线粒体在偏头痛发病机制中的研究进展
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摘要
偏头痛是临床常见的慢性疾病。其发病机制复杂多样,尚不明确。因此探讨偏头痛的发病机制,进行明确治疗就显得极其重要。线粒体功能众多,不仅可为细胞提供能量,还参与细胞凋亡等多种生物过程。近年来,越来越多的研究表明线粒体功能异常参与了偏头痛发病过程。线粒体可能在偏头痛发病机制中发挥着重要作用,具体表现在线粒体生化学、形态学、遗传学、线粒体甲基化等多个方面。文章就线粒体在偏头痛发病机制中的研究进展做一综述。
Migraine is a common chronic disease in the clinic,which causes great trouble to people's lives and increases the social burden. Its pathogenesis is complex and diverse, and it is not clear. Therefore, it is extremely important to explore the pathogenesis of migraine and to carry out clear treatment. There are many mitochondrial functions, which not only provide energy for cells, but also participate in various biological processes such as apoptosis. In recent years, more and more studies have shown that mitochondrial dysfunction is involved in the pathogenesis of migraine. Mitochondria may play an important role in the pathogenesis of migraine, which can be expressed in many aspects from mitochondrial biochemistry, morphology, genetics, and mitochondrial methylation. This article provides a brief review of the research progress of mitochondria in the pathogenesis of migraine.
Migraine is a common chronic disease in the clinic,which causes great trouble to people's lives and increases the social burden. Its pathogenesis is complex and diverse, and it is not clear. Therefore, it is extremely important to explore the pathogenesis of migraine and to carry out clear treatment. There are many mitochondrial functions, which not only provide energy for cells, but also participate in various biological processes such as apoptosis. In recent years, more and more studies have shown that mitochondrial dysfunction is involved in the pathogenesis of migraine. Mitochondria may play an important role in the pathogenesis of migraine, which can be expressed in many aspects from mitochondrial biochemistry, morphology, genetics, and mitochondrial methylation. This article provides a brief review of the research progress of mitochondria in the pathogenesis of migraine.
引文
[1]Abajobir AA, Abate KH, Abbafati C, et al. Global, regional, and national incidence, prevalence, and years lived with disability for328 diseases and injuries for 195 countries, 1990-2016:a systematic analysis for the Global Burden of Disease Study 2016[J]. Lancet,2017,390(10100):1211-1259. DOI:10. 1016/S0140-6736(17)32154-2.
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[3]于生元.从宏观到微观认识头痛[J].中国疼痛医学杂志,2014,20(1):2-4. DOI:10. 3969/j. issn. 1006-9852. 2014. 01.002.
[4]裴培,陈怀珍,王艳昕,等.电针对偏头痛大鼠中脑导水管周围灰质5-羟色胺7受体和血浆降钙素基因相关肽表达的影响[J].针刺研究,2017,42(6):510-513. DOI:10.13702/j.1000-0607.2017.06.008.
[5]杨小艳,石国霰,曾利,等.天麻素对偏头痛患者外周血CGRP、NO和ET-1表达的影响[J].南京中医药大学学报.2017,33(1):23-25. DOI:10. 14148/j. issn. 1672-0482. 2017.0023.
[6] Dong X, Guan X, Chen K, et al. Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine[J]. Neuroscience Letters, 2017,636:127-133. DOI:10.1016/j.neulet.2016.10.054.
[7]周金玲,杨玉芳,黄振光,等.三七总皂苷通过HIF-1α/BNIP3途径增强线粒体自噬保护大鼠顺铂肾损伤[J].中国药学杂志,2017,52(3):196-200. DOI:10.11669/cpj.2017.03.007.
[8]吴琼,张淑静,张宇晨,等.参知健脑方对缺氧致认知功能障碍大鼠脑线粒体损伤的保护机制研究[J].世界中医药,2017,12(10):2403-2407. DOI:10. 3969/j. issn. 1673-7202. 2017. 10.033.
[9] Semenza GL. Hypoxia-inducible factors in physiology and medicine[J]. Cell, 2012,148(3):399-408. DOI:10. 1016/j. cell. 2012.01.021.
[10] Ma L, Liu JY, Dong JX, et al. Toxicity of Pb~(2+)on rat liver mitochondria induced by oxidative stress and mitochondrial permeability transition[J]. Toxicology Research, 2017,6(6):29-39. DOI:10.1039/C7TX00204A.
