卫矛属药用植物不同提取部位药理活性研究进展
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摘要
卫矛属药用植物由于其在抗炎、活血止血、调节血糖血脂以及抗肿瘤方面具有突出活性而被广泛使用.研究了卫矛属药用植物因不同提取部位所表现出的生物活性差异特性,并着重分析了水提液部位和醇提液部位所产生的活性差别及其物质基础.研究发现水提液主要表现为降血糖血脂、凝血、止血等作用;而醇提部位主要表现出抗肿瘤、抗氧化、抗炎等活性作用.为该属植物的植物化学、药理学及其进一步的临床应用提供参考依据.
The Euonymus genera has been widely used as medicinal plants in China as it mainly exhibits anti-inflammatory,promoting blood circulation,hemostatic,anti-diabetic,stabilizing blood lipids level,anti-tumor and other pharmacological properties. In this paper,we discussed about the pharmacological activities of different extracts from these medicinal plants and analyzed the differences and material basis between water-extracts and alcohol-extracts. It was found that the water-extracts mainly exhibited anti-diabetic,blood lipid regulation,coagulation and hemostatic effect while the alcohol-extracts mainly showed the activity of anti-tumor,anti-oxidation and anti-inflammation. The study can provides theoretical basis for further research on phytochemistry,pharmacology and clinical application of these medicinal plants.
The Euonymus genera has been widely used as medicinal plants in China as it mainly exhibits anti-inflammatory,promoting blood circulation,hemostatic,anti-diabetic,stabilizing blood lipids level,anti-tumor and other pharmacological properties. In this paper,we discussed about the pharmacological activities of different extracts from these medicinal plants and analyzed the differences and material basis between water-extracts and alcohol-extracts. It was found that the water-extracts mainly exhibited anti-diabetic,blood lipid regulation,coagulation and hemostatic effect while the alcohol-extracts mainly showed the activity of anti-tumor,anti-oxidation and anti-inflammation. The study can provides theoretical basis for further research on phytochemistry,pharmacology and clinical application of these medicinal plants.
引文
[1]林士杰,刘原樟,徐加顺.卫矛属种质资源开发利用研究概述[J].吉林林业科技,2009(2):17-19.
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[3]姚祖培,陈建新,李福如.鬼箭羽化学、药理及临床应用概况[J].中国中医药信息杂志,2000,7(12):31-33.
[4]朱红梅,钟鸣.扶芳藤及其提取物的有关药理作用的实验研究[J].中国中医药科技,2000(3):170-174.
[5]王巍,王晋桦.鸡血藤,鬼箭羽和土鳖虫调脂作用的比较[J].中国中药杂志,1991,16(5):299-301.
[6]尚文斌,程海波,唐含艳.鬼箭羽对糖尿病小鼠血糖及全血粘度的影响[J].南京中医药大学学报,2000,16(3):166-167.
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[8]赵蒙蒙,谢梦洲,李路丹,等.鬼箭羽对2型糖尿病大鼠胰岛β细胞形态学的影响[J].湖南中医药大学学报,2010,30(3):14-16.
[9]孙学斌,程明,李娜,等.卫矛不同有效部位总黄酮含量及抗氧化性的研究[J].植物研究,2007,27(5):619-621.
[10]齐昉,刘根尚,佘靖,等.鬼箭羽对实验性糖尿病小鼠血糖及血脂的影响[J].中国中医药信息杂志,1998,5(7):19-20.
[11]吴玉强.常春卫矛及爬行卫矛提取物止血消瘀药效研究[J].中国实验方剂学杂志,2011,17(12):132-136.
[12]朱智德,罗宇东,蒋林,等.瑶药扶芳藤对血管内皮细胞缺氧损伤的保护作用[J].中国医药导报,2017,14(10):26-30.
[13]农毅清,蒋林,罗宇东,等.常春卫矛提取物对H2O2诱导的血管内皮细胞损伤的保护作用[J].中国药师,2017,20(5):805-808.
[14]孙荣花,周元飞,邵莹,等.桃叶卫矛叶提取物的体外抗氧化活性及对CCL_4致小鼠急性肝损伤的保护作用[J].辽宁中医药大学学报,2015(11):28-31.
