冷诱导RNA结合蛋白的调控与功能研究进展
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摘要
冷诱导RNA结合蛋白(Cirbp)是进化上保守的RNA结合蛋白,包含一个RNA识别结构域(RRM)和富含精氨酸-甘氨酸(RGG)结构域,在温度改变、低氧、辐射、药物、生长因子等作用下表达发生改变,从而对转录、转录后和翻译等进行调控。综述了Cirbp跨物种的进化保守性以及分子间的相互作用、细胞功能和在不同的生理和病理过程中的作用,包括昼夜节律、炎症、神经可塑性、干细胞的特性和癌症的发生发展等。
Cold induced RNA binding protein( Cirbp) is an evolutionary conservative RNA binding protein,including a RNA domain( RRM) and a arginine-glycine( RGG) domain. The expression of Cirbp changes in temperature,hypoxia,radiation,drugs,growth factors and so on,so as to regulate transcriptional,post transcriptional,and translation. This article reviews the evolutionary conservatism and intermolecular interaction,cell function and role in different physiological and pathological processes,including circadian rhythm,inflammation,nerve plasticity,stem cell characteristics and cancer.
Cold induced RNA binding protein( Cirbp) is an evolutionary conservative RNA binding protein,including a RNA domain( RRM) and a arginine-glycine( RGG) domain. The expression of Cirbp changes in temperature,hypoxia,radiation,drugs,growth factors and so on,so as to regulate transcriptional,post transcriptional,and translation. This article reviews the evolutionary conservatism and intermolecular interaction,cell function and role in different physiological and pathological processes,including circadian rhythm,inflammation,nerve plasticity,stem cell characteristics and cancer.
引文
[1]WILLIAMS D R,EPPERSON L E,LI W,et al. Seasonally hibernating phenotype assessed through transcript screening[J]. Physiological Genomics,2005,24(1):13-22.
[2]SANO Y,SHIINA T,NAITOU K,et al. Hibernation-specific alternative splicing of the mRNA encoding cold-inducible RNA-binding protein in the hearts of hamsters[J]. Biochemical and Biophysical Research Communications,2015,462(4):322-325.
[3]CIUZAN O,HANCOCK J,PAMFIL D,et al. The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation[J]. Plant Physiology,2015,153(1):1-11.
[4]UOCHI T,ASASHIMA M. XCIRP(Xenopus homolog of cold-inducible RNA-binding protein)is expressed transiently in developing pronephros and neural tissue[J]. Gene,1998,211(2):245-250.
[5]BHATIA R,DUBE D K,GAUR A,et al. Expression of axolotl RNA-binding protein during development of the Mexican axolotl[J]. Cell Tissue Research,1999,297(2):283-290.
[6]DANNO S,NISHIYAMA H,HIGASHITSUJI H,et al. Increased transcript level of RBM3,a member of the glycine-rich RNA-binding protein family,in human cells in response to cold stress[J]. Biochemical and Biophysical Research Communications,1997,236(3):804-807.
[7]WANG X,CHE H,ZHANG W,et al. Effects of mild chronic intermittent cold exposure on rat organs[J]. International Journal of Biological Sciences,2015,11(10):1171-1180.
[8]AOKI K,ISHII Y,MATSUMOTO K,et al. Methylation of xenopus CIRP2regulates its arginine-and glycine-rich region-mediated nucleocytoplasmic distribution[J]. Nucleic Acids Research,2002,30(23):5182-5192.
[9]DE LEEUW F,ZHANG T,WAUQUIER C,et al. The cold-inducible RNAbinding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor[J].Experimental Cell Research,2007,313(20):4130-4144.
[10]TONG G,ENDERSFELDER S,ROSENTHAL L M,et al. Effects of moderate and deep hypothermia on RNA-binding proteins RBM3 and CIRP expressions in murine hippocampal brain slices[J]. Brain Research,2013,1504:74-84.
[11]AL-FAGEEH M B,SMALES C M. Alternative promoters regulate cold inducible RNA-binding(CIRP)gene expression and enhance transgene expression in mammalian cells[J]. Molecular Biotechnology,2013,54(2):238-249.
[12]AL-FAGEEH M B,SMALES C M. Corrigendum:cold-inducible RNA binding protein(CIRP)expression is modulated by alternative mRNAs[J]. RNA,2017,23(12):1961.
