老年高血压血压变异性与靶器官损伤相关性研究进展
摘要
近年来,随着对老年高血压研究的深入,老年高血压病人血压变异性(BPV)与靶器官损伤相关性成为研究的热点。本文主要对老年高血压BPV与靶器官损伤相关性研究进展进行综述,以期临床工作者重视老年高血压病人的BPV,更好地控制血压,减少并发症,提高病人的远期生存率。
引文
[1] JAMES P A,OPARIL S,CARTER B L,et al.2014evidence-based guideline for the management of high blood pressure in adults:report from the panel members appointed to the Eighth Joint National Committee(JNC 8)[J].JAMA:the Journal of the American Medical Association,2014,311(5):507-520.
[2] WILLIAMS B,LINDHOLM L H,SEVER P.Systolic pressure is all that matters[J].Lancet,2008,371(9631):2219-2221.
[3] ROTHWELL P M,HOWARD S C,DOLAN E,et al.Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke[J].Lancet Neurology,2010,9(5):469-480.
[4] WEBB A J,FISCHER U,MEHTA Z,et al.Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke:a systematic review and metaanalysis[J].Lancet,2010,375(9718):906-915.
[5] ROTHWELL P M,HOWARD S C,DOLAN E,et al.Prognostic significance of visit-to-visit variability,maximum systo-lic blood pressure,and episodic hypertension[J].Lancet,2010,375(9718):895-905.
[6]陈鲁原.血压变异的临床意义与实践[J].岭南心血管病杂志,2011,17(6):430-432.
[7] KADAM P D.Rectocutaneous fistula with transmigration of the suture:a rare delayed complication of vault fixation withthe sacrospinous ligament[J].International Urogynecology Journal,2016,27(3):1-3.
[8]崔华,范利,张梦,等.1993—2008年影响住院老年高血压患者靶器官损害危险因素的回顾性分析[J].中华高血压杂志,2012,20(7):307-312.
[9] BONORA M,WIECKOWSKI M R,CHINOPOULOS C,et al.Molecular mechanisms of cell death:central implication of ATP synthase in mitochondrial permeability transition[J].Oncogene,2015,34(12):1475-1486.
[10]QUINAGLIA T,MARTINS L C,FIGUEIREDO V N,et al.Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension[J].Journal of Human Hypertension,2011,25(11):656-664.
[11]TAN J,PEI Y H,HUA Q,et al.Aortic pulse wave velocity is associated with measures of subclinical target organ damage in patients with mild hypertension[J].Cell Biochemistry and Biophysics,2014,70(1):167-171.
[12]徐海霞,牟建军,刘富强,等.钠钾对血压盐敏感者短时血压变异性的影响[J].中华高血压杂志,2012,20(6):580-583.
[13]FUKUI M,USHIGOME E,TANAKA Muhei,et al.Home blood pressure variability on one occasion is a novel factor associated with arterial stiffness in patients with type 2diabetes[J].Hypertension Research,2013,36(3):219-225.
[14]PARATI G,OCHOA J E,LOMBARDI C,et al.Assessment and management of blood-pressure variability[J].Nature Reviews Cardiology,2013,10(3):143-155.
[15]JOHANSSON J K,NIIRANEN T J,PUUKKA P J,et al.Factors affecting the variability of home-measured blood pressure and heart rate:the Finn-home study[J].Journal of Hypertension,2010,28(9):1836-1845.
[16]GRASSI G,BOMBELLI M,BRAMBILLA G,et al.Total cardiovascular risk,blood pressure variability and adrenergic overdrive in hypertension:evidence,mechanisms and clinical implications[J].Current Hypertension Reports,2012,14(4):333-338.
[17]MADDEN J M,O′FLYNN A M,DOLAN E,et al.Shortterm blood pressure variability over 24 hand target organ damage in middle-aged men and women[J].Journal of Human Hypertension,2015,29(12):719-725.
[18]MADDEN J M,O′FLYNN A M,FITZGERALD A P,et al.Correlation between short-term blood pressure variability and left-ventricular mass index:a meta-analysis[J].Hypertension Research,2016,39(3):171-177.
[19]KAI H,KUDO H,TAKAYAMA N,et al.Large blood pressure variability and hypertensive cardiac remodeling—role of cardiac inflammation[J].Circulation Journal,2009,73(12):2198-2203.
[20]FAGARD R H,CELIS H,THIJS L,et al.Daytime and nighttime blood pressure as predictors of death and causespecific cardiovascular events in hypertension[J].Hypertension,2008,51(1):55-61.
