有氧运动预干预对睡眠剥夺大鼠氧化应激水平的影响
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摘要
目的:分析有氧运动预干预对睡眠剥夺大鼠氧化应激水平的影响。方法:选择40只8周龄健康雄性SD大鼠为研究对象,分为安静组、有氧运动组、睡眠剥夺组、有氧运动预干预睡眠剥夺组。其中,安静组不做特殊处理,有氧运动组及有氧运动预干预睡眠剥夺组均接受跑台有氧运动锻炼,睡眠剥夺组及有氧运动预干预睡眠剥夺组均接受睡眠剥夺处理。结果:睡眠剥夺组大鼠形成氧化应激损伤,表现为血清MDA升高,血清SOD及GSH-px活性降低,而有氧运动预干预睡眠剥夺组大鼠血清MDA、血清SOD、血清GSH-px水平均优于睡眠剥夺组,且二者的血清MDA含量差异显著(P <0.05)。结论:有氧运动预干预用于睡眠剥夺大鼠,可改善其氧化应激损伤。
Objective: To analyze the effect of aerobic exercise pre-intervention on oxidative stress in rats with sleep deprivation. Methods: Forty healthy 8 weeksold SD rats were selected as the study group, which were divided into quiet group, aerobic exercise group, sleep deprivation group and aerobic exercise pre-intervention sleep deprivation group. Among them, the quiet group did not do special treatment, the aerobic exercise group and the aerobic exercise pre-intervention sleep deprivation group all received running aerobic exercise, sleep deprivation group and aerobic exercise pre-intervention sleep deprivation group were treated with sleep deprivation. Results: Oxidative stress injury was observed in the rats in the sleep deprivation group, which showed elevated serum MDA, decreased serum SOD and GSH-px activities, and aerobic exercise pre-intervention in the sleep deprived group of rats with serum MDA, serum SOD, and serum GSH-px. The average level of water was better than that of the sleep deprivation group, and the serum MDA content of the two groups was significantly different(P<0.05). Conclusion: Pre-intervention of aerobic exercise for sleep deprivation of rats can improve oxidative stress damage.
Objective: To analyze the effect of aerobic exercise pre-intervention on oxidative stress in rats with sleep deprivation. Methods: Forty healthy 8 weeksold SD rats were selected as the study group, which were divided into quiet group, aerobic exercise group, sleep deprivation group and aerobic exercise pre-intervention sleep deprivation group. Among them, the quiet group did not do special treatment, the aerobic exercise group and the aerobic exercise pre-intervention sleep deprivation group all received running aerobic exercise, sleep deprivation group and aerobic exercise pre-intervention sleep deprivation group were treated with sleep deprivation. Results: Oxidative stress injury was observed in the rats in the sleep deprivation group, which showed elevated serum MDA, decreased serum SOD and GSH-px activities, and aerobic exercise pre-intervention in the sleep deprived group of rats with serum MDA, serum SOD, and serum GSH-px. The average level of water was better than that of the sleep deprivation group, and the serum MDA content of the two groups was significantly different(P<0.05). Conclusion: Pre-intervention of aerobic exercise for sleep deprivation of rats can improve oxidative stress damage.
引文
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