柳茶降脂、降糖研究的新进展
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摘要
<正>柳茶是藏族民间用于治疗消化不良等疾病的药材,是蔷薇科植物窄叶鲜卑花Sibiraea angustata(Rehd.)Hand-Mazz和鲜卑花Sibiraea Laevigata(L.)Maxim的枝叶,属高山植物,生长于3 000~4 000 m海拔的地方,多分布于青海、甘肃、云南、四川等地;本文将近几年对柳茶的化学成分及在降脂、降糖药理作用方面的新进展做一综述。
引文
1闫志慧,陈立书,朱仝飞,等.藏药柳茶叶乙醇水提取物中化学成分的鉴定[J].应用化学学报,2014;31(2):237-41.
2 于民丰,邵赟,陶燕铎.藏药鲜卑花化学成分研究[J].中草药,2014;45(24):3528-31.
3 王章伟,徐向红,陈笑天,等.窄叶鲜卑花地上部分化学成分研究[J].中药材,2014;37(1):57-60.
4 Wang ZW,Li B,Yu SS,et al.Eight New Monoterpene Acylglucosides from Sibiraea angustata[J].Phytochem Lett,2013;6(3):461-6.
5 Deng Y,Zhao JQ,Mei LJ,et al.Two new monoterpenes from Sibiraea laevigata[J].J Asian Nat Prod Res,2016;21:1-7.
6 王佳冰,柴成奎,陈平,等.藏药柳茶提取物对单纯性肥胖大鼠脂质代谢的影响[J].中药新药与临床药理,2010;21(2):148-9.
7 姚莉,焦海胜,李晓强.柳茶对高脂血症大鼠血脂、超氧化物歧化酶及丙二醛的影响[J].兰州大学学报(医学版),2010;36(2):68-70.
8 孙雯雯,颉宾芳,刘卉,等.高胆固醇血症在阿尔兹海默病发生中的作用及藏药柳茶提取物的治疗效应[J].中药材,2012;35(4):596-602.
9 夏苗,王晶宇,马晓燕,等.藏药柳茶提取物调节肥胖大鼠脂代谢的作用机制研究[J].中药材,2011;34(6):922-6.
10 Elise F,van den Hil H,Keijer J,et al.Quercetin Induces Hepatic Lipid Omega-Oxidation and Lowers Serum Lipid Levels in Mice[J].PLo S One,2013;8(1):e51588.
11 Jung CH,Cho I,Ahn J,et al.Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes[J].Phytother Res,2013;27(1):139-43.
12 Ying HZ,Liu YH,Yu B,et al.Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils[J].Food Chem Toxicol,2013;52:53-60.
13 Vidyashankar S,Sandeep Varma R,Patki PS,et al.Quercetin ameliorate insulin resistance and p-regulates cellular antioxidants during oleic acid induced hepatic steatosis in Hep G2 cells[J].Toxicol Vitro,2013;27(2):945-53.
14 Jeong SM,Kang MJ,Choi HN,et al.Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice[J].Nutr Res Practice,2012;6(3):201-7.
15 Cui Y,Hou P,Li F,et al.Quercetin improves macrophage reverse cholesterol transport in apolipoprotein E-deficient mice fed a high-fat diet[J].Lipids Health Dis,2017;14;16(1):9.
16 Liu HW,Tsai YT,Chang SJ.Toona sinensis leaf extract inhib-its lipid accumulation through up-regulation of genes involved in lipolysis and fatty acid oxidation in adipocytes[J].J Agric Food Chem,2014;62(25):5887.
17 Rosillo MA,Sanchez-Hidalgo M,Cardeno A,et al.Protective effect of ellagic acid,a natural polyphenolic compound,in a murine model of Crohn's disease[J].Biochem Pharmacol,2011;82:737-45.
18 卫阳飞,杨永建,李建银,等.藏药柳茶提取物对四氧嘧啶糖尿病小鼠降糖作用的研究[J].时珍国医国药,2011;22(10):2460-1.
19 Ramachandra R,Shetty AK,Salimath PV.Quercetin alleviates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats[J].Mol Nutr Food Res,2005;49(4):355.
20 Haddad P,Eid H,Nachar A,et al.The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes[J].Pharmacognosy Magazine,2015;11(41):74.
21 Youl E,Bardy G,Magous R,et al.Quercetin potentiates insulin secretion and protects INS-1 pancreaticβ-cells against oxidative damage via the ERK1/2 pathway[J].Br J Pharmacol,2010;161(4):799-814.
