瓦松总三萜皂苷硬胶囊的制备及质量评价
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摘要
研究瓦松总三萜皂苷硬胶囊的制备工艺及质量评价.以吸湿率和休止角为考察指标,筛选出最佳辅料及辅料量,并用堆密度来确定胶囊装量,以吸湿率为考察指标确定装胶囊的相对临界湿度.在质量检查的过程中,对硬胶囊的崩解时限、水分含量进行检查.实验优化得到瓦松总三萜皂苷硬胶囊的制备工艺条件,对其质量进行了评价,确保了产品的质量稳定性与可靠性,为工业化生产提供了科学的理论依据.
The preparation technology,quality evaluation of total triterpenoid saponins hard capsule from Orostachys fimbriatus( Turcz) Berger were discussed in this paper.Taking the moisture absorption rate and the angle of repose as the indicators,the best excipients and amount of auxiliary materials were selected,and the bulk density was used to determine the capsule loading,determine the relative critical humidity of filling capsules by using moisture absorption rate as an indicator. In the process of quality inspection,the disintegration time and moisture content of hard capsules were examined.The preparation process conditions of the total triterpenoid saponins hard capsule from Orostachys fimbriatus( Turcz) Berger were optimized by experiments,which ensured the quality stability and reliability of the products and provided scientific theoretical basis for industrial production.
The preparation technology,quality evaluation of total triterpenoid saponins hard capsule from Orostachys fimbriatus( Turcz) Berger were discussed in this paper.Taking the moisture absorption rate and the angle of repose as the indicators,the best excipients and amount of auxiliary materials were selected,and the bulk density was used to determine the capsule loading,determine the relative critical humidity of filling capsules by using moisture absorption rate as an indicator. In the process of quality inspection,the disintegration time and moisture content of hard capsules were examined.The preparation process conditions of the total triterpenoid saponins hard capsule from Orostachys fimbriatus( Turcz) Berger were optimized by experiments,which ensured the quality stability and reliability of the products and provided scientific theoretical basis for industrial production.
引文
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[7]成乐琴,张跃伟,李延春,等.基于D101C大孔吸附树脂的原人参三醇组皂苷的分离研究[J].吉林化工学院学报,2018,35(7):48-52.
[8]王洪彪,王鹏辉,秦嘉驹,等.植物黄酮类化合物的提纯和含量测定方法研究概况[J].吉林化工学院学报,2018,35(7):44-47.
[9]王亚红,周明,戴开武,等.大孔吸附树脂纯化瓦松总三萜成分的工艺[J].分子植物育种,2017,15(11):4654-4658.
[10]贾超,朱琳,王守涛.对执行《中国药品检验标准操作规范》2010年版装量差异检查方法的探讨[J].中国药事,2013,27(5):475-478.
[2]丁芬,王亚茹.狼爪瓦松粗体物抑菌效果研究[J].黑龙江医药,2013,26(2):227-228.
[3]张万博,朴炫春,杨帆,等.植物生长调节剂和蔗糖浓度对狼爪瓦松愈伤组织生物量及有效物质积累的影响[J].北方园艺,2016(19):171-175.
[4] JH Lee,SJ Lee,,S Park,Set al.Characterisation of fla-vonoids in Orostachys japonicus A.Berger using HPLC-MS/MS:Contribution to the overall antioxidant effect[J]Food Chemistry:2011,124(4):1627-1633.
[5]任荣,柴军红,金志民,等.狼爪瓦松全草粗提物体外抑菌作用研究[J].安徽农业科学,2011,39(14):8353-8354.
[6]唐瑶,陈洋,曹婉鑫.三萜皂苷结构及应用的研究进展[J].安徽化工,2015,41(2):13-15+22.
[7]成乐琴,张跃伟,李延春,等.基于D101C大孔吸附树脂的原人参三醇组皂苷的分离研究[J].吉林化工学院学报,2018,35(7):48-52.
[8]王洪彪,王鹏辉,秦嘉驹,等.植物黄酮类化合物的提纯和含量测定方法研究概况[J].吉林化工学院学报,2018,35(7):44-47.
[9]王亚红,周明,戴开武,等.大孔吸附树脂纯化瓦松总三萜成分的工艺[J].分子植物育种,2017,15(11):4654-4658.
[10]贾超,朱琳,王守涛.对执行《中国药品检验标准操作规范》2010年版装量差异检查方法的探讨[J].中国药事,2013,27(5):475-478.