长链非编码RNA在急性心肌梗死中的研究进展
摘要
总结近年来在急性心肌梗死(AMI)中发现的lncRNA作用机制以及其作为AMI治疗靶点的潜在应用。目前,非编码RNA(ncRNA)的研究成为AMI的治疗靶点。NcRNAs作为一类通常不编码蛋白质的RNA分子被分成几个亚组,其中,长链非编码RNA(lncRNA)被广泛研究并用于调节AMI的几个病理学方面,包括心肌细胞凋亡、炎症、血管生成和纤维化形成等。
引文
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[5]CHEN G,WANG Z,WANG D,et al.LncRNA disease:a database for long-non-coding RNA-associated diseases[J].Nucleic Acids Res,2013,41(Database issue):D983-986.
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[7]NECSULEA A,SOUMILLON M,WARNEFORS M,et al.The evolution of lncRNA repertoires and expression patterns in tetrapods[J].Nature,2014,505(7485):635-640.
[8]ULITSKY I,BARTEL D P.lincRNAs:genomics,evolution,and mechanisms[J].Cell,2013,154(1):26-46.
[9]DERRIEN T,JOHNSON R,BUSSOTTI G,et al.The GEN-CODE v7catalog of human long noncoding RNAs:analysis of their gene structure,evolution,and expression[J].Genome Res,2012,22(9):1775-1789.
[10]ZHANG Y,SUN L,XUAN L,et al.Reciprocal changes of circulating long non-coding RNAs ZFAS1and CDR1AS predict acute myocardial infarction[J].Sci Rep,2016,6:22384.
[11]YAN Y,ZHANG B,LIU N,et al.Circulating long noncoding RNA UCA1as a novel biomarker of acute myocardial infarction[J].Biomed Res Int,2016,2016:8079372.
[12]ZANGRANDO J,ZHANG L,VAUSORT M,et al.Identification of candidate long non-coding RNAs in response to myocardial infarction[J].BMC Genomics,2014,15:460.
[13]ZHANG J,GAO C,MENG M,et al.Long noncoding RNAMHRT protects cardiomyocytes against H2O2-induced apoptosis[J].biomol ther(Seoul),2016,24(1):19-24.
[14]WANG K,LIU C Y,ZHOU L Y,et al.APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p[J].Nat Commun,2015,6:6779.
[15]WANG K,LONG B,ZHOU L Y,et al.CARL incRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2downregulation[J].Nat Commun,2014,5:3596.
[16]WANG J X,ZHANG X J,LI Q,et al.MicroRNA-103/107regulate programmed necrosis and myocardial ischemia/reperfusion injury through targeting FADD[J].Circ Res,2015,117(4):352-363.
[17]WANG K,LIU F,LIU C Y,et al.The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873[J].Cell Death Differ,2016,23(8):1394-1405.
[18]SANDERS L N,SCHOENHARD J A,SALEH M A,et al.BMPantagonist gremlin 2limits inflammation after myocardial infarction[J].Circulation Research,2016,119(3):434-449.
[19]VAUSORT M,WAGNER D R,DEVAUX Y.Long noncoding RNAs in patients with acute myocardial infarction[J].Circulation Research,2014,115(7):668-677.
[20]YAN B,YAO J,LIU J Y,et al.lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA[J].Circ Res,2015,116(7):1143-1156.
[21]QU X,SONG X,YUAN W,et al.Expression signature of lncR-NAs and their potential roles in cardiac fibrosis of post-infarct mice[J].Biosci Rep,2016,36(3):e00337.
[22]WANG K,LIU F,ZHOU L Y,et al.The long noncoding RNACHRF regulates cardiac hypertrophy by targeting miR-489[J].Circ Res,2014,114(9):1377-1388.