Regulatory perspective of antibiotic biosynthesis in Streptomyces
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摘要
<正>Streptomycetes are Gram-positive bacteria with high GC DNA content. They produce the most abundant secondary metabolites including over two-thirds of the clinically used antibiotics of natural origin (Barka et al., 2016), for example,the important broad-spectrum antimicrobials oxytetracycline(OTC) and chlortetracycline, which are the tetracycline antibiotics, produced by Streptomyces rimosus and Strepto-
引文
Barka,E.A.,Vatsa,P.,Sanchez,L.,Gaveau-Vaillant,N.,Jacquard,C.,Meier-Kolthoff,J.P.,Klenk,H.P.,Clément,C.,Ouhdouch,Y.,and van Wezel,G.P.(2016).Taxonomy,physiology,and natural products of actinobacteria.Microbiol Mol Biol Rev 80,1-43.
Butala,M.,Zgur-Bertok,D.,and Busby,S.J.W.(2009).The bacterial LexAtranscriptional repressor.Cell Mol Life Sci 66,82-93.
Chen,W.,Huang,T.,He,X.,Meng,Q.,You,D.,Bai,L.,Li,J.,Wu,M.,Li,R.,Xie,Z.,et al.(2009).Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H.J Biol Chem 284,10627-10638.
Gottelt,M.,Kol,S.,Gomez-Escribano,J.P.,Bibb,M.,and Takano,E.(2010).Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2).Microbiology 156,2343-2353.
He,J.M.,Zhu,H.,Zheng,G.S.,Liu,P.P.,Wang,J.,Zhao,G.P.,Zhu,G.Q.,Jiang,W.H.,and Lu,Y.H.(2016).Direct involvement of the master nitrogen metabolism regulator GlnR in antibiotic biosynthesis in Streptomyces.J Biol Chem 291,26443-26454.
Laureti,L.,Song,L.,Huang,S.,Corre,C.,Leblond,P.,Challis,G.L.,and Aigle,B.(2011).Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.Proc Natl Acad Sci USA 108,6258-6263.
Liu,G.,Chater,K.F.,Chandra,G.,Niu,G.,and Tan,H.(2013).Molecular regulation of antibiotic biosynthesis in Streptomyces.Microbiol Mol Biol Rev 77,112-143.
Liu,P.,Zhu,H.,Zheng,G.,Jiang,W.,and Lu,Y.(2017).Metabolic engineering of Streptomyces coelicolor for enhanced prodigiosins(RED)production.Sci China Life Sci 60,948-957.
Lu,F.,Hou,Y.,Zhang,H.,Chu,Y.,Xia,H.,and Tian,Y.(2017).Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces.3 Biotech 7:250,1-15.
Meng,X.,Wang,W.,Xie,Z.,Li,P.,Li,Y.,Guo,Z.,Lu,Y.,Yang,J.,Guan,K.,Lu,Z.,et al.(2017).Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387.Sci China Life Sci 60,980-991.
Niu,G.,Zheng,J.,and Tan,H.(2017).Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics.Sci China Life Sci 60,939-947.
Ohnishi,Y.,Yamazaki,H.,Kato,J.Y.,Tomono,A.,and Horinouchi,S.(2005).AdpA,a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus.Biosci Biotech Biochem 69,431-439.
Petkovi?,H.,Luke?i?,T.,and?u?kovi?,J.(2017).Biosynthesis of oxytetracycline by Streptomyces rimosus:past,present and future directions in the development of tetracycline antibiotics.Food Technol Biotechnol 55,3-13.
Rigali,S.,Titgemeyer,F.,Barends,S.,Mulder,S.,Thomae,A.W.,Hopwood,D.A.,and van Wezel,G.P.(2008).Feast or famine:the global regulator DasR links nutrient stress to antibiotic production by Streptomyces.EMBO Rep 9,670-675.
Sheeler,N.L.,MacMillan,S.V.,and Nodwell,J.R.(2005).Biochemical activities of the absA two-component system of Streptomyces coelicolor.J Bacteriol 187,687-696.
?wi?tek,M.A.,Gubbens,J.,Bucca,G.,Song,E.,Yang,Y.H.,Laing,E.,Kim,B.G.,Smith,C.P.,and van Wezel,G.P.(2013).The ROK family regulator Rok7B7 pleiotropically affects xylose utilization,carbon catabolite repression,and antibiotic production in Streptomyces coelicolor.J Bacteriol 195,1236-1248.
Uguru,G.C.,Stephens,K.E.,Stead,J.A.,Towle,J.E.,Baumberg,S.,and McDowall,K.J.(2005).Transcriptional activation of the pathwayspecific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor.Mol Microbiol 58,131-150.
van Wezel,G.P.,and McDowall,K.J.(2011).The regulation of the secondary metabolism of Streptomyces:new links and experimental advances.Nat Prod Rep 28,1311-1333.
Wang,R.,Mast,Y.,Wang,J.,Zhang,W.,Zhao,G.,Wohlleben,W.,Lu,Y.,and Jiang,W.(2013).Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor.Mol Microbiol 87,30-48.
Wei,J.,He,L.,and Niu,G.(2018).Regulation of antibiotic biosynthesis in actinomycetes:Perspectives and challenges.Synth Syst Biotech 3,229-235.
Xu,J.,Zhang,J.,Zhuo,J.,Li,Y.,Tian,Y.,and Tan,H.(2017).Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene,adpA,in Streptomyces ansochromogenes.JBiol Chem 292,19708-19720.
Yin,S.,Wang,X.,Shi,M.,Yuan,F.,Wang,H.,Jia,X.,Yuan,F.,Sun,J.,Liu,T.,Yang,K.,et al.(2017).Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus.Sci China Life Sci 60,992-999.
Yin,S.,Wang,W.,Wang,X.,Zhu,Y.,Jia,X.,Li,S.,Yuan,F.,Zhang,Y.,and Yang,K.(2015).Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.Microb Cell Fact 14,1-12.
Yu,Z.,Zhu,H.,Dang,F.,Zhang,W.,Qin,Z.,Yang,S.,Tan,H.,Lu,Y.,and Jiang,W.(2012).Differential regulation of antibiotic biosynthesis by DraR-K,a novel two-component system in Streptomyces coelicolor.Mol Microbiol 85,535-556.
Zhuo,Y.,Zhang,W.,Chen,D.,Gao,H.,Tao,J.,Liu,M.,Gou,Z.,Zhou,X.,Ye,B.C.,Zhang,Q.,et al.(2010).Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis.Proc Natl Acad Sci USA 107,11250-11254.
Butala,M.,Zgur-Bertok,D.,and Busby,S.J.W.(2009).The bacterial LexAtranscriptional repressor.Cell Mol Life Sci 66,82-93.
Chen,W.,Huang,T.,He,X.,Meng,Q.,You,D.,Bai,L.,Li,J.,Wu,M.,Li,R.,Xie,Z.,et al.(2009).Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H.J Biol Chem 284,10627-10638.
Gottelt,M.,Kol,S.,Gomez-Escribano,J.P.,Bibb,M.,and Takano,E.(2010).Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2).Microbiology 156,2343-2353.
He,J.M.,Zhu,H.,Zheng,G.S.,Liu,P.P.,Wang,J.,Zhao,G.P.,Zhu,G.Q.,Jiang,W.H.,and Lu,Y.H.(2016).Direct involvement of the master nitrogen metabolism regulator GlnR in antibiotic biosynthesis in Streptomyces.J Biol Chem 291,26443-26454.
Laureti,L.,Song,L.,Huang,S.,Corre,C.,Leblond,P.,Challis,G.L.,and Aigle,B.(2011).Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens.Proc Natl Acad Sci USA 108,6258-6263.
Liu,G.,Chater,K.F.,Chandra,G.,Niu,G.,and Tan,H.(2013).Molecular regulation of antibiotic biosynthesis in Streptomyces.Microbiol Mol Biol Rev 77,112-143.
Liu,P.,Zhu,H.,Zheng,G.,Jiang,W.,and Lu,Y.(2017).Metabolic engineering of Streptomyces coelicolor for enhanced prodigiosins(RED)production.Sci China Life Sci 60,948-957.
Lu,F.,Hou,Y.,Zhang,H.,Chu,Y.,Xia,H.,and Tian,Y.(2017).Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces.3 Biotech 7:250,1-15.
Meng,X.,Wang,W.,Xie,Z.,Li,P.,Li,Y.,Guo,Z.,Lu,Y.,Yang,J.,Guan,K.,Lu,Z.,et al.(2017).Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387.Sci China Life Sci 60,980-991.
Niu,G.,Zheng,J.,and Tan,H.(2017).Biosynthesis and combinatorial biosynthesis of antifungal nucleoside antibiotics.Sci China Life Sci 60,939-947.
Ohnishi,Y.,Yamazaki,H.,Kato,J.Y.,Tomono,A.,and Horinouchi,S.(2005).AdpA,a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus.Biosci Biotech Biochem 69,431-439.
Petkovi?,H.,Luke?i?,T.,and?u?kovi?,J.(2017).Biosynthesis of oxytetracycline by Streptomyces rimosus:past,present and future directions in the development of tetracycline antibiotics.Food Technol Biotechnol 55,3-13.
Rigali,S.,Titgemeyer,F.,Barends,S.,Mulder,S.,Thomae,A.W.,Hopwood,D.A.,and van Wezel,G.P.(2008).Feast or famine:the global regulator DasR links nutrient stress to antibiotic production by Streptomyces.EMBO Rep 9,670-675.
Sheeler,N.L.,MacMillan,S.V.,and Nodwell,J.R.(2005).Biochemical activities of the absA two-component system of Streptomyces coelicolor.J Bacteriol 187,687-696.
?wi?tek,M.A.,Gubbens,J.,Bucca,G.,Song,E.,Yang,Y.H.,Laing,E.,Kim,B.G.,Smith,C.P.,and van Wezel,G.P.(2013).The ROK family regulator Rok7B7 pleiotropically affects xylose utilization,carbon catabolite repression,and antibiotic production in Streptomyces coelicolor.J Bacteriol 195,1236-1248.
Uguru,G.C.,Stephens,K.E.,Stead,J.A.,Towle,J.E.,Baumberg,S.,and McDowall,K.J.(2005).Transcriptional activation of the pathwayspecific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor.Mol Microbiol 58,131-150.
van Wezel,G.P.,and McDowall,K.J.(2011).The regulation of the secondary metabolism of Streptomyces:new links and experimental advances.Nat Prod Rep 28,1311-1333.
Wang,R.,Mast,Y.,Wang,J.,Zhang,W.,Zhao,G.,Wohlleben,W.,Lu,Y.,and Jiang,W.(2013).Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor.Mol Microbiol 87,30-48.
Wei,J.,He,L.,and Niu,G.(2018).Regulation of antibiotic biosynthesis in actinomycetes:Perspectives and challenges.Synth Syst Biotech 3,229-235.
Xu,J.,Zhang,J.,Zhuo,J.,Li,Y.,Tian,Y.,and Tan,H.(2017).Activation and mechanism of a cryptic oviedomycin gene cluster via the disruption of a global regulatory gene,adpA,in Streptomyces ansochromogenes.JBiol Chem 292,19708-19720.
Yin,S.,Wang,X.,Shi,M.,Yuan,F.,Wang,H.,Jia,X.,Yuan,F.,Sun,J.,Liu,T.,Yang,K.,et al.(2017).Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus.Sci China Life Sci 60,992-999.
Yin,S.,Wang,W.,Wang,X.,Zhu,Y.,Jia,X.,Li,S.,Yuan,F.,Zhang,Y.,and Yang,K.(2015).Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.Microb Cell Fact 14,1-12.
Yu,Z.,Zhu,H.,Dang,F.,Zhang,W.,Qin,Z.,Yang,S.,Tan,H.,Lu,Y.,and Jiang,W.(2012).Differential regulation of antibiotic biosynthesis by DraR-K,a novel two-component system in Streptomyces coelicolor.Mol Microbiol 85,535-556.
Zhuo,Y.,Zhang,W.,Chen,D.,Gao,H.,Tao,J.,Liu,M.,Gou,Z.,Zhou,X.,Ye,B.C.,Zhang,Q.,et al.(2010).Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis.Proc Natl Acad Sci USA 107,11250-11254.