辅助生殖技术与单卵双胎的研究进展
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摘要
随着辅助生殖技术在不孕症治疗中发挥着越来越重要的作用,由此导致的单卵双胎发生率亦增高,了解单卵双胎的发生机制及影响因素,对于提高辅助生殖技术的安全性具有重要意义。本文就单卵双胎的发生机制及影响因素做一综述。
The assisted reproductive technology(ART)has played an increasing important role in infertility treatment.ART has also resulted in increasing incidence of monozygotic twins.In order to improve the security of ART,it is important to understand the mechanism and influence factors of monozygotic twins.This paper reviews the generation mechanism and influence factors of monozygotic twins in ART.
The assisted reproductive technology(ART)has played an increasing important role in infertility treatment.ART has also resulted in increasing incidence of monozygotic twins.In order to improve the security of ART,it is important to understand the mechanism and influence factors of monozygotic twins.This paper reviews the generation mechanism and influence factors of monozygotic twins in ART.
引文
[1]Martin JA,Hamilton BE,Sutton PD,et al.Births:final data for 2008[J].Natl Vital Stat Rep,2010,59:3-71.
[2]Williams CL,Bunch KJ,Stiller CA,et al.Cancer risk among children born after assisted conception[J].N Engl J Med,2013,369:1819-1827.
[3]Jain JK,Boostanfar R,Slater CC,et al.Monozygotic twins and triplets in association with blastocyst transfer[J].J Assist Reprod Genet,2004,21:103-107.
[4]Boghossian NS,Page GP,Bell EF,et al.Late-onset sepsis in very low birth weight infants from singleton and multiplegestation births[J].J Pediatr,2013,162:1120-1124.
[5]Avraham S,Seidman DS.The multiple birth epidemic:revisited[J].J Obstet Gynaecol India,2012,62:386-390.
[6]Napier S.Twinning,identity,and moral status[J].Am J Bioeth,2013,13:42-43.
[7]Cohen J,Malter H,Wright G,et al.Partial zona dissection of human oocytes when failure of zona pellucida penetration is anticipated[J].Hum Reprod,1989,4:435-442.
[8]von Hagel A.Banking on infertility:medical ethics and the marketing of fertility loans[J].Hastings Cent Rep,2013,43:151-157.
[9]Gelbaya TA,Tsoumpou I,Nardo LG.The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage:a systematic review and metaanalysis[J].Fertil Steril,2010,94:936-945.
[10]高明霞,张学红,赵丽辉,等.体外受精中单卵双胎的成因及相关因素分析[J].生殖医学杂志,2011,20:369-373.
[11]Surakka I,Whitfield JB,Perola M,et al.A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol[J].Twin Res Hum Genet,2012,15:691-699.
[12]Zhao J,Goldberg J,Bremner JD,et al.Association between promoter methylation of serotonin transporter gene and depressive symptoms:a monozygotic twin study[J].Psychosom Med,2013,75:523-529.
[13]Cohen J,Feldberg D.Effects of the size and number of zona pellucida openings on hatching and trophoblast outgrowth in the mouse embryo[J].Mol Reprod Dev,1991,30:70-78.
[14]Knopman J,Krey LC,Lee J,et al.Monozygotic twinning:an eight-year experience at a large IVF center[J].Fertil Steril,2010,94:502-510.
[15]邵小光,王磊,史艳彬.在辅助生殖技术中应对双胎妊娠的策略[J].国际生殖健康/计划生育杂志,2009,28:217-220.
[16]Talens RP,Christensen K,Putter H,et al.Epigenetic variation during the adult lifespan:cross-sectional and longitudinal data on monozygotic twin pairs[J].Aging Cell.2012,11:694-703.
[17]Kawachiya S,Bodri D,Shimada N,et al.Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer[J].Fertil Steril,2011,95:2140-2142.
[18]McDade E,Boeve BF,Burrus TM,et al.Similar clinical and neuroimaging features in monozygotic twin pair with mutation in progranulin[J].Neurology,2012,78:1245-1249.
[19]Tong S.Dizygotic to monozygotic twinning ratio at The Royal Women's Hospital,Melbourne 1947-1997,compared with Australian national twinning incidence[J].Twin Res,2000,3:12-16.
[20]刘芸.辅助生殖技术并发症及防治[J/OL].中华临床医师杂志(电子版),2012,6:562-566.
[21]Schachter M,Raziel A,Friedler S,et al.Monozygotic twinning after assisted reproductive techniques:a phenomenon independent of micromanipulation[J].Hum Reprod,2001,16:1264-1269.