[13]CHEN J K,LIN W L,CHEN Z,et al. PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability[J]. PNAS,2018,115(8):E1759-E1768.
[14]SUMITOMO Y,HIGASHITSUJI H,LIU Y,et al. Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein(cirp)expression in mammalian cells[J]. BMC Biotechnology,2012,12:72.
[15]MORF J,REY G,SCHNEIDER K,et al. Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally[J]. Science,2012,338(6105):379-383.
[16]XIA Z,ZHENG X,ZHENG H,et al. Cold-inducible RNA-binding protein(CIRP)regulates target mRNA stabilization in the mouse testis[J]. FEBS Letters,2012,586(19):3299-3308.
[17]YANG C,CARRIER F. The UV-inducible RNA-binding protein A18(A18 hnRNP)plays a protective role in the genotoxic stress response[J].The Journal of Biological Chemistry,2001,276(50):47277-47284.
[18]YANG R,WEBER D J,CARRIER F. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18[J]. Nucleic Acids Research,2006,34(4):1224-1236.
[19]PIROK E W,3RD,DOMOWICZ M S,HENRY J,et al. APBP-1,a DNA/RNA-binding protein,interacts with the chick aggrecan regulatory region[J]. The Journal of Biological Chemistry,2005,280(42):35606-35616.
[20]TAN H K,LEE M M,YAP M G,et al. Overexpression of cold-inducible RNA-binding protein increases interferon-gamma production in Chinesehamster ovary cells[J]. Biotechnology and Applied Biochemistry,2008,49(Pt 4):247-257.
[21]XUE J H,NONOGUCHI K,FUKUMOTO M,et al. Effects of ischemia and H2O2on the cold stress protein CIRP expression in rat neuronal cells[J]. Free Radical Biology Medicine,1999,27(11/12):1238-1244.
[22]LIU A,ZHANG Z,LI A,et al. Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain[J]. Brain Research,2010,1347:104-110.
[23]LIU J,XUE J,ZHANG H,et al. Cloning,expression,and purification of cold inducible RNA-binding protein and its neuroprotective mechanism of action[J]. Brain Research,2015,1597:189-195.
[24]ZHOU M,YANG W L,JI Y,et al. Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia[J]. Biochimica et Biophystica Acta,2014,1840(7):2253-2261.
[25]NISHIYAMA H,XUE J H,SATO T,et al. Diurnal change of the cold-inducible RNA-binding protein(Cirp)expression in mouse brain[J]. Biochemical and Biophysical Research Communications,1998,245(2):534-538.
[26]SUGIMOTO K,JIANG H. Cold stress and light signals induce the expression of cold-inducible RNA binding protein(cirp)in the brain and eye of the Japanese treefrog(Hyla japonica)[J]. Comparative Biochemistry and Physiology Part A:Molecular&Integrative Physiology,2008,151(4):628-636.
[27]MORF J,SCHIBLER U. Body temperature cycles:gatekeepers of circadian clocks[J]. Cell Cycle,2013,12(4):539-540.
[28]GERBER A,SAINI C,CURIE T,et al. The systemic control of circadian gene expression[J]. Diabetes Obes Metab,2015,17(Suppl 1):23-32.
[29]OISHI K,YAMAMOTO S,UCHIDA D,et al. Ketogenic diet and fasting induce the expression of cold-inducible RNA-binding protein with time-dependent hypothermia in the mouse liver[J]. FEBS Open Biology,2013,3:192-195.
[30]DODDS P N,RATHJEN J P. Plant immunity:towards an integrated view of plant-pathogen interactions[J]. Nature Reviews Genetics,2010,11(8):539-548.
[31]RAJAMUTHIAH R,MYLONAKIS E. Effector triggered immunity[J].Virulence,2014,5(7):697-702.
[32]NICAISE V,JOE A,JEONG B R,et al. Pseudomonas Hop U1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7[J]. EMBO Journal,2013,32(5):701-712.
[33]QIANG X,YANG W L,WU R,et al. Cold-inducible RNA-binding protein(CIRP)triggers inflammatory responses in hemorrhagic shock and sepsis[J]. Nature Medicine,2013,19(11):1489-1495.
