氟尼辛葡甲胺对患呼吸道疾病奶牛的解热效果
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摘要
为了研究氟尼辛葡甲胺对患呼吸道疾病奶牛的解热效果,试验选75头患呼吸道疾病泌乳期的奶牛并分为5个组,分别为高剂量组(氟尼辛葡甲胺4.4 mg/kg·bw土霉素20 mg/kg·bw)、中剂量组(推荐剂量,氟尼辛葡甲胺2.2 mg/kg·bw土霉素20 mg/kg·bw)、低剂量组(氟尼辛葡甲胺1.1 mg/kg·bw土霉素20 mg/kg·bw)、药物对照组(福乃达2.2 mg/kg·bw土霉素20 mg/kg·bw)和土霉素组(20 mg/kg·bw),每组15头奶牛。在给药前和最后一次给药后的第1、2、3、7天和14天分别记录奶牛的直肠温度、呼吸频率、食欲、呼吸困难以及咳嗽情况,并依据评分表进行打分。结果在最后一次给药后的第1、2、3、7天和14天,高剂量组、中剂量组和药物对照组之间,直肠温度无显著差异(P>0.05);在最后一次给药后的第14天,高剂量组与中剂量组均比土霉素组在降低动物直肠温度方面具有更显著的效果(P≤0.05)。最后1次给药后的第14天,高剂量组、中剂量组与土霉素组相比,临床症状得分降低更显著(P≤0.05);高剂量组、中剂量组、低剂量组与药物对照组相比,临床症状得分虽然无显著性差异(P>0.05),但是临床症状得分数值上,高剂量组、中剂量组均略低于药物对照组。在最后1次给药后的第14天,高剂量组、中剂量组、低剂量组、土霉素组和药物对照组对奶牛呼吸道疾病的治愈率分别为80.00%、73.33%、60.00%、53.33%和66.67%。结论:建议氟尼辛葡甲胺注射液临床上用于治疗呼吸道疾病引起的奶牛高热时,给药方式为静脉给氟尼辛葡甲胺注射液2.2 mg/kg·bw,每日1次,连用5 d,并单次肌肉注射土霉素注射液20 mg/kg·bw,连用5 d。
The objective of this experiment is to study the antipyretic effect of Flunixin Meglumine on respiratory diseases cows.75 dairy cows with respiratory disease during lactation were selected in the experiment, and were divided into 5 groups. Such as, high dose group(Flunixin Meglumine 4.4 mg/kg bw, Oxytetracycline 20 mg/kg bw), middle dose group(recommended dose, Flunixin Meglumine 2.2 mg/kg bw, Oxytetracycline 20 mg/kg·bw), low dose group(Flunixin Meglumine 1.1 mg/kg, Oxytetracycline 20 mg/kg·bw) and control group(Finadyne 2.2 mg/kg·bw, Oxytetracycline 20 mg/kg·bw) and Oxytetracycline group(20 mg/kg·bw), 15 cows in each group. The rectal temperature, respiratory frequency, appetite, dyspnea and cough were recorded before the administration and 1, 2, 3, 7,14 days after the last administration The scores were marked according to the score table.There was no significant difference in rectal temperature between the high-dose group and the middle dose group and the control group in 1, 2, 3, 7 and 14 days after the last administration(P>0.05); the high dose group and the middle dose group were more effective than the Oxytetracycline group in reducing rectal temperature of animals in 14 days after the last administration(P≤0.05). 14 days after the last administration, compared with the Oxytetracycline group, the score of clinical symptoms of the high and middle group decreased more significantly(P≤0.05); compared with the control group, although the high, middle and low dose group had no significant difference in the score of clinical symptoms(P>0.05), the score of clinical symptoms was slightly lower than that of the control group. 14 days after the last administration,the cure rates of high,middle,low dose,Oxytetracycline and control group were 80%,73. 33%,60%,53. 33% and 66. 67% respectively. For the treatment of high fever of cows cauesed by piratory diseases,Flunixin Meglumin injection was given 2. 2 mg/kg bw by intravenous administration in 1 times a day for 5 successive days,and Oxytetracycline injection 20 mg/kg bw was given by intramuscular injection for 5 successive days simultaneously.
