基于活塞挤出式3D打印制备PLA/PCL生物支架的研究
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摘要
以聚乳酸(PLA)、聚己内酯(PCL)为原料,乙酰柠檬酸三丁酯为相容剂,采用熔融共混法制备了PCL含量不同的PLA/PCL复合材料,结合新型活塞挤出式三维打印技术打印多孔生物支架,并进行材料的孔隙率计算、接触角测量、表面形貌观察、力学性能测试。结果表明:随着PCL用量的增加,复合材料疏水倾向增大;支架成型难度增加,孔隙率变小,纤维表面变得光滑,压缩强度下降,冲击韧性更好。
Poly(lactic acid)(PLA) and polycaprolactone(PCL) were used as raw materials and acetyl tributyl citrate(ATBC) as compatibilizer to prepare PLA/PCL composites in different contents of PCL via melt blending method. The composites was used to print porous bio-scaffold by a new piston extrusion three dimensional(3 D) printing technology. The porosity calculation,contact angle measurement,observation of surface morphology and characterization of mechanical properties of the composite material were carried out.The results show that the hydrophobic tendency of the composites grows with the increasing amount of PCL,which contributes to the difficulty in formation of the scaffold and reduction of the porosity,the smooth surface morphology of the fiber,and the lower compressive strength and the higher impact toughness.
Poly(lactic acid)(PLA) and polycaprolactone(PCL) were used as raw materials and acetyl tributyl citrate(ATBC) as compatibilizer to prepare PLA/PCL composites in different contents of PCL via melt blending method. The composites was used to print porous bio-scaffold by a new piston extrusion three dimensional(3 D) printing technology. The porosity calculation,contact angle measurement,observation of surface morphology and characterization of mechanical properties of the composite material were carried out.The results show that the hydrophobic tendency of the composites grows with the increasing amount of PCL,which contributes to the difficulty in formation of the scaffold and reduction of the porosity,the smooth surface morphology of the fiber,and the lower compressive strength and the higher impact toughness.
引文
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[3]李莹,伍权,汤耿,等.镁骨组织工程支架的打印制备及性能特征[J].中国组织工程研究,2018,22(6):827-832.
[4]王志刚,胡广,任杰.聚乳酸基生物降解共混物的制备及应用[J].塑料,2017,46(2):125-129.
[5]张朝刚.聚己内酯材料的改性及在3D打印中的应用[J].工程塑料应用,2017,45(11):140-144.
[6]肖淼,杨其,蔡盛梅,等. PCL增韧PLA共混材料的制备与性能研究[J].塑料工业,2010,38(6):15-18.
[7]宋中波,甄卫军. PCL增韧PLA材料的流变行为及其热降解动力学[J].塑料,2017,46(4):32-38.
[8]李鸿如,陈岩,张劲草,等.具有不同孔隙率多孔介质内的蒸发特性[J].化工学报,2017,68(9):3380-3387.
[9]黄江鸿,王大平,熊建义,等.三维打印双相磁性纳米复合支架材料的性能测定[J].生物骨科材料与临床研究,2017,14(1):10-15.
[10]王亮亮,赵波,殷森.金属表面疏水性研究进展[J].表面技术,2017,46(12):153-161.
[11]王宝和,强伟丽,王甜,等.纳米水滴在纳米粗糙壁面上润湿行为的分子动力学模拟[J].高校化学工程学报,2017,31(5):1169-1176.
[12]滕健,张亮青,林胜强,等.多孔再生纤维素/聚乳酸复合材料的制备与性能[J].高分子材料科学与工程,2017,33(4):143-147.
[13]贾先,谭栓斌,雷鸿春,等. 3D打印工艺参数对PLA压缩性能的影响研究[J].制造技术与机床,2018,4(3):29-32.
[14]朱亮,冯焱颖,叶雄英,等.粗糙表面的可控润湿性研究[J].传感技术学报,2006,19(5):1709-1712.
[15]郑浩勇,王猛,王修星,等.基于Wenzel模型的粗糙界面异质形核分析[J].物理学报,2011,60(6):530-535.
[16]郭树虎,于志家,罗明宝,等.超疏水表面润湿理论研究进展[J].材料导报,2012,26(3):74-78.
[17]曹富华.三维连通网状结构富铜钼铜复合材料的制备及动态压缩性能研究[D].湘潭:湖南科技大学,2016.