22 王斯慧,黄琬凌,陈庆松,等.芦丁、槲皮素对α-葡萄糖苷酶活性抑制研究[J].中国酿造,2012;31(1):133-5.
2 于民丰,邵赟,陶燕铎.藏药鲜卑花化学成分研究[J].中草药,2014;45(24):3528-31.
3 王章伟,徐向红,陈笑天,等.窄叶鲜卑花地上部分化学成分研究[J].中药材,2014;37(1):57-60.
4 Wang ZW,Li B,Yu SS,et al.Eight New Monoterpene Acylglucosides from Sibiraea angustata[J].Phytochem Lett,2013;6(3):461-6.
5 Deng Y,Zhao JQ,Mei LJ,et al.Two new monoterpenes from Sibiraea laevigata[J].J Asian Nat Prod Res,2016;21:1-7.
6 王佳冰,柴成奎,陈平,等.藏药柳茶提取物对单纯性肥胖大鼠脂质代谢的影响[J].中药新药与临床药理,2010;21(2):148-9.
7 姚莉,焦海胜,李晓强.柳茶对高脂血症大鼠血脂、超氧化物歧化酶及丙二醛的影响[J].兰州大学学报(医学版),2010;36(2):68-70.
8 孙雯雯,颉宾芳,刘卉,等.高胆固醇血症在阿尔兹海默病发生中的作用及藏药柳茶提取物的治疗效应[J].中药材,2012;35(4):596-602.
9 夏苗,王晶宇,马晓燕,等.藏药柳茶提取物调节肥胖大鼠脂代谢的作用机制研究[J].中药材,2011;34(6):922-6.
10 Elise F,van den Hil H,Keijer J,et al.Quercetin Induces Hepatic Lipid Omega-Oxidation and Lowers Serum Lipid Levels in Mice[J].PLo S One,2013;8(1):e51588.
11 Jung CH,Cho I,Ahn J,et al.Quercetin reduces high-fat diet-induced fat accumulation in the liver by regulating lipid metabolism genes[J].Phytother Res,2013;27(1):139-43.
12 Ying HZ,Liu YH,Yu B,et al.Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils[J].Food Chem Toxicol,2013;52:53-60.
13 Vidyashankar S,Sandeep Varma R,Patki PS,et al.Quercetin ameliorate insulin resistance and p-regulates cellular antioxidants during oleic acid induced hepatic steatosis in Hep G2 cells[J].Toxicol Vitro,2013;27(2):945-53.
14 Jeong SM,Kang MJ,Choi HN,et al.Quercetin ameliorates hyperglycemia and dyslipidemia and improves antioxidant status in type 2 diabetic db/db mice[J].Nutr Res Practice,2012;6(3):201-7.
15 Cui Y,Hou P,Li F,et al.Quercetin improves macrophage reverse cholesterol transport in apolipoprotein E-deficient mice fed a high-fat diet[J].Lipids Health Dis,2017;14;16(1):9.
16 Liu HW,Tsai YT,Chang SJ.Toona sinensis leaf extract inhib-its lipid accumulation through up-regulation of genes involved in lipolysis and fatty acid oxidation in adipocytes[J].J Agric Food Chem,2014;62(25):5887.
17 Rosillo MA,Sanchez-Hidalgo M,Cardeno A,et al.Protective effect of ellagic acid,a natural polyphenolic compound,in a murine model of Crohn's disease[J].Biochem Pharmacol,2011;82:737-45.
18 卫阳飞,杨永建,李建银,等.藏药柳茶提取物对四氧嘧啶糖尿病小鼠降糖作用的研究[J].时珍国医国药,2011;22(10):2460-1.
19 Ramachandra R,Shetty AK,Salimath PV.Quercetin alleviates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats[J].Mol Nutr Food Res,2005;49(4):355.
20 Haddad P,Eid H,Nachar A,et al.The molecular basis of the antidiabetic action of quercetin in cultured skeletal muscle cells and hepatocytes[J].Pharmacognosy Magazine,2015;11(41):74.
21 Youl E,Bardy G,Magous R,et al.Quercetin potentiates insulin secretion and protects INS-1 pancreaticβ-cells against oxidative damage via the ERK1/2 pathway[J].Br J Pharmacol,2010;161(4):799-814.
22 王斯慧,黄琬凌,陈庆松,等.芦丁、槲皮素对α-葡萄糖苷酶活性抑制研究[J].中国酿造,2012;31(1):133-5.