[22]Raghavan KR,Ambani LM,Ratnaparki SK,et al.Monozygotic twinning and sirenomelia[J].Indian Pediatr,1983,20:308-309.
[23]Kupfer O,Ridall LA,Hoffman LM,et al.Pulmonary capillaritis in monozygotic twin boys[J].Pediatrics,2013,132:e1445-1448.
[24]Nijs M,Vanderzwalmen P,Segal-Bertin G,et al.A monozygotic twin pregnancy after application of zona rubbing on a frozenthawed blastocyst[J].Hum Reprod,1993,8:127-129.
[25]Sills ES,Moomjy M,Zaninovic N,et al.Human zona pellucida micromanipulation and monozygotic twinning frequency after IVF[J].Hum Reprod,2000,15:890-895.
[26]Cogulu O,Pariltay E,Koroglu OA,et al.Genome wide analysis in a discordant monozygotic twin with caudal appendage and multiple congenital anomalies[J].Genet Couns,2013,24:85-91.
[27]Tagawa M,Matoba S,Narita M,et al.Production of monozygotic twin calves using the blastomere separation technique and Well of the Well culture system[J].Theriogenology,2008,69:574-582.
[28]Kaye SM,Pietilinen KH,Kotronen A,et al.Obesity-related derangements of coagulation and fibrinolysis:a study of obesity-discordant monozygotic twin pairs[J].Obesity(Silver Spring),2012,20:88-94.
[29]Katayama M,Ellersieck MR,Roberts RM.Development of monozygotic twin mouse embryos from the time of blastomere separation at the two-cell stage to blastocyst[J].Biol Reprod,2010,82:1237-1247.
[30]张琪瑶,管群,菅福琴.胚胎透明带显微操作与单卵双胎妊娠[J].生殖医学杂志,2007,16:383-386.
[31]Peramo B,Ricciarelli E,Cuadros-Fernández JM,et al.Blastocyst transfer and monozygotic twinning[J].Fertil Steril,1999,72:1116-1117.
[32]Feng G,Zhang B,Zhou H,et al.Comparable clinical outcomes and live births after single vitrified-warmed and fresh blastocyst transfer[J/OL].Reprod Biomed Online,2012,25:466-473.
[33]张晓慧,曹云霞,魏兆莲.辅助生育技术中单卵双胎及其妊娠相关因素分析[J].生殖医学杂志,2008,17:135-136.
[34]Milki AA,Jun SH,Hinckley MD.et al.Incidence ofmonozygotic twinning with blastocyst transfer compared to cleavage-stage transfer[J].Fertil Steril,2003,79:503-506.
[35]Sheiner E,Kivilevitch Z,Levitas E,et al.Monozygotic twins following blastocyst transfer:a report of two cases[J].Eur J Obstet Gynecol Reprod Biol,2001,98:135-138.
[36]Jonsdottir I,Lundin K,Bergh C.Double embryo transfer gives good pregnancy and live birth rates in poor responders with a modest increase in multiple birth rates:results from an observational study[J].Acta Obstet Gynecol Scand,2011,90:761-766.
[37]Van Voorhis BJ,Ryan GL.Ethical obligation for restricting the number of embryos transferred to women:combating the multiple-birth epidemic from in vitro fertilization[J].Semin Reprod Med,2010,28:287-294.
[38]吴庚香,杨菁,徐望明,等.体外受精-胚胎移植妊娠数目与母儿结局分析[J].生殖医学杂志,2010,19:91-94.
[39]许伟标,杨桂艳,蔡结.最优胚胎行单胚胎移植的临床结局分析[J].生殖医学杂志,2013,22:320-323.
[40]Ménézo YJ,Sakkas D.Monozygotic twinning:is it related to apoptosis in the embryo?[J].Hum Reprod,2002,17:247-248.
[41]Wright V,Schieve LA,Vahratian A,et al.Monozygotic twinning associated with day 5embryo transfer in pregnancies conceived after IVF[J].Hum Reprod,2004,19:1831-1836.
[42]Elizur SE,Levron J,Shrim A,et al.Monozygotic twinning is not associated with zona pellucida micromanipulation procedures but increases with high-order multiple pregnancies[J].Fertil Steril,2004,82:500-501.
[43]Scott L.The origin of monozygotic twinning[J/OL].Reprod Biomed Online,2002,5:276-284.
