维生素B_(12)与糖尿病的相关性研究进展
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摘要
维生素B_(12)(VitB_(12))是人类必需的维生素之一,参与DNA合成和细胞代谢。诸多研究表明VitB_(12)的缺乏与糖尿病及其并发症的发生、发展密切相关。因此,定期的检测与合理的补充VitB_(12)有助于防治糖尿病并发症。文章主要就VitB_(12)与糖尿病的相关性及VitB_(12)在糖尿病患者中的应用进展综述。
Vitamin B_(12)(VitB_(12))is one of the essential vitamins in humans and is involved in DNA synthesis and cellular metabolism. Many studies have shown that the lack of VitB_(12) is closely related to the occurrence and development of diabetes and its complications. Therefore,regular testing and reasonable supplementation of VitB_(12) can help prevent diabetes complications. The article reviews the relationship between VitB_(12) and diabetes as well as the application of VitB_(12) in diabetic patients.
Vitamin B_(12)(VitB_(12))is one of the essential vitamins in humans and is involved in DNA synthesis and cellular metabolism. Many studies have shown that the lack of VitB_(12) is closely related to the occurrence and development of diabetes and its complications. Therefore,regular testing and reasonable supplementation of VitB_(12) can help prevent diabetes complications. The article reviews the relationship between VitB_(12) and diabetes as well as the application of VitB_(12) in diabetic patients.
引文
[1]马芳菲,李婷,单梦婷,等.二甲双胍对2型糖尿病大鼠骨骼肌Toll样受体/髓样分化因子88信号通路的影响及机制[J].医学研究生学报,2018,31(8):813-817.
[2]张树光,严杰,孙玉娇,等.中青年2型糖尿病患者规律运动行为的阶段分布及其影响因素[J].医学研究生学报,2018,31(9):957-961.
[3]Briani C,Dalla Torre C,Citton V,et al.Cobalamin deficiency:clinical picture and radiological findings[J].Nutrients,2013,5(11):4521-4539.
[4]Hunger M,Wurst K,Krautler B.Synthesis,solution and crystal structure of the coenzyme B(12)analogue Co(beta)-2'-fluoro-2',5'-dideoxyadenosylcobalamin[J].J Inorg Biochem,2015,148(6):2-8.
[5]Green R.Vitamin B 12:Physiology,Dietary Sources,and Requirements[J].Ency Hum Nutr,2013,11(1):351-356.
[6]Khan A,Shafiq`I,Shah MH.Prevalence of Vitamin B12 Deficiency in Patients with Type II Diabetes Mellitus on Metformin:A Study from Khyber Pakhtunkhwa[J].Cureus,2017,9(8):e1577.
[7]Lai JS,Pang WW,Cai S,et al.High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus[J].Clin Nutr,2018,37(3):940-944.
[8]Knight BA,Shields BM,Brook A,et al.Lower Circulating B12Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population[J].Plos One,2015,10(8):e0135268.
[9]Zheng LD,Linarelli LE,Liu L,et al.Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans[J].Clin Epigenetics,2015,7(1):60.
[10]Adaikalakoteswari A,Vatish M,Alam MT,et al.Low vitamin B12 in pregnancy is associated with adipose derived circulating miRs targeting PPARγand insulin resistance[J].J Clin Endocrinol Metab,2017,102(11):4200-4209.
[11]Krishnaveni GV,Hill JC,Veena SR,et al.Low plasma vitamin B12 in pregnancy is associated with gestational‘diabesity’and later diabetes[J].Diabetologia,2009,52(11):2350-2358.
[12]董美娟,刘媛媛,姚迪,等.初诊2型糖尿病患者血清维生素D及胰岛素抵抗与炎症因子关系[J].医学研究生学报,2017,30(10):1057-1060.
[13]Plows JF,Budin F,Andersson RAM,et al.The Effects of MyoInositol and B and D Vitamin Supplementation in the db/+Mouse Model of Gestational Diabetes Mellitus[J].Nutrients,2017,9(2):141.
[14]Guariguata L,Linnenkamp U,Beagley J,et al.Global estimates of the prevalence of hyperglycaemia in pregnancy[J].Diabetes Res Clin Pract,2014,103(2):176-185.
[15]Sukumar N,Venkataraman H,Wilson S,et al.Vitamin B12Status among Pregnant Women in the UK and Its Association with Obesity and Gestational Diabetes[J].Nutrients,2016,8(12):768.
[16]Tian G,Jing W,Mei Y,et al.Serum homocysteine level and gestational diabetes mellitus:A meta-analysis[J].J Diabetes Investig,2015,7(4):622-628.
[17]Katre P,Bhat D,Lubree H,et al.Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status[J].Asia Pac J Clin Nutr,2010,19(3):335-343.
[18]Ahmed MA.Metformin and Vitamin B12 Deficiency:Where Do We Stand?[J].J Pharm Pharm Sci,2016,19(3):382-398.
[19]Chapman LE,Darling AL,Brown JE.Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes:A systematic review and meta-analysis[J].Diabetes Metab,2016,42(5):316-327.
