逍遥散治疗应激性疾病研究概述
|
摘要
通过对逍遥散临床应用和实验研究的总结发现,逍遥散在治疗应激性疾病方面有较好疗效,应激性刺激作用可以导致头痛、不寐、高血压、焦虑、抑郁、帕金森吞咽障碍等各种疾病,只要辨证准确,逍遥散对这类疾病都有很好的临床疗效。逍遥散对大脑内SP物质、β-内啡肽、色甘酸、5-羟色胺、脑源性神经营养因子、多巴胺、去甲肾上腺素、促肾上腺皮质激素释放激素、精氨酸血管加压素等含量均有调节作用,而且具备调节下丘脑-垂体-肾上腺轴和肾素-血管紧张素-醛固酮系统的作用,随着研究人员对逍遥散的深入研究,其治疗疾病的范围还将扩展。
By summarizing the clinical application and experimental research of Xiaoyao powder, it is found that Xiaoyao powder has a comparatively good therapeutic effect on the treatment of stress diseases. Stress stimulation may lead to headache, insomnia, hypertension, anxiety, depression, Parkinson dysphagia, etc. When the syndrome is accurately differentiated,Xiaoyao powder can have good curative effects on these diseases.Xiaoyao powder has the regulatory function on the content of SP substances in brain, β-endorphin, intal, 5-HT, brain-derived neurotrophic factor, dopamine, norepinephrine, corticotropin-releasing hormone(CRH) and arginine vasopressin(AVP). And it also has the regulatory function on the hypothalamic-pituitary-adrenal axis and the renin-angiotensin-aldosterone system(RAAS). With more study on Xiaoyao powder, the scope of its treatment on diseases will be further expanded.
By summarizing the clinical application and experimental research of Xiaoyao powder, it is found that Xiaoyao powder has a comparatively good therapeutic effect on the treatment of stress diseases. Stress stimulation may lead to headache, insomnia, hypertension, anxiety, depression, Parkinson dysphagia, etc. When the syndrome is accurately differentiated,Xiaoyao powder can have good curative effects on these diseases.Xiaoyao powder has the regulatory function on the content of SP substances in brain, β-endorphin, intal, 5-HT, brain-derived neurotrophic factor, dopamine, norepinephrine, corticotropin-releasing hormone(CRH) and arginine vasopressin(AVP). And it also has the regulatory function on the hypothalamic-pituitary-adrenal axis and the renin-angiotensin-aldosterone system(RAAS). With more study on Xiaoyao powder, the scope of its treatment on diseases will be further expanded.
引文
[1] 李荣俊.电针对偏头痛伴抑郁大鼠血浆及脑5-HT、NE及MAO含量的影响[D].北京:中国中医科学院,2014.
[2] 李晓红,梁媛,谢宇晴,等.逍遥散对慢性束缚应激肝郁脾虚证模型大鼠SP、VIP基因表达的影响[J].中国中医基础医学杂志,2014,20(7):901-903,931.
[3] 李艳,徐碧云,欧碧阳,等.加味逍遥散对心理应激性失眠患者AVP的影响[J].中国康复,2008,23(5):325-327.
[4] 陈建昊,张嘉良.逍遥散加减治疗偏头痛的临床疗效分析[J].心理医生月刊,2012,18(6):331-332.
[5] 池名,青雪梅,潘彦舒,等.120例抑郁症患者大脑多神经递质变化初探[J].中国中药杂志,2014,39(8):1516-1524.
[6] ZUNSZAIN PA,ANACKER C,CATTANEO A,et al.Glucocorticoids,cytokines and brain abnormalities in depression[J].Prog Neuropsychopharmacol Biol Psychiatry,2011,35(3):722-729.
[7] 焦海燕,严志祎,姜幼明,等.慢性束缚应激抑郁症大鼠模型的复制及逍遥散对海马色氨酸代谢途径的调节作用[J].环球中医药,2017,10(11):1298-1302.
[8] KAREGE F,SCHWALD M,CLSSE M.Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets[J].Neurosci lett,2002,328(3):261-264.
[9] GREENWOOD BN,STRONG PV,FOLEY TE,et al.Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus[J].Neuroscience,2007,144(4):1193-1208.
[10] 彭希,曾南,龚锡萍,等.逍遥散抗抑郁作用BNDF/CREB信号机制[J].中药药理与临床,2012,28(3):9-12.
[11] 冯光明,田俊生,武嫣斐,等.逍遥散治疗抑郁症临床研究[J].辽宁中医杂志,2014,41(3):512-516.
