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~(18)F-FDG 符合线路显像对骨组织恶性浸润的评价作用
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摘要
目的:分析双探头~(18)F-FDG符合线路显像对骨组织恶性浸润(BMI)的评价作用。方法:回顾性分析2013年9月至2014年5月的48例肿瘤或疑为肿瘤患者,以骨髓穿刺活检(BMB)或64排CT或随访3~8个月作为BMI参考标准。结合目测法与半定量分析(最大最浓层面的感性热区T,与肝脏相同面积的放射性计数N的比值即T/N)。阳性组:T/N>1,阴性组:T/N≤1。比较阳性组与阴性组间良恶性病变构成比及T/N的差异;使用ROC曲线确定T/N值的最佳阈值。结果:(1)阳性组28例和阴性组20例,差异有统计学意义(χ2=9.011,P=0.003);(2)局灶性浓集39例,弥漫性浓集9例,前者阳性组与阴性组间差异有统计学意义。(3)良恶性T/N值分别为0.97±0.37与2.51±1.54,差异有统计学意义(t=3.914,P=0.000)(4)T/N的最佳阈值为1.34。结论:淋巴瘤或血液系统疾病BMI主要表现为放射性弥漫性浓集。18FFDG符合线路显像半定量指标T/N值﹥1高度提示骨恶性浸润可能,最佳阈值以1.34为佳。
        
引文
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