[44]Aston KI,Peterson CM,Carrell DT.Monozygotic twinning associated with assisted reproductive technologies:a review[J].Reproduction,2008,136:377-386.
[45]Steinman G.The mechanism initiating and controlling monozygotic twinning in humans remains to be elucidated[J].Twin Res,2000,3:337.
[46]Quintero R,Kontopoulos EV,Barness E,et al.Twin-twin transfusion syndrome in a dichorionic-monozygotic twin pregnancy:The end of a paradigm?[J].Fetal Pediatr Pathol,2010,29:81-88.
[2]Williams CL,Bunch KJ,Stiller CA,et al.Cancer risk among children born after assisted conception[J].N Engl J Med,2013,369:1819-1827.
[3]Jain JK,Boostanfar R,Slater CC,et al.Monozygotic twins and triplets in association with blastocyst transfer[J].J Assist Reprod Genet,2004,21:103-107.
[4]Boghossian NS,Page GP,Bell EF,et al.Late-onset sepsis in very low birth weight infants from singleton and multiplegestation births[J].J Pediatr,2013,162:1120-1124.
[5]Avraham S,Seidman DS.The multiple birth epidemic:revisited[J].J Obstet Gynaecol India,2012,62:386-390.
[6]Napier S.Twinning,identity,and moral status[J].Am J Bioeth,2013,13:42-43.
[7]Cohen J,Malter H,Wright G,et al.Partial zona dissection of human oocytes when failure of zona pellucida penetration is anticipated[J].Hum Reprod,1989,4:435-442.
[8]von Hagel A.Banking on infertility:medical ethics and the marketing of fertility loans[J].Hastings Cent Rep,2013,43:151-157.
[9]Gelbaya TA,Tsoumpou I,Nardo LG.The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage:a systematic review and metaanalysis[J].Fertil Steril,2010,94:936-945.
[10]高明霞,张学红,赵丽辉,等.体外受精中单卵双胎的成因及相关因素分析[J].生殖医学杂志,2011,20:369-373.
[11]Surakka I,Whitfield JB,Perola M,et al.A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol[J].Twin Res Hum Genet,2012,15:691-699.
[12]Zhao J,Goldberg J,Bremner JD,et al.Association between promoter methylation of serotonin transporter gene and depressive symptoms:a monozygotic twin study[J].Psychosom Med,2013,75:523-529.
[13]Cohen J,Feldberg D.Effects of the size and number of zona pellucida openings on hatching and trophoblast outgrowth in the mouse embryo[J].Mol Reprod Dev,1991,30:70-78.
[14]Knopman J,Krey LC,Lee J,et al.Monozygotic twinning:an eight-year experience at a large IVF center[J].Fertil Steril,2010,94:502-510.
[15]邵小光,王磊,史艳彬.在辅助生殖技术中应对双胎妊娠的策略[J].国际生殖健康/计划生育杂志,2009,28:217-220.
[16]Talens RP,Christensen K,Putter H,et al.Epigenetic variation during the adult lifespan:cross-sectional and longitudinal data on monozygotic twin pairs[J].Aging Cell.2012,11:694-703.
[17]Kawachiya S,Bodri D,Shimada N,et al.Blastocyst culture is associated with an elevated incidence of monozygotic twinning after single embryo transfer[J].Fertil Steril,2011,95:2140-2142.
[18]McDade E,Boeve BF,Burrus TM,et al.Similar clinical and neuroimaging features in monozygotic twin pair with mutation in progranulin[J].Neurology,2012,78:1245-1249.
[19]Tong S.Dizygotic to monozygotic twinning ratio at The Royal Women's Hospital,Melbourne 1947-1997,compared with Australian national twinning incidence[J].Twin Res,2000,3:12-16.
[20]刘芸.辅助生殖技术并发症及防治[J/OL].中华临床医师杂志(电子版),2012,6:562-566.
[21]Schachter M,Raziel A,Friedler S,et al.Monozygotic twinning after assisted reproductive techniques:a phenomenon independent of micromanipulation[J].Hum Reprod,2001,16:1264-1269.
[22]Raghavan KR,Ambani LM,Ratnaparki SK,et al.Monozygotic twinning and sirenomelia[J].Indian Pediatr,1983,20:308-309.
[23]Kupfer O,Ridall LA,Hoffman LM,et al.Pulmonary capillaritis in monozygotic twin boys[J].Pediatrics,2013,132:e1445-1448.
