肺炎支原体肺炎患者血清中Clara细胞分泌蛋白及SP-D的表达及意义
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摘要
目的探讨肺炎支原体肺炎患者血清中Clara细胞分泌蛋白及肺表面活性物质相关蛋白D(SP-D)的表达及意义。方法选取90例肺炎支原体肺炎患者作为观察组,其中急性期49例,恢复期41例,另选择同时期收治的健康体检者40例作为对照组。对比三组血清中Clara细胞分泌蛋白及SP-D的表达水平。结果与恢复期组和对照组比较,急性期组相比血清中Clara细胞分泌蛋白表达水平较低,SP-D表达水平较高,差异具有统计学意义(P<0.05);与对照组比较,恢复期组血清中Clara细胞分泌蛋白表达水平较低,SP-D表达水平较高,差异具有统计学意义(P<0.05)。急性期组和恢复期组中,与轻症组相比,重症组血清中Clara细胞分泌蛋白表达水平较低,SP-D表达水平较高,差异具有统计学意义(P<0.05)。急性期组中患者血清中Clara细胞分泌蛋白及SP-D表达水平呈显著的负相关性(r=-0.81,P<0.05),恢复期组患者血清中Clara细胞分泌蛋白及SP-D表达水平无显著相关性(r=-0.08,P>0.05)。结论血清中Clara细胞分泌蛋白及SP-D参与了肺炎支原体肺炎的发生与发展,且在不同病情患者中呈现出有差异的表达水平。
Objective To discuss the expression of serum Clara cell secretory protein and SP-D in mycoplasma pneumoniae pneumonia patients and the significance. Methods 90 cases of children with mycoplasma pneumoniae pneumonia were selected as observation group,including acute phase 49 cases and recovery phase 41 cases. 40 healthy check-up children were selected as control group. The expression of clara cell secretory protein in serum and SP-D were compared. Results Compared with the recovery group and the control group,the expression level of Clara cell secreted protein in the acute phase group was lower,and the expression level of SP-D in the acute phase group was higher( P < 0. 05).Compared with the control group,the expression level of Clara cells was lower and the expression of SP-D was higher in the recovery group( P< 0. 05). Acute group and recovery group,compared with the mild group,the expression level of Clara cells was lower and the expression level of SP-D was higher in the severe group( P < 0. 05). Children with acute stage of Clara cell secretory protein and SP-D expression level was significantly negative correlated( r = 0. 81,P < 0. 05). The Clara cell secretory protein and SP-D expression level in recovery group had no obvious correlation( r = 0. 08,P > 0. 08). Conclusion Serum Clara cell secretory protein and SP-D participate in the occurrence and development of mycoplasma pneumoniae pneumonia,and there are differences in different condition present in children with expression level.
Objective To discuss the expression of serum Clara cell secretory protein and SP-D in mycoplasma pneumoniae pneumonia patients and the significance. Methods 90 cases of children with mycoplasma pneumoniae pneumonia were selected as observation group,including acute phase 49 cases and recovery phase 41 cases. 40 healthy check-up children were selected as control group. The expression of clara cell secretory protein in serum and SP-D were compared. Results Compared with the recovery group and the control group,the expression level of Clara cell secreted protein in the acute phase group was lower,and the expression level of SP-D in the acute phase group was higher( P < 0. 05).Compared with the control group,the expression level of Clara cells was lower and the expression of SP-D was higher in the recovery group( P< 0. 05). Acute group and recovery group,compared with the mild group,the expression level of Clara cells was lower and the expression level of SP-D was higher in the severe group( P < 0. 05). Children with acute stage of Clara cell secretory protein and SP-D expression level was significantly negative correlated( r = 0. 81,P < 0. 05). The Clara cell secretory protein and SP-D expression level in recovery group had no obvious correlation( r = 0. 08,P > 0. 08). Conclusion Serum Clara cell secretory protein and SP-D participate in the occurrence and development of mycoplasma pneumoniae pneumonia,and there are differences in different condition present in children with expression level.
引文
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[15]Nabe T.Tumor Necrosis Factor Alpha-Mediated Asthma[J].Int Arch Allery Immunol,2012,160(2):111-113.
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[3]李政.肺表面活性蛋白A、D水平监测在间质性肺疾病诊治中的临床价值[J].临床和实验医学杂志,2017,16(2):173-175.
[4]Liu Y,Yu HJ,Wang N,et al.Clara cell 10-k Da protein inhibits T(H)17 responses through modulating dendritic cells in the setting of allergic rhinitis[J].J Allergy Clin Immunol,2013,131(2):387-394.
[5]郝瑞瑞,姜春燕.老年重症肺炎并发多器官功能衰竭患者临床危险因素分析[J].临床和实验医学杂志,2013,12(23):90-91.
[6]李玉红,王金荣.Clara细胞分泌蛋白、白介素-17在支原体肺炎患者血清中的表达及意义[J].临床儿科杂志,2014,32(10):123-124.
[7]王鑫纳,金玉.支原体肺炎患儿血清CCSP、IL-17水平及与肺炎病情的相关性[J].中国妇幼保健,2015,30(27):4635-4636.
[8]温志红,胡琼燕,周薇雅,等.社区获得性肺炎患儿Clara细胞分泌蛋白的变化及临床意义[J].中国临床新医学,2012,5(9):812-815.
[9]李羚,谢娟娟,钱俊,等.RSV感染毛细支气管炎患儿血清Clara细胞分泌蛋白、总Ig E及ECP的临床研究[J].临床儿科杂志,2009,27(4):350-351,358.
[10]李玉红.Clara细胞分泌蛋白、Il-17在支原体肺炎患儿血清中的表达和意义[D].济南:山东大学,2014.
[11]柴玲彦,赵红,刘连凤,等.肺炎支原体肺炎患儿血清及支气管肺泡灌洗液中SP-A、SP-D和KL-6含量变化及意义[J].陕西医学杂志,2015,44(7):806-809.
[12]舒林华,尚云晓,蔡栩栩,等.肺炎支原体肺炎患儿支气管肺泡灌洗液和血清中肺表面活性蛋白的变化及意义[J].中国当代儿科杂志,2012,14(12):928-932.
[13]王鹂鹂,郑首燕,任洛,等.肺炎患儿支气管肺泡灌洗液中肺表面活性蛋白A和D表达及其与肺炎临床特征的相关性[J].中国当代儿科杂志,2016,18(5):386-390.
[14]Shu LH,Shang YX,Cai XX,et al.Alterations of SP-A,SP-D and KL-6 in serum and bronchoalveolar lavage fluid in children with mycoplasma pneumoniae pneumonia[J].Zhonghua Er Ke Za Zhi,2013,51(10):779-782.
[15]Nabe T.Tumor Necrosis Factor Alpha-Mediated Asthma[J].Int Arch Allery Immunol,2012,160(2):111-113.