中国组织工程基础研究实力:基于文献计量学的分析
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摘要
背景:组织工程的发展具有极大的社会意义及经济意义,了解中国在该领域的研究实力,能够为相应的发展策略制定提供参考。目的:评价中国在组织工程领域的基础研究实力。方法:采用MESH主题词联合自由词在PubMed数据库中检索组织工程基础研究论文和顶尖论文。以全球为背景,基于论文数量、论文数量增速和顶尖论文数量及占比,从基础研究规模、增速和质量等角度分析中国在组织工程领域的基础研究实力。另外,通过论文量多少判断中国与全球的研究热点子领域。结果与结论:(1)组织工程领域发文量排名前5位的国家依次是美国、中国、日本、德国和英国,中国在该领域的论文总数达17031篇,仅次于美国;(2)中国论文数量的年复合增长率为19.9%,顶尖论文数量为195篇,在前5强国中分别排首位和末位。中国8家机构的发文量进入全球前30位,其发文量平均增速为21.2%,显著高于全球前30位机构的平均增速14.2%(P <0.001),但中国机构的顶尖论文产出较少,顶尖论文比例显著低于前30位机构平均水平(2.0%,5.2%,P=0.002);(3)从学者来看,中国有5名研究者的发文量进入全球前25位;(4)中国在组织工程领域的研究集中在骨和软骨、神经、肝脏、皮肤、心脏及眼等子领域,与全球一致;(5)结果显示,中国在组织工程与再生医学领域的基础研究竞争力强,规模大且增速快,已积累了一定数量的顶尖研究成果,但比例仍较低;众多中国机构和中国学者在组织工程与再生医学领域基础研究竞争中跻身全球前列且发展势头强劲,顶尖研究成果数量仍有上升空间;建议在重视转化和临床需求引导的情况下注重材料科学等基础学科的发展,为组织工程领域发展奠定基础。
BACKGROUND: The development of tissue engineering is of great social and economic significance. Understanding the current status of basic research in this field can provide reference for developing corresponding development strategies. OBJECTIVE: To evaluate China's basic research current status in the field of tissue engineering. METHODS: A computer-based online search of Pubmed was performed to retrieve basic research papers and top papers in the field of tissue engineering using search terms MESH terms AND free-text word. In the context of global background, China's ability of basic research in the field of tissue engineering was analyzed based on the number of papers, the growth of the number of papers, the number and proportion of top papers. In addition, the number of papers was used to identify the global research hotspots in the field of tissue engineering. RESULTS AND CONCLUSION: The top five countries in the field of tissue engineering were the United States, China, Japan, Germany and the United Kingdom. The total number of papers in this field published by Chinese scholars reached 17,031, second only to the United States. The compound annual growth rate of the number of papers was 19.9%, and the number of top papers was 195, ranking first and last among the top five countries, respectively. Eight Chinese institutions ranked top 30 in the number of papers in this field, with an average growth rate of 21.2%, far higher than that of all the top 30 institutions in the world(21.2% vs. 14.2, P < 0.001). However, Chinese institutions produced fewer top papers as compared to other top institutions, with the proportion of top papers significantly lower than that of the average level of the top 30 institutions(2.0% vs. 5.2%; P=0.002). There were five Chinese researchers whose total publications entered top 25 of the world. China's research in tissue engineering focuses on the areas of bone and cartilage, nerves, liver, skin, heart and eye tissue engineering, which is consistent with the global status. China's basic research in the field of tissue engineering ranks second in the world and expands rapidly in recent years. A number of academic institutions and individuals with great achievements have emerged. However, China's research quality in this field is relatively low as compared to other top institutions. It is suggested to guide researchers to pay more attention to the quality and transformation of research output, and to support the development of basic subjects such as material science to lay a good foundation for the development of tissue engineering in China.
BACKGROUND: The development of tissue engineering is of great social and economic significance. Understanding the current status of basic research in this field can provide reference for developing corresponding development strategies. OBJECTIVE: To evaluate China's basic research current status in the field of tissue engineering. METHODS: A computer-based online search of Pubmed was performed to retrieve basic research papers and top papers in the field of tissue engineering using search terms MESH terms AND free-text word. In the context of global background, China's ability of basic research in the field of tissue engineering was analyzed based on the number of papers, the growth of the number of papers, the number and proportion of top papers. In addition, the number of papers was used to identify the global research hotspots in the field of tissue engineering. RESULTS AND CONCLUSION: The top five countries in the field of tissue engineering were the United States, China, Japan, Germany and the United Kingdom. The total number of papers in this field published by Chinese scholars reached 17,031, second only to the United States. The compound annual growth rate of the number of papers was 19.9%, and the number of top papers was 195, ranking first and last among the top five countries, respectively. Eight Chinese institutions ranked top 30 in the number of papers in this field, with an average growth rate of 21.2%, far higher than that of all the top 30 institutions in the world(21.2% vs. 14.2, P < 0.001). However, Chinese institutions produced fewer top papers as compared to other top institutions, with the proportion of top papers significantly lower than that of the average level of the top 30 institutions(2.0% vs. 5.2%; P=0.002). There were five Chinese researchers whose total publications entered top 25 of the world. China's research in tissue engineering focuses on the areas of bone and cartilage, nerves, liver, skin, heart and eye tissue engineering, which is consistent with the global status. China's basic research in the field of tissue engineering ranks second in the world and expands rapidly in recent years. A number of academic institutions and individuals with great achievements have emerged. However, China's research quality in this field is relatively low as compared to other top institutions. It is suggested to guide researchers to pay more attention to the quality and transformation of research output, and to support the development of basic subjects such as material science to lay a good foundation for the development of tissue engineering in China.
引文
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[20]孙晓北.组织工程及其我国发展问题对策研究[D].北京:中国协和医科大学,2009.
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[26]Wu C,Zhou Y,Xu M,et al.Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity,osteostimulation and antibacterial activity.Biomaterials.2013;34(2):422-433.
[27]郝文丽,张平,吴训伟.组织工程皮肤的现状和展望[J].北京生物医学工程,2016,35(1):94-99.
[2]王莉莎,贾红春.对临床康复、组织工程、再生医学学科定义以及相关内涵的认识与理解[J].中国组织工程研究与临床康复,2007,11(5):801-806.
[3]Langer R.Perspectives and challenges in tissue engineering and regenerative medicine.Adv Mater.2009;21(32-33):3235-3236.
[4]Atala A.Organ preservation,organ and cell transplantation,tissue engineering,and regenerative medicine:the terms may change,but the goals remain the same.Tissue Eng Part A.2014;20(3-4):445-446.
[5]Atala A.Tissue engineering and regenerative medicine:concepts for clinical application.Rejuvenation Res.2004;7(1):15-31.
[6]Liu W,Cao Y.Translational Research of Tissue Engineering in China.Tissue Eng Part A.2019;25(7-8):518-521.
[7]Caplan AI.Tissue Engineering:Then,Now and the Future.Tissue Eng Part A.2019;25(7-8):515-517.
[8]Milne CP,Kaitin KI.Challenge and Change at the Forefront of Regenerative Medicine.Clin Ther.2018;40(7):1056-1059.
[9]Trommelmans L.The challenge of regenerative medicine.Hastings Cent Rep.2010;40(6):24-26.
[10]王正国.中国再生医学研究现状及展望[J].中国实用内科杂志,2012,32(8):561-564.
[11]谭谦.再生医学与组织工程[J].医学研究生学报,2011,24(2):113-116.
[12]石颖.从国际顶级期刊的论文发表看广东省基础研究的水平与影响力[J].现代情报,2014,34(1):69-73.
[13]吴国雄,赵庚新.基于SCI论文的海峡两岸基础研究领域合作状况研究[J].中国基础科学,2013,15(2):36-41.
[14]李国栋.基于SCI论文产出的我国基础研究比较分析[J].北华航天工业学院学报,2010,20(4):21-23.
[15]陈娟,贾晓峰.我国医学基础理论研究水平、学科分布及趋势分析[J].中华医学科研管理杂志,2015,28(6):453-456,460.
[16]Bornmann L,Daniel HD.Selecting scientific excellence through committee peer review-A citation analysis of publications previously published to approval or rejection of post-doctoral research fellowship applicants.Scientometrics.2006;68(3):427-440.
[17]刘雪立.基于Web of Science和ESI数据库高被引论文的界定方法[J].中国科技期刊研究,2012,23(6):975-978.
[18]池慧,欧阳昭连.中国医疗器械创新力发展报告[M].北京:科学出版社,2018.
[19]陈娟,张婷,欧阳昭连.我国医疗器械领域基础研究态势分析[J].医疗卫生装备,2019,40(1):69-72.
[20]孙晓北.组织工程及其我国发展问题对策研究[D].北京:中国协和医科大学,2009.
[21]陈兆莹.关于科技评价和科技评价改革的讨论[J].科学通报,2018,63(7):611-617.
[22]王海燕,张昕妍.我国科技评价体系改革的困境与对策[J].中国软科学,2018,33(4):10-17.
[23]Gu X,Ding F,Yang Y,et al.Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration.Prog Neurobiol.2011;93(2):204-230.
[24]曹谊林.“耳郭软骨组织工程的研究进展”点评[J].中国眼耳鼻喉科杂志,2018,18(4):238-239.
[25]刘宁华,张天宇.耳郭软骨组织工程的研究进展[J].中国眼耳鼻喉科杂志,2018,18(4):234-237.
[26]Wu C,Zhou Y,Xu M,et al.Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity,osteostimulation and antibacterial activity.Biomaterials.2013;34(2):422-433.
[27]郝文丽,张平,吴训伟.组织工程皮肤的现状和展望[J].北京生物医学工程,2016,35(1):94-99.
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