[24]Nijs M,Vanderzwalmen P,Segal-Bertin G,et al.A monozygotic twin pregnancy after application of zona rubbing on a frozenthawed blastocyst[J].Hum Reprod,1993,8:127-129.
[25]Sills ES,Moomjy M,Zaninovic N,et al.Human zona pellucida micromanipulation and monozygotic twinning frequency after IVF[J].Hum Reprod,2000,15:890-895.
[26]Cogulu O,Pariltay E,Koroglu OA,et al.Genome wide analysis in a discordant monozygotic twin with caudal appendage and multiple congenital anomalies[J].Genet Couns,2013,24:85-91.
[27]Tagawa M,Matoba S,Narita M,et al.Production of monozygotic twin calves using the blastomere separation technique and Well of the Well culture system[J].Theriogenology,2008,69:574-582.
[28]Kaye SM,Pietilinen KH,Kotronen A,et al.Obesity-related derangements of coagulation and fibrinolysis:a study of obesity-discordant monozygotic twin pairs[J].Obesity(Silver Spring),2012,20:88-94.
[29]Katayama M,Ellersieck MR,Roberts RM.Development of monozygotic twin mouse embryos from the time of blastomere separation at the two-cell stage to blastocyst[J].Biol Reprod,2010,82:1237-1247.
[30]张琪瑶,管群,菅福琴.胚胎透明带显微操作与单卵双胎妊娠[J].生殖医学杂志,2007,16:383-386.
[31]Peramo B,Ricciarelli E,Cuadros-Fernández JM,et al.Blastocyst transfer and monozygotic twinning[J].Fertil Steril,1999,72:1116-1117.
[32]Feng G,Zhang B,Zhou H,et al.Comparable clinical outcomes and live births after single vitrified-warmed and fresh blastocyst transfer[J/OL].Reprod Biomed Online,2012,25:466-473.
[33]张晓慧,曹云霞,魏兆莲.辅助生育技术中单卵双胎及其妊娠相关因素分析[J].生殖医学杂志,2008,17:135-136.
[34]Milki AA,Jun SH,Hinckley MD.et al.Incidence ofmonozygotic twinning with blastocyst transfer compared to cleavage-stage transfer[J].Fertil Steril,2003,79:503-506.
[35]Sheiner E,Kivilevitch Z,Levitas E,et al.Monozygotic twins following blastocyst transfer:a report of two cases[J].Eur J Obstet Gynecol Reprod Biol,2001,98:135-138.
[36]Jonsdottir I,Lundin K,Bergh C.Double embryo transfer gives good pregnancy and live birth rates in poor responders with a modest increase in multiple birth rates:results from an observational study[J].Acta Obstet Gynecol Scand,2011,90:761-766.
[37]Van Voorhis BJ,Ryan GL.Ethical obligation for restricting the number of embryos transferred to women:combating the multiple-birth epidemic from in vitro fertilization[J].Semin Reprod Med,2010,28:287-294.
[38]吴庚香,杨菁,徐望明,等.体外受精-胚胎移植妊娠数目与母儿结局分析[J].生殖医学杂志,2010,19:91-94.
[39]许伟标,杨桂艳,蔡结.最优胚胎行单胚胎移植的临床结局分析[J].生殖医学杂志,2013,22:320-323.
[40]Ménézo YJ,Sakkas D.Monozygotic twinning:is it related to apoptosis in the embryo?[J].Hum Reprod,2002,17:247-248.
[41]Wright V,Schieve LA,Vahratian A,et al.Monozygotic twinning associated with day 5embryo transfer in pregnancies conceived after IVF[J].Hum Reprod,2004,19:1831-1836.
[42]Elizur SE,Levron J,Shrim A,et al.Monozygotic twinning is not associated with zona pellucida micromanipulation procedures but increases with high-order multiple pregnancies[J].Fertil Steril,2004,82:500-501.
[43]Scott L.The origin of monozygotic twinning[J/OL].Reprod Biomed Online,2002,5:276-284.
[44]Aston KI,Peterson CM,Carrell DT.Monozygotic twinning associated with assisted reproductive technologies:a review[J].Reproduction,2008,136:377-386.
[45]Steinman G.The mechanism initiating and controlling monozygotic twinning in humans remains to be elucidated[J].Twin Res,2000,3:337.
[46]Quintero R,Kontopoulos EV,Barness E,et al.Twin-twin transfusion syndrome in a dichorionic-monozygotic twin pregnancy:The end of a paradigm?[J].Fetal Pediatr Pathol,2010,29:81-88.