部分生化指标对酒精性脂肪肝与非酒精性脂肪肝鉴别诊断意义的探讨
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摘要
目的探究对酒精性脂肪肝患者与非酒精性脂肪肝患者实施生化指标进行诊断的效果,为临床提供指导。方法随机抽取2016年2月—2018年10月该院60例酒精性脂肪肝患者(1组)、60例非酒精性脂肪肝患者(2组)及60例同期来该院行健康体检者(对照组)作为观察对象,抽取所有观察对象血液标本,对部分生化指标实施检测,对其结果进行比较分析。结果①1组患者m-AST [(42.28±13.46)U/L、m-AST/AST (0.62±0.18)、γ-GGT [(157.79±42.42)U/L]均高于2组患者[(26.34±8.48)U/L、(0.39±0.20)、(91.24±36.78)U/L和对照组(8.28±3.52)U/L、(0.24±0.15)、(33.62±8.26)U/L],(P<0.05),且1组和2组患者ALT、AST、m-AST同功酶、m-AST/AST、γ-GGT均高于对照组(P<0.05);②1组患者和2组患者TG、TC、HDL-C均和对照组存在显著差异(P<0.05),且2组患者TG高于1组患者(P<0.05);③1组患者BUN、SCR及UA水平均高于2组患者及对照组,且观察2组患者UA水平亦高于对照组(P<0.05)。结论对酒精性脂肪肝患者与非酒精性脂肪肝患者实施生化指标进行诊断具有较好的效果,可为医师鉴别上述疾病提供有效依据,值得各医院实践推广。
Objective To investigate the effect of biochemical indicators in patients with alcoholic fatty liver disease and nonalcoholic fat-ty liver disease, and provide guidance for clinical practice. Methods From Feburary 2016 to October 2018, 60 patients with alcoholic fatty liver disease(group 1), 60 patients with nonalcoholic fatty liver disease(group 2) and 60 patients who had come to our hospital for health checkups during the same period( the control group) was used as the observation objects, and all the blood samples of the observation objects were taken, and some biochemical indicators were tested, and the results were compared and analyzed. Results 1.Patients in group 1 had higher m-AST [(42.28±13.46) U/L, m-AST/AST(0.62±0.18), and γ-GGT(157.79±42.42)U/L, higher than group 2(26.34±8.48) U/L,(0.39±0.20),(91.24±36.78) U/L and the control group(8.28±3.52)U/L,(0.24±0.15),(33.62± 8.26)U/L], P<0.05, and ALT, AST, m-AST isozyme, m-AST/AST, γ-GGT in group 1 and group 2 were higher than the control group(P<0.05); 2.There was significant difference between TG, TC and HDL-C in group 1 and group 2(P<0.05), and TG in group 2 was higher than 1 group, P<0.05; 3.BUN, SCR and UA levels in group 1 were higher than those of the group 2 and the control group, and the UA level of the group 2 was also higher than that of the control group(P<0.05). Conclusion It is effective to diagnose biochemical indicators in patients with alcoholic fatty liver disease and nonalcoholic fatty liver disease, which can provide effective evidence for doctors to iden-tify the above diseases. It is worthy of practice in hospitals.
Objective To investigate the effect of biochemical indicators in patients with alcoholic fatty liver disease and nonalcoholic fat-ty liver disease, and provide guidance for clinical practice. Methods From Feburary 2016 to October 2018, 60 patients with alcoholic fatty liver disease(group 1), 60 patients with nonalcoholic fatty liver disease(group 2) and 60 patients who had come to our hospital for health checkups during the same period( the control group) was used as the observation objects, and all the blood samples of the observation objects were taken, and some biochemical indicators were tested, and the results were compared and analyzed. Results 1.Patients in group 1 had higher m-AST [(42.28±13.46) U/L, m-AST/AST(0.62±0.18), and γ-GGT(157.79±42.42)U/L, higher than group 2(26.34±8.48) U/L,(0.39±0.20),(91.24±36.78) U/L and the control group(8.28±3.52)U/L,(0.24±0.15),(33.62± 8.26)U/L], P<0.05, and ALT, AST, m-AST isozyme, m-AST/AST, γ-GGT in group 1 and group 2 were higher than the control group(P<0.05); 2.There was significant difference between TG, TC and HDL-C in group 1 and group 2(P<0.05), and TG in group 2 was higher than 1 group, P<0.05; 3.BUN, SCR and UA levels in group 1 were higher than those of the group 2 and the control group, and the UA level of the group 2 was also higher than that of the control group(P<0.05). Conclusion It is effective to diagnose biochemical indicators in patients with alcoholic fatty liver disease and nonalcoholic fatty liver disease, which can provide effective evidence for doctors to iden-tify the above diseases. It is worthy of practice in hospitals.
引文
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[2]叶彬,潘发愤.酒精性脂肪肝和肝硬化患者各种血清酶的检测及其临床评价[J].浙江临床医学,2006,8(12):1252-1253.
[3]张勇勇,李三强,宋影,等.中国近10年脂肪肝常见病因的分析[J].中国临床药理学杂志,2018,34(20):2445-2448.
[4]范建高,颜士岩.代谢综合征与脂肪肝[J].临床肝胆病杂志,2016,32(3):407-410.
[5]朱方超,黄智铭.非酒精性脂肪肝危险因素流行病学论述[J].实用医学杂志,2010,26(18):3452-3454.
[6]张海博,王宇.非酒精性脂肪肝的现代研究进展[J].海南医学,2017,28(10):1651-1653.
[7]杨蕊旭,范建高.非酒精性脂肪性肝病的流行现状[J].临床内科杂志,2015(5):293-296.
[8]谢松生,钟万芬,李文郎,等.8项生化指标对酒精性脂肪肝诊断的临床价值研究[J].临床和实验医学杂志,2013,12(21):1752-1754.