[15]Byung-Yoon C,Chan-Jo P,Dong-Gyu L,et al.Inhibitory effect of methanol extract of Euonymus alatus on matrix metalloproteinase-9[J].Journal of Ethnopharmacology,2003,85(1):163-167.
[16]Seo U K,Lee Y J,Kim J K,et al.Large-scale and effective screening of Korean medicinal plants for inhibitory activity on matrix metalloproteinase-9[J].Journal of Ethnopharmacology,2005,97(1):101-106.
[17]方振峰.中药鬼箭羽的化学成分及抗肿瘤活性研究[D].沈阳:沈阳药科大学,2007.
[18]方振峰,李占林,王宇,等.鬼箭羽的化学成分研究[J].中草药,2015,38(13):810-812.
[19]Chung T W.Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells:complete regression of hepatoma growth and metastasis by dual mechanism[J].The Faseb Journal,2004,18(14):1670-1681.
[20]毛士龙.宝兴卫矛和山海螺化学成分及活性研究[D].上海:中国科学院上海药物研究所,1999.
[21]吴建国,曾凡波,杨敬.绿舒筋生物总碱的体外抗乳腺癌细胞株效应[J].华中科技大学学报(医学版),2003,32(6):665-666.
[22]Kitanaka S,Takido M,Mizoue K,et al.Cytotoxic Cardenolides from Woods of Euonymus alata.[J].Chemical&Pharmaceutical Bulletin,1996,44(3):615-617.
[23]Li F,Ma J,Li C J,et al.Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius[J].Phytochemistry,2017,135(Complete):144-150.
[24]谷树珍.鬼箭羽醇提物的抑菌、抗炎作用研究[J].湖北民族学院学报(医学版),2006,23(1):17-19.
[25]罗宇东,张强,蒋林等.常春卫矛提取物体外及体内抑菌作用的试验研究[J].中国当代医药,2014(18):9-11.
[26]Zhou J,Wei X H,Zhang D M,et al.Anti-inflammatory pentacyclic triterpenes from the stems of Euonymus carnosus.[J].Fitoterapia,2017,118:21-26.
[27]Yang Y L,Yang X Y,Guo Y Q.Bioactive terpenoids from Euonymus verrucosus var.pauciβorus showing NOinhibitory activities.[J].Bioorganic Chemistry,2019,87:447-456.
[28]Park S H,Ko S K,Chung S H.Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice.[J].Journal of Ethnopharmacology,2005,102(3):326-335.
[29]Van B N,San-Lang W,Thi N,et al.Novel Potent Hypoglycemic Compounds from Euonymus laxiflorus Champ.and Their Effect on Reducing Plasma Glucose in an ICR Mouse Model[J].Molecules,2018,23(8):1928.
[30]Wan X,Huang H C,Wang X P,et al.Euonymus alatus and its monomers alleviate liver fibrosis both in mice and LX2 cells by blocking TβR1-Smad2/3 and TNF-α-NF-κB pathways.[J].Am J Transl Res,2019,11(1):106-119.
[2]中国科学院中国植物志委员会.中国植物志:第四十五卷第三分册[M].北京:科学出版社,1999:123.
[3]姚祖培,陈建新,李福如.鬼箭羽化学、药理及临床应用概况[J].中国中医药信息杂志,2000,7(12):31-33.
[4]朱红梅,钟鸣.扶芳藤及其提取物的有关药理作用的实验研究[J].中国中医药科技,2000(3):170-174.
[5]王巍,王晋桦.鸡血藤,鬼箭羽和土鳖虫调脂作用的比较[J].中国中药杂志,1991,16(5):299-301.
[6]尚文斌,程海波,唐含艳.鬼箭羽对糖尿病小鼠血糖及全血粘度的影响[J].南京中医药大学学报,2000,16(3):166-167.
[7]夏卫军,程海波,张莉.鬼箭羽治疗2型糖尿病实验研究[J].陕西中医,2001,22(8):505-507.
[8]赵蒙蒙,谢梦洲,李路丹,等.鬼箭羽对2型糖尿病大鼠胰岛β细胞形态学的影响[J].湖南中医药大学学报,2010,30(3):14-16.
[9]孙学斌,程明,李娜,等.卫矛不同有效部位总黄酮含量及抗氧化性的研究[J].植物研究,2007,27(5):619-621.
