艾蒿花粉过敏患者呼出一氧化氮及肺功能相关性研究
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摘要
目的了解在艾蒿过敏患者中,呼出一氧化氮(fractional exhale nitric oxide,FeNO)与肺功能是否具有相关性,病程、鼻炎评分与FeNO和肺功能是否具有相关性。方法对2018年8～9月间就诊的88例艾蒿花粉过敏患者的FeNO和肺功能结果进行统计分析。结果病程﹤5年的患者与病程≥9年的患者相比,FeNO和第1秒用力呼气容积占预计值百分比(FEV_1%)差异具有统计学意义(P=0.004,P=0.032),且随着病程的延长FeNO也相应增高,而FEV_1%则逐渐下降。FeNO与FEF_(25%-75%)占预计值百分比(FEF_(25%-75%pred))、FEV_1%呈负相关,而与FEV1占预计值百分比(FEV_1%pred)无相关性。鼻炎评分与FeNO呈正相关;与FEV_1%pred、FEV1%、FEF25%-75%pred无相关性。结论随着艾蒿过敏患者病情进展,其气流受限的几率也相应增大;FeNO在一定程度上可以早期预测气道功能的改变,能够作为哮喘预测的监测指标;FeNO值可以反应出机体炎症程度,可用于变应性鼻炎患者病情严重程度的辅助诊断。
OBJECTIVE To investigate the correlation between fractional exhaled nitric oxide(FeNO)and lung function in artemisia argyi allergy patients.Whether the course of disease and rhinitis score are correlated with FeNO and lung function. METHODS A total of 88 patients with mugwort pollen allergy, who visited the hospital between August and September 2017 and August and September 2018, the results of their FeNO and Pulmonary ventilation function, were included in this study.RESULTS Compared with patients with a duration of 9 years or more, FeNO and FEVi% of patients with a duration of 5 years were significantly different(P=0.004,P=0.032),and FeNO increased with the extension of the duration,while FEV_1% decreased gradually. FeNO was negatively correlated with FEF25%-75%pred and FEV1%,while there was no correlation with FEV_1%Pred. Rhinitis score was positively correlated with FeNO. There was no correlation with FEV_1%pred, FEV_1%, FEF25%-75%pred. CONCLUSION With the development of mugwort pollen allergy, the probability of airflow limitation is also increased. To some extent, FeNO can predict the changes of airway function early, and can be used as a monitoring indicator for asthma prediction.FeNO value can reflect the degree of inflammation of the body,and can be used in the auxiliary diagnosis of the severity of allergic rhinitis patients.
OBJECTIVE To investigate the correlation between fractional exhaled nitric oxide(FeNO)and lung function in artemisia argyi allergy patients.Whether the course of disease and rhinitis score are correlated with FeNO and lung function. METHODS A total of 88 patients with mugwort pollen allergy, who visited the hospital between August and September 2017 and August and September 2018, the results of their FeNO and Pulmonary ventilation function, were included in this study.RESULTS Compared with patients with a duration of 9 years or more, FeNO and FEVi% of patients with a duration of 5 years were significantly different(P=0.004,P=0.032),and FeNO increased with the extension of the duration,while FEV_1% decreased gradually. FeNO was negatively correlated with FEF25%-75%pred and FEV1%,while there was no correlation with FEV_1%Pred. Rhinitis score was positively correlated with FeNO. There was no correlation with FEV_1%pred, FEV_1%, FEF25%-75%pred. CONCLUSION With the development of mugwort pollen allergy, the probability of airflow limitation is also increased. To some extent, FeNO can predict the changes of airway function early, and can be used as a monitoring indicator for asthma prediction.FeNO value can reflect the degree of inflammation of the body,and can be used in the auxiliary diagnosis of the severity of allergic rhinitis patients.
引文
[1]魏庆宇.花粉症的诊治及预防.中国实用内科杂志,2012,32(2):89-91.
[2]王瑞琦,张宏誉.20万项次过敏原特异性IgE检测结果.中华临床免疫和变态反应杂志,2012,6(1):18-23.
[3]姜洪杰.吉林地区蒿属花粉调查与致敏疾病临床应用研究.中国继续医学教育,2015,7(31):34-36.
[4]尹佳,岳凤敏,王良录,等.夏秋季花粉症患者变应性鼻炎发展至变应性哮喘进程的临床研究.中华医学杂志,2006,86(23):1628-1632.
[5]杜慧敏,徐珏,罗旭东,等.呼出气一氧化氮与变应性鼻炎的相关性分析.中国耳鼻咽喉头颈外科,2016,23(5):279-281.
[6]殷明德.变应性鼻炎与支气管哮喘相互关系新概念.临床耳鼻咽喉科杂志,2004,18(2):65-66.
[7]吕晓飞,锡琳,韩德民,等.哮喘对变应性鼻炎患者精神心理的影响.中国耳鼻咽喉头颈外科,2014,21(11):577-580.
[8]Matsunaga K,Hirano T,Oka A,et al.Persistently high exhaled nitric oxide and loss of lung function in controlled asthma.Allergol Int,2016,65(3):266-271.
[9]钱迪,高春生,张红伟.变应性鼻炎患者肺通气功能和呼吸阻力的改变.临床耳鼻咽喉头颈外科杂志,2011,25(2):82-84.
[10]Bake B,Viklund E,Olin AC.Effects of pollen season on central and peripheral nitric oxide production in subjects with pollen asthma.Respir Med,2014,108(9):1277-1283.2018-09-11
[2]王瑞琦,张宏誉.20万项次过敏原特异性IgE检测结果.中华临床免疫和变态反应杂志,2012,6(1):18-23.
[3]姜洪杰.吉林地区蒿属花粉调查与致敏疾病临床应用研究.中国继续医学教育,2015,7(31):34-36.
[4]尹佳,岳凤敏,王良录,等.夏秋季花粉症患者变应性鼻炎发展至变应性哮喘进程的临床研究.中华医学杂志,2006,86(23):1628-1632.
[5]杜慧敏,徐珏,罗旭东,等.呼出气一氧化氮与变应性鼻炎的相关性分析.中国耳鼻咽喉头颈外科,2016,23(5):279-281.
[6]殷明德.变应性鼻炎与支气管哮喘相互关系新概念.临床耳鼻咽喉科杂志,2004,18(2):65-66.
[7]吕晓飞,锡琳,韩德民,等.哮喘对变应性鼻炎患者精神心理的影响.中国耳鼻咽喉头颈外科,2014,21(11):577-580.
[8]Matsunaga K,Hirano T,Oka A,et al.Persistently high exhaled nitric oxide and loss of lung function in controlled asthma.Allergol Int,2016,65(3):266-271.
[9]钱迪,高春生,张红伟.变应性鼻炎患者肺通气功能和呼吸阻力的改变.临床耳鼻咽喉头颈外科杂志,2011,25(2):82-84.
[10]Bake B,Viklund E,Olin AC.Effects of pollen season on central and peripheral nitric oxide production in subjects with pollen asthma.Respir Med,2014,108(9):1277-1283.2018-09-11
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