热熔融流化床液固接触包衣特性的CFD-DEM模拟
|
摘要
为了研究热熔融流化床包衣的影响因素,优化包衣过程,采用计算流体力学(CFD)与离散单元法(DEM)耦合的方法,在4种流化速度下(u_(mf),1. 5 u_(mf),2. 5 u_(mf),3. 5 u_(mf))模拟熔融液滴与流化粉体的接触过程;研究热熔融流化床包衣过程中的参数变化对包衣过程的影响。结果表明,当液滴与粉体接触成粒时,产生聚并和破碎现象;顶喷流化床比中喷流化床的液滴与粉体的接触次数更多更充分;较理想的流化速度为1. 5 u_(mf)。
The purposes of this paper were to study the factors which affected the coating characteristics in hot-melt fluidized bed and further to optimize its the coating process. The computational fluid dynamics( CFD) and discrete element method( DEM) were used to simulate the contact process between droplets and powders at four fluidization velocities( umf,1. 5 u_(mf),2. 5 u_(mf),3. 5 u_(mf)). Through the coupling of CFD and DEM,the effects of parameters changes during the coating process in hot-melt fluidized bed on the coating process were studied. The results show that the droplets are more fully contacted with the powders under the condition of top spray fluidized bed rather than the middle spray. When the droplets contacting with the powders,the combination of the particles and the droplets causes the phenomenon of aggregation and breakage. The optimal condition is 1. 5 u_(mf) in this study for the performance of coating.
The purposes of this paper were to study the factors which affected the coating characteristics in hot-melt fluidized bed and further to optimize its the coating process. The computational fluid dynamics( CFD) and discrete element method( DEM) were used to simulate the contact process between droplets and powders at four fluidization velocities( umf,1. 5 u_(mf),2. 5 u_(mf),3. 5 u_(mf)). Through the coupling of CFD and DEM,the effects of parameters changes during the coating process in hot-melt fluidized bed on the coating process were studied. The results show that the droplets are more fully contacted with the powders under the condition of top spray fluidized bed rather than the middle spray. When the droplets contacting with the powders,the combination of the particles and the droplets causes the phenomenon of aggregation and breakage. The optimal condition is 1. 5 u_(mf) in this study for the performance of coating.
引文
[1]TAN H S,SALMAN A D,HOUNSLOW M J.Kinetics of fluidised bed melt granulation I:the effect of process variables[J].Chemical Engineering Science,2006,61(5):1585-1601.
[2]NUTTANAN S,VARAPORN J,AMPOL M.Application of hot-melt coating for controlled release of propranolol hydrochloride pellets[J].Powder Technology,2004,141(3):203-209.
[3]WALKER G M,BELL S E J,ANDREWS G,et al.Co-melt fluidised bed granulation of pharmaceutical powders:improvements in drug bioavailability[J].Chemical Engineering Science,2007,62(1):451-462.
[4]KULAH G,KAYA O.Investigation and scale-up of hot-melt coating of pharmaceuticals in fluidized beds[J].Powder Technology,2011,208(1):175-184.
[5]MORAGA S V,VILLA M P,BERTíN D E,et al.Fluidized-bed melt granulation:the effect of operating variables on process performance and granule properties[J].Powder Technology,2015,286(6):654-667.
[6]MILANOVIC A,ALEKSIC I,IBRIC S,et al.Hot-melt coating with Precirol ATO 5 in a fluidized-bed apparatus:application of experimental design in the optimization of process parameters[J].Journal of Drug Delivery Science and Technology,2018,46:274-284.
[7]ANSARI M A,STEPANEK F.Formation of hollow core granules by fluid bed in situ melt granulation:modelling and experiments[J].International Journal of Pharmaceutics,2006,321(1/2):108-116.
[8]MA?ICI,ILIC I,DREU R,et al.An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation[J].International Journal of Pharmaceutics,2012,423(2):202-212.
[9]XU Q,LI M M,ZHANG J,et al.Hot-melt fluidized bed encapsulation of citric acid with lipid[J].International Journal of Food Engineering,2017,13(5):Article20160247.
[10]VILLA M P,BERTIN D E,COTABARREN I M,et al.Fluidizedbed melt granulation:coating and agglomeration kinetics and growth regime prediction[J].Powder Technology,2016,300:61-72.
[11]MATTHIAS B,ANDREAS B,EVANGELOUS E.DEM-CFD investigation of particle residence time distribution in top-spray fluidised bed granulation[J].Chemical Engineering Science,2017,161:187-197.