[34]SAKURAI T,KUDO M,WATANABE T,et al. Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production[J]. Digestive Diseases and Sciences,2013,31(5/6):440-446.
[35]GODWIN A,YANG W L,SHARMA A,et al. Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury[J].Shock,2015,43(1):24-30.
[36]KIZIL C,KYRITSIS N,BRAND M. Effects of inflammation on stem cells:together they strive?[J]. EMBO Reports,2015,16(4):416-426.
[37]SAKURAI T,YADA N,WATANABE T,et al. Cold-inducible RNA-binding protein promotes the development of liver cancer[J]. Cancer Science,2015,106(4):352-358.
[38]SAKURAI T,KASHIDA H,WATANABE T,et al. Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer[J].Cancer Research,2014,74(21):6119-6128.
[39]JIAN F,CHEN Y,NING G,et al. Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway[J]. Oncotarget,2016,7(8):9175-9187.
[40]REN W H,ZHANG L M,LIU H Q,et al. Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma:an immunohistochemical and clinical correlation analysis[J]. Medical Oncology,2014,31(8):120.
[41]HAMID A A,MANDAI M,FUJITA J,et al. Expression of cold-inducible RNA-binding protein in the normal endometrium,endometrial hyperplasia,and endometrial carcinoma[J]. Internation Journal of Gynecological Pathology,2003,22(3):240-247.
[42]GUO X,WU Y,HARTLEY R S. Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer[J]. Molecular Carcinogenesis,2010,49(2):130-140.
[43]NISHIYAMA H,DANNO S,KANEKO Y,et al. Decreased expression of cold-inducible RNA-binding protein(CIRP)in male germ cells at elevated temperature[J]. The American Journal Pathology,1998,152(1):289-296.
[44]BANKS S,KING S A,IRVINE D S,et al. Impact of a mild scrotal heat stress on DNA integrity in murine spermatozoa[J]. Reproduction,2005,129(4):505-514.
[45]RAO M,MA S,HU S,et al. Isobaric tags for relative and absolute quantification-based proteomic analysis of testis biopsies in rhesus monkeys treated with transient scrotal hyperthermia[J]. Oncotarget,2017,8(49):85909-85925.
[46]XIA Z P,ZHENG X M,ZHENG H,et al. Downregulation of cold-inducible RNA-binding protein activates mitogen-activated protein kinases and impairs spermatogenic function in mouse testes[J]. Asian Journal of Andrology,2012,14(6):884-889.
[47]ZHOU K W,ZHENG X M,YANG Z W,et al. Overexpression of CIRP may reduce testicular damage induced by cryptorchidism[J]. Clinical and Investigative Medicine,2009,32(2):E103-E111.
[48]MASUDA T,ITOH K,HIGASHITSUJI H,et al. Cold-inducible RNAbinding protein(Cirp)interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice[J]. Proceedings of the National Academy of Sciences of the United States of America,2012,109(27):10885-10890.
[2]SANO Y,SHIINA T,NAITOU K,et al. Hibernation-specific alternative splicing of the mRNA encoding cold-inducible RNA-binding protein in the hearts of hamsters[J]. Biochemical and Biophysical Research Communications,2015,462(4):322-325.
[3]CIUZAN O,HANCOCK J,PAMFIL D,et al. The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation[J]. Plant Physiology,2015,153(1):1-11.
[4]UOCHI T,ASASHIMA M. XCIRP(Xenopus homolog of cold-inducible RNA-binding protein)is expressed transiently in developing pronephros and neural tissue[J]. Gene,1998,211(2):245-250.
[5]BHATIA R,DUBE D K,GAUR A,et al. Expression of axolotl RNA-binding protein during development of the Mexican axolotl[J]. Cell Tissue Research,1999,297(2):283-290.
[6]DANNO S,NISHIYAMA H,HIGASHITSUJI H,et al. Increased transcript level of RBM3,a member of the glycine-rich RNA-binding protein family,in human cells in response to cold stress[J]. Biochemical and Biophysical Research Communications,1997,236(3):804-807.
[7]WANG X,CHE H,ZHANG W,et al. Effects of mild chronic intermittent cold exposure on rat organs[J]. International Journal of Biological Sciences,2015,11(10):1171-1180.
