中成药联合HAART治疗艾滋病疗效Meta分析
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摘要
目的:系统评价中成药联合高效抗逆转录病毒(highly active antiretroviral therapy,HAART)治疗艾滋病疗效。方法:检索日期为2013年1月至2018年4月,计算机检索的外文数据库主要是PubMed和Cochrane图书馆,中文文献数据库主要是CNKI、VIP、CBM和万方数据库,主要阅读国内中成药联合HAART治疗艾滋病的各类研究文献,符合临床随机对照试验,并不要求具体的分配隐藏和盲法类别。研究文献为全文文献,语言为中文和英文,并应用R3.5.0软件中的Meta程序包对本系统评价的指标进行分析。结果:共纳入10篇文献,中药益气扶正法联合HAART可以提高艾滋病患者的CD_4~+T淋巴细胞水平、体质量,提高疗效,改善中医证候积分。结论:根据现有文献显示,中西医联合HAART治疗艾滋病具有一定的疗效,但是所纳入的文献都存在一定程度的选择偏倚,从而影响结果的论证强度,而结论的可靠性还需要进一步大样本多中心的试验研究来证实。
Objective:To systematically evaluate the efficacy of Chinese medicine and HAART in treatment of AIDS.Methods:The search date is from January 2013 to April 2018.The foreign language databases,which are mainly PubMed and Cochrane libraries,are primarily searched by the computer.The Chinese literature databases are mainly CNKI,VIP,CBM and Wanfang database.It mainly reads various research literatures on domestic Chinese patent medicine combined with HAART in the treatment of AIDS.It is in line with clinical randomized controlled trials and does not require specific allocation hidden and blinded categories.The research literature is full-text literature,the language is Chinese and English,and the Meta-package in R3.5.0 software is used to analyze the indicators of this system evaluation.Results:A total of 10 articles were included.The combination of traditional Chinese medicine Yiqi Fuzheng method and HAART can improve CD_4~+,body mass,improve curative effect and promote TCM syndrome scores.Conclusion:According to the existing literature,it is shown that Chinese and Western medicine combined with HAART has certain curative effect on AIDS,but the included literature has a certain degree of selection bias,which affects the strength of the demonstration of the results,and the reliability of the conclusion needs further large sample.The center′s experimental study confirmed.
Objective:To systematically evaluate the efficacy of Chinese medicine and HAART in treatment of AIDS.Methods:The search date is from January 2013 to April 2018.The foreign language databases,which are mainly PubMed and Cochrane libraries,are primarily searched by the computer.The Chinese literature databases are mainly CNKI,VIP,CBM and Wanfang database.It mainly reads various research literatures on domestic Chinese patent medicine combined with HAART in the treatment of AIDS.It is in line with clinical randomized controlled trials and does not require specific allocation hidden and blinded categories.The research literature is full-text literature,the language is Chinese and English,and the Meta-package in R3.5.0 software is used to analyze the indicators of this system evaluation.Results:A total of 10 articles were included.The combination of traditional Chinese medicine Yiqi Fuzheng method and HAART can improve CD_4~+,body mass,improve curative effect and promote TCM syndrome scores.Conclusion:According to the existing literature,it is shown that Chinese and Western medicine combined with HAART has certain curative effect on AIDS,but the included literature has a certain degree of selection bias,which affects the strength of the demonstration of the results,and the reliability of the conclusion needs further large sample.The center′s experimental study confirmed.
引文
[1]桑锋,许前磊,谢世平,等.中医药调节HIV/AIDS患者免疫功能研究现状与思考[J].中医学报,2017,32(8):1351-1354.
[2]吴茜茜,姜枫.艾滋病中医体质研究述评[J].中医学报,2018,33(3):341-345.
[3]李亮平,徐立然,扶伟,等.中医药综合干预对艾滋病病毒感染者/艾滋病患者免疫功能和机会性感染的长期影响[J].中医学报,2016,31(1):1-6.
[4]罗伟生,王仕衍,黄瑞,等.中药复方制剂联合HAART对HIV/AIDS病人免疫重建的系统评价[J].中国艾滋病性病,2017,23(1):28-32.
[5]黄瑞,罗伟生,唐宏亮,等.中成药联合抗病毒治疗HIV、AIDS的病人的疗效和安全性[J].中国艾滋病性病,2016,22(9):694-698.
[6]张扬武,罗伟生,黄瑞,等.益气扶正法联合高效抗逆转录病毒治疗对艾滋病患者免疫重建的Meta分析[J].辽宁中医杂志,2016,43(10):2042-2047.
[7]刘明,余花,孟伟民,等.抗艾扶正胶囊联合抗逆转录病毒(HAART)治疗青海地区艾滋病的临床疗效观察[J].青海医药杂志,2013,43(9):66-70.
[8]厍启录,马英莲.青海地区抗-HIV药联合中药治疗艾滋病及防治机会性感染62例临床分析[J].高原医学杂志,2013,23(4):34-36.
[9]马秀珍.中药扶正抗艾胶囊、联合西药治疗中老年艾滋病的有效性及安全性[J].中国老年学杂志,2013,33(4):783-784.
