天津地区面部皮炎及手湿疹患者香料变应原检测
|
摘要
目的筛查天津地区面部皮炎及手湿疹患者中的主要香料变应原,从而为临床提供预防及诊治的依据。方法应用中国筛查系列变应原对门诊101例面部皮炎及手湿疹患者进行斑贴试验,并且针对性选取18例对所测变应原中香料1、2及香料混合物斑贴阳性及38例可疑阳性以及怀疑化妆品过敏的患者共56例使用荷兰香料变应原进行斑贴试验,判读结果按照国际接触性皮炎研究组的推荐标准进行判读。结果 101例患者中香料阳性率为12.87%,56例荷兰香料变应原斑贴试验,阳性率为37.50%,其中最高的为丁子香酚,阳性率6.93%,其次是苯甲醇,阳性率为4.95%,再次是肉桂醇和树苔提取物,阳性率均为3.96%。结论香料是面部皮炎及手湿疹患者的重要要致敏原之一,在荷兰香料变应原斑贴试验中丁子香酚是香料变应原中最常见的致敏原,其次是苯甲醇、肉桂醇和树苔提取物。斑贴试验是接触性皮炎的重要检测手段之一。
Objective In order to analyze the common perfume allergens of patients with facial dermatitis and hand eczema in Tianjin. Methods Totally 101 cases with facial allergic dermatitis and hand eczema were tested with patch test of Chinese common allergens. And 56 cases who were choosed in 101 patients were tested with Holond perfume allergens. Eighteen patients were positive of perfume in Chinese patch test and 38 patients were doubtful of sensitive with cosmetic. Test results were determined according to the International Contact Dermatitis Research Group(ICDRG) recommendation. Results The positive rate of fragrance mix was 12.87% in 101 cases with facial dermatitis and hand eczema.The positive rate of perfume allergens was 37.50% and the top allergen was Eugenol and the positive rate was 6.93%. The second allergen was Benzyl alcohol,Cinnamyl alcohol and Tree moss. The positive rate were 4.95%,3.96% and 3.96%. Conclusion Fragrance is one of the common allergens of patients with facial dermatitis and hand eczema. Eugenol,benzyl alcohol,cinnamyl alcohol and tree moss are the main allergens of Holond perfume allergens. Patch test is the important method.
Objective In order to analyze the common perfume allergens of patients with facial dermatitis and hand eczema in Tianjin. Methods Totally 101 cases with facial allergic dermatitis and hand eczema were tested with patch test of Chinese common allergens. And 56 cases who were choosed in 101 patients were tested with Holond perfume allergens. Eighteen patients were positive of perfume in Chinese patch test and 38 patients were doubtful of sensitive with cosmetic. Test results were determined according to the International Contact Dermatitis Research Group(ICDRG) recommendation. Results The positive rate of fragrance mix was 12.87% in 101 cases with facial dermatitis and hand eczema.The positive rate of perfume allergens was 37.50% and the top allergen was Eugenol and the positive rate was 6.93%. The second allergen was Benzyl alcohol,Cinnamyl alcohol and Tree moss. The positive rate were 4.95%,3.96% and 3.96%. Conclusion Fragrance is one of the common allergens of patients with facial dermatitis and hand eczema. Eugenol,benzyl alcohol,cinnamyl alcohol and tree moss are the main allergens of Holond perfume allergens. Patch test is the important method.
引文
[1]Mortz CG,Andersen KE.Fragrance mixⅠpatch test reactions in5006 consecutive dermatitis patients tested simultaneously with TRUE Test誖and Trolab誖test material[J].Contact Dermatitis,2010,63:248-253.
[2]Scheinman PL.Prevalence of fragrance allergy[J].Dermatology,2002,205:98-102.
[3]Marks JG Jr,Belsito DV,DeLeo VA,et al.North American Contact Dermatitis Group patch-test results,1996-1998[J].Arch Dermatol,2000,136:272-273.
[4]Buckley DA,Wakelin SH,Seed PT,et al.The frequency of fragrance allergy in a patch-test population over a 17-year period[J].Br J Dermatol,2000,142:279-283.
[5]张玉頔,张健,马亚梅.慢性湿疹患者328例斑贴试验结果分析[J].中国医学文摘皮肤科学,2013,30(2):69-70.
[6]Tanko Z,Shab A,Thomas Ludwig Diepgen,et al.Polyvalent type IVsensitizations to multiple fragrances and a skin protection cream in a metalworker[J].JDDG,2009,7:541-543.
[7]Metin A,Calka O,Akdeniz N,et al.Phytodermatitis from Ceratocephalus falcatus[J].Contact Dermatitis,2005,52:314-316.
[8]王鹰,李海东,廖军,等.229例接触过敏性皮肤病患者斑贴试验结果分析[J].中国麻风皮肤病杂志,2015,31(10):612-614.
[2]Scheinman PL.Prevalence of fragrance allergy[J].Dermatology,2002,205:98-102.
[3]Marks JG Jr,Belsito DV,DeLeo VA,et al.North American Contact Dermatitis Group patch-test results,1996-1998[J].Arch Dermatol,2000,136:272-273.
[4]Buckley DA,Wakelin SH,Seed PT,et al.The frequency of fragrance allergy in a patch-test population over a 17-year period[J].Br J Dermatol,2000,142:279-283.
[5]张玉頔,张健,马亚梅.慢性湿疹患者328例斑贴试验结果分析[J].中国医学文摘皮肤科学,2013,30(2):69-70.
[6]Tanko Z,Shab A,Thomas Ludwig Diepgen,et al.Polyvalent type IVsensitizations to multiple fragrances and a skin protection cream in a metalworker[J].JDDG,2009,7:541-543.
[7]Metin A,Calka O,Akdeniz N,et al.Phytodermatitis from Ceratocephalus falcatus[J].Contact Dermatitis,2005,52:314-316.
[8]王鹰,李海东,廖军,等.229例接触过敏性皮肤病患者斑贴试验结果分析[J].中国麻风皮肤病杂志,2015,31(10):612-614.