中药对细菌生物被膜作用机制的研究进展
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摘要
如今越来越多耐药细菌的出现,对于细菌耐药的研究显得更为迫切,而现今的研究已经发现细菌的生物被膜是其耐药作用的一个独特机制。许多中药被发现对于细菌的生物被膜具有抑制作用,是细菌耐药性研究中一个独特的研究领域。通过查阅分析国内外有关中药对细菌生物被膜抗菌作用的文献,从细菌生物被膜形成过程、细菌生物被膜的耐药机制以及中药对于细菌生物被膜的作用等方面进行综述,为进一步研究中药的抗菌作用提供参考。
With the emergence of more and more drug-resistant bacteria, the research on bacterial resistance is much more urgent, and many researchers have found that the biofilm of bacteria is a unique mechanism of its drug resistance. Many traditional Chinese medicine have been found to inhibit the biofilm of bacteria and provoked unique research field in bacterial resistance. By consulting and analyzing the local and international researches on the antibacterial effect of traditional Chinese medicine on bacterial biofilms,from aspects of bacterial biofilm formation process, biofilm resistance mechanism as well as how traditional Chinese medicine affecting biofilms, to provide references for further researches on antibacterial action of traditional Chinese medicine.
With the emergence of more and more drug-resistant bacteria, the research on bacterial resistance is much more urgent, and many researchers have found that the biofilm of bacteria is a unique mechanism of its drug resistance. Many traditional Chinese medicine have been found to inhibit the biofilm of bacteria and provoked unique research field in bacterial resistance. By consulting and analyzing the local and international researches on the antibacterial effect of traditional Chinese medicine on bacterial biofilms,from aspects of bacterial biofilm formation process, biofilm resistance mechanism as well as how traditional Chinese medicine affecting biofilms, to provide references for further researches on antibacterial action of traditional Chinese medicine.
引文
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[12]Li Y H,Zhou Y H,Ren Y Z,et al.Inhibition of Streptococcus suis adhesion and biofilm formation in vitro by water extracts of Rhizoma Coptidis[J].Front Pharmacol,2018,9:371.
[13]He J,Wang S,Wu T,et al.Effects of ginkgoneolic acid on the growth,acidogenicity,adherewnce,and biofilm of Streptococcus mutans in vitro[J].Folia Microbiol(Praha),2013,58(2):147-153.
[14]Wang T,Huang W,Duan Q,et al.Sodium houttuyfonate in vitro inhibits biofilm dispersion and expression of bdlAin Pseudomonas aeruginosa[J].Mol Biol Rep,2018,46(1):471-477.
[15]Shao J,Cheng H,Wang C,et al.A phytoantieipin derivative,sodiu houttuyfonate,induces in vitro synergisticeffects with levofloxacin against biofilm formation by Pseudomonas aeruginosa[J].Molecules,2012,17(9):1242-1254.
[16]Zeng Z,Qian L,Cao L,et al.Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa[J].Appl Microbiol Biotechnol,2008,79(1):119-126.
[17]申凤鸽.甘草查耳酮A抗金黄色葡萄球菌生物被膜的分子机制初步研究[D].长春:吉林大学,2013.
[18]卢佳琨.败酱草中黄酮类化合物的提取及其抗氧化活性[D].锦州:渤海大学,2013.
[19]王业梅,程惠娟.连翘苷对铜绿假单胞菌黏附功能及生物被膜形成能力的影响[J].中成药,2013,35(4):832-834.
[20]向丽,李蓉,周铁军,等.五倍子鞣质对生物被膜型白假丝酵母的干预作用[J].安徽农业科学,2012,40(27):13262-13264,13269.
[2]Wang W D,Zhang N N,Chanda W,et al.Antibacterial and anti-biofilm activity of the lipid extract from Mantidis ootheca on Pseudomonas aeruginosa[J].J Zhejiang Univ Sci B,2018,19(5):364-371.
[3]张忠斌,高天,丁文雅,等.大黄提取物对猪链球菌生物被膜的消除作用[J].黑龙江医药,2016,29(6):1056-1058.
[4]郭冰怡,董燕红.细菌群体感应抑制剂研究进展[J].农药学学报,2018,20(4):408-424.
[5]Ding T,Li T,Li J.Identification of natural product compounds as quorum sensing inhibitors in Pseudomonas fluorescens P07 through virtual screening[J].Bioorg Med Chem,2018,26(14):4088-4099.
[6]Luo J,Dong B,Wang K,et al.Baicalin inhibits biofilm formation,attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model[J].PLo SOne,2017,12(4):e0176883.
[7]陈思敏.穿心莲内酯干预铜绿假单胞菌形成及系统相关基因表达的实验研究[D].成都:成都中医药大学,2013.
[8]吕子敏,邓丽,廖芳,等.原白头翁素对铜绿假单胞菌群体感应系统调控的毒力因子表达量的影响[J].现代药物与临床,2013,28(2):155-159.
[9]Fu B,Wu Q,Dang M,et al.Inhibition of Pseudomonas aeruginosa biofilm formation by traditional Chinese medicinal herb Herba Patriniae[J].Biomed Res Int,2017:9584703.
[10]Zhong H,Hu D D,Hu G H,et al.Activity of sanguinarine against Candida albicans biofilms[J].Antimicrob Agents Chemother,2017,61(5):e02259-16.
[11]Wajima T,Anzai Y,Yamada T,et al.Oldenlandia diffusa extract inhibits biofilm formation by haemophilus influenzae clinical isolates[J].PLo S One,2016,11(11):e0167335.
[12]Li Y H,Zhou Y H,Ren Y Z,et al.Inhibition of Streptococcus suis adhesion and biofilm formation in vitro by water extracts of Rhizoma Coptidis[J].Front Pharmacol,2018,9:371.
[13]He J,Wang S,Wu T,et al.Effects of ginkgoneolic acid on the growth,acidogenicity,adherewnce,and biofilm of Streptococcus mutans in vitro[J].Folia Microbiol(Praha),2013,58(2):147-153.
[14]Wang T,Huang W,Duan Q,et al.Sodium houttuyfonate in vitro inhibits biofilm dispersion and expression of bdlAin Pseudomonas aeruginosa[J].Mol Biol Rep,2018,46(1):471-477.
[15]Shao J,Cheng H,Wang C,et al.A phytoantieipin derivative,sodiu houttuyfonate,induces in vitro synergisticeffects with levofloxacin against biofilm formation by Pseudomonas aeruginosa[J].Molecules,2012,17(9):1242-1254.
[16]Zeng Z,Qian L,Cao L,et al.Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa[J].Appl Microbiol Biotechnol,2008,79(1):119-126.
[17]申凤鸽.甘草查耳酮A抗金黄色葡萄球菌生物被膜的分子机制初步研究[D].长春:吉林大学,2013.
[18]卢佳琨.败酱草中黄酮类化合物的提取及其抗氧化活性[D].锦州:渤海大学,2013.
[19]王业梅,程惠娟.连翘苷对铜绿假单胞菌黏附功能及生物被膜形成能力的影响[J].中成药,2013,35(4):832-834.
[20]向丽,李蓉,周铁军,等.五倍子鞣质对生物被膜型白假丝酵母的干预作用[J].安徽农业科学,2012,40(27):13262-13264,13269.