[10]李璇,苏齐鉴,李益忠,等.参灵扶正胶囊联合高效抗逆转录病毒疗法治疗艾滋病病毒感染者或艾滋病患者60例[J].中医杂志,2013,54(19):1653-1656.
[11]陈仁芳,杨崎恩,徐淑凡,等.贞芪扶正胶囊联合HAART治疗艾滋病临床分析[J].现代中西医结合杂志,2014,23(24):2664-2665.
[12]许文芳,吴勇,潘国绍,等.芪灵汤联合高效抗逆转录病毒疗法对HIV/AIDS患者Th17和Treg细胞表达水平的影响[J].中国中西医结合杂志,2014,34(2):157-161.
[13]苗慧,王江蓉,陆云飞,等.复方芪术汤联合HAART治疗AIDS病人的疗效及安全性[J].中国艾滋病性病,2015,21(2):96-98,102.
[14]刘建忠,陈瑶,肖明中,等.扶正抗艾颗粒联合HAART疗法对HIV/AIDS患者临床疗效和不良反应的临床研究[J].世界科学技术-中医药现代化,2017,19(8):1360-1364.
[15]沈露,张金武,朱建光.扶正排毒方联合高效抗逆转录病毒疗法治疗艾滋病合并神经系统病变临床研究[J].中医学报,2017,32(3):313-317.
[16]邹雯,王健,刘颖,等.中药联合HAART治疗对艾滋病免疫功能重建不全患者TLR相关基因mRNA水平的影响[J].中华中医药杂志,2017,32(12):5672-5674.
[17]徐立然.无症状HIV感染期的诊疗研究及展望[J].中国中西医结合杂志,2012,32(6):729-732.
[18]许前磊,李青雅,金艳涛,等.后HAART时期中医药防治艾滋病的切入点[J].中国中西医结合杂志,2016,36(9):1128-1131.
[2]吴茜茜,姜枫.艾滋病中医体质研究述评[J].中医学报,2018,33(3):341-345.
[3]李亮平,徐立然,扶伟,等.中医药综合干预对艾滋病病毒感染者/艾滋病患者免疫功能和机会性感染的长期影响[J].中医学报,2016,31(1):1-6.
[4]罗伟生,王仕衍,黄瑞,等.中药复方制剂联合HAART对HIV/AIDS病人免疫重建的系统评价[J].中国艾滋病性病,2017,23(1):28-32.
[5]黄瑞,罗伟生,唐宏亮,等.中成药联合抗病毒治疗HIV、AIDS的病人的疗效和安全性[J].中国艾滋病性病,2016,22(9):694-698.
[6]张扬武,罗伟生,黄瑞,等.益气扶正法联合高效抗逆转录病毒治疗对艾滋病患者免疫重建的Meta分析[J].辽宁中医杂志,2016,43(10):2042-2047.
[7]刘明,余花,孟伟民,等.抗艾扶正胶囊联合抗逆转录病毒(HAART)治疗青海地区艾滋病的临床疗效观察[J].青海医药杂志,2013,43(9):66-70.
[8]厍启录,马英莲.青海地区抗-HIV药联合中药治疗艾滋病及防治机会性感染62例临床分析[J].高原医学杂志,2013,23(4):34-36.
[9]马秀珍.中药扶正抗艾胶囊、联合西药治疗中老年艾滋病的有效性及安全性[J].中国老年学杂志,2013,33(4):783-784.
[10]李璇,苏齐鉴,李益忠,等.参灵扶正胶囊联合高效抗逆转录病毒疗法治疗艾滋病病毒感染者或艾滋病患者60例[J].中医杂志,2013,54(19):1653-1656.
[11]陈仁芳,杨崎恩,徐淑凡,等.贞芪扶正胶囊联合HAART治疗艾滋病临床分析[J].现代中西医结合杂志,2014,23(24):2664-2665.
[12]许文芳,吴勇,潘国绍,等.芪灵汤联合高效抗逆转录病毒疗法对HIV/AIDS患者Th17和Treg细胞表达水平的影响[J].中国中西医结合杂志,2014,34(2):157-161.
[13]苗慧,王江蓉,陆云飞,等.复方芪术汤联合HAART治疗AIDS病人的疗效及安全性[J].中国艾滋病性病,2015,21(2):96-98,102.
[14]刘建忠,陈瑶,肖明中,等.扶正抗艾颗粒联合HAART疗法对HIV/AIDS患者临床疗效和不良反应的临床研究[J].世界科学技术-中医药现代化,2017,19(8):1360-1364.
[15]沈露,张金武,朱建光.扶正排毒方联合高效抗逆转录病毒疗法治疗艾滋病合并神经系统病变临床研究[J].中医学报,2017,32(3):313-317.
[16]邹雯,王健,刘颖,等.中药联合HAART治疗对艾滋病免疫功能重建不全患者TLR相关基因mRNA水平的影响[J].中华中医药杂志,2017,32(12):5672-5674.
[17]徐立然.无症状HIV感染期的诊疗研究及展望[J].中国中西医结合杂志,2012,32(6):729-732.
[18]许前磊,李青雅,金艳涛,等.后HAART时期中医药防治艾滋病的切入点[J].中国中西医结合杂志,2016,36(9):1128-1131.