鼻咽癌患者的MKK4、MACC1、p-IRE1蛋白表达水平及其临床意义研究
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摘要
目的观察鼻咽癌患者MKK4、MACC1、p-IRE1蛋白表达水平,并分析其临床意义。方法选取2016年2月-2018年2月在我院接受治疗的鼻咽癌患者为研究对象,同时选取同期在我院接受鼻息肉治疗的患者为对照。观察两组患者MKK4蛋白、MACC1蛋白、p-IRE1蛋白表达情况,比较不同特征鼻咽癌患者MKK4蛋白、MACC1蛋白、p-IRE1蛋白表达的差异,分析影响鼻咽癌患者MKK4蛋白、MACC1蛋白、p-IRE1蛋白表达的因素。结果鼻咽癌组患者的MACC1、p-IRE1蛋白阳性表达率高于鼻息肉组患者,MKK4蛋白阳性表达率低于鼻息肉组患者;临床分期为Ⅲ期、分化程度为中、低分化、有淋巴结转移的鼻咽癌患者的MKK4、MACC1、p-IRE1蛋白阳性表达率较高,不同年龄、性别患者的MKK4、MACC1、p-IRE1蛋白阳性表达率无差别;将单因素分析有意义的因素作为自变量,以患者MKK4、MACC1、p-IRE1蛋白表达情况作为因变量,进行回归分析。结果临床分期和淋巴结转移进入回归方程。结论鼻咽癌患者MKK4、MACC1、p-IRE1蛋白阳性表达率较高,且受临床分期和淋巴结转移的影响。
Objective To observe the expression level of MKK4,MACC1 and p-IRE1 protein in nasopharyngeal carcinoma patients and to analyze its clinical significance. Methods Nasopharyngeal carcinoma patients in our hospital from February 2016 to February 2018 were selected as the research object,and the patients receiving nasal polyps treatment in our hospital at the same time were selected as the control. The expression of MKK4 protein,MACC1 protein and p-IRE1 protein in both groups were observed. The differences in the expression of MKK4 protein,MACC1 protein and p-IRE1 protein in patients with nasopharyngeal carcinoma were compared,and the factors affecting the expression of MKK4 protein,MACC1 protein and p-IRE1 protein in nasopharyngeal carcinoma patients were analyzed. Results The positive expression rates of MACC1 and p-IRE1 protein in nasopharyngeal carcinoma group were higher than that in nasal polyp group,and the positive expression rate of MKK4 protein was lower than that in nasal polyp group. The positive expression rates of MKK4,MACC1 and p-IRE1 in patients with nasopharyngeal carcinoma with middle,low differentiation and lymph node metastasis were higher in clinical stage. There were no difference between the positive expression rates of MKK4,MACC1 and p-IRE1 in different age and sex patients. The significance of single factor analysis was taken as the independent variable,and the expressions of MKK4,MACC1 and p-IRE1 were used as the dependent variables. Results the clinical stage and lymph node metastasis entered the regression equation. Conclusion The positive expression rates of MKK4,MACC1 and p-IRE1 protein in nasopharyngeal carcinoma patients are high,and are affected by clinical stage and lymph node metastasis.
Objective To observe the expression level of MKK4,MACC1 and p-IRE1 protein in nasopharyngeal carcinoma patients and to analyze its clinical significance. Methods Nasopharyngeal carcinoma patients in our hospital from February 2016 to February 2018 were selected as the research object,and the patients receiving nasal polyps treatment in our hospital at the same time were selected as the control. The expression of MKK4 protein,MACC1 protein and p-IRE1 protein in both groups were observed. The differences in the expression of MKK4 protein,MACC1 protein and p-IRE1 protein in patients with nasopharyngeal carcinoma were compared,and the factors affecting the expression of MKK4 protein,MACC1 protein and p-IRE1 protein in nasopharyngeal carcinoma patients were analyzed. Results The positive expression rates of MACC1 and p-IRE1 protein in nasopharyngeal carcinoma group were higher than that in nasal polyp group,and the positive expression rate of MKK4 protein was lower than that in nasal polyp group. The positive expression rates of MKK4,MACC1 and p-IRE1 in patients with nasopharyngeal carcinoma with middle,low differentiation and lymph node metastasis were higher in clinical stage. There were no difference between the positive expression rates of MKK4,MACC1 and p-IRE1 in different age and sex patients. The significance of single factor analysis was taken as the independent variable,and the expressions of MKK4,MACC1 and p-IRE1 were used as the dependent variables. Results the clinical stage and lymph node metastasis entered the regression equation. Conclusion The positive expression rates of MKK4,MACC1 and p-IRE1 protein in nasopharyngeal carcinoma patients are high,and are affected by clinical stage and lymph node metastasis.