[11] Kalogeris T, Bao Y, Korthuis RJ. Mitochondrial reactive oxygen species:a double edged sword in ischemia/reperfusion vs preconditioning[J]. Redox Biology, 2014,2:702-714. DOI:10. 1016/j. redox.2014.05.006.[12] Yao N, Li YJ, Zhang DM, et al. B4G2 Induces Mitochondrial Ap-
optosis by the ROS-Mediated Opening of Ca~(2+)-Dependent Permeability Transition Pores[J]. Cellular Physiology&Biochemistry International Journal of Experimental Cellular Physiology Biochemistry&Pharmacology, 2015,37(3):838-852. DOI:10.1159/000430212.
[13]Barsukova A, Komarov A, Hajnóczky G, et al. Activation of the mitochondrial permeability transition pore modulates Ca~(2+)responses to physiological stimuli in adult neurons[J]. European Journal of Neuroscience, 2015,33(5):831-842. DOI:10. 1111/j. 1460-9568.2010.07576.x.
[14] Xin D, Guan X, Chen K, et al. Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine[J]. Neuroscience Letters, 2017,636:127-133. DOI:10.1016/j. neulet.2016.10.054.
[15] Christensen AF, Esserlind AL, Werge T, et al. The influence of genetic constitution on migraine drug responses[J]. Cephalalgia,2016,36(7):624-639. DOI:10.1177/0333102415610874.
[16] Kodde A,van der Beek EM, Phielix E, et al. Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice[J].Nutrition&Metabolism, 2017,14(1):37. DOI:10. 1186/s12986-017-0191-5.
[17] Jr YW. Hardison HH. Mitochondrial dysfunction in migraine[J].Seminars in Pediatric Neurology, 2013,20(3):188-193. DOI:10.1016/j. spen. 2013.09.002.
[18] Borkum JM. The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress:Preliminary Evidence for a Theory[J]. Headache, 2018,58(1):118-135. DOI:10.1111/head. 13214.
[19] Domitrz I, Koter MD,Cholojczyk M, et al. Changes in serum aminoacids in migraine patients without and with aura and their possible usefulness in the study of migraine pathogenesis[J]. CNS&Neurological Disorders-Drug Targets,2015,14(3):1871-1875. DOI:10.2174/18715273146 66150225144300.
[20] Saygi S, Erol L, Alehan F, et al. Superoxide Dismutase and Catalase Genotypes in Pediatric Migraine Patients[J]. Journal of Child Neurology, 2015, 30(12):1586-1590. DOI:10. 1177/0883073815575366.
[21]Balbi T, Fusco M, Vasapollo D, et al. The presence of trace amines in postmortem cerebrospinal fluid in humans[J]. Journal of Forensic Sciences, 2005,50(3):630-632. DOI:10.1520/JFS2003385.
[22] DAndrea G, Granella F, Leone M, et al. Abnormal platelet trace amine profiles in migraine with and without aura[J]. Cephalalgia,2010,26(8):968-972. DOI:10.1111/j. 1468-2982.2006.01141.x.
[23] Ito K, Kudo M, Sasaki M, et al. Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging:preliminary findings[J]. Neuroradiology, 2016,58(2):115-120. DOI:10.1007/s00234-015-1603-8.
[24] Wisnowski JL, Schmithorst VJ, Rosser T, et al. Magnetic resonance spectroscopy markers of axons and astrogliosis in relation to specific features of white matter injury in preterm infants[J]. Neuroradiology, 2014,56(9):771-779. DOI:10.1007/s00234-014-1380-9.
[25] Zielman R, Teeuwisse WM, Bakels F, et al. Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla1H-MRS[J]. Cephalalgia An International Journal of Headache,2014,34(12):959-967. DOI:10.1177/0333102414527016.
[26] Barbagallo G, Arabia G, Novellino F, et al. Increased glutamate+glutamine levels in the thalamus of patients with essential tremor:A preliminary proton MR spectroscopic study[J]. Parkinsonism&Related Disorders, 2017,47:57-63. DOI:10. 1016/j. parkreldis.2017.11.345.
[27] Ambrosini A, D'Alessio C, Magis D, et al. Targeting pericranial nerve branches to treat migraine:current approaches and perspectives[J]. Cephalalgia An International Journal of Headache, 2015,35(14):1308-1322. DOI:10.1177/0333102415573511.