The objective of this experiment is to study the antipyretic effect of Flunixin Meglumine on respiratory diseases cows.75 dairy cows with respiratory disease during lactation were selected in the experiment, and were divided into 5 groups. Such as, high dose group(Flunixin Meglumine 4.4 mg/kg bw, Oxytetracycline 20 mg/kg bw), middle dose group(recommended dose, Flunixin Meglumine 2.2 mg/kg bw, Oxytetracycline 20 mg/kg·bw), low dose group(Flunixin Meglumine 1.1 mg/kg, Oxytetracycline 20 mg/kg·bw) and control group(Finadyne 2.2 mg/kg·bw, Oxytetracycline 20 mg/kg·bw) and Oxytetracycline group(20 mg/kg·bw), 15 cows in each group. The rectal temperature, respiratory frequency, appetite, dyspnea and cough were recorded before the administration and 1, 2, 3, 7,14 days after the last administration The scores were marked according to the score table.There was no significant difference in rectal temperature between the high-dose group and the middle dose group and the control group in 1, 2, 3, 7 and 14 days after the last administration(P>0.05); the high dose group and the middle dose group were more effective than the Oxytetracycline group in reducing rectal temperature of animals in 14 days after the last administration(P≤0.05). 14 days after the last administration, compared with the Oxytetracycline group, the score of clinical symptoms of the high and middle group decreased more significantly(P≤0.05); compared with the control group, although the high, middle and low dose group had no significant difference in the score of clinical symptoms(P>0.05), the score of clinical symptoms was slightly lower than that of the control group. 14 days after the last administration,the cure rates of high,middle,low dose,Oxytetracycline and control group were 80%,73. 33%,60%,53. 33% and 66. 67% respectively. For the treatment of high fever of cows cauesed by piratory diseases,Flunixin Meglumin injection was given 2. 2 mg/kg bw by intravenous administration in 1 times a day for 5 successive days,and Oxytetracycline injection 20 mg/kg bw was given by intramuscular injection for 5 successive days simultaneously.
引文
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[6] 陶大勇,陈英,张伟,等.维生素B1与安乃近、安痛定配伍在牛病中的使用 [J].中国草食动物,2002,22(2):46-47.
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[9] 封海波,彭广能,白永平.双黄连配合抗生素治疗奶牛夏季呼吸道感染 [J].中国兽医杂志,2006,42(10):24-24.
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[13] 余祖功,蒋春茂,郭永刚,等.猪静注、肌注氟尼辛葡甲胺的药物动力学研究[J].中国农业科学,2007,40(9):2 068-2 072.
[14] 李世江,张克云,张彬,等.氟尼辛葡甲胺注射液与氟苯尼考注射液联用对人工感染猪巴氏杆菌的治疗试验[J].中国畜牧兽医,2007,34(8):120-122.
[15] Papich M G.Flunixin Meglumine[J].Saunders Handbook of Veterinary Drugs,2016,336-338.
[16] Kasimanickam R K,Hall J B,Estill C T,et al.Flunixin meglumine improves pregnancy rate in embryo recipient beef cows with an excitable temperament[J].Theriogenology,2017,107:70-77.
[17] Wagner S A,Young J M,Tena J K,et al.Short communication:Behavioral evaluation of the analgesic effect of flunixin meglumine in lame dairy cows [J].Journal of Dairy Science,2017,100(8):6 562-6 566.
[18] Giammarco M,Fusaro I,Vignola G,et al.Effects of a single injection of Flunixin meglumine or Carprofen postpartum on haematological parameters,productive performance and fertility of dairy cattle[J].Animal Production Science,2016,58(2):322-331.
[19] Newby N C,Leslie K E,Dingwell H D,et al.The effects of periparturient administration of flunixin meglumine on the health and production of dairy cattle[J].Journal of Dairy Science,2017,100(1):582-587.
[20] Friton G M,Cajal C,Ramirezromero R.Long-term effects of meloxicam in the treatment of respiratory disease in fattening cattle[J].Veterinary Record,2005,156(25):809-811.
[21] Friton G M,Cajal C,Ramirez R R,et al.Clinical efficacy of meloxicam (Metacam) and flunixin (Finadyne) as adjuncts to antibacterial treatment of respiratory disease in fattening cattle[J].Berl Munch Tierarztl Wochenschr,2004,117(7-8):304-309.
[22] Bednarek D,Zdzisinska B,Kondrachi M,et al.Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia[J].Veterinary Microbiology,2003,96(1):53-67.
[23] Kleinhenz M D,Gorden P J,Smith J,et al.21 Evaluation of Transdermal Flunixin Meglumine on Experimentally Induced Lameness in Adult Dairy Cattle[J].Journal of Animal Science,2018,96:11-11.
[24] Whalins Halin L,Pairis-Garcia M,Proudfoot K,et al.Validating behavioral sampling techniques for lame sows administered flunixin meglumine and meloxicam[J].Livestock Science,2016,191:103-107.
[25] 陈大健,胡屹屹,冯秀娟,等.新兽药氟尼辛葡甲胺的解热镇痛作用[J].中国兽医学报,2008,28(5):562-565.
[26] 丁焕中,孙永学,曾振灵,等.氟尼辛葡甲胺对猪实验性链球菌感染的解热作用[J].中国兽医杂志,2008,44(8):76-77.
[27] Odensvik K,Magnusson U.Effect of oral administration of flunixin meglumine on the inflammatory response to endotoxin in heifers[J].American Journal of Veterinary Research,1996,57(2):201-204.
[28] Pairis-Garcia M D,Karriker L A,Johnson A K,et al.Pharmacokinetics of flunixin meglumine in mature swine after intravenous,intramuscular and oral administration[J].BMC Veterinary Research,2013,9(1):165-171.
[2] Velasova M,Damaso A,Prakashbabu B C,et al.Herd-level prevalence of selected endemic infectious diseases of dairy cows in Great Britain[J].Journal of Dairy Science,2017,100(11):1-20.
