八珍汤联合参芪扶正注射液治疗气血亏虚型晚期胃癌癌因性疲乏的临床疗效研究
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摘要
目的:探讨气血亏虚型晚期胃癌患者经八珍汤和参芪扶正注射液治疗对改善癌因性疲乏(Cancer-Related Fatigue,CRF)的临床效果。方法:纳入我院2013年12月-2016年9月进行治疗的胃癌晚期患者共60例,将60例患者随机分为对照组和观察组各30例,对照组采用常规营养支持,将复方氨基酸18AA共250 mL、水溶维生素10 mL和脂溶性维生素10 m L进行静脉滴注,观察组在此基础上加用八珍汤联合参芪扶正注射液进行治疗,八珍汤组方:党参、茯苓、熟地黄、白芍、当归各15 g,白术12 g,川芎及炙甘草各10 g,加水煎至200 mL,每日1剂,早晚口服,参芪扶正注射液250 mL进行静脉滴注,共治疗2周为一个疗程,两组患者共治疗2个疗程。结果:两组患者治疗前的情感、行为、认知、疲乏及躯体评分对比差异无显著统计学意义(P> 0.05),治疗后评分较治疗前均出现下降(P <0.05),观察组治疗后的评分较对照组下降更为明显(P <0.05),对比差异存在统计学意义。在治疗前两组患者的生命质量测定量表(EORTC QLQ-C30)评分对比差异无统计学意义(P> 0.05),治疗后评分较治疗前均出现升高(P <0.05),观察组治疗后的评分较对照组升高更为明显(P <0.05),对比差异存在统计学意义。结论:经八珍汤联合参芪扶正注射液治疗后能有效的改善气血亏虚型晚期胃癌患者的CRF症状,提高了患者的生活质量。
Objective: To investigate the clinical efficacy of the Bazhen decoction( 八珍汤) and Shenqi Fuzheng injection( 参芪扶正注射液) on cancer-related fatigue of advanced gastric cancer of the Qixue Kuixu type( 气血亏虚型). Methods: 60 patients were randomly divided into the control group and the observation group, 30 cases in each. The control group was given conventional nutritional support. The observation group was given the Bazhen decoction and Shenqi Fuzheng injection. Results: The emotion, behavior, cognition, fatigue and somatic score did not show significant difference before treatment between two groups(P>0.05); those were decreased after treatment(P<0.05), and those in the observation group were more obvious than the control group(P<0.05), with significant differences. The QLQ-BR30 score did not show significant difference between two groups before treatment(P>0.05), that was higher after treatment(P<0.05), and that in the observation group was more obvious than the control group(P<0.05), with a significant difference. Conclusion: The Bazhen decoction and Shenqi Fuzheng injection can effectively improve the CRF symptoms and the quality of life.
Objective: To investigate the clinical efficacy of the Bazhen decoction( 八珍汤) and Shenqi Fuzheng injection( 参芪扶正注射液) on cancer-related fatigue of advanced gastric cancer of the Qixue Kuixu type( 气血亏虚型). Methods: 60 patients were randomly divided into the control group and the observation group, 30 cases in each. The control group was given conventional nutritional support. The observation group was given the Bazhen decoction and Shenqi Fuzheng injection. Results: The emotion, behavior, cognition, fatigue and somatic score did not show significant difference before treatment between two groups(P>0.05); those were decreased after treatment(P<0.05), and those in the observation group were more obvious than the control group(P<0.05), with significant differences. The QLQ-BR30 score did not show significant difference between two groups before treatment(P>0.05), that was higher after treatment(P<0.05), and that in the observation group was more obvious than the control group(P<0.05), with a significant difference. Conclusion: The Bazhen decoction and Shenqi Fuzheng injection can effectively improve the CRF symptoms and the quality of life.
引文
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[4]卫生部卫生统计信息中心,协和医院世界卫生组织疾病分类合作中心.国际疾病分类(ICD-10)应用指导手册[M].北京:中国协和医科大学出版社,2001:32-38.
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[7]王岩,朱琳,陈鹏.肿瘤患者生命质量测定量表EORTC QLQ-C30维文版评价[J].中国卫生统计,2015,32(03):512-513.
[8]曹凤.康艾注射液联合化疗对胃癌治疗的临床分析[J].中医临床研究,2015,7(21):147-148.