[21]HANSEN T W,LI Yan,BOGGIA J,et al.Predictive role of the nighttime blood pressure[J].Hypertension,2011,57(1):3-10.
[22]ARASHI H,OGAWA H,YAMAGUCHI J I,et al.Impact of visit-to-visit variability and systolic blood pressure control on subsequent outcomes in hypertensive patients with coronary artery disease(from the HIJ-CREATE substudy)[J].The American Journal of Cardiology,2015,116(2):236-242.
[23]DIAZ K M,TANNER R M,FALZON L,et al.Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality:a systematic review and meta-analysis[J].Hypertension,2014,64(5):965-982.
[24]CHOWDHURY E K,OWEN A,KRUM H,et al.Systolic blood pressure variability is an important predictor of cardiovascular outcomes in elderly hypertensive patients[J].Journal of Hypertension,2014,32(3):525-533.
[25]STERGIOU G S,NASOTHIMIOU E G.Home monitoring is the optimal method for assessing blood pressure variability[J].Hypertension Research,2011,34(12):1246-1248.
[26] MASUGATA H,SENDA S,MURAO K,et al.Visit-tovisit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients[J].Hypertension Research,2011,34(7):846-850.
[27]NAGAI M,HOSHIDE S,ISHIKAWA J,et al.Visit-to-visit blood pressure variations:new independent determinants for cognitive function in the elderly at high risk of cardiovascular disease[J].Journal of Hypertension,2012,30(8):1556-1563.
[28]KAWAI T,OHISHI M,KAMIDE K,et al.The impact of visit-to-visit variability in blood pressure on renal function[J].Hypertension Research,2012,35(2):239-243.
[29]YASUOKA S,KAI H,KAJIMOTO H,et al.Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats[J].Circulation Journal,2013,77(6):1474-1481.
[30]吴明祥,陈运枝,方丽娅,等.颈动脉粥样硬化与不同类型冠心病的相关性分析[J].中国动脉硬化杂志,2011,19(9):773-776.
[31]FILOMENA J,RIBA-LLENA I,VINYOLES E,et al.Short-term blood pressure variability relates to the presence of subclinical brain small vessel disease in primary hypertension[J].Hypertension,2015,66(3):634-640,445.
[32] MANCIA G,PARATI G,HENNIG M,et al.Relation between blood pressure variability and carotid artery damage in hypertension:baseline data from the European Lacidipine Study on Atherosclerosis(ELSA)[J].Journal of Hypertension,2001,19(11):1981-1989.
[33]CHEN Y J,XIONG H H,WU D,et al.Relationship of short-term blood pressure variability with carotid intima-media thickness in hypertensive patients[J].Biomedical Engineering Online,2015,14(1):71-81.
[34]TURAK O,AFSAR B,OZCAN F,et al.Relationship be-tween elevated morning blood pressure surge,uric acid,and cardiovascular outcomes in hypertensive patients[J].Journal of Clinical Hypertension(Greenwich,Conn.),2014,16(7):530-535.
[35]SONG H B,WEI F,LIU Z D,et al.Visit-to-visit variability in systolic blood pressure:correlated with the changes of arterial stiffness and myocardial perfusion in on-treated hypertensive patients[J].Clinical and Experimental Hypertension(New York,N.Y.:1993),2015,37(1):63-69.
[36]RIBEIRO A H,LOTUFO P A,FUJITA A,et al.Association between short-term systolic blood pressure variability and carotid intima-media thickness in ELSA-Brasil baseline[J].American Journal of Hypertension,2017,30(10):954-960.
[37]KAMARUZZAMAN S,WATT H,CARSON C,et al.The association between orthostatic hypotension and medication use in the British Women′s Heart and Health Study[J].Age and Ageing,2010,39(1):51-56.
[38]TSIOUFIS C,ANDRIKOU I,THOMOPOULOS C,et al.Comparative prognostic role of nighttime blood pressure and nondipping profile on renal outcomes[J].American Journal of Nephrology,2011,33(3):277-288.
[39]TAMURA K,AZUSHIMA K,UMEMURA S.Day-by-day home-measured blood pressure variability:another important factor in hypertension with diabetic nephropathy[J]?Hypertension Research:Official Journal of the Japanese Society of Hypertension,2011,34(12):1249-1250.
[40]OKADA T,MATSUMOTO H,NAGAOKA Y,et al.Association of home blood pressure variability with progression of chronic kidney disease[J].Blood Pressure Monitoring,2012,17(1):1-7.