[28] Rijpma A, Graaf MVD, Meulenbroek O, et al. Altered brain highenergy phosphate metabolism in mild Alzheimer's disease:A 3-dimensional 31P MR spectroscopic imaging study[J]. Neuroimage Clinical, 2018,18:254-261. DOI:10.1016/j. nicl.2018.01.031.
[29] Vollono C, Primiano G, Della MG, et al. Migraine in mitochondrial disorders:prevalence and characteristics[J]. Cephalalgia An International Journal of Headache, 2017,38(6):1093-1106. DOI:10.1177/0333102417723568.
[30] Guedj E, Belenotti P, Serratrice J, et al. Partially reversible cortical metabolic dysfunction in familial hemiplegic migraine with prolonged aura[J]. Headache, 2010,50(5):872-877. DOI:10. 1111/j.1526-4610.2010.01634.x.
[31] Lott MT. Mitochondrial DNA variation in human evolution and disease[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015,163(1):33-38. DOI:10. 1016/j.cell. 2015.08.067.(上接634页)
[32] Ye Z, Xue A, Huang Y, et al. Children with cyclic vomiting syndrome:phenotypes, disease burden and mitochondrial DNA analysis[J]. Bmc Gastroenterology, 2018,18:104. DOI:10. 1186/s12876-018-0836-5.
[33] Rajakulendran S, Pitceathly RDS, Taanman JW, et al. A Clinical,Neuropathological and Genetic Study of Homozygous A467T POLGRelated Mitochondrial Disease[J]. PloS One, 2016, 11(1):e0145500. DOI:10.1371/journal. pone. 0145500.
[34] Cámara MS, Martin BM, Mendioroz IM. Epigenetic changes in headache[J]. Neurologia, 2017,10(10):1150-1157. DOI:10.1016/j.nrl. 2017.10.010.
[35] Gao D, Zhu B, Sun H, et al. Mitochondrial DNA Methylation and Related Disease[J]. Annals of Neurology, 2017,12(11):1102-1121. DOI:10.1007/978-981-10-6674-0_9.
[36] Sharifulina SA, Komandirov MA,Uzdensky AB. Epigenetic regulation of death of crayfish glial cells but not neurons induced by photo-dynamic impact[J]. Brain Research Bulletin, 2014,102(5):15-21. DOI:10. 1016/j. brainresbull. 2014.01.005.
[37] Esterhuizen K, Lindeque JZ,Mason S, et al. A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes(MELAS)[J]. Mitochondrion, 2018,2(3):1567-1574. DOI:10.1016/j. mito. 2018.02.003.
[38] Stefano GB, Kream RM. Mitochondrial DNA heteroplasmy in human health and disease[J]. Biomedical Reports, 2016,4(3):259-262.DOI:10.3892/br. 2016.590.
[39] Stuart S, Benton MC, Eccles DA, et al. Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility[J]. Molecular Genetics&Genomic Medicine,2017,5(2):157-163. DOI:10.1002/mgg3.270.
[40] Powers SW, Coffey CS, Chamberlin LA, et al. Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine[J]. N Engl J Med, 2017,376(2):115-124. DOI:10.1056/NEJMoa1610384.
[2] Zhang Y, Kong Q,Chen J, et al. International Classification of Headache Disorders 3rd edition beta-based field testing of vestibular migraine in China:Demographic, clinical characteristics, audiometric findings and diagnosis statues[J]. Cephalalgia, 2016,36(3):240-248. DOI:10. 1177/0333102415587704.
[3]于生元.从宏观到微观认识头痛[J].中国疼痛医学杂志,2014,20(1):2-4. DOI:10. 3969/j. issn. 1006-9852. 2014. 01.002.
[4]裴培,陈怀珍,王艳昕,等.电针对偏头痛大鼠中脑导水管周围灰质5-羟色胺7受体和血浆降钙素基因相关肽表达的影响[J].针刺研究,2017,42(6):510-513. DOI:10.13702/j.1000-0607.2017.06.008.
[5]杨小艳,石国霰,曾利,等.天麻素对偏头痛患者外周血CGRP、NO和ET-1表达的影响[J].南京中医药大学学报.2017,33(1):23-25. DOI:10. 14148/j. issn. 1672-0482. 2017.0023.
[6] Dong X, Guan X, Chen K, et al. Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine[J]. Neuroscience Letters, 2017,636:127-133. DOI:10.1016/j.neulet.2016.10.054.
