congenital heart disease epidemiology in the United States:Blindly feeling for the charging elephant.[J].Circulation,2016,134(2):110.
[3]Chen X,Zhao S,Yang X.OC12.03:A national survey of fetal congenital heart diseases in China[J].Ultrasound in Obstetrics&Gynecology,2015,66(16):C224-C224.
[4]Van Der Linde D,Konings EE,Slager MA,et al.Birth prevalence of congenital heart disease worldwide:a systematic review and meta-analysis[J].J Am Coll Cardiol,2011,58(21):2241-2247.
[5]马丹华,徐厚明,林宁,等.中国围产儿先天性心脏病危险因素Meta分析[J].南京医科大学学报:自然科学版,2014,59(9):1273-1278.
[6]吕茂霞,郑必海,颜有富,等.高海拔地区世居藏族先天性心脏病发病率筛查[J].齐齐哈尔医学院学报,2013,34(23):3515-3516.
[7]Liu FZ,Xue YM,Liao HT,et al.Five-year epidemiological survey of valvular heart disease:changes in morbidity,etiological spectrum and management in a cardiovascular center of Southern China[J].J Thorac Dis,2014,6(12):1724.
[8]Epstein JA.Franklin H,Epstein L.Cardiac development and implications for heart disease[J].N Engl J Med,2010,363(17):1638-1647.
[9]Johnson MC,Hing A,Wood MK,et al.Chromosome abnormalities in congenital heart disease[J].Am J Med Genet,1997,70(3):292-298.
[10]Schott JJ,Benson DW,Basson CT,et al.Congenital heart disease caused by mutations in the transcription factor NKX2-5[J].Science,1998,281(5373):108-111.
[11]Li QY,Newbury-Ecob RA,Terrett JA,et al.Holt-Oram syndrome is caused by mutations in TBX5,a member of the Brachyury(T)gene family[J].Nat Genet,1997,15(1):21-29.
[12]Delling FN,Vasan RS.Epidemiology and pathophysiology of mitral valve prolapse:new insights into disease progression,genetics,and molecular basis[J].Circulation,2014,129(21):2158-2170.
[13]Pierpont ME,Magoulas PL,Adi S,et al.Cardio-facio-cutaneous syndrome:Clinical features,diagnosis,and management guidelines[J].Pediatrics,2014,134(4):e1149-62.
[14]Roberts AE,Allanson JE,Tartaglia M,et al.Noonan syndrome[J].Lancet,2013,381(9863):333-342.
[15]Mori AD,Bruneau BG.TBX5 mutations and congenital heart disease:Holt-Oram syndrome revealed[J].Curr Opin Cardiol,2004,19(3):211-215.
[16]Cross SJ,Ching YH,Li QY,et al.The mutation spectrum in Holt-Oram syndrome[J].J Med Genet,2000,37(10):785-787.
[17]Penny DJ,Vick GW.Ventricular septal defect[J].Lancet,2011,377(9771):1103-1112.
[18]Geva T,Martins JD,Wald RM.Atrial septal defects[J].Lancet,2014,383(9932):1921-1932.
[19]Trevisan P,Rosa RF,Koshiyama DB,et al.Congenital heart disease and chromossomopathies detected by the karyotype[J].Rev Paul Pediatr,2014,32(2):262-271.
[20]Yan Y,Wu Q,Zhang L,et al.Detection of submicroscopic chromosomal aberrations by array-based comparative genomic hybridization in fetuses with congenital heart disease[J].Ultrasound Obstet Gynecol,2014,43(4):404-412.
[21]Gorini F,Chiappa E,Gargani L,et al.Potential effects of environmental chemical contamination in congenital heart disease[J].Pediatr Cardiol,2014,35(4):559-568.
[22]卢荣鑫,钟前进,冯永建.中国人群先天性心脏病发病危险因素的Meta分析[J].第三军医大学学报,2011,33(12):1265-1268.
[23]王珺,张振业,桂珂,等.母亲高龄与儿童先天性心脏病关系的Meta分析[J].现代预防医学,2015,42(7):1214-1216.
[24]Liu S,Joseph KS,Lisonkova S,et al.Association between maternal chronic conditions and congenital heart defects:a population-based cohort study[J].Circulation,2013,128(6):583-589.
[25]包艳娟,陈小伟,魏敏.三维和四维超声产前诊断胎儿心脏畸形的临床进展[J].医学综述,2011,17(9):1392-1395.
[26]Peterson C,Dawson A,Grosse SD,et al.Hospitalizations,costs,and mortality among infants with critical congenital heart disease:how important is timely detection?[J].Birth Defects Res A Clin Mol Teratol,2013,97(10):664-672.