引文
[1]杨雀飞,何彪,谭贵海.鼻咽癌患者外周血淋巴细胞中EB病毒DNA载量与临床分期的关系研究[J].实验与检验医学,2014,32(2):150-152.
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[11]鲁明骞,孔庆志,许新华,等.鼻咽癌组织中MKK4蛋白表达变化及其与MKK4基因启动子区-1304 T/G多态性的关系[J].山东医药,2016,56(31):63-65.
[12]秦铀,胡彦,杨辰苏,等.鼻咽癌血清生物标志物研究新进展[J].中国癌症防治杂志,2017,9(4):272-276.
[13]曾谷清,黄丽芳,廖力.鼻咽癌放疗抵抗的分子机制研究进展[J].中国现代医学杂志,2016,26(3):82-86.
[14]Li A,Zhang Y,Zhang C,et al.Pathologic study of tumour extension for clinically localized unilateral nasopharyngeal carcinoma:Should the contralateral side be included in the clinical target volume?[J].J Med Imaging Radiat Oncol,2018,28(6):34-36.
[15]樊建雨,张昱,郭强.以MACC1为中心的肿瘤转移调控网络研究进展[J].世界华人消化杂志,2017,25(11):989-995.
[2]Li Y,Huang X,Jiang J,et al.Clinical Variables for Prediction of the Therapeutic Effects of Bevacizumab Monotherapy in Nasopharyngeal Carcinoma Patients With Radiation-Induced Brain Necrosis[J].Int J Gynecol Cancer,2018,100(3):621-629.
[3]辛露,袁勇,韦学英,等.鼻咽癌组织Ezrin、MACC1、E-cadherin表达及其与放疗敏感性及预后的相关性探究[J].中国医学前沿杂志(电子版),2017,9(8):98-102.
[4]鲁明骞,孔庆志,许新华,等.鼻咽癌MKK4蛋白表达与-1044A/T多态性的相关性分析[J].中国免疫学杂志,2016,32(8):1137-1140.
[5]王欢,乔俏,解海涛,等.鼻咽癌p-IRE1蛋白表达与放射治疗预后的关系[J].中国医科大学学报,2016,45(10):926-931.
[6]Chan SL,Ng LS,Goh X,et al.Time course and clinical characterization of cisplatin-induced ototoxicity after treatment for nasopharyngeal carcinoma in a South East Asian population[J].Head&Neck,2018,34(6):78-80.
[7]Chan SHV,Woo YMP,Wong KSA,et al.The angiographic and clinical outcomes of intracranial aneurysms following irradiation in patients with nasopharyngeal carcinoma:A 13-year experience and literature review[J].Neuroradiology,2018,30(5):103-105.
[8]Chen Z,Xu L,Xu X,et al.The clinical value of detecting circulating tumour cells in the peripheral blood of nasopharyngeal carcinoma patients[J].Oncol Lett,2018,30(5):56-58.
[9]Peng H,Chen L,Chen Y,et al.The current status of clinical trials focusing on nasopharyngeal carcinoma:A comprehensive analysis of ClinicalTrials.gov database[J].Plos One,2018,13(5):730-732.
[10]黎敏.MACC1和CIP2A蛋白表达的相关性及其与胃癌预后的关系[J].中国现代医学杂志,2016,26(21):25-29.
[11]鲁明骞,孔庆志,许新华,等.鼻咽癌组织中MKK4蛋白表达变化及其与MKK4基因启动子区-1304 T/G多态性的关系[J].山东医药,2016,56(31):63-65.
[12]秦铀,胡彦,杨辰苏,等.鼻咽癌血清生物标志物研究新进展[J].中国癌症防治杂志,2017,9(4):272-276.
[13]曾谷清,黄丽芳,廖力.鼻咽癌放疗抵抗的分子机制研究进展[J].中国现代医学杂志,2016,26(3):82-86.
[14]Li A,Zhang Y,Zhang C,et al.Pathologic study of tumour extension for clinically localized unilateral nasopharyngeal carcinoma:Should the contralateral side be included in the clinical target volume?[J].J Med Imaging Radiat Oncol,2018,28(6):34-36.
[15]樊建雨,张昱,郭强.以MACC1为中心的肿瘤转移调控网络研究进展[J].世界华人消化杂志,2017,25(11):989-995.