[20]Gupta K,Jain A,Rohatgi A.An observational study of vitamin b12 levels and peripheral neuropathy profile in patients of diabetes mellitus on metformin therapy[J].Diabetes Metab Syndr,2018,12(1):51.
[21]Ko SH,Ko SH,Ahn YB,et al.Association of Vitamin B12 Deficiency and Metformin Use in Patients with Type 2 Diabetes[J].J Korean Med Sci,2014,29(7):965.
[22]Wang D,Zhai JX,Liu DW.Serum folate,vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes:A metaanalysis[J].Mol Cell Endocrinol,2017,443:72-79.
[23]American Diabetes.A.9.Pharmacologic Approaches to Glycemic Treatment[J].Diabetes Care,2017,40(1):S90-S102.
[24]Teresa SC,Paloma GE,Rosario RF,et al.Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency:a pragmatic,randomised,multicentre,non-inferiority clinical trial undertaken in the primary healthcare setting(Project OB12)[J].Bmc Public Health,2012,12(1):1-11.
[25]Vidal-alaball J,Butler C,Cannings-john R,et al.Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency[J].Fam Pract,2006,23(3):279-285.
[26]Vinik AI,Nevoret ML,Casellini C,et al.Diabetic neuropathy[J].Endocrinol Metab Clin North Am,2013,42(4):747-787.
[27]Ahmed MA,George M,Paul R.Vitamin B12 deficiency in metformin-treated type-2 diabetes patients,prevalence and association with peripheral neuropathy[J].Bmc Pharmacol Toxicol,2016,17(1):44.
[28]Fotiou P,Raptis A,Apergis G,et al.Vitamin status as a determinant of serum homocysteine concentration in type 2 diabetic retinopathy[J].J Diabetes Res,2015,2014(16):807209.
[29]Satyanarayana A,Balakrishna N,Pitla S,et al.Status of B-Vitamins and Homocysteine in Diabetic Retinopathy:Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia[J].Plos One,2011,6(11):e26747.
[30]Smolek MK,Notaroberto NF,Jaramillo AG,et al.Intervention with vitamins in patients with nonproliferative diabetic retinopathy:a pilot study[J].Clin Ophthalmol,2013,7:1451-1458.
[31]Kwok T,Lee J,Ma RC,et al.A randomized placebo controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B12[J].Clin Nutr,2017,36(6):1509-1515.
[32]潘玉萍,李树德,邹英鹰.NF-κB及其相关因子与糖尿病认知功能障碍关系的研究进展[J].医学研究生学报,2016,29(7):754-758.
[33]Biemans E,Hart HE,Rutten GE,et al.Cobalamin status and its relation with depression,cognition and neuropathy in patients with type 2 diabetes mellitus using metformin[J].Acta Diabetol,2015,52(2):383-393.
[34]Fujita S,Kozawa J,Ishibashi C,et al.An Impaired Awareness of Hypoglycemia Improved After Vitamin B12Treatment in a Type 1 Diabetic Patient[J].Intern Med,2017,56(11):1383-1385.
[2]张树光,严杰,孙玉娇,等.中青年2型糖尿病患者规律运动行为的阶段分布及其影响因素[J].医学研究生学报,2018,31(9):957-961.
[3]Briani C,Dalla Torre C,Citton V,et al.Cobalamin deficiency:clinical picture and radiological findings[J].Nutrients,2013,5(11):4521-4539.
[4]Hunger M,Wurst K,Krautler B.Synthesis,solution and crystal structure of the coenzyme B(12)analogue Co(beta)-2'-fluoro-2',5'-dideoxyadenosylcobalamin[J].J Inorg Biochem,2015,148(6):2-8.
[5]Green R.Vitamin B 12:Physiology,Dietary Sources,and Requirements[J].Ency Hum Nutr,2013,11(1):351-356.
[6]Khan A,Shafiq`I,Shah MH.Prevalence of Vitamin B12 Deficiency in Patients with Type II Diabetes Mellitus on Metformin:A Study from Khyber Pakhtunkhwa[J].Cureus,2017,9(8):e1577.
[7]Lai JS,Pang WW,Cai S,et al.High folate and low vitamin B12 status during pregnancy is associated with gestational diabetes mellitus[J].Clin Nutr,2018,37(3):940-944.
[8]Knight BA,Shields BM,Brook A,et al.Lower Circulating B12Is Associated with Higher Obesity and Insulin Resistance during Pregnancy in a Non-Diabetic White British Population[J].Plos One,2015,10(8):e0135268.
[9]Zheng LD,Linarelli LE,Liu L,et al.Insulin resistance is associated with epigenetic and genetic regulation of mitochondrial DNA in obese humans[J].Clin Epigenetics,2015,7(1):60.
[10]Adaikalakoteswari A,Vatish M,Alam MT,et al.Low vitamin B12 in pregnancy is associated with adipose derived circulating miRs targeting PPARγand insulin resistance[J].J Clin Endocrinol Metab,2017,102(11):4200-4209.
