瑞舒伐他汀联合曲美他嗪对老年慢性心力衰竭患者心功能及血管内皮功能的影响
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摘要
目的探讨瑞舒伐他汀联合曲美他嗪对老年慢性心力衰竭(CHF)患者心功能及血管内皮功能的影响。方法老年CHF患者400例,按照乱数表法分为观察组和对照组各200例,对照组给予酒石酸美托洛尔缓释片治疗,观察组给予瑞舒伐他汀联合曲美他嗪治疗。对比治疗后两组临床疗效,观察并比较两组治疗前后心功能指标及血管内皮功能。结果观察组总有效率高于对照组(P<0. 05);治疗后两组左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)降低,左心室射血分数(LVEF)及6 min步行距离(6MWT)升高(P<0. 05),且观察组LVEF高于对照组,LVEDV、LVESV均低于对照组,6MWT长于对照组(P<0. 05);治疗后观察组肱动脉血流介导血管舒张功能(FMD)及血清一氧化氮(NO)、一氧化氮合酶(NOS)活性显著高于治疗前及对照组,非对称性二甲基精氨酸(ADMA)水平显著低于治疗前及对照组,差异均有统计学意义(P<0. 05)。结论瑞舒伐他汀联合曲美他嗪治疗老年CHF有较好临床疗效,且能有效改善患者心功能及血管内皮功能。
引文
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4王磊,王军,刘树文,等.曲美他嗪对慢性心力衰竭患者血管内皮功能的影响[J].现代生物医学进展,2017;17(21):4159-62.
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12曹平,梁丹清,段雯,等.参芪扶正液对慢性心力衰竭患者血管内皮舒张功能及NT pro BNP的影响[J].中西医结合心脑血管病杂志,2015;13(1):9-11.
13杜惠莲.参脉注射液与阿托伐他汀治疗冠心病慢性心力衰竭患者的效果[J].中国生化药物杂志,2017;37(9):60-1,64.
14彭环庆,彭志允,范志勇,等.阿托伐他汀对不同血脂水平的慢性心力衰竭患者血管内皮功能的影响[J].中国老年学杂志,2015;35(19):5486-7.
15 Wan P,Su W,Zhang Y,et al.Trimetazidine protects retinal ganglion cells from acute glaucoma via the Nrf2/Ho-1 pathway[J].Clin Sci(Lond),2017;131(18):2363-75.
16姚恩辉,李世春,王华军,等.心脉隆注射液对老年慢性心力衰竭患者血管内皮功能的影响[J].中国医院药学杂志,2014;34(23):2037-40.
17马庆平,郇赛,顾莹,等.有氧运动训练对老年冠心病伴慢性心力衰竭患者红细胞参数、血管内皮功能的影响[J].海南医学院学报,2017;23(15):2025-8.
2 Ramírez J,Orini M,MincholéA,et al.Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model[J].PLoS One,2017;12(10):e0186152.
3 Aldahl M,Jensen AC,Davidsen L,et al.Associations of serum potassium levels with mortality in chronic heart failure patients[J].Eur Heart J,2017;38(38):2890-6.
4王磊,王军,刘树文,等.曲美他嗪对慢性心力衰竭患者血管内皮功能的影响[J].现代生物医学进展,2017;17(21):4159-62.
5 Wang J,Shi J,Wei J,et al.Safety and efficacy of Qishen granules in patients with chronic heart failure:study protocol for a randomized controlled trial[J].Trials,2017;18(1):468.
6何明,王丽慧,刘金涛,等.贝那普利联合阿托伐他汀对慢性心力衰竭患者的疗效及对血浆NT-proBNP的影响[J].中国生化药物杂志,2017;37(1):194-6.
7 Betto M,Fares J,Saliba N,et al.Efficacy and safety of a generic rosuvastatin in a real-world setting:prospective,observational clinical study in Lebanese patients[J].Ann Saudi Med,2017;37(5):366-74.
8 Cosgun T,Iskender I,Yamada Y,et al.Ex vivo administration of trimetazidine improves post-transplant lung function in pig model[J].Eur J Cardiothorac Surg,2017;52(1):171-7.
9中华医学会心血管病学分会,中华心血管病杂志编辑委员会.中国心力衰竭诊断和治疗指南2014[J].中华心血管病杂志,2014;42(2):98-122.
10 Ding H,Jayasena R,Maiorana A,et al.Innovative telemonitoring enhanced care programme for chronic heart failure(ITEC-CHF)to improve guideline compliance and collaborative care:protocol of a multicentre randomised controlled trial[J].BMJ Open,2017;7(10):e017550.
11李婷.慢性心力衰竭患者心理弹性对其自我护理行为的影响研究[J].中国实用护理杂志,2016;32(31):2414-7.
12曹平,梁丹清,段雯,等.参芪扶正液对慢性心力衰竭患者血管内皮舒张功能及NT pro BNP的影响[J].中西医结合心脑血管病杂志,2015;13(1):9-11.
13杜惠莲.参脉注射液与阿托伐他汀治疗冠心病慢性心力衰竭患者的效果[J].中国生化药物杂志,2017;37(9):60-1,64.
14彭环庆,彭志允,范志勇,等.阿托伐他汀对不同血脂水平的慢性心力衰竭患者血管内皮功能的影响[J].中国老年学杂志,2015;35(19):5486-7.
15 Wan P,Su W,Zhang Y,et al.Trimetazidine protects retinal ganglion cells from acute glaucoma via the Nrf2/Ho-1 pathway[J].Clin Sci(Lond),2017;131(18):2363-75.
16姚恩辉,李世春,王华军,等.心脉隆注射液对老年慢性心力衰竭患者血管内皮功能的影响[J].中国医院药学杂志,2014;34(23):2037-40.
17马庆平,郇赛,顾莹,等.有氧运动训练对老年冠心病伴慢性心力衰竭患者红细胞参数、血管内皮功能的影响[J].海南医学院学报,2017;23(15):2025-8.