[8]AOKI K,ISHII Y,MATSUMOTO K,et al. Methylation of xenopus CIRP2regulates its arginine-and glycine-rich region-mediated nucleocytoplasmic distribution[J]. Nucleic Acids Research,2002,30(23):5182-5192.
[9]DE LEEUW F,ZHANG T,WAUQUIER C,et al. The cold-inducible RNAbinding protein migrates from the nucleus to cytoplasmic stress granules by a methylation-dependent mechanism and acts as a translational repressor[J].Experimental Cell Research,2007,313(20):4130-4144.
[10]TONG G,ENDERSFELDER S,ROSENTHAL L M,et al. Effects of moderate and deep hypothermia on RNA-binding proteins RBM3 and CIRP expressions in murine hippocampal brain slices[J]. Brain Research,2013,1504:74-84.
[11]AL-FAGEEH M B,SMALES C M. Alternative promoters regulate cold inducible RNA-binding(CIRP)gene expression and enhance transgene expression in mammalian cells[J]. Molecular Biotechnology,2013,54(2):238-249.
[12]AL-FAGEEH M B,SMALES C M. Corrigendum:cold-inducible RNA binding protein(CIRP)expression is modulated by alternative mRNAs[J]. RNA,2017,23(12):1961.
[13]CHEN J K,LIN W L,CHEN Z,et al. PARP-1-dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability[J]. PNAS,2018,115(8):E1759-E1768.
[14]SUMITOMO Y,HIGASHITSUJI H,LIU Y,et al. Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein(cirp)expression in mammalian cells[J]. BMC Biotechnology,2012,12:72.
[15]MORF J,REY G,SCHNEIDER K,et al. Cold-inducible RNA-binding protein modulates circadian gene expression posttranscriptionally[J]. Science,2012,338(6105):379-383.
[16]XIA Z,ZHENG X,ZHENG H,et al. Cold-inducible RNA-binding protein(CIRP)regulates target mRNA stabilization in the mouse testis[J]. FEBS Letters,2012,586(19):3299-3308.
[17]YANG C,CARRIER F. The UV-inducible RNA-binding protein A18(A18 hnRNP)plays a protective role in the genotoxic stress response[J].The Journal of Biological Chemistry,2001,276(50):47277-47284.
[18]YANG R,WEBER D J,CARRIER F. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18[J]. Nucleic Acids Research,2006,34(4):1224-1236.
[19]PIROK E W,3RD,DOMOWICZ M S,HENRY J,et al. APBP-1,a DNA/RNA-binding protein,interacts with the chick aggrecan regulatory region[J]. The Journal of Biological Chemistry,2005,280(42):35606-35616.
[20]TAN H K,LEE M M,YAP M G,et al. Overexpression of cold-inducible RNA-binding protein increases interferon-gamma production in Chinesehamster ovary cells[J]. Biotechnology and Applied Biochemistry,2008,49(Pt 4):247-257.
[21]XUE J H,NONOGUCHI K,FUKUMOTO M,et al. Effects of ischemia and H2O2on the cold stress protein CIRP expression in rat neuronal cells[J]. Free Radical Biology Medicine,1999,27(11/12):1238-1244.
[22]LIU A,ZHANG Z,LI A,et al. Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain[J]. Brain Research,2010,1347:104-110.
[23]LIU J,XUE J,ZHANG H,et al. Cloning,expression,and purification of cold inducible RNA-binding protein and its neuroprotective mechanism of action[J]. Brain Research,2015,1597:189-195.
[24]ZHOU M,YANG W L,JI Y,et al. Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia[J]. Biochimica et Biophystica Acta,2014,1840(7):2253-2261.
[25]NISHIYAMA H,XUE J H,SATO T,et al. Diurnal change of the cold-inducible RNA-binding protein(Cirp)expression in mouse brain[J]. Biochemical and Biophysical Research Communications,1998,245(2):534-538.
[26]SUGIMOTO K,JIANG H. Cold stress and light signals induce the expression of cold-inducible RNA binding protein(cirp)in the brain and eye of the Japanese treefrog(Hyla japonica)[J]. Comparative Biochemistry and Physiology Part A:Molecular&Integrative Physiology,2008,151(4):628-636.
