负载Cu_2O/MOF-5微晶纤维素基水凝胶的抗菌性能研究
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摘要
以微晶纤维素(MCC)为基体材料制备微晶纤维素基水凝胶,再采用原位沉积法负载Cu_2O和MOF-5,制备Cu_2O/MOF-5/MCC水凝胶三元复合材料.通过对Cu_2O和MOF-5加料比例的调控,制备出系列微晶纤维素基水凝胶复合材料,并以大肠杆菌(Escherichia coli,E.Coli)为试验菌种对其抗菌性能进行研究.通过FT-IR、XRD、SEM对样品结构和形貌进行表征,结果表明利用原位沉积法成功制备出了Cu_2O/MOF-5/MCC三元复合材料;Cu_2O和MOF-5具有协同抗菌作用,且当添加总量一定、Cu_2O与MOF-5比例为7∶3时,三元复合材料表现出最佳抗菌性能.
Cu_2O/MOF-5/microcrystalline cellulose(MCC)ternary composites were prepared by in situ deposition of Cu_2O and MOF-5 onto MCC hydrogel which was made from MCC.A series of Cu_2O/MOF-5/MCC ternary composites have been prepared by adjusting the amount of Cu_2O and MOF-5,and antibacterial ability was evaluated via measuring the diameter of the inhibition zone when Escherichia coli(E.Coli)was used as a test strain.The structure and morphology of the composite were characterized by FT-IR,XRD,SEM,and the results indicated that Cu_2O/MOF-5/MCC ternary composites were successfully obtained.Besides,Cu_2O and MOF-5 had a significant synergistic antibacterial effect,and the composites exhibited the best antibacterial effect when the ratio of Cu_2O to MOF-5 was 7∶3.
Cu_2O/MOF-5/microcrystalline cellulose(MCC)ternary composites were prepared by in situ deposition of Cu_2O and MOF-5 onto MCC hydrogel which was made from MCC.A series of Cu_2O/MOF-5/MCC ternary composites have been prepared by adjusting the amount of Cu_2O and MOF-5,and antibacterial ability was evaluated via measuring the diameter of the inhibition zone when Escherichia coli(E.Coli)was used as a test strain.The structure and morphology of the composite were characterized by FT-IR,XRD,SEM,and the results indicated that Cu_2O/MOF-5/MCC ternary composites were successfully obtained.Besides,Cu_2O and MOF-5 had a significant synergistic antibacterial effect,and the composites exhibited the best antibacterial effect when the ratio of Cu_2O to MOF-5 was 7∶3.
引文
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[3]段为甲,郑敏,李容,等.氧化亚铜空心球的制备及其抗菌性能研究[J].印染助剂,2017,34(3):13-15.
[4]夏卓英,梁桥发,郑明艺,等.银负载纳米氧化亚铜沸石复合物的制备和抗菌性能[J].功能材料,2017,48(12):12 156-12 161.
[5]王明雪.金属有机骨架化合物MOF-5的合成及其耐水性能研究[D].长沙:中南大学,2014.
[6]Sharma V K,Yngard R A,Lin Y.Silver nanoparticles:Green synthesis and their antimicrobial activities[J].Advances in Colloid and Interface Science,2009,145(1):83-96.
[7]Libor Kvítek,Aleˇs Pan`cek,Jana Soukupov,et al.Effect of surfactants and polymers on stability and antibacterial activity of silver nanoparticles(NPs)[J].Journal of Physical Chemistry C,2008,112(15):5 825-5 834.
[8]杨强,张美云,宋顺喜.金属有机骨架化合物及其在特种纸中的潜在应用[J].中国造纸,2016,35(7):64-69.
[9]Pezeshkpour V,Khosravani S A,Ghaedi M,et al.Ultrasound assisted extraction of phenolic acids from broccoli vegetable and using sonochemistry for preparation of MOF-5nanocubes:Comparative study based on micro-dilution broth and plate count method for synergism antibacterial effect[J].Ultrasonics Sonochemistry,2018,40(Pt A):1 031-1 038.
[10]葛伟青,苑少强,郝斌.无机抗菌材料的应用及其抗菌性能测试和评价[J].陶瓷,2007(7):53-55.
[11]Huang Limin,Wang Huanting,Chen Jinxi,et al.Synthesis,morphology control,and properties of porous metalorganic coordination polymers[J].Microporous&Mesoporous Materials,2003,58(2):105-114.
[12]周丽姣.MOF-5的合成及Ru(Pd)/AC掺杂研究[D].长沙:中南大学,2012.
[13]Prabhakaran G,Murugan R.Synthesis of Cu2O nanospheres and cubes:Their structural,optical and magnetic properties[J].Advanced Materials Research,2014,938:114-117.
[14]王静,张美云,李金宝.两种来源的针叶木及进口微晶纤维素性能的对比[J].造纸科学与技术,2018,37(1):25-28,42.
[15]于振花.氧化亚铜的制备、表征及其氧化动力学[D].青岛:中国海洋大学,2005.
[16]Kaye S S,Dailly A,Yaghi O M,et al.Impact of preparation and handling on the hydrogen storage properties of Zn4O(1,4-benzenedicarboxylate)3(MOF-5)[J].Journal of the American Chemical Society,2007,129(46):14 176-14 177.
[17]Panella B,Hirscher M,Pütter H,et al.Hydrogen adsorption in metal-organic frameworks:Cu-MOFs and ZnMOFs compared[J].Advanced Functional Materials,2010,16(4):520-524.
[18]胡婷,柳欢欢,周竹君,等.纳米SiO2复合改性绝缘纸的制备[J].绝缘材料,2017,50(6):22-26.
[19]孙马钰,金裕鹏,许恒毅.常见金属抗菌机制的研究进展[J].中国药理学与毒理学杂志,2016,30(4):415-420.
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