[12] KALIA L V,LANG AE.Parkinson’s disease[J].Lancet,2015,386(9996):896-912.
[13] 李雨濛,时晶,李婷,等.帕金森病抑郁的中医证候要素特征研究[J].环球中医药,2018,11(1):50-53.
[14] SUGAMA S,SEKEYAMA K,KODAMA T,et al.Chronic restraint stress triggers the dopaminergic and noradrenergic neurodegeneration:Possible role of chronic stress in the onset of Parkinson’s disease[J] .Brain behav Immun,2016,51 :39-46.
[15] 江东,郭维,孙琪,等.逍遥散抗抑郁作用机制研究进展[J].辽宁中医杂志,2018,45(1),214-217.
[16] DJAMSHIDIAN A,LEES AJ.Can stress trigger Parkinson's disease[J].J Neurol Neurosurg Psychiatry,2014,85(8):878-881.
[17] 敖海清,孙琪,富文俊,等.逍遥散对慢性应激状态下大鼠海马神经细胞内糖皮质激素受体表达的影响[J].中医药学报,2010,38(5):58-62.
[18] 富文俊,曹国平,富丽俊.慢性应激触发帕金森病神经损伤的分子生物学机制及调肝方药逍遥散保护作用的探讨[J].时珍国医国药,2017,28(1):239-242.
[19] KHALIL H,ALOMARI MA,KHABOUR OF,et al.Relationship of circulatory BDNF with cognitive deficits in people with Parkinson’s disease[J].J Neurol Sci ,2016,362:217-220.
[20] LEDREUX A,BOGER HA,HINSON VK,et al.BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson’disease[J].Brain Res,2016,1631:34-45.
[21] 潘晓明,杨小清,王维明,等.加味逍遥散联合腹针引气归元治疗帕金森病吞咽障碍[J].广州中医药大学学报,2017,34(4):538-542.
[22] 徐碧云.从睡眠时相及神经递质探讨加味逍遥散调治心理应激性失眠的机制[D].广州:广州中医药大学,2008.
[23] 徐碧,云李艳,肖芳,等.加味逍遥散对心理应激性失眠患者单胺类神经递质的影响[J].中华中医药杂志,2009,24(6):720-723.
[24] 汪洋.逍遥散加减治疗原发性失眠的疗效观察[J].中国药物评价,2015,32(6):344-346.
[25] 贾文睿.针刺对应激性高血压前期大鼠心脏基因表达谱的影响[D].北京:北京中医药大学,2017.
[26] ZHANG Y,CHEN Y,Ma L.Depression and cardiovascular disease in elderly:Current understanding[J].J Clin Neurosci,2018,47:1-5.
[27] LIU MY,LI N,LI WA,et al.Association between psychosocial stress and hypertension:a systematic review and meta-analysis[J].Neurol Res,2017,39(6):573-580.
[28] 唐燕,姚恩生,席燕,等.焦虑抑郁对高血压患者的血压及血管紧张素Ⅱ影响[J].农垦医学,2017,39(3):205-207.
[29] 崔杰,郑兴宇,高晓霞,等.逍遥散抗抑郁作用最佳剂量筛选[J].中国实验方剂学杂志,2010,16(13):194-198.
[30] 钱海凌,龚超奇,虢沛.逍遥散治疗高血压病的概况[J].广西中医学院学报,2010,13(2):85-86.
[31] 王文宏,李桂元,张世勤,等.身心调节联合丹栀逍遥散化裁治疗原发性高血压45例临床观察[J].河北中医,2014,36(4):519-520.
[2] 李晓红,梁媛,谢宇晴,等.逍遥散对慢性束缚应激肝郁脾虚证模型大鼠SP、VIP基因表达的影响[J].中国中医基础医学杂志,2014,20(7):901-903,931.
[3] 李艳,徐碧云,欧碧阳,等.加味逍遥散对心理应激性失眠患者AVP的影响[J].中国康复,2008,23(5):325-327.
[4] 陈建昊,张嘉良.逍遥散加减治疗偏头痛的临床疗效分析[J].心理医生月刊,2012,18(6):331-332.
[5] 池名,青雪梅,潘彦舒,等.120例抑郁症患者大脑多神经递质变化初探[J].中国中药杂志,2014,39(8):1516-1524.
[6] ZUNSZAIN PA,ANACKER C,CATTANEO A,et al.Glucocorticoids,cytokines and brain abnormalities in depression[J].Prog Neuropsychopharmacol Biol Psychiatry,2011,35(3):722-729.
