多种药物中毒患者的药学监护
摘要
目的通过临床药师对1例地西泮、氨氯地平、水银中毒、割腕患者的药学监护,小结临床药师参与多种药物中毒救治中的工作。方法临床药师参与查房,查阅中毒、感染相关文献,参与制定治疗方案,提出药物调整建议,实施药学监护。结果患者住院8 d,病情显著好转,未发生明显药物不良反应。结论临床药师参与患者诊疗过程,从药学的角度提供治疗建议,能够提高药物治疗疗效与安全性。
引文
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[3] SPASOVA A P,LOGINOV A V,JUROVICKIJ V L,et al.Acase of severe amlodipine poisoning[J].Anesteziol Reanimatol,2015,60(6):61-64.
[4] 钟皎,赵霞.氨氯地平过量致中毒文献综合分析[J].中国药业,2015,24(15):58-60.
[5] DJORDJEVIC C,JOVIC-STOSIC J,KILIBARDA V,et al.Determination of flumazenil in serum by liquid chromatography-mass spectrometry:application to kinetics study in acute diazepam overdose[J].Vojnosanit Pregl,2016,73(2):146-151.
[6] NAHA K,SURYANARAYANA J,AZIZ R A,et al.Amlodipine poisoning revisited:acidosis,acute kidney injury and acute respiratory distress syndrome[J].Indian J Crit Care Med,2014,18(7):467-469.
[7] WOOD D M,WRIGHT K D,JONES A L,et al.Metaraminol (Aramine) in the management of a significant amlodipine overdose[J].Hum Exp Toxicol,2005,24(7):377-381.
[8] 谢悦良,彭玥,董李晨,等.临床药师参与大剂量左旋氨氯地平中毒解救的药学实践[J].中国医院药学杂志,2015,35(4):350-354.
[9] JANG D H,NELSON L S,HOFFMAN R S.Methylene blue in the treatment of refractory shock from an amlodipine overdose[J].Ann Emerg Med,2011,58(6):565-567.
[10] 毛国合,张喜英,张志坚.大剂量苯磺酸氨氯地平急性中毒死亡一例报道并文献复习[J].海南医学,2015,43(5):765-766.
[11] 何怀武,刘大为.血浆置换抢救难治重症氨氯地平过量中毒一例[J].中华医学杂志,2010,90(5):359-360.
[12] ST-ONGE M,DUBéP A,GOSSELIN S,et al.Treatment for calcium channel blocker poisoning:a systematic review[J].Clin Toxicol (Phila),2014,52(9):926-944.
[13] GARG S K,GOYAL P K,KUMAR R,et al.Management of life-threatening calcium channel blocker overdose with continuous veno-venous hemodiafiltration with charcoal hemoperfusion[J].Indian J Crit Care Med,2014,18(6):399-401.
[14] 罗婷,魏日胞,贾楠,等.汞中毒相关膜性肾病的临床治疗并文献复习[J].中国药物应用与监测,2013,10(6):355-358.
[15] BERNHOFT R A.Mercury toxicity and treatment:a review of the literature[J].J Environ Public Health,2012,2012:460508.
[16] MO T,SUN S,WANG Y,et al.Mercury poisoning caused by Chinese folk prescription (CFP):a case report and analysis of both CFP and quackery[J].Medicine (Baltimore),2016,95(44):e5162.
[17] STANEK E J,NELSON C E,DENOFRIO D.Amlodipine overdose[J].Ann Pharmaco ther,1997,31 (7-8):853-856.
[18] ELLIE J C,GOLDSTEIND M,CITRONK L,et al.In vitro activity of biapenem plus RPX7009,a carbapenem combined with a serine β-lactamase Inhibitor,against anaerobic bacteria[J].Antimicrob Agents Chemother,2013,57(6):2620-2630.