[41]LEONCINI G,VIAZZI F,STORACE G,et al.Blood pressure variability and multiple organ damage in primary hypertension[J].Journal of Human Hypertension,2013,27(11):663-670.
[2] WILLIAMS B,LINDHOLM L H,SEVER P.Systolic pressure is all that matters[J].Lancet,2008,371(9631):2219-2221.
[3] ROTHWELL P M,HOWARD S C,DOLAN E,et al.Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke[J].Lancet Neurology,2010,9(5):469-480.
[4] WEBB A J,FISCHER U,MEHTA Z,et al.Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke:a systematic review and metaanalysis[J].Lancet,2010,375(9718):906-915.
[5] ROTHWELL P M,HOWARD S C,DOLAN E,et al.Prognostic significance of visit-to-visit variability,maximum systo-lic blood pressure,and episodic hypertension[J].Lancet,2010,375(9718):895-905.
[6]陈鲁原.血压变异的临床意义与实践[J].岭南心血管病杂志,2011,17(6):430-432.
[7] KADAM P D.Rectocutaneous fistula with transmigration of the suture:a rare delayed complication of vault fixation withthe sacrospinous ligament[J].International Urogynecology Journal,2016,27(3):1-3.
[8]崔华,范利,张梦,等.1993—2008年影响住院老年高血压患者靶器官损害危险因素的回顾性分析[J].中华高血压杂志,2012,20(7):307-312.
[9] BONORA M,WIECKOWSKI M R,CHINOPOULOS C,et al.Molecular mechanisms of cell death:central implication of ATP synthase in mitochondrial permeability transition[J].Oncogene,2015,34(12):1475-1486.
[10]QUINAGLIA T,MARTINS L C,FIGUEIREDO V N,et al.Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension[J].Journal of Human Hypertension,2011,25(11):656-664.
[11]TAN J,PEI Y H,HUA Q,et al.Aortic pulse wave velocity is associated with measures of subclinical target organ damage in patients with mild hypertension[J].Cell Biochemistry and Biophysics,2014,70(1):167-171.
[12]徐海霞,牟建军,刘富强,等.钠钾对血压盐敏感者短时血压变异性的影响[J].中华高血压杂志,2012,20(6):580-583.
[13]FUKUI M,USHIGOME E,TANAKA Muhei,et al.Home blood pressure variability on one occasion is a novel factor associated with arterial stiffness in patients with type 2diabetes[J].Hypertension Research,2013,36(3):219-225.
[14]PARATI G,OCHOA J E,LOMBARDI C,et al.Assessment and management of blood-pressure variability[J].Nature Reviews Cardiology,2013,10(3):143-155.
[15]JOHANSSON J K,NIIRANEN T J,PUUKKA P J,et al.Factors affecting the variability of home-measured blood pressure and heart rate:the Finn-home study[J].Journal of Hypertension,2010,28(9):1836-1845.
[16]GRASSI G,BOMBELLI M,BRAMBILLA G,et al.Total cardiovascular risk,blood pressure variability and adrenergic overdrive in hypertension:evidence,mechanisms and clinical implications[J].Current Hypertension Reports,2012,14(4):333-338.
[17]MADDEN J M,O′FLYNN A M,DOLAN E,et al.Shortterm blood pressure variability over 24 hand target organ damage in middle-aged men and women[J].Journal of Human Hypertension,2015,29(12):719-725.
[18]MADDEN J M,O′FLYNN A M,FITZGERALD A P,et al.Correlation between short-term blood pressure variability and left-ventricular mass index:a meta-analysis[J].Hypertension Research,2016,39(3):171-177.
[19]KAI H,KUDO H,TAKAYAMA N,et al.Large blood pressure variability and hypertensive cardiac remodeling—role of cardiac inflammation[J].Circulation Journal,2009,73(12):2198-2203.
[20]FAGARD R H,CELIS H,THIJS L,et al.Daytime and nighttime blood pressure as predictors of death and causespecific cardiovascular events in hypertension[J].Hypertension,2008,51(1):55-61.
[21]HANSEN T W,LI Yan,BOGGIA J,et al.Predictive role of the nighttime blood pressure[J].Hypertension,2011,57(1):3-10.
[22]ARASHI H,OGAWA H,YAMAGUCHI J I,et al.Impact of visit-to-visit variability and systolic blood pressure control on subsequent outcomes in hypertensive patients with coronary artery disease(from the HIJ-CREATE substudy)[J].The American Journal of Cardiology,2015,116(2):236-242.
[23]DIAZ K M,TANNER R M,FALZON L,et al.Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality:a systematic review and meta-analysis[J].Hypertension,2014,64(5):965-982.
[24]CHOWDHURY E K,OWEN A,KRUM H,et al.Systolic blood pressure variability is an important predictor of cardiovascular outcomes in elderly hypertensive patients[J].Journal of Hypertension,2014,32(3):525-533.
[25]STERGIOU G S,NASOTHIMIOU E G.Home monitoring is the optimal method for assessing blood pressure variability[J].Hypertension Research,2011,34(12):1246-1248.
[26] MASUGATA H,SENDA S,MURAO K,et al.Visit-tovisit variability in blood pressure over a 1-year period is a marker of left ventricular diastolic dysfunction in treated hypertensive patients[J].Hypertension Research,2011,34(7):846-850.
[27]NAGAI M,HOSHIDE S,ISHIKAWA J,et al.Visit-to-visit blood pressure variations:new independent determinants for cognitive function in the elderly at high risk of cardiovascular disease[J].Journal of Hypertension,2012,30(8):1556-1563.
[28]KAWAI T,OHISHI M,KAMIDE K,et al.The impact of visit-to-visit variability in blood pressure on renal function[J].Hypertension Research,2012,35(2):239-243.
[29]YASUOKA S,KAI H,KAJIMOTO H,et al.Blood pressure variability activates cardiac mineralocorticoid receptor and induces cardiac remodeling in hypertensive rats[J].Circulation Journal,2013,77(6):1474-1481.
[30]吴明祥,陈运枝,方丽娅,等.颈动脉粥样硬化与不同类型冠心病的相关性分析[J].中国动脉硬化杂志,2011,19(9):773-776.
[31]FILOMENA J,RIBA-LLENA I,VINYOLES E,et al.Short-term blood pressure variability relates to the presence of subclinical brain small vessel disease in primary hypertension[J].Hypertension,2015,66(3):634-640,445.
[32] MANCIA G,PARATI G,HENNIG M,et al.Relation between blood pressure variability and carotid artery damage in hypertension:baseline data from the European Lacidipine Study on Atherosclerosis(ELSA)[J].Journal of Hypertension,2001,19(11):1981-1989.
[33]CHEN Y J,XIONG H H,WU D,et al.Relationship of short-term blood pressure variability with carotid intima-media thickness in hypertensive patients[J].Biomedical Engineering Online,2015,14(1):71-81.
[34]TURAK O,AFSAR B,OZCAN F,et al.Relationship be-tween elevated morning blood pressure surge,uric acid,and cardiovascular outcomes in hypertensive patients[J].Journal of Clinical Hypertension(Greenwich,Conn.),2014,16(7):530-535.
[35]SONG H B,WEI F,LIU Z D,et al.Visit-to-visit variability in systolic blood pressure:correlated with the changes of arterial stiffness and myocardial perfusion in on-treated hypertensive patients[J].Clinical and Experimental Hypertension(New York,N.Y.:1993),2015,37(1):63-69.
[36]RIBEIRO A H,LOTUFO P A,FUJITA A,et al.Association between short-term systolic blood pressure variability and carotid intima-media thickness in ELSA-Brasil baseline[J].American Journal of Hypertension,2017,30(10):954-960.
[37]KAMARUZZAMAN S,WATT H,CARSON C,et al.The association between orthostatic hypotension and medication use in the British Women′s Heart and Health Study[J].Age and Ageing,2010,39(1):51-56.
[38]TSIOUFIS C,ANDRIKOU I,THOMOPOULOS C,et al.Comparative prognostic role of nighttime blood pressure and nondipping profile on renal outcomes[J].American Journal of Nephrology,2011,33(3):277-288.
[39]TAMURA K,AZUSHIMA K,UMEMURA S.Day-by-day home-measured blood pressure variability:another important factor in hypertension with diabetic nephropathy[J]?Hypertension Research:Official Journal of the Japanese Society of Hypertension,2011,34(12):1249-1250.
[40]OKADA T,MATSUMOTO H,NAGAOKA Y,et al.Association of home blood pressure variability with progression of chronic kidney disease[J].Blood Pressure Monitoring,2012,17(1):1-7.
[41]LEONCINI G,VIAZZI F,STORACE G,et al.Blood pressure variability and multiple organ damage in primary hypertension[J].Journal of Human Hypertension,2013,27(11):663-670.