[7] 焦海燕,严志祎,姜幼明,等.慢性束缚应激抑郁症大鼠模型的复制及逍遥散对海马色氨酸代谢途径的调节作用[J].环球中医药,2017,10(11):1298-1302.
[8] KAREGE F,SCHWALD M,CLSSE M.Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets[J].Neurosci lett,2002,328(3):261-264.
[9] GREENWOOD BN,STRONG PV,FOLEY TE,et al.Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus[J].Neuroscience,2007,144(4):1193-1208.
[10] 彭希,曾南,龚锡萍,等.逍遥散抗抑郁作用BNDF/CREB信号机制[J].中药药理与临床,2012,28(3):9-12.
[11] 冯光明,田俊生,武嫣斐,等.逍遥散治疗抑郁症临床研究[J].辽宁中医杂志,2014,41(3):512-516.
[12] KALIA L V,LANG AE.Parkinson’s disease[J].Lancet,2015,386(9996):896-912.
[13] 李雨濛,时晶,李婷,等.帕金森病抑郁的中医证候要素特征研究[J].环球中医药,2018,11(1):50-53.
[14] SUGAMA S,SEKEYAMA K,KODAMA T,et al.Chronic restraint stress triggers the dopaminergic and noradrenergic neurodegeneration:Possible role of chronic stress in the onset of Parkinson’s disease[J] .Brain behav Immun,2016,51 :39-46.
[15] 江东,郭维,孙琪,等.逍遥散抗抑郁作用机制研究进展[J].辽宁中医杂志,2018,45(1),214-217.
[16] DJAMSHIDIAN A,LEES AJ.Can stress trigger Parkinson's disease[J].J Neurol Neurosurg Psychiatry,2014,85(8):878-881.
[17] 敖海清,孙琪,富文俊,等.逍遥散对慢性应激状态下大鼠海马神经细胞内糖皮质激素受体表达的影响[J].中医药学报,2010,38(5):58-62.
[18] 富文俊,曹国平,富丽俊.慢性应激触发帕金森病神经损伤的分子生物学机制及调肝方药逍遥散保护作用的探讨[J].时珍国医国药,2017,28(1):239-242.
[19] KHALIL H,ALOMARI MA,KHABOUR OF,et al.Relationship of circulatory BDNF with cognitive deficits in people with Parkinson’s disease[J].J Neurol Sci ,2016,362:217-220.
[20] LEDREUX A,BOGER HA,HINSON VK,et al.BDNF levels are increased by aminoindan and rasagiline in a double lesion model of Parkinson’disease[J].Brain Res,2016,1631:34-45.
[21] 潘晓明,杨小清,王维明,等.加味逍遥散联合腹针引气归元治疗帕金森病吞咽障碍[J].广州中医药大学学报,2017,34(4):538-542.
[22] 徐碧云.从睡眠时相及神经递质探讨加味逍遥散调治心理应激性失眠的机制[D].广州:广州中医药大学,2008.
[23] 徐碧,云李艳,肖芳,等.加味逍遥散对心理应激性失眠患者单胺类神经递质的影响[J].中华中医药杂志,2009,24(6):720-723.
[24] 汪洋.逍遥散加减治疗原发性失眠的疗效观察[J].中国药物评价,2015,32(6):344-346.
[25] 贾文睿.针刺对应激性高血压前期大鼠心脏基因表达谱的影响[D].北京:北京中医药大学,2017.
[26] ZHANG Y,CHEN Y,Ma L.Depression and cardiovascular disease in elderly:Current understanding[J].J Clin Neurosci,2018,47:1-5.
[27] LIU MY,LI N,LI WA,et al.Association between psychosocial stress and hypertension:a systematic review and meta-analysis[J].Neurol Res,2017,39(6):573-580.
[28] 唐燕,姚恩生,席燕,等.焦虑抑郁对高血压患者的血压及血管紧张素Ⅱ影响[J].农垦医学,2017,39(3):205-207.
[29] 崔杰,郑兴宇,高晓霞,等.逍遥散抗抑郁作用最佳剂量筛选[J].中国实验方剂学杂志,2010,16(13):194-198.
[30] 钱海凌,龚超奇,虢沛.逍遥散治疗高血压病的概况[J].广西中医学院学报,2010,13(2):85-86.
[31] 王文宏,李桂元,张世勤,等.身心调节联合丹栀逍遥散化裁治疗原发性高血压45例临床观察[J].河北中医,2014,36(4):519-520.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |