叉头框转录因子M1与肿瘤的研究新进展
摘要
<正>叉头框转录因子M1(FoxM1)是Fox家族中重要的成员之一,其仅在具有分裂能力的细胞及肿瘤细胞中表达,与肿瘤的发生、发展及转移密切相关。本文根据国内外FoxM1的最新研究进展,对FoxM1的结构、生物学作用及与肿瘤的关系进行综述。1 FoxM1的结构特点人的Fox基因家族包括40多个亚家族成员,FoxM1是Fox基因家族中的重要成员。人类第一个FoxM1基因是从宫颈癌HeLa细胞系中鉴定出的~[1],其定位于12p13.33,包
引文
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[21]Nandi D,Cheema PS,Jaiswal N,et al.Fox M1:Repurposing an oncogene as a biomarker[J].Semin Cancer Biol,2018,52(pt 1):94-84.DOI:10.1016/j.semcancer.2017.08.009.
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[24]Tan X,Fu Y,Chen L,et al.miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer[J].Oncotarget,2016,7(1):293-307.DOI:10.18632/oncotarget.6344.
[25]Wang Y,Zeng J,Pan J,et al.MiR-320a inhibits gastric carcinoma by targeting activity in the Fox M1-P27KIP1 axis[J].Oncotarget,2016,7(20):29275-29286.DOI:10.18632/oncotarget.8676.
[26]Barger CJ,Zhang W,Hillman J,et al.Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression[J].Oncotarget,2015,6(29):27613-27627.DOI:10.18632/oncotarget.4546.
[27]Delahaye-Sourdeix M,Oliver J,Timofeeva MN,et al.The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract[J].PLo S One,2015,10(3):e117639.DOI:10.1371/journal.pone.0117639.
[28]Maekawa A,Kohashi K,Kuda M,et al.Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas[J].BMC Cancer,2016(16):511.DOI:10.1186/s12885-016-2542-4.
[29]Li L,Wu D,Yu Q,et al.Prognostic value of FOXM1 in solid tumors:a systematic review and meta-analysis[J].Oncotarget,2017,8(19):32298-32308.DOI:10.18632/oncotarget.15764.
[2]Teh MT,Wong ST,Neill GW,et al.FOXM1 is a downstream target of Gli1 in basal cell carcinomas[J].Cancer Res,2002,62(16):4773-4780.
[3]Krupczak-Hollis K,Wang X,Kalinichenko VV,et al.The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis[J].Dev Biol,2004,276(1):74-88.DOI:10.1016/j.ydbio.2004.08.022.
[4]Wierstra I.The transcription factor FOXM1(Forkhead box M1):proliferation-specific expression,transcription factor function,target genes,mouse models,and normal biological roles[J].Adv Cancer Res,2013(118):97-398.DOI:10.1016/B978-0-12-407173-5.00004-2.
[5]Yoshida Y,Wang IC,Yoder HM,et al.The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancer[J].Gastroenterology,2007,132(4):1420-1431.DOI:10.1053/j.gastro.2007.01.036.
[6]Lam EW,Brosens JJ,Gomes AR,et al.Forkhead box proteins:tuning forks for transcriptional harmony[J].Nat Rev Cancer,2013,13(7):482-495.DOI:10.1038/nrc3539.
[7]Yung MM,Chan DW,Liu VW,et al.Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade[J].BMC Cancer,2013(13):327.DOI:10.1186/1471-2407-13-327.
[8]Chan DW,Hui WW,Wang JJ,et al.DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-beta/SMAD4 signaling[J].Oncogene,2017,36(10):1404-1416.DOI:10.1038/onc.2016.307.
[9]Pratheeshkumar P,Divya SP,Parvathareddy SK,et al.Fox M1 and beta-catenin predicts aggressiveness in Middle Eastern ovarian cancer and their co-targeting impairs the growth of ovarian cancer cells[J].Oncotarget,2018,9(3):3590-3604.DOI:10.18632/oncotarget.23338.
[10]Yang YF,Pan YH,Cao Y,et al.PDZ binding kinase,regulated by Fox M1,enhances malignant phenotype via activation of beta-Catenin signaling in hepatocellular carcinoma[J].Oncotarget,2017,8(29):47195-47205.DOI:10.18632/oncotarget.17587.
[11]Liu Y,Liu Y,Yuan B,et al.FOXM1 promotes the progression of prostate cancer by regulating PSA gene transcription[J].Oncotarget,2017,8(10):17027-17037.DOI:10.18632/oncotarget.15224.
[12]Yang X,Shi Y,Yan J,et al.Downregulation of Fox M1 inhibits cell growth and migration and invasion in bladder cancer cells[J].Am JTransl Res,2018,10(2):629-638.
[13]Luo X,Yao J,Nie P,et al.FOXM1 promotes invasion and migration of colorectal cancer cells partially dependent on HSPA5 transactivation[J].Oncotarget,2016,7(18):26480-26495.DOI:10.18632/oncotarget.8419.
[14]Huang C,Xie D,Cui J,et al.FOXM1c promotes pancreatic cancer epithelial-to-mesenchymal transition and metastasis via upregulation of expression of the urokinase plasminogen activator system[J].Clin Cancer Res,2014,20(6):1477-1488.DOI:10.1158/1078-0432.CCR-13-2311.
[15]Xue J,Lin X,Chiu WT,et al.Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-beta-dependent cancer metastasis[J].J Clin Invest,2014,124(2):564-579.DOI:10.1172/JCI71104.
[16]Peake BF,Eze SM,Yang L,et al.Growth differentiation factor 15mediates epithelial mesenchymal transition and invasion of breast cancers through IGF-1R-FoxM1 signaling[J].Oncotarget,2017,8(55):94393-94406.DOI:10.18632/oncotarget.21765.
[17]Zhang C,Wang Y,Feng Y,et al.Gli1 promotes colorectal cancer metastasis in a Foxm1-dependent manner by activating EMT and PI3K-AKT signaling[J].Oncotarget,2016,7(52):86134-86147.DOI:10.18632/oncotarget.13348.
[18]Miao L,Xiong X,Lin Y,et al.Down-regulation of Fox M1 leads to the inhibition of the epithelial-mesenchymal transition in gastric cancer cells[J].Cancer Genet,2014,207(3):75-82.DOI:10.1016/j.cancergen.2014.02.008.
[19]Kruiswijk F,Hasenfuss SC,Sivapatham R,et al.Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling[J].Oncogene,2016,35(17):2166-2177.DOI:10.1038/onc.2015.282.
[20]Jiang L,Wang P,Chen L,et al.Down-regulation of Fox M1 by thiostrepton or small interfering RNA inhibits proliferation,transformation ability and angiogenesis,and induces apoptosis of nasopharyngeal carcinoma cells[J].Int J Clin Exp Pathol,2014,7(9):5450-5460.
[21]Nandi D,Cheema PS,Jaiswal N,et al.Fox M1:Repurposing an oncogene as a biomarker[J].Semin Cancer Biol,2018,52(pt 1):94-84.DOI:10.1016/j.semcancer.2017.08.009.
[22]Vishnubalaji R,Hamam R,Yue S,et al.MicroRNA-320 suppresses colorectal cancer by targeting SOX4,FOXM1,and FOXQ1[J].Oncotarget,2016,7(24):35789-35802.DOI:10.18632/oncotarget.8937.
[23]Cao S,Lin L,Xia X,et al.MicroRNA-761 promotes the sensitivity of colorectal cancer cells to 5-Fluorouracil through targeting FOXM1[J].Oncotarget,2017,9(1):321-331.DOI:10.18632/oncotarget.20109.
[24]Tan X,Fu Y,Chen L,et al.miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer[J].Oncotarget,2016,7(1):293-307.DOI:10.18632/oncotarget.6344.
[25]Wang Y,Zeng J,Pan J,et al.MiR-320a inhibits gastric carcinoma by targeting activity in the Fox M1-P27KIP1 axis[J].Oncotarget,2016,7(20):29275-29286.DOI:10.18632/oncotarget.8676.
[26]Barger CJ,Zhang W,Hillman J,et al.Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression[J].Oncotarget,2015,6(29):27613-27627.DOI:10.18632/oncotarget.4546.
[27]Delahaye-Sourdeix M,Oliver J,Timofeeva MN,et al.The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract[J].PLo S One,2015,10(3):e117639.DOI:10.1371/journal.pone.0117639.
[28]Maekawa A,Kohashi K,Kuda M,et al.Prognostic significance of FOXM1 expression and antitumor effect of FOXM1 inhibition in synovial sarcomas[J].BMC Cancer,2016(16):511.DOI:10.1186/s12885-016-2542-4.
[29]Li L,Wu D,Yu Q,et al.Prognostic value of FOXM1 in solid tumors:a systematic review and meta-analysis[J].Oncotarget,2017,8(19):32298-32308.DOI:10.18632/oncotarget.15764.
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