妊娠期代谢性疾病与胎盘发育
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摘要
通常妊娠期代谢性疾病的症状会伴随着胎儿和胎盘的娩出而缓解、暂时或完全恢复,所以胎儿和(或)胎盘在妊娠期的存在被认为是妊娠期代谢性疾病的主要病因或诱因。文章对妊娠期代谢性疾病与胎盘发育相关研究进行阐述,以期通过对现有研究进展、研究方法以及近期研究趋势的了解,为本领域将来的研究方法和方向、疾病的早期诊断和防治以及改善孕期和母子健康提供参考和依据。
Usually,the symptoms of metabolic disorders during pregnancy are relieved or disappear completely or partially when the fetuses and/or the placenta is delivered.So,the presence of fetus and/or the placenta has been believed to be the main cause or trigger of the metabolic disorders during pregnancy.In this review,we summarize the recent research progress and new approaches related to the investigation of metabolic disorders during pregnancy and placenta development,hoping to provide reference for the diagnosis and treatment of the diseases and improve the health of mother and child during pregnancy and postpartum through understanding the existing research progress and methods as well as the recent research trend.
Usually,the symptoms of metabolic disorders during pregnancy are relieved or disappear completely or partially when the fetuses and/or the placenta is delivered.So,the presence of fetus and/or the placenta has been believed to be the main cause or trigger of the metabolic disorders during pregnancy.In this review,we summarize the recent research progress and new approaches related to the investigation of metabolic disorders during pregnancy and placenta development,hoping to provide reference for the diagnosis and treatment of the diseases and improve the health of mother and child during pregnancy and postpartum through understanding the existing research progress and methods as well as the recent research trend.
引文
[1]Bao W,Dar S,Zhu Y,et al.Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus:A longitudinal study[J].J Diabetes,2018,10(6):487-495.
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[3]Sivan E,Weisz B,Shteinman N,et al.Alterations in segmentary branch pulmonary artery blood flow velocimetry in fetuses of diabetic mothers[J].J Ultrasound Med,2004,23(3):339-345.
[4]Louwagie EJ,Larsen TD,Wachal AL,et al.Placental lipid processing in response to a maternal high-fat diet and diabetes in rats[J].Pediatr Res,2018,83(3):712-722.
[5]Jones ML,Mark PJ,Waddell BJ.Maternal dietary omega-3 fatty acids and placental function[J].Reproduction,2014,147(5):R143-152.
[6]Stuart TJ,O'Neill K,Condon D,et al.Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse[J].Biol Reprod,2018,98(6):795-809.
[7]Edu A,Teodorescu C,Dobjanschi CG,et al.Placenta changes in pregnancy with gestational diabetes[J].Rom J Morphol Embryol,2016,57(2):507-512.
[8]Wong CH,Chen CP,Sun FJ,et al.Comparison of placental three-dimensional power Doppler indices and volume in the first and second trimesters of pregnancy complicated by gestational diabetes mellitus[J].J Matern Fetal Neonatal Med,2018:1-181.
[9]Loegl J,Nussbaumer E,Cvitic S,et al.GDM alters paracrine regulation of feto-placental angiogenesis via the trophoblast[J].Lab Invest,2017,97(4):409-418.
[10]Roberts DJ,Post MD.The placenta in pre-eclampsia and intrauterine growth restriction[J].J Clin Pathol,2008,61(12):1254-1260.
[11]Visiedo F,Bugatto F,Carrasco-Fernández C,et al.Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism[J].Placenta,2015,36(4):381-388.
[12]Fattuoni C,MandòC,Palmas F,et al.Preliminary metabolomics analysis of placenta in maternal obesity[J].Placenta,2018,61:89-95.
[13]Fan X,Petitt M,Gamboa M,et al.Transient,inducible,placenta-specific gene expression in mice[J].Endocrinology,2012,153(11):5637-5644.
[14]Zhang B,Tan L,Yu Y,et al.Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice[J].Theranostics,2018,8(10):2765-2781.
[15]Cureton N,Korotkova I,Baker B,et al.Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy[J].Theranostics,2017,7(15):3715-3731.
[2]Vrijkotte TG,Krukziener N,Hutten BA,et al.Maternal lipid profile during early pregnancy and pregnancy complications and outcomes:the ABCD study[J].J Clin Endocrinol Metab,2012,97(11):3917-3925.
[3]Sivan E,Weisz B,Shteinman N,et al.Alterations in segmentary branch pulmonary artery blood flow velocimetry in fetuses of diabetic mothers[J].J Ultrasound Med,2004,23(3):339-345.
[4]Louwagie EJ,Larsen TD,Wachal AL,et al.Placental lipid processing in response to a maternal high-fat diet and diabetes in rats[J].Pediatr Res,2018,83(3):712-722.
[5]Jones ML,Mark PJ,Waddell BJ.Maternal dietary omega-3 fatty acids and placental function[J].Reproduction,2014,147(5):R143-152.
[6]Stuart TJ,O'Neill K,Condon D,et al.Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse[J].Biol Reprod,2018,98(6):795-809.
[7]Edu A,Teodorescu C,Dobjanschi CG,et al.Placenta changes in pregnancy with gestational diabetes[J].Rom J Morphol Embryol,2016,57(2):507-512.
[8]Wong CH,Chen CP,Sun FJ,et al.Comparison of placental three-dimensional power Doppler indices and volume in the first and second trimesters of pregnancy complicated by gestational diabetes mellitus[J].J Matern Fetal Neonatal Med,2018:1-181.
[9]Loegl J,Nussbaumer E,Cvitic S,et al.GDM alters paracrine regulation of feto-placental angiogenesis via the trophoblast[J].Lab Invest,2017,97(4):409-418.
[10]Roberts DJ,Post MD.The placenta in pre-eclampsia and intrauterine growth restriction[J].J Clin Pathol,2008,61(12):1254-1260.
[11]Visiedo F,Bugatto F,Carrasco-Fernández C,et al.Hepatocyte growth factor is elevated in amniotic fluid from obese women and regulates placental glucose and fatty acid metabolism[J].Placenta,2015,36(4):381-388.
[12]Fattuoni C,MandòC,Palmas F,et al.Preliminary metabolomics analysis of placenta in maternal obesity[J].Placenta,2018,61:89-95.
[13]Fan X,Petitt M,Gamboa M,et al.Transient,inducible,placenta-specific gene expression in mice[J].Endocrinology,2012,153(11):5637-5644.
[14]Zhang B,Tan L,Yu Y,et al.Placenta-specific drug delivery by trophoblast-targeted nanoparticles in mice[J].Theranostics,2018,8(10):2765-2781.
[15]Cureton N,Korotkova I,Baker B,et al.Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy[J].Theranostics,2017,7(15):3715-3731.
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