[3] Rodr Guez E M,Ar S A,Bach A.Associations between subclinical hypocalcemia and postparturient diseases in dairy cows[J].Journal of Dairy Science,2017,100(9):7 427-7 434.
[4] K Nigsson K,T Rneke K,Engeland I V,et al.Pharmacokinetics and Pharmacodynamic Effects of Flunixin after Intravenous,Intramuscular and Oral Administration to Dairy Goats [J].Acta Veterinaria Scandinavica,2003,44(4):153-159.
[5] 曹斌斌,张振新,赵勐,等.美洛昔康治疗奶牛急性乳房炎效果观察 [J].中国兽医杂志,2011,47(8):79-80.
[6] 陶大勇,陈英,张伟,等.维生素B1与安乃近、安痛定配伍在牛病中的使用 [J].中国草食动物,2002,22(2):46-47.
[7] 韦人,徐平,孙红玲,等.北方地区秋冬季奶牛呼吸道疾病防治探析 [J].河南畜牧兽医:综合版,2015,36(12):18-19.
[8] 林春驿,盖金.冰蟾熊胆针治疗犊牛支气管炎临床观察[J].中兽医学杂志,2004,40(6):18-18.
[9] 封海波,彭广能,白永平.双黄连配合抗生素治疗奶牛夏季呼吸道感染 [J].中国兽医杂志,2006,42(10):24-24.
[10] British Pharmacopoeia Commission.British Pharmacopoeia (Veterinary)2007 [Z].London:The Stationery Office,2007-06.
[11] The United States Pharmacopeial Convention Inc.The United States Pharmacopeia (USP 26th revision)[Z].Maryland:2003-03.
[12] 吴文学,王中杰,李金祥.新兽药氟尼辛葡甲胺的研究 [J].中国兽医杂志,2006,42(1):51-53.
[13] 余祖功,蒋春茂,郭永刚,等.猪静注、肌注氟尼辛葡甲胺的药物动力学研究[J].中国农业科学,2007,40(9):2 068-2 072.
[14] 李世江,张克云,张彬,等.氟尼辛葡甲胺注射液与氟苯尼考注射液联用对人工感染猪巴氏杆菌的治疗试验[J].中国畜牧兽医,2007,34(8):120-122.
[15] Papich M G.Flunixin Meglumine[J].Saunders Handbook of Veterinary Drugs,2016,336-338.
[16] Kasimanickam R K,Hall J B,Estill C T,et al.Flunixin meglumine improves pregnancy rate in embryo recipient beef cows with an excitable temperament[J].Theriogenology,2017,107:70-77.
[17] Wagner S A,Young J M,Tena J K,et al.Short communication:Behavioral evaluation of the analgesic effect of flunixin meglumine in lame dairy cows [J].Journal of Dairy Science,2017,100(8):6 562-6 566.
[18] Giammarco M,Fusaro I,Vignola G,et al.Effects of a single injection of Flunixin meglumine or Carprofen postpartum on haematological parameters,productive performance and fertility of dairy cattle[J].Animal Production Science,2016,58(2):322-331.
[19] Newby N C,Leslie K E,Dingwell H D,et al.The effects of periparturient administration of flunixin meglumine on the health and production of dairy cattle[J].Journal of Dairy Science,2017,100(1):582-587.
[20] Friton G M,Cajal C,Ramirezromero R.Long-term effects of meloxicam in the treatment of respiratory disease in fattening cattle[J].Veterinary Record,2005,156(25):809-811.
[21] Friton G M,Cajal C,Ramirez R R,et al.Clinical efficacy of meloxicam (Metacam) and flunixin (Finadyne) as adjuncts to antibacterial treatment of respiratory disease in fattening cattle[J].Berl Munch Tierarztl Wochenschr,2004,117(7-8):304-309.
[22] Bednarek D,Zdzisinska B,Kondrachi M,et al.Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia[J].Veterinary Microbiology,2003,96(1):53-67.
[23] Kleinhenz M D,Gorden P J,Smith J,et al.21 Evaluation of Transdermal Flunixin Meglumine on Experimentally Induced Lameness in Adult Dairy Cattle[J].Journal of Animal Science,2018,96:11-11.
[24] Whalins Halin L,Pairis-Garcia M,Proudfoot K,et al.Validating behavioral sampling techniques for lame sows administered flunixin meglumine and meloxicam[J].Livestock Science,2016,191:103-107.
[25] 陈大健,胡屹屹,冯秀娟,等.新兽药氟尼辛葡甲胺的解热镇痛作用[J].中国兽医学报,2008,28(5):562-565.
[26] 丁焕中,孙永学,曾振灵,等.氟尼辛葡甲胺对猪实验性链球菌感染的解热作用[J].中国兽医杂志,2008,44(8):76-77.
[27] Odensvik K,Magnusson U.Effect of oral administration of flunixin meglumine on the inflammatory response to endotoxin in heifers[J].American Journal of Veterinary Research,1996,57(2):201-204.
[28] Pairis-Garcia M D,Karriker L A,Johnson A K,et al.Pharmacokinetics of flunixin meglumine in mature swine after intravenous,intramuscular and oral administration[J].BMC Veterinary Research,2013,9(1):165-171.