健康成年男性血清睾酮水平对血脂代谢影响的初步研究
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摘要
目的初步探讨健康成年男性血清睾酮水平对血脂代谢等的影响。方法采用常规方法检测188例健康成年男性(素食者86例,杂食者102例)血脂等生化指标及睾酮水平,用气相色谱法测定血浆磷脂脂肪酸构成。结果睾酮与总蛋白、前白蛋白、总胆固醇、低密度脂蛋白胆固醇无显著性相关(P>0.05),与白蛋白、肌酐、高密度脂蛋白胆固醇呈显著正相关(P<0.05),与甘油三酯、尿酸、尿素、葡萄糖、血浆硬脂酸(C18:00)、γ-亚麻酸(C18:3n-6)和顺-11-二十烯酸(C20:1n-9)呈显著负相关(P<0.05);睾酮、白蛋白、甘油三酯、硬脂酸(C18:00)在杂食组与素食组间差异无统计学意义(P>0.05)。结论睾酮广泛参与血脂等的代谢,其对甘油三酯水平和血浆硬脂酸(C18:00)含量的影响大于饮食脂肪摄入对其的影响,关注睾酮水平及补充睾酮治疗可能对血脂等代谢相关疾病具有积极意义。
Objective To observe the influence of testosterone level on lipid metabolism in healthy adult males. Methods The levels of lipid and testosterone of 188 healthy adult males(86 vegetarians, 102 omnivores) were tested by routine method, and the construction of plasma phospholipid fatty acids was tested by gas chromatographic method. Results Testosterone had no significant correlation with serum total albumin, prealbumin, total cholesterol and low density lipoprotein cholesterol(P>0.05), and significantly positive correlation with albumin, creatinine, and high density lipoprotein cholesterol(P<0.05), while it had negative correlation with triglyceride, uric acid, urea, glucose, plasma stearic acid(C18:00), γ-linolenic acid(C18:3 n-6) and cis-11-Eicosenoic acid(C20:1 n-9)(P<0.05). The differences of testosterone, albumin, triglyceride and stearic acid(C18:00) were not statistically significant between vegetarian group and omnivorous group(P>0.05). Conclusion Testosterone participates in lipid metabolism and influence triglyceride as well as stearic acid(C18:00) deeper than lipid intake. And it will be of high value to pay attention to the testosterone level and testosterone administration for lipid metabolic disorders.
Objective To observe the influence of testosterone level on lipid metabolism in healthy adult males. Methods The levels of lipid and testosterone of 188 healthy adult males(86 vegetarians, 102 omnivores) were tested by routine method, and the construction of plasma phospholipid fatty acids was tested by gas chromatographic method. Results Testosterone had no significant correlation with serum total albumin, prealbumin, total cholesterol and low density lipoprotein cholesterol(P>0.05), and significantly positive correlation with albumin, creatinine, and high density lipoprotein cholesterol(P<0.05), while it had negative correlation with triglyceride, uric acid, urea, glucose, plasma stearic acid(C18:00), γ-linolenic acid(C18:3 n-6) and cis-11-Eicosenoic acid(C20:1 n-9)(P<0.05). The differences of testosterone, albumin, triglyceride and stearic acid(C18:00) were not statistically significant between vegetarian group and omnivorous group(P>0.05). Conclusion Testosterone participates in lipid metabolism and influence triglyceride as well as stearic acid(C18:00) deeper than lipid intake. And it will be of high value to pay attention to the testosterone level and testosterone administration for lipid metabolic disorders.
引文
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[24] Kelly DM,Akhtar S,Sellers DJ,et al.Testosterone differentially regulates targets of lipid and glucose metabolism in liver,muscle and adipose tissues of the testicular feminised mouse[J].Endocrine,2016,54(2):504-515.
[2] Shores MM,Matsumoto AM.Testosterone,aging and survival:biomarker or deficiency[J].Curr Opin Endocrinol Diabetes Obes,2014,21(3):209-216.
[3] Tuck SP,Francis RM.Testosterone,bone and osteoporosis[J].Front Horm Res,2009,37:123-132.
[4] Yeap BB.Testosterone and cardiovascular disease risk[J].Curr Opin Endocrinol Diabetes Obes,2015,22(3):193-202.
[5] Ruige JB,Mahmoud AM,De Bacquer D,et al.Endogenous testosterone and cardiovascular disease in healthy men:a meta-analysis [J].Heart,2011,97(11):870-875.
[6] Herring MJ,Oskui PM,Hale SL,et al.Testosterone and the cardiovascular system:a comprehensive review of the basic science literature[J].J Am Heart Assoc,2013,2(4):e000271.
[7] Liao CH,Lin FY,Wu YN,et al.Androgens inhibit tumor necrosis factor-alpha-induced cell adhesion and promote tube formation of human coronary artery endothelial cells[J].Steroids,2012,77(7):756-764.
[8] Kaplan SA,Johnson-Levonas AO,Lin J,et al.Elevated high sensitivity C-reactive protein levels in aging men with low testosterone[J].Aging Male,2010,13(2):108-112.
[9] Singh R,Artaza JN,Taylor WE,et al.Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway[J].Endocrinology,2003,144(11):5081-5088.
[10] Birzniece V.Hepatic actions of androgens in the regulation of metabolism[J].Curr Opin Endocrinol Diabetes Obes,2018,25(3):201-208.
[11] Monroe AK,Dobs AS.The effect of androgens on lipids[J].Curr Opin Endocrinol Diabetes Obes,2013,20(2):132-139.
[12] Pham NH,Bena J,Bhatt DL,et al.Increased free testosterone levels in men with uncontrolled type 2 diabetes five years after randomization to bariatric surgery [J].Obes Surg,2018,28 (1):277-280.
[13] Smith MR.Obesity and sex steroids during gonadotropin-releasing hormone agonist treatment for prostate cancer[J].Clin Cancer Res,2007,13(1):241-245.
[14] Santosa S,Bush NC,Jensen MD.Acute testosterone deficiency alters adipose tissue fatty acid storage[J].J Clin Endocrinol Metab,2017,102(8):3056-3064.
[15] Agledahl I,Skjaerpe PA,Hansen JB,et al.Low serum testosterone in men is inversely associated with non-fasting serum triglycerides:the Tromso study[J].Nutr Metab Cardiovasc Dis,2008,18(4):256-262.
[16] Makinen JI,Perheentupa A,Irjala K,et al.Endogenous testosterone and serum lipids in middle-aged men[J].Atherosclerosis,2008,197(2):688-693.
[17] Hartgens F,Kuipers H.Effects of androgenic-anabolic steroids in athletes[J].Sports Med,2004,34(8):513-554.
[18] Birzniece V,Meinhardt UJ,Handelsman DJ,et al.Testosterone stimulates extra-hepatic but not hepatic fat oxidation (Fox):comparison of oral and transdermal testosterone administration in hypopituitary men[J].Clin Endocrinol (Oxf),2009,71(5):715-721.
[19] Mínguez-Alarcón L,Chavarro J,Mendiola J,et al.Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men[J].Asian J Androl,2017,19(2):184.
[20] Lam T,Poljak A,McLean M,et al.Testosterone prevents protein loss via the hepatic urea cycle in human[J].Eur J Endocrinol,2017,176(4):489-496.
[21] Shuprovych AA,Hurina NM,Korpacheva-Zinych OV.Disorders of uric acid metabolism in rats with fructose-induced experimental insulin resistance syndrome[J].Fiziol Zh,2011,57 (1):72-81.
[22] Hurina NM,Korpacheva-Zinych OV,Shuprovych AA.Interrelations of uric acid metabolism indices with insulin and testosterone levels in men with type 2 diabetes[J].Fiziol Zh,2010,56(6):93-99.
[23] Pitteloud N,Mootha VK,Dwyer AA,et al.Relationship between testosterone levels,insulin sensitivity,and mitochondrial function in men[J].Diabetes Care,2005,28(7):1636-1642.
[24] Kelly DM,Akhtar S,Sellers DJ,et al.Testosterone differentially regulates targets of lipid and glucose metabolism in liver,muscle and adipose tissues of the testicular feminised mouse[J].Endocrine,2016,54(2):504-515.