ASL技术基本原理及在血管性认知障碍中的研究进展
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摘要
血管性认知障碍(vascular cognitive impairment,VCI)是从轻度认知功能障碍到痴呆的一组综合征。动脉自旋标记(arterial spin labeling,ASL)作为一种功能性磁共振成像(functional MRI,fMRI)技术,通过特定脉冲标记动脉血中的氢质子,在不依赖血脑屏障的情况下,能真实反映各个阶段VCI患者脑血流量(cerebral blood flow,CBF),具有良好时间分辨率,已成为诊断和随访VCI的重要影像学手段。作者就ASL技术基本原理及近年来在VCI中的研究进展进行综述。
Vascular cognitive impairment(VCI) is a group of syndromes ranging from mild cognitive impairment to dementia. As a functional magnetic resonance imaging(fMRI)technique, arterial spin labeling(ASL) can mark the cerebral blood of VCI patients at various stages without relying on the blood-brain barrier by marking the hydrogen protons in arterial blood with specific pulses. Flow rate with good time resolution has become an important imaging tool for diagnosis and follow-up of VCI. This paper reviews the basic principles of ASL technology and the research progress in VCI in recent years.
Vascular cognitive impairment(VCI) is a group of syndromes ranging from mild cognitive impairment to dementia. As a functional magnetic resonance imaging(fMRI)technique, arterial spin labeling(ASL) can mark the cerebral blood of VCI patients at various stages without relying on the blood-brain barrier by marking the hydrogen protons in arterial blood with specific pulses. Flow rate with good time resolution has become an important imaging tool for diagnosis and follow-up of VCI. This paper reviews the basic principles of ASL technology and the research progress in VCI in recent years.
引文
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[9]Patel B,Lawrence AJ,Chung AW,et al.Cerebral microbleeds and cognition in patients with symptomatic small vessel disease.Stroke,2013,44(2):356-361.
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[11]Dolui S,Vidorreta M,Wang Z,et al.Comparison of PASL,PCASL,and background-suppressed 3D PCASL in mild cognitive impairment.Hum Brain Mapp,2017,38(10):5260-5273.
[12]R?hrich R,Hoekmeijer C,Osorio CI,et al.Quantifying single plasmonic nanostructure far-fields with interferometric and polarimetric k-space microscopy.Light Sci Appl,2018,12(9):59-77.
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[14]Hu Y,Chen L,Xiao Y,et al.Optimal post label delay of 3D-ASLcerebral blood perfusion in normal people.Chin J Med Imaging Technol,2016,32(9):1330-1335.胡英,陈莉,肖艳,等.正常人3D-ASL脑血流灌注最佳标记后延迟时间分析.中国医学影像技术,2016,32(9):1330-1335.
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[17]Nedelska Z,Senjem ML,Przybelski SA,et al.Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies:associations with clinical severity,glucose metabolism and tau PET.Neuroimage Clin,2018,19(6):939-947.
[18]Sun Y,Cao W,Ding W,et al.Cerebral blood flow alterations as assessed by 3D ASL in cognitive impairment in patients with subcortical vascular cognitive impairment:a marker for disease severity.Front Aging Neurosci,2016,8(31):211-220.
[19]Knopman DS,Gottesman RF,Sharrett AR,et al.Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life:the atherosclerosis risk in communities Study.Alzheimers Dement,2018,14(11):1406-1415.
[20]Zhu J,Wang Y,Li J,et al.Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease.Neurology,2014,82(10):842-849.
[21]Kapasi A,Schneider JA.Vascular contributions to cognitive impairment,clinical Alzheimer's disease,and dementia in older persons.Biochim Biophys,2016,1862(5):878-886.
[22]Dai W,Lopez OL,Carmichael OT,et al.Mild cognitive impairment and alzheimer disease:patterns of altered cerebral blood flow at MRimaging.Radiology,2009,250(3):856-866.
[23]Alexopoulos P,Sorg C,F?rschler A,et al.Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI.Eur Arch Psychiatry Clin Neurosci,2012,262(1):69-77.
[24]Xekardaki A,Rodriguez C,Montandon ML,et al.Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals.Radiology,2015,274(2):490-499.