[12]FRIES L,ANTONYUK S,HEINRICH S,et al.Collision dynamics in fluidised bed granulators:a DEM-CFD study[J].Chemical Engineering Science,2013,86(4):108-123.
[13]FRIES L,ANTONYUK S,HEINRICH S,et al.DEM-CFD modeling of a fluidized bed spray granulator[J].Chemical Engineering Science,2011,66(11):2340-2355.
[14]李苗苗,徐俊,王新,等.基于PBM和DPM的喷雾冷冻流化床液滴雾化的数值模拟[J].中国粉体技术,2018,24(1):46-51.
[15]王福军.计算流体动力学分析-CFD软件原理与应用[M].北京:清华大学出版社,2004:7-11.
[16]XU H,ZHONG W,YUAN Z,et al.CFD-DEM study on cohesive particles in a spouted bed[J].Powder Technology,2017,314:377-386.
[17]HOU Q F,DONG K J,YU A B.DEM study of the flow of cohesive particles in a screw feeder[J].Powder Technology,2014,256(2):529-539.
[18]WEN C Y,YU Y H.A generalized method for predicting the minimum fluidization velocity[J].AIChE Journal,1966,12(3):610-612.
[2]NUTTANAN S,VARAPORN J,AMPOL M.Application of hot-melt coating for controlled release of propranolol hydrochloride pellets[J].Powder Technology,2004,141(3):203-209.
[3]WALKER G M,BELL S E J,ANDREWS G,et al.Co-melt fluidised bed granulation of pharmaceutical powders:improvements in drug bioavailability[J].Chemical Engineering Science,2007,62(1):451-462.
[4]KULAH G,KAYA O.Investigation and scale-up of hot-melt coating of pharmaceuticals in fluidized beds[J].Powder Technology,2011,208(1):175-184.
[5]MORAGA S V,VILLA M P,BERTíN D E,et al.Fluidized-bed melt granulation:the effect of operating variables on process performance and granule properties[J].Powder Technology,2015,286(6):654-667.
[6]MILANOVIC A,ALEKSIC I,IBRIC S,et al.Hot-melt coating with Precirol ATO 5 in a fluidized-bed apparatus:application of experimental design in the optimization of process parameters[J].Journal of Drug Delivery Science and Technology,2018,46:274-284.
[7]ANSARI M A,STEPANEK F.Formation of hollow core granules by fluid bed in situ melt granulation:modelling and experiments[J].International Journal of Pharmaceutics,2006,321(1/2):108-116.
[8]MA?ICI,ILIC I,DREU R,et al.An investigation into the effect of formulation variables and process parameters on characteristics of granules obtained by in situ fluidized hot melt granulation[J].International Journal of Pharmaceutics,2012,423(2):202-212.
[9]XU Q,LI M M,ZHANG J,et al.Hot-melt fluidized bed encapsulation of citric acid with lipid[J].International Journal of Food Engineering,2017,13(5):Article20160247.
[10]VILLA M P,BERTIN D E,COTABARREN I M,et al.Fluidizedbed melt granulation:coating and agglomeration kinetics and growth regime prediction[J].Powder Technology,2016,300:61-72.
[11]MATTHIAS B,ANDREAS B,EVANGELOUS E.DEM-CFD investigation of particle residence time distribution in top-spray fluidised bed granulation[J].Chemical Engineering Science,2017,161:187-197.
[12]FRIES L,ANTONYUK S,HEINRICH S,et al.Collision dynamics in fluidised bed granulators:a DEM-CFD study[J].Chemical Engineering Science,2013,86(4):108-123.
[13]FRIES L,ANTONYUK S,HEINRICH S,et al.DEM-CFD modeling of a fluidized bed spray granulator[J].Chemical Engineering Science,2011,66(11):2340-2355.
[14]李苗苗,徐俊,王新,等.基于PBM和DPM的喷雾冷冻流化床液滴雾化的数值模拟[J].中国粉体技术,2018,24(1):46-51.
[15]王福军.计算流体动力学分析-CFD软件原理与应用[M].北京:清华大学出版社,2004:7-11.
[16]XU H,ZHONG W,YUAN Z,et al.CFD-DEM study on cohesive particles in a spouted bed[J].Powder Technology,2017,314:377-386.
[17]HOU Q F,DONG K J,YU A B.DEM study of the flow of cohesive particles in a screw feeder[J].Powder Technology,2014,256(2):529-539.
[18]WEN C Y,YU Y H.A generalized method for predicting the minimum fluidization velocity[J].AIChE Journal,1966,12(3):610-612.