[7]周金玲,杨玉芳,黄振光,等.三七总皂苷通过HIF-1α/BNIP3途径增强线粒体自噬保护大鼠顺铂肾损伤[J].中国药学杂志,2017,52(3):196-200. DOI:10.11669/cpj.2017.03.007.
[8]吴琼,张淑静,张宇晨,等.参知健脑方对缺氧致认知功能障碍大鼠脑线粒体损伤的保护机制研究[J].世界中医药,2017,12(10):2403-2407. DOI:10. 3969/j. issn. 1673-7202. 2017. 10.033.
[9] Semenza GL. Hypoxia-inducible factors in physiology and medicine[J]. Cell, 2012,148(3):399-408. DOI:10. 1016/j. cell. 2012.01.021.
[10] Ma L, Liu JY, Dong JX, et al. Toxicity of Pb~(2+)on rat liver mitochondria induced by oxidative stress and mitochondrial permeability transition[J]. Toxicology Research, 2017,6(6):29-39. DOI:10.1039/C7TX00204A.
[11] Kalogeris T, Bao Y, Korthuis RJ. Mitochondrial reactive oxygen species:a double edged sword in ischemia/reperfusion vs preconditioning[J]. Redox Biology, 2014,2:702-714. DOI:10. 1016/j. redox.2014.05.006.[12] Yao N, Li YJ, Zhang DM, et al. B4G2 Induces Mitochondrial Ap-
optosis by the ROS-Mediated Opening of Ca~(2+)-Dependent Permeability Transition Pores[J]. Cellular Physiology&Biochemistry International Journal of Experimental Cellular Physiology Biochemistry&Pharmacology, 2015,37(3):838-852. DOI:10.1159/000430212.
[13]Barsukova A, Komarov A, Hajnóczky G, et al. Activation of the mitochondrial permeability transition pore modulates Ca~(2+)responses to physiological stimuli in adult neurons[J]. European Journal of Neuroscience, 2015,33(5):831-842. DOI:10. 1111/j. 1460-9568.2010.07576.x.
[14] Xin D, Guan X, Chen K, et al. Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine[J]. Neuroscience Letters, 2017,636:127-133. DOI:10.1016/j. neulet.2016.10.054.
[15] Christensen AF, Esserlind AL, Werge T, et al. The influence of genetic constitution on migraine drug responses[J]. Cephalalgia,2016,36(7):624-639. DOI:10.1177/0333102415610874.
[16] Kodde A,van der Beek EM, Phielix E, et al. Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice[J].Nutrition&Metabolism, 2017,14(1):37. DOI:10. 1186/s12986-017-0191-5.
[17] Jr YW. Hardison HH. Mitochondrial dysfunction in migraine[J].Seminars in Pediatric Neurology, 2013,20(3):188-193. DOI:10.1016/j. spen. 2013.09.002.
[18] Borkum JM. The Migraine Attack as a Homeostatic, Neuroprotective Response to Brain Oxidative Stress:Preliminary Evidence for a Theory[J]. Headache, 2018,58(1):118-135. DOI:10.1111/head. 13214.
[19] Domitrz I, Koter MD,Cholojczyk M, et al. Changes in serum aminoacids in migraine patients without and with aura and their possible usefulness in the study of migraine pathogenesis[J]. CNS&Neurological Disorders-Drug Targets,2015,14(3):1871-1875. DOI:10.2174/18715273146 66150225144300.
[20] Saygi S, Erol L, Alehan F, et al. Superoxide Dismutase and Catalase Genotypes in Pediatric Migraine Patients[J]. Journal of Child Neurology, 2015, 30(12):1586-1590. DOI:10. 1177/0883073815575366.
[21]Balbi T, Fusco M, Vasapollo D, et al. The presence of trace amines in postmortem cerebrospinal fluid in humans[J]. Journal of Forensic Sciences, 2005,50(3):630-632. DOI:10.1520/JFS2003385.
[22] DAndrea G, Granella F, Leone M, et al. Abnormal platelet trace amine profiles in migraine with and without aura[J]. Cephalalgia,2010,26(8):968-972. DOI:10.1111/j. 1468-2982.2006.01141.x.
[23] Ito K, Kudo M, Sasaki M, et al. Detection of changes in the periaqueductal gray matter of patients with episodic migraine using quantitative diffusion kurtosis imaging:preliminary findings[J]. Neuroradiology, 2016,58(2):115-120. DOI:10.1007/s00234-015-1603-8.