[25]Birdsill AC,Carlsson CM,Willette AA,et al.Low cerebral blood flow is associated with lower memory function in metabolic syndrome.Obesity,2013,21(7):1313-1320.
[26]Henderson TA.The diagnosis and evaluation of dementia and mild cognitive impairment with emphasis on SPECT perfusion neuroimaging.Cns Spectrums,2012,17(4):176-206.
[27]Austin BP,Nair VA,Meier TB,et al.Effects of hypoperfusion in Alzheimer's disease.J Alzheimers Dis,2011,26(3):123-133.
[28]Galvan V,Hart MJ.Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease.Biochim Biophys Acta,2016,1862(5):992-1007.
[29]Ding B,Ling HW,Zhang Y,et al.Pattern of cerebral hyperperfusion in Alzheimer's disease and amnestic mild cognitive impairment using voxel-based analysis of 3D arterial spin-labeling imaging:initial experience.Clin Interv Aging,2014,9(3):493-500.
[30]Sierramarcos A.Regional cerebral blood flow in mild cognitive impairment and Alzheimer's disease measured with arterial spin labeling magnetic resonance imaging.Int J Alzheimers Dis,2017,3(1):547-597.
[31]Thong JY,Du J,Ratnarajah N,et al.Abnormalities of cortical thickness,subcortical shapes,and white matter integrity in subcortical vascular cognitive impairment.Hum Brain Mapp,2013,35(5):2320-2332.
[32]Banerjee G,Wilson D,J?ger HR,et al.Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment.Biochim Biophys Acta,2016,1862(5):926-938.
[33]Van Osch MJ,Teeuwisse WM,Chen Z,et al.Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow.JCereb Blood Flow Metab,2018,38(9):1461-1480.
[2]Bouvy WH,Zwanenburg JJ,Reinink R,et al.Perivascular spaces on 7Tesla brain MRI are related to markers of small vessel disease but not to age or cardiovascular risk factors.J Cereb Blood Flow Metab,2016,36(10):1708-1717.
[3]Malojcic B,Giannakopoulos P,Sorond F A,et al.Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer's disease.BMC Med,2017,15(1):1-27.
[4]Liu H,Zhang J.Cerebral hypoperfusion and cognitive impairment:the pathogenic role of vascular oxidative stress.Int J Neurosci,2012,122(9):494-499.
[5]Wang YH,An Y,Fan XT,et al.Comparison between simultaneously acquired arterial spin labeling and(18)F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG.Neuroimage Clin,2018,19(6):824-830.
[6]Rockwood K,Black SE,Song X,et al.Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study.J Neural Sci,2006,240(1-2):7-14.
[7]Cao X,Guo Q,Zhao Q,et al.The neuropsychological characteristics and regional cerebral blood flow of vascular cognitive impairment-no dementia.Int J Geriatr Psychiatry,2010,25(11):1168-1176.
[8]Hooghiemstra AM,Bertens AS,Leeuwis AE,et al.The missing link in the pathophysiology of vascular cognitive impairment:design of the heart-brain study.Cerebrovasc Dis Extra,2017,7(3):140-152.
[9]Patel B,Lawrence AJ,Chung AW,et al.Cerebral microbleeds and cognition in patients with symptomatic small vessel disease.Stroke,2013,44(2):356-361.
[10]Wallin A,Kapaki E,Boban M,et al.Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease:a consensus report.BMC Neurol,2017,17(1):877-883.
[11]Dolui S,Vidorreta M,Wang Z,et al.Comparison of PASL,PCASL,and background-suppressed 3D PCASL in mild cognitive impairment.Hum Brain Mapp,2017,38(10):5260-5273.
[12]R?hrich R,Hoekmeijer C,Osorio CI,et al.Quantifying single plasmonic nanostructure far-fields with interferometric and polarimetric k-space microscopy.Light Sci Appl,2018,12(9):59-77.
[13]Takahara K,Morioka T,Shimogawa T,et al.Hemodynamic state of periictal hyperperfusion revealed by arterial spin-labeling perfusion MRimages with dual postlabeling delay.eNeurologicalSci,2018,12(9):5-18.
