关节软骨钙化层相关研究进展
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摘要
关节软骨钙化层(calcified cartilage zone, CCZ)是软骨组织中一层重要的界面结构,对骨软骨组织生理功能的发挥有着重要意义。相关基础研究及临床研究表明钙化层结构有利于骨关节炎的防治以及软骨组织的再生修复,本文对钙化层的理化性质,及在防治骨关节炎和软骨修复方面的研究进展作一综述。
Calcified cartilage zone is an important interface structure in cartilage tissue, which plays an important role in the physiological function of osteochondral tissue. Relevant basic and clinical studies have shown that calcified cartilage zone is beneficial to the prevention and control of osteoarthritis and the regeneration and repair of cartilage tissue. In this paper, the physical and chemical properties of calcified layer and the progress in the prevention and control of osteoarthritis and cartilage repair are reviewed.
Calcified cartilage zone is an important interface structure in cartilage tissue, which plays an important role in the physiological function of osteochondral tissue. Relevant basic and clinical studies have shown that calcified cartilage zone is beneficial to the prevention and control of osteoarthritis and the regeneration and repair of cartilage tissue. In this paper, the physical and chemical properties of calcified layer and the progress in the prevention and control of osteoarthritis and cartilage repair are reviewed.
引文
[1]王富友,杨柳,段小军,等.正常膝关节软骨钙化层形态结构研究[J].中国修复重建外科杂志,2008,5:524-527.
[2]Wang F,Ying Z,Duan X,et al.Histomorphometric analysis of adult articular calcified cartilage zone[J].J Struct Biol,2009,168(3):359-365.
[3]Antons J,Marascio MGM,Nohava J,et al.Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements[J].J Mater Sci Mater Med,2018,29(5):57.
[4]段小军,王富友,杨柳.骨软骨组织界面结构及骨软骨复合组织构建研究[J].中国矫形外科杂志,2013,21(17):1729-1733.
[5]Hoemann C,Lafantaisie-Favreau CH,Lascau-Coman V,et al.The cartilage-bone interface[J].J Knee Surg,2012,25(2):85-98.
[6]Boushell M,Hung C,Hunziker E,et al.Current strategies for integrative cartilage repair[J].Connect Tissue Res,2017,58(5):393-406.
[7]Zhang Y,Wang F,Tan H,et al.Analysis of the mineral composition of the human calcified cartilage zone[J].Int J Med Sci,2012,9(5):353-360.
[8]段小军,左镇华,杨柳.细胞移植技术修复关节软骨缺损的临床应用进展[J/CD].中华关节外科杂志(电子版),2010,4(1):74-76.
[9]Sandy JD,Plaas A.The role of superficial layer cells in maintenance of articular cartilage surface integrity[J].J Xiangya Med,2017,2(23-23).
[10]Lee WD,Hurtig MB,Pilliar RM,et al.Engineering of hyaline cartilage with a calcified zone using bone marrow stromal cells[J].Osteoarthritis Cartilage,2015,23(8):1307-1315.
[11]Arbabi V,Pouran B,Weinans H,et al.Neutral solute transport across osteochondral interface:a finite element approach[J].J Biomech,2016,49(16):3833-3839.
[12]Arkill KP,Winlove CP.Solute transport in the deep and calcified zones of articular cartilage[J].Osteoarthritis Cartilage,2008,16(6):708-714.
[13]Pouran B,Arbabi V,Bleys RL,et al.Solute transport at the interface of cartilage and subchondral bone plate:Effect of micro-architecture[J].J Biomech,2017,52(148-154):1-10.
[14]Yu J,Liang F,Huang H,et al.Effects of loading on chondrocyte hypoxia,HIF-1alpha and VEGF in the mandibular condylar cartilage of young rats[J].Orthod Craniofac Res,2018,21(1):41-47.
[15]Mansfield JC,Peter Winlove C.A multi-modal multiphoton investigation of microstructure in the deep zone and calcified cartilage[J].J Anat,2012,220(4):405-416.
[16]Pan J,Wang B,Li W,et al.Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints[J].Bone,2012,51(2):212-217.
[17]Du J,Carl M,Bae WC,et al.Dual inversion recovery ultrashort echo time(DIR-UTE)imaging and quantification of the zone of calcified cartilage(ZCC)[J].Osteoarthritis Cartilage,2013,21(1):77-85.
[18]Li Z,Jia S,Xiong Z,et al.3D-printed scaffolds with calcified layer for osteochondral tissue engineering[J].J Biosci Bioeng,2018,21(1):11-17.
[19]Loeser RF,Goldring SR,Scanzello CR,et al.Osteoarthritis:a disease of the joint as an organ[J].Arthritis Rheum,2012,64(6):1697-1707.
[20]Zhou Q,Li S,Ma Y,et al.Detection of repair of the zone of calcified cartilage with osteoarthritis through mesenchymal stem cells by ultrashort echo time magnetic resonance imaging[J].Chin Med J,2018,17(1):27-31.
[21]Laverty S,Lacourt M,Gao C,et al.High density infill in cracks and protrusions from the articular calcified cartilage in osteoarthritis in standardbred horse carpal bones[J].Int Molecular Sci,2015,16(5):9600-9611.
[22]Prein C,Warmbold N,Farkas Z,et al.Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy[J].Matrix Biol,2016,50:1-15.
[23]Mwale F,Yao G,Ouellet J,et al.Effect of parathyroid hormone on type X and type II collagen expression in mesenchymal stem cells from osteoarthritic patients[J].Tissue Eng Part A,2010,16(11):3449-3455.
[24]Ley C,Ekman S,Hansson K,et al.Osteochondral lesions in distal tarsal joints of Icelandic horses reveal strong associations between hyaline and calcified cartilage abnormalities[J].Eur Cell Mater,2014,27:213-236.
[25]Hargrave-Thomas EJ,Thambyah A,McGlashan SR,et al.The bovine patella as a model of early osteoarthritis[J].J Anat,2013,223(6):651-664.
[26]段小军,王富友,杨柳,等.应用凝胶接种技术体外分层构建工程化骨软骨复合组织的初步研究[J].第三军医大学学报,2009,20:1969-1972.
[27]Atesok K,Doral MN,Karlsson J,et al.Multilayer scaffolds in orthopaedic tissue engineering[J].Knee Surg Sports Traumatol Arthrosc,2014,24(7):2365-2373.
[28]Chen K,Ng KS,Ravi S,et al.In vitro generation of whole osteochondral constructs using rabbit bone marrow stromal cells,employing a two-chambered co-culture well design[J].J Tissue Eng Regen Med,2016,10(4):294-304.
[29]Pina S,Oliveira JM,Reis RL.Natural-based nanocomposites for bone tissue engineering and regenerative medicine:a review[J].Adv Mater,2015,27(7):1143-1169.
[30]Yahara Y,Takemori H,Okada M,et al.Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3[J].Nat Commun,2016,7:10959.
[2]Wang F,Ying Z,Duan X,et al.Histomorphometric analysis of adult articular calcified cartilage zone[J].J Struct Biol,2009,168(3):359-365.
[3]Antons J,Marascio MGM,Nohava J,et al.Zone-dependent mechanical properties of human articular cartilage obtained by indentation measurements[J].J Mater Sci Mater Med,2018,29(5):57.
[4]段小军,王富友,杨柳.骨软骨组织界面结构及骨软骨复合组织构建研究[J].中国矫形外科杂志,2013,21(17):1729-1733.
[5]Hoemann C,Lafantaisie-Favreau CH,Lascau-Coman V,et al.The cartilage-bone interface[J].J Knee Surg,2012,25(2):85-98.
[6]Boushell M,Hung C,Hunziker E,et al.Current strategies for integrative cartilage repair[J].Connect Tissue Res,2017,58(5):393-406.
[7]Zhang Y,Wang F,Tan H,et al.Analysis of the mineral composition of the human calcified cartilage zone[J].Int J Med Sci,2012,9(5):353-360.
[8]段小军,左镇华,杨柳.细胞移植技术修复关节软骨缺损的临床应用进展[J/CD].中华关节外科杂志(电子版),2010,4(1):74-76.
[9]Sandy JD,Plaas A.The role of superficial layer cells in maintenance of articular cartilage surface integrity[J].J Xiangya Med,2017,2(23-23).
[10]Lee WD,Hurtig MB,Pilliar RM,et al.Engineering of hyaline cartilage with a calcified zone using bone marrow stromal cells[J].Osteoarthritis Cartilage,2015,23(8):1307-1315.
[11]Arbabi V,Pouran B,Weinans H,et al.Neutral solute transport across osteochondral interface:a finite element approach[J].J Biomech,2016,49(16):3833-3839.
[12]Arkill KP,Winlove CP.Solute transport in the deep and calcified zones of articular cartilage[J].Osteoarthritis Cartilage,2008,16(6):708-714.
[13]Pouran B,Arbabi V,Bleys RL,et al.Solute transport at the interface of cartilage and subchondral bone plate:Effect of micro-architecture[J].J Biomech,2017,52(148-154):1-10.
[14]Yu J,Liang F,Huang H,et al.Effects of loading on chondrocyte hypoxia,HIF-1alpha and VEGF in the mandibular condylar cartilage of young rats[J].Orthod Craniofac Res,2018,21(1):41-47.
[15]Mansfield JC,Peter Winlove C.A multi-modal multiphoton investigation of microstructure in the deep zone and calcified cartilage[J].J Anat,2012,220(4):405-416.
[16]Pan J,Wang B,Li W,et al.Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints[J].Bone,2012,51(2):212-217.
[17]Du J,Carl M,Bae WC,et al.Dual inversion recovery ultrashort echo time(DIR-UTE)imaging and quantification of the zone of calcified cartilage(ZCC)[J].Osteoarthritis Cartilage,2013,21(1):77-85.
[18]Li Z,Jia S,Xiong Z,et al.3D-printed scaffolds with calcified layer for osteochondral tissue engineering[J].J Biosci Bioeng,2018,21(1):11-17.
[19]Loeser RF,Goldring SR,Scanzello CR,et al.Osteoarthritis:a disease of the joint as an organ[J].Arthritis Rheum,2012,64(6):1697-1707.
[20]Zhou Q,Li S,Ma Y,et al.Detection of repair of the zone of calcified cartilage with osteoarthritis through mesenchymal stem cells by ultrashort echo time magnetic resonance imaging[J].Chin Med J,2018,17(1):27-31.
[21]Laverty S,Lacourt M,Gao C,et al.High density infill in cracks and protrusions from the articular calcified cartilage in osteoarthritis in standardbred horse carpal bones[J].Int Molecular Sci,2015,16(5):9600-9611.
[22]Prein C,Warmbold N,Farkas Z,et al.Structural and mechanical properties of the proliferative zone of the developing murine growth plate cartilage assessed by atomic force microscopy[J].Matrix Biol,2016,50:1-15.
[23]Mwale F,Yao G,Ouellet J,et al.Effect of parathyroid hormone on type X and type II collagen expression in mesenchymal stem cells from osteoarthritic patients[J].Tissue Eng Part A,2010,16(11):3449-3455.
[24]Ley C,Ekman S,Hansson K,et al.Osteochondral lesions in distal tarsal joints of Icelandic horses reveal strong associations between hyaline and calcified cartilage abnormalities[J].Eur Cell Mater,2014,27:213-236.
[25]Hargrave-Thomas EJ,Thambyah A,McGlashan SR,et al.The bovine patella as a model of early osteoarthritis[J].J Anat,2013,223(6):651-664.
[26]段小军,王富友,杨柳,等.应用凝胶接种技术体外分层构建工程化骨软骨复合组织的初步研究[J].第三军医大学学报,2009,20:1969-1972.
[27]Atesok K,Doral MN,Karlsson J,et al.Multilayer scaffolds in orthopaedic tissue engineering[J].Knee Surg Sports Traumatol Arthrosc,2014,24(7):2365-2373.
[28]Chen K,Ng KS,Ravi S,et al.In vitro generation of whole osteochondral constructs using rabbit bone marrow stromal cells,employing a two-chambered co-culture well design[J].J Tissue Eng Regen Med,2016,10(4):294-304.
[29]Pina S,Oliveira JM,Reis RL.Natural-based nanocomposites for bone tissue engineering and regenerative medicine:a review[J].Adv Mater,2015,27(7):1143-1169.
[30]Yahara Y,Takemori H,Okada M,et al.Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3[J].Nat Commun,2016,7:10959.