[10]齐昉,刘根尚,佘靖,等.鬼箭羽对实验性糖尿病小鼠血糖及血脂的影响[J].中国中医药信息杂志,1998,5(7):19-20.
[11]吴玉强.常春卫矛及爬行卫矛提取物止血消瘀药效研究[J].中国实验方剂学杂志,2011,17(12):132-136.
[12]朱智德,罗宇东,蒋林,等.瑶药扶芳藤对血管内皮细胞缺氧损伤的保护作用[J].中国医药导报,2017,14(10):26-30.
[13]农毅清,蒋林,罗宇东,等.常春卫矛提取物对H2O2诱导的血管内皮细胞损伤的保护作用[J].中国药师,2017,20(5):805-808.
[14]孙荣花,周元飞,邵莹,等.桃叶卫矛叶提取物的体外抗氧化活性及对CCL_4致小鼠急性肝损伤的保护作用[J].辽宁中医药大学学报,2015(11):28-31.
[15]Byung-Yoon C,Chan-Jo P,Dong-Gyu L,et al.Inhibitory effect of methanol extract of Euonymus alatus on matrix metalloproteinase-9[J].Journal of Ethnopharmacology,2003,85(1):163-167.
[16]Seo U K,Lee Y J,Kim J K,et al.Large-scale and effective screening of Korean medicinal plants for inhibitory activity on matrix metalloproteinase-9[J].Journal of Ethnopharmacology,2005,97(1):101-106.
[17]方振峰.中药鬼箭羽的化学成分及抗肿瘤活性研究[D].沈阳:沈阳药科大学,2007.
[18]方振峰,李占林,王宇,等.鬼箭羽的化学成分研究[J].中草药,2015,38(13):810-812.
[19]Chung T W.Novel and therapeutic effect of caffeic acid and caffeic acid phenyl ester on hepatocarcinoma cells:complete regression of hepatoma growth and metastasis by dual mechanism[J].The Faseb Journal,2004,18(14):1670-1681.
[20]毛士龙.宝兴卫矛和山海螺化学成分及活性研究[D].上海:中国科学院上海药物研究所,1999.
[21]吴建国,曾凡波,杨敬.绿舒筋生物总碱的体外抗乳腺癌细胞株效应[J].华中科技大学学报(医学版),2003,32(6):665-666.
[22]Kitanaka S,Takido M,Mizoue K,et al.Cytotoxic Cardenolides from Woods of Euonymus alata.[J].Chemical&Pharmaceutical Bulletin,1996,44(3):615-617.
[23]Li F,Ma J,Li C J,et al.Bioactive isopimarane diterpenoids from the stems of Euonymus oblongifolius[J].Phytochemistry,2017,135(Complete):144-150.
[24]谷树珍.鬼箭羽醇提物的抑菌、抗炎作用研究[J].湖北民族学院学报(医学版),2006,23(1):17-19.
[25]罗宇东,张强,蒋林等.常春卫矛提取物体外及体内抑菌作用的试验研究[J].中国当代医药,2014(18):9-11.
[26]Zhou J,Wei X H,Zhang D M,et al.Anti-inflammatory pentacyclic triterpenes from the stems of Euonymus carnosus.[J].Fitoterapia,2017,118:21-26.
[27]Yang Y L,Yang X Y,Guo Y Q.Bioactive terpenoids from Euonymus verrucosus var.pauciβorus showing NOinhibitory activities.[J].Bioorganic Chemistry,2019,87:447-456.
[28]Park S H,Ko S K,Chung S H.Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice.[J].Journal of Ethnopharmacology,2005,102(3):326-335.
[29]Van B N,San-Lang W,Thi N,et al.Novel Potent Hypoglycemic Compounds from Euonymus laxiflorus Champ.and Their Effect on Reducing Plasma Glucose in an ICR Mouse Model[J].Molecules,2018,23(8):1928.
[30]Wan X,Huang H C,Wang X P,et al.Euonymus alatus and its monomers alleviate liver fibrosis both in mice and LX2 cells by blocking TβR1-Smad2/3 and TNF-α-NF-κB pathways.[J].Am J Transl Res,2019,11(1):106-119.