[27]MORF J,SCHIBLER U. Body temperature cycles:gatekeepers of circadian clocks[J]. Cell Cycle,2013,12(4):539-540.
[28]GERBER A,SAINI C,CURIE T,et al. The systemic control of circadian gene expression[J]. Diabetes Obes Metab,2015,17(Suppl 1):23-32.
[29]OISHI K,YAMAMOTO S,UCHIDA D,et al. Ketogenic diet and fasting induce the expression of cold-inducible RNA-binding protein with time-dependent hypothermia in the mouse liver[J]. FEBS Open Biology,2013,3:192-195.
[30]DODDS P N,RATHJEN J P. Plant immunity:towards an integrated view of plant-pathogen interactions[J]. Nature Reviews Genetics,2010,11(8):539-548.
[31]RAJAMUTHIAH R,MYLONAKIS E. Effector triggered immunity[J].Virulence,2014,5(7):697-702.
[32]NICAISE V,JOE A,JEONG B R,et al. Pseudomonas Hop U1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7[J]. EMBO Journal,2013,32(5):701-712.
[33]QIANG X,YANG W L,WU R,et al. Cold-inducible RNA-binding protein(CIRP)triggers inflammatory responses in hemorrhagic shock and sepsis[J]. Nature Medicine,2013,19(11):1489-1495.
[34]SAKURAI T,KUDO M,WATANABE T,et al. Hypothermia protects against fulminant hepatitis in mice by reducing reactive oxygen species production[J]. Digestive Diseases and Sciences,2013,31(5/6):440-446.
[35]GODWIN A,YANG W L,SHARMA A,et al. Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury[J].Shock,2015,43(1):24-30.
[36]KIZIL C,KYRITSIS N,BRAND M. Effects of inflammation on stem cells:together they strive?[J]. EMBO Reports,2015,16(4):416-426.
[37]SAKURAI T,YADA N,WATANABE T,et al. Cold-inducible RNA-binding protein promotes the development of liver cancer[J]. Cancer Science,2015,106(4):352-358.
[38]SAKURAI T,KASHIDA H,WATANABE T,et al. Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer[J].Cancer Research,2014,74(21):6119-6128.
[39]JIAN F,CHEN Y,NING G,et al. Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway[J]. Oncotarget,2016,7(8):9175-9187.
[40]REN W H,ZHANG L M,LIU H Q,et al. Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma:an immunohistochemical and clinical correlation analysis[J]. Medical Oncology,2014,31(8):120.
[41]HAMID A A,MANDAI M,FUJITA J,et al. Expression of cold-inducible RNA-binding protein in the normal endometrium,endometrial hyperplasia,and endometrial carcinoma[J]. Internation Journal of Gynecological Pathology,2003,22(3):240-247.
[42]GUO X,WU Y,HARTLEY R S. Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer[J]. Molecular Carcinogenesis,2010,49(2):130-140.
[43]NISHIYAMA H,DANNO S,KANEKO Y,et al. Decreased expression of cold-inducible RNA-binding protein(CIRP)in male germ cells at elevated temperature[J]. The American Journal Pathology,1998,152(1):289-296.
[44]BANKS S,KING S A,IRVINE D S,et al. Impact of a mild scrotal heat stress on DNA integrity in murine spermatozoa[J]. Reproduction,2005,129(4):505-514.
[45]RAO M,MA S,HU S,et al. Isobaric tags for relative and absolute quantification-based proteomic analysis of testis biopsies in rhesus monkeys treated with transient scrotal hyperthermia[J]. Oncotarget,2017,8(49):85909-85925.
[46]XIA Z P,ZHENG X M,ZHENG H,et al. Downregulation of cold-inducible RNA-binding protein activates mitogen-activated protein kinases and impairs spermatogenic function in mouse testes[J]. Asian Journal of Andrology,2012,14(6):884-889.
[47]ZHOU K W,ZHENG X M,YANG Z W,et al. Overexpression of CIRP may reduce testicular damage induced by cryptorchidism[J]. Clinical and Investigative Medicine,2009,32(2):E103-E111.
[48]MASUDA T,ITOH K,HIGASHITSUJI H,et al. Cold-inducible RNAbinding protein(Cirp)interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice[J]. Proceedings of the National Academy of Sciences of the United States of America,2012,109(27):10885-10890.