[11]Krishnaveni GV,Hill JC,Veena SR,et al.Low plasma vitamin B12 in pregnancy is associated with gestational‘diabesity’and later diabetes[J].Diabetologia,2009,52(11):2350-2358.
[12]董美娟,刘媛媛,姚迪,等.初诊2型糖尿病患者血清维生素D及胰岛素抵抗与炎症因子关系[J].医学研究生学报,2017,30(10):1057-1060.
[13]Plows JF,Budin F,Andersson RAM,et al.The Effects of MyoInositol and B and D Vitamin Supplementation in the db/+Mouse Model of Gestational Diabetes Mellitus[J].Nutrients,2017,9(2):141.
[14]Guariguata L,Linnenkamp U,Beagley J,et al.Global estimates of the prevalence of hyperglycaemia in pregnancy[J].Diabetes Res Clin Pract,2014,103(2):176-185.
[15]Sukumar N,Venkataraman H,Wilson S,et al.Vitamin B12Status among Pregnant Women in the UK and Its Association with Obesity and Gestational Diabetes[J].Nutrients,2016,8(12):768.
[16]Tian G,Jing W,Mei Y,et al.Serum homocysteine level and gestational diabetes mellitus:A meta-analysis[J].J Diabetes Investig,2015,7(4):622-628.
[17]Katre P,Bhat D,Lubree H,et al.Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status[J].Asia Pac J Clin Nutr,2010,19(3):335-343.
[18]Ahmed MA.Metformin and Vitamin B12 Deficiency:Where Do We Stand?[J].J Pharm Pharm Sci,2016,19(3):382-398.
[19]Chapman LE,Darling AL,Brown JE.Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes:A systematic review and meta-analysis[J].Diabetes Metab,2016,42(5):316-327.
[20]Gupta K,Jain A,Rohatgi A.An observational study of vitamin b12 levels and peripheral neuropathy profile in patients of diabetes mellitus on metformin therapy[J].Diabetes Metab Syndr,2018,12(1):51.
[21]Ko SH,Ko SH,Ahn YB,et al.Association of Vitamin B12 Deficiency and Metformin Use in Patients with Type 2 Diabetes[J].J Korean Med Sci,2014,29(7):965.
[22]Wang D,Zhai JX,Liu DW.Serum folate,vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes:A metaanalysis[J].Mol Cell Endocrinol,2017,443:72-79.
[23]American Diabetes.A.9.Pharmacologic Approaches to Glycemic Treatment[J].Diabetes Care,2017,40(1):S90-S102.
[24]Teresa SC,Paloma GE,Rosario RF,et al.Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency:a pragmatic,randomised,multicentre,non-inferiority clinical trial undertaken in the primary healthcare setting(Project OB12)[J].Bmc Public Health,2012,12(1):1-11.
[25]Vidal-alaball J,Butler C,Cannings-john R,et al.Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency[J].Fam Pract,2006,23(3):279-285.
[26]Vinik AI,Nevoret ML,Casellini C,et al.Diabetic neuropathy[J].Endocrinol Metab Clin North Am,2013,42(4):747-787.
[27]Ahmed MA,George M,Paul R.Vitamin B12 deficiency in metformin-treated type-2 diabetes patients,prevalence and association with peripheral neuropathy[J].Bmc Pharmacol Toxicol,2016,17(1):44.
[28]Fotiou P,Raptis A,Apergis G,et al.Vitamin status as a determinant of serum homocysteine concentration in type 2 diabetic retinopathy[J].J Diabetes Res,2015,2014(16):807209.
[29]Satyanarayana A,Balakrishna N,Pitla S,et al.Status of B-Vitamins and Homocysteine in Diabetic Retinopathy:Association with Vitamin-B12 Deficiency and Hyperhomocysteinemia[J].Plos One,2011,6(11):e26747.
[30]Smolek MK,Notaroberto NF,Jaramillo AG,et al.Intervention with vitamins in patients with nonproliferative diabetic retinopathy:a pilot study[J].Clin Ophthalmol,2013,7:1451-1458.
[31]Kwok T,Lee J,Ma RC,et al.A randomized placebo controlled trial of vitamin B12 supplementation to prevent cognitive decline in older diabetic people with borderline low serum vitamin B12[J].Clin Nutr,2017,36(6):1509-1515.
[32]潘玉萍,李树德,邹英鹰.NF-κB及其相关因子与糖尿病认知功能障碍关系的研究进展[J].医学研究生学报,2016,29(7):754-758.
[33]Biemans E,Hart HE,Rutten GE,et al.Cobalamin status and its relation with depression,cognition and neuropathy in patients with type 2 diabetes mellitus using metformin[J].Acta Diabetol,2015,52(2):383-393.
[34]Fujita S,Kozawa J,Ishibashi C,et al.An Impaired Awareness of Hypoglycemia Improved After Vitamin B12Treatment in a Type 1 Diabetic Patient[J].Intern Med,2017,56(11):1383-1385.