[14]Hu Y,Chen L,Xiao Y,et al.Optimal post label delay of 3D-ASLcerebral blood perfusion in normal people.Chin J Med Imaging Technol,2016,32(9):1330-1335.胡英,陈莉,肖艳,等.正常人3D-ASL脑血流灌注最佳标记后延迟时间分析.中国医学影像技术,2016,32(9):1330-1335.
[15]Kaneta T,Katsuse O,Hirano T,et al.Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer's disease:a cross-sectional study.BMCNeurol,2017,17(1):870-883.
[16]Takahashi H,Ishii K,Hosokawa C,et al.Clinical application of 3Darterial spin-labeled brain perfusion imaging for Alzheimer disease:comparison with brain perfusion SPECT.AJNR Am J Neuroradiol,2014,35(5):906-911.
[17]Nedelska Z,Senjem ML,Przybelski SA,et al.Regional cortical perfusion on arterial spin labeling MRI in dementia with Lewy bodies:associations with clinical severity,glucose metabolism and tau PET.Neuroimage Clin,2018,19(6):939-947.
[18]Sun Y,Cao W,Ding W,et al.Cerebral blood flow alterations as assessed by 3D ASL in cognitive impairment in patients with subcortical vascular cognitive impairment:a marker for disease severity.Front Aging Neurosci,2016,8(31):211-220.
[19]Knopman DS,Gottesman RF,Sharrett AR,et al.Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life:the atherosclerosis risk in communities Study.Alzheimers Dement,2018,14(11):1406-1415.
[20]Zhu J,Wang Y,Li J,et al.Intracranial artery stenosis and progression from mild cognitive impairment to Alzheimer disease.Neurology,2014,82(10):842-849.
[21]Kapasi A,Schneider JA.Vascular contributions to cognitive impairment,clinical Alzheimer's disease,and dementia in older persons.Biochim Biophys,2016,1862(5):878-886.
[22]Dai W,Lopez OL,Carmichael OT,et al.Mild cognitive impairment and alzheimer disease:patterns of altered cerebral blood flow at MRimaging.Radiology,2009,250(3):856-866.
[23]Alexopoulos P,Sorg C,F?rschler A,et al.Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI.Eur Arch Psychiatry Clin Neurosci,2012,262(1):69-77.
[24]Xekardaki A,Rodriguez C,Montandon ML,et al.Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals.Radiology,2015,274(2):490-499.
[25]Birdsill AC,Carlsson CM,Willette AA,et al.Low cerebral blood flow is associated with lower memory function in metabolic syndrome.Obesity,2013,21(7):1313-1320.
[26]Henderson TA.The diagnosis and evaluation of dementia and mild cognitive impairment with emphasis on SPECT perfusion neuroimaging.Cns Spectrums,2012,17(4):176-206.
[27]Austin BP,Nair VA,Meier TB,et al.Effects of hypoperfusion in Alzheimer's disease.J Alzheimers Dis,2011,26(3):123-133.
[28]Galvan V,Hart MJ.Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease.Biochim Biophys Acta,2016,1862(5):992-1007.
[29]Ding B,Ling HW,Zhang Y,et al.Pattern of cerebral hyperperfusion in Alzheimer's disease and amnestic mild cognitive impairment using voxel-based analysis of 3D arterial spin-labeling imaging:initial experience.Clin Interv Aging,2014,9(3):493-500.
[30]Sierramarcos A.Regional cerebral blood flow in mild cognitive impairment and Alzheimer's disease measured with arterial spin labeling magnetic resonance imaging.Int J Alzheimers Dis,2017,3(1):547-597.
[31]Thong JY,Du J,Ratnarajah N,et al.Abnormalities of cortical thickness,subcortical shapes,and white matter integrity in subcortical vascular cognitive impairment.Hum Brain Mapp,2013,35(5):2320-2332.
[32]Banerjee G,Wilson D,J?ger HR,et al.Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment.Biochim Biophys Acta,2016,1862(5):926-938.
[33]Van Osch MJ,Teeuwisse WM,Chen Z,et al.Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow.JCereb Blood Flow Metab,2018,38(9):1461-1480.