[24] Wisnowski JL, Schmithorst VJ, Rosser T, et al. Magnetic resonance spectroscopy markers of axons and astrogliosis in relation to specific features of white matter injury in preterm infants[J]. Neuroradiology, 2014,56(9):771-779. DOI:10.1007/s00234-014-1380-9.
[25] Zielman R, Teeuwisse WM, Bakels F, et al. Biochemical changes in the brain of hemiplegic migraine patients measured with 7 tesla1H-MRS[J]. Cephalalgia An International Journal of Headache,2014,34(12):959-967. DOI:10.1177/0333102414527016.
[26] Barbagallo G, Arabia G, Novellino F, et al. Increased glutamate+glutamine levels in the thalamus of patients with essential tremor:A preliminary proton MR spectroscopic study[J]. Parkinsonism&Related Disorders, 2017,47:57-63. DOI:10. 1016/j. parkreldis.2017.11.345.
[27] Ambrosini A, D'Alessio C, Magis D, et al. Targeting pericranial nerve branches to treat migraine:current approaches and perspectives[J]. Cephalalgia An International Journal of Headache, 2015,35(14):1308-1322. DOI:10.1177/0333102415573511.
[28] Rijpma A, Graaf MVD, Meulenbroek O, et al. Altered brain highenergy phosphate metabolism in mild Alzheimer's disease:A 3-dimensional 31P MR spectroscopic imaging study[J]. Neuroimage Clinical, 2018,18:254-261. DOI:10.1016/j. nicl.2018.01.031.
[29] Vollono C, Primiano G, Della MG, et al. Migraine in mitochondrial disorders:prevalence and characteristics[J]. Cephalalgia An International Journal of Headache, 2017,38(6):1093-1106. DOI:10.1177/0333102417723568.
[30] Guedj E, Belenotti P, Serratrice J, et al. Partially reversible cortical metabolic dysfunction in familial hemiplegic migraine with prolonged aura[J]. Headache, 2010,50(5):872-877. DOI:10. 1111/j.1526-4610.2010.01634.x.
[31] Lott MT. Mitochondrial DNA variation in human evolution and disease[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015,163(1):33-38. DOI:10. 1016/j.cell. 2015.08.067.(上接634页)
[32] Ye Z, Xue A, Huang Y, et al. Children with cyclic vomiting syndrome:phenotypes, disease burden and mitochondrial DNA analysis[J]. Bmc Gastroenterology, 2018,18:104. DOI:10. 1186/s12876-018-0836-5.
[33] Rajakulendran S, Pitceathly RDS, Taanman JW, et al. A Clinical,Neuropathological and Genetic Study of Homozygous A467T POLGRelated Mitochondrial Disease[J]. PloS One, 2016, 11(1):e0145500. DOI:10.1371/journal. pone. 0145500.
[34] Cámara MS, Martin BM, Mendioroz IM. Epigenetic changes in headache[J]. Neurologia, 2017,10(10):1150-1157. DOI:10.1016/j.nrl. 2017.10.010.
[35] Gao D, Zhu B, Sun H, et al. Mitochondrial DNA Methylation and Related Disease[J]. Annals of Neurology, 2017,12(11):1102-1121. DOI:10.1007/978-981-10-6674-0_9.
[36] Sharifulina SA, Komandirov MA,Uzdensky AB. Epigenetic regulation of death of crayfish glial cells but not neurons induced by photo-dynamic impact[J]. Brain Research Bulletin, 2014,102(5):15-21. DOI:10. 1016/j. brainresbull. 2014.01.005.
[37] Esterhuizen K, Lindeque JZ,Mason S, et al. A urinary biosignature for mitochondrial myopathy, encephalopathy, lactic acidosis and stroke like episodes(MELAS)[J]. Mitochondrion, 2018,2(3):1567-1574. DOI:10.1016/j. mito. 2018.02.003.
[38] Stefano GB, Kream RM. Mitochondrial DNA heteroplasmy in human health and disease[J]. Biomedical Reports, 2016,4(3):259-262.DOI:10.3892/br. 2016.590.
[39] Stuart S, Benton MC, Eccles DA, et al. Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility[J]. Molecular Genetics&Genomic Medicine,2017,5(2):157-163. DOI:10.1002/mgg3.270.
[40] Powers SW, Coffey CS, Chamberlin LA, et al. Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine[J]. N Engl J Med, 2017,376(2):115-124. DOI:10.1056/NEJMoa1610384.