雷公藤药理作用及临床应用研究进展
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摘要
雷公藤具有抗炎、免疫抑制、抗生育、抗肿瘤、抗菌、止痛作用,为目前临床研究热点,但因其毒副作用大阻碍了其临床应用,笔者主要阅读了近5年有关雷公藤药理作用及临床应用方面的国内外资料,发现近年雷公藤研究热点在肿瘤、免疫抗炎、神经退行性疾病等方面。笔者总结了近年国内外对雷公藤活性成分,药理作用、机制,临床应用以及不良反应方面的最新成果,通过多方面阐述,使对雷公藤有更全面的了解,促进其在临床上更安全有效的使用。
引文
[1]佚名.基于网络药理学方法的雷公藤药理、毒理机制研究[J].中国中西医结合杂志,2018,38(8):1006-1010.
[2]Menghuiyuan He,Bing Xie,Xiaohua Cai.Study on the resources of Tripterygium WilfordiiHook[D].Guizhou Minzu University,2016(5):62-68.
[3]钟点,陈渊,赵伟.雷公藤红素抗炎及免疫抑制的研究进展[J].药物生物技术,2018(1):64-69.
[4]Senyang Gao,Xiaoyan Wu,Yingying Zhang,et al.Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats.[J].International Immunopharmacology,2017(43):108-115.
[5]Yang Y,Ye Y,Qiu Q,et al.Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNKMAPK pathway[J].International Immunopharmacology,2016(41):8-16.
[6]Guo X,Xue M,Li C J,et al.Protectiveeffects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy[J].Journal of Ethnopharmacology,2016(193):333-344.
[7]乔尉真,曹曦,张志荣,等.巨噬细胞膜包裹的PEG-PLGA载雷公藤红素纳米粒靶向治疗重症急性胰腺炎的大鼠体内药效学研究[J].药学学报,2018(1):127-132.
[8]Keying Zhang,Chunkui Zhang,Jun Tang,et al.Triptolide(T10)rats improved CFA induced inflammatory pain by inhibiting activation of glial cells in the spinal cord of the mechanism of[J].Chinese Journal of neuroanatomy,2014(06):621-628.
[9]陶玲,管咏梅,陈丽华,等.雷公藤配伍减毒研究进展[J].中国实验方剂学杂志,2018(4):229-234.
[10]Wu J,Hong C,Pan H,et al.Medicinal Compound Celastrol As a Potential Clinical Anticancer Drug:Lessons Learned From Preclinical Studies[J].Clinical Cancer Drugs,2016,27(12):1970-1970.
[11]许阳贤,宋海燕,季光.雷公藤红素对肝癌细胞SMMC-7721凋亡和周期的调控作用及机制[J].中成药,2015(06):1153-1157.
[12]贾歌刘畅,庞晶瑶,马致洁,等.雷公藤肝毒性化学成分、毒性机制及减毒方法研究进展[J].中国药房,2016(13):1857-1861.
[13]熊智慧,周小青.雷公藤多苷成分测定的研究进展[J].世界最新医学信息文摘,2017,17(99):50-51,56.
[2]Menghuiyuan He,Bing Xie,Xiaohua Cai.Study on the resources of Tripterygium WilfordiiHook[D].Guizhou Minzu University,2016(5):62-68.
[3]钟点,陈渊,赵伟.雷公藤红素抗炎及免疫抑制的研究进展[J].药物生物技术,2018(1):64-69.
[4]Senyang Gao,Xiaoyan Wu,Yingying Zhang,et al.Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats.[J].International Immunopharmacology,2017(43):108-115.
[5]Yang Y,Ye Y,Qiu Q,et al.Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNKMAPK pathway[J].International Immunopharmacology,2016(41):8-16.
[6]Guo X,Xue M,Li C J,et al.Protectiveeffects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy[J].Journal of Ethnopharmacology,2016(193):333-344.
[7]乔尉真,曹曦,张志荣,等.巨噬细胞膜包裹的PEG-PLGA载雷公藤红素纳米粒靶向治疗重症急性胰腺炎的大鼠体内药效学研究[J].药学学报,2018(1):127-132.
[8]Keying Zhang,Chunkui Zhang,Jun Tang,et al.Triptolide(T10)rats improved CFA induced inflammatory pain by inhibiting activation of glial cells in the spinal cord of the mechanism of[J].Chinese Journal of neuroanatomy,2014(06):621-628.
[9]陶玲,管咏梅,陈丽华,等.雷公藤配伍减毒研究进展[J].中国实验方剂学杂志,2018(4):229-234.
[10]Wu J,Hong C,Pan H,et al.Medicinal Compound Celastrol As a Potential Clinical Anticancer Drug:Lessons Learned From Preclinical Studies[J].Clinical Cancer Drugs,2016,27(12):1970-1970.
[11]许阳贤,宋海燕,季光.雷公藤红素对肝癌细胞SMMC-7721凋亡和周期的调控作用及机制[J].中成药,2015(06):1153-1157.
[12]贾歌刘畅,庞晶瑶,马致洁,等.雷公藤肝毒性化学成分、毒性机制及减毒方法研究进展[J].中国药房,2016(13):1857-1861.
[13]熊智慧,周小青.雷公藤多苷成分测定的研究进展[J].世界最新医学信息文摘,2017,17(99):50-51,56.