结肠靶向给药系统的研究现状
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摘要
对近年来结肠靶向给药系统的制剂学手段和评价方法等最新研究成果时行梳理,为科研工作者提供理论依据。
In the paper, the latest studies on preparation measures, assessment methods and others of colon targeted drug delivery system in the recent years are reviewed in order to provide theoretical evidence for scientific workers.
In the paper, the latest studies on preparation measures, assessment methods and others of colon targeted drug delivery system in the recent years are reviewed in order to provide theoretical evidence for scientific workers.
引文
[1]Pinto JF.Site-specific drug delvery systems within the gastro-intestinal tract:from the mouth to the colon[J].International Journal of Pharmaceutics,2010,395(1/2):44-52.
[2]Bai JP,Chang LL,Guo JH.Targeting of peptide and protein drugs to specific sites in the oral route[J].Critical Reviews in Therapeutic Drug Carrier Systems,1995,12(4):339-371.
[3]孙锡维,周芝芳,孙洁胤.结肠靶向给药制剂研究的新进展[J].中国现代应用药学杂志,2002,19(3):196-198.
[4]江延辉.薄膜包衣技术的应用[J].中国实用医药,2007,2(24):124-125.
[5]詹璐璐,尹东东,王杏林,等.结肠靶向给药制备技术的研究进展[J].中国新药杂志,2014,23(16):1868-1874.
[6]李小芳,曹小勇,熊婷婷.p H-酶依赖型肠康宁结肠靶向片的包衣工艺研究[J].成都中医药大学学报,2009,32(4):69-73.
[7]Shah N,Shah T,Amin A.Polysaccharides:a targeting strategy for colonic drug delivery[J].Expert Opiniion on Drug Delivery,2011,8(6):779-796.
[8]Rubinstein A,Radai R,Ezra M,et al.In vitro evaluation of calcium pectinate:a potential colonspecific drug delivery carrier[J].Pharmaceutical Research,1993,10(10):258-260.
[9]Sinha VR,Kumria R.Polysaccharides in colon-specific drug delivery[J].International Journal of Pharmaceutics,2001,224(122):19-38.
[10]Kong H,Kim H,Do H,et al.Structural effects of naromatic acyamino acid conjugates on their deconjugation in the cecal contents of rats:implication in design of a colon-specific prodrug with controlled conversion rate at the target site[J].Biopharmaceutics&Drug Disposition,2011,32(6):343-354.
[11]Udo K,Hokonohara K,Motoyama K,et al.5-fluorouracil acetic acid/beta-cyclodextrin conjugates:drug release behavior in enzymatic and rat cecal media[J].International JournalofPharmaceutics,2010,388(1-2):95-100.
[12]Sharma R,Rawal RK,Malhotra M,et al.Design,synthesis and ex-vivo release studies of colon-specific polyphosphazene-anti-cancer drug conjugates[J].Bioorg Med Chem,2014,22(3):1104-1114.
[13]FerrariPC,SouzaFM,GiorgettiL,etal.Development and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery[J].Carbohydr Polym,2013,91(1):244-252.
[14]Huang Y,Tian R,HU W,et al.A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS[J].Carbohydr Polym,2013,92(2):2218-2223.
[15]Xu M,Sun M,Qiao H,et al.Preparation and evaluation of colon adhesive pellets of 5-aminosalicylic acid[J].Int J Pharm,2014,468(1-2):165-171.
[16]付帮翠,张芸,郭苗苗,等.基于纳米技术的结肠靶向给药系统研究进展[J].中国药师,2012,15(5):633-636.
[17]Kshirsagar SJ,Bhalekar MR,Patel JN,et al.Preparation and characterization of nanocapsules for colon-targeted drug delivery system[J].Pharm Dev Technol,2012,17(5):607-613.
[18]Verma S,Kaul M,Saini S,et al.Solid dispersion:a strategy for solubility enhancement[J].Int J Pharm Tech,2011,3(2):1062-1099.
[19]田力,刘红宁,管咏梅,等.白头翁总皂苷结肠定位固体分散体制备[J].中成药,2015,37(12):2619-2623.
[20]严红梅,张振海,蒋艳荣,等.黄芩苷结肠定位固体分散体的制备及其体外释放度评价[J].中国中药杂志,2014,39(1):71-74.
[21]Nokhodchi A,Jelvehgari M,Siahi Mr,et al.Factors affectingthe morphology of benzoyl peroxide mic rosponges[J]Micron,2007,38(8):834-840.
[22]张林,刘秀菊,翟光喜.口服结肠靶向给药系统的研究进展[J].中国新药与临床杂志,2011,30(8):574-579.
[23]Orlum E,Araman A.Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges[J].Int J Pharm,2006,318(1-2):103-117.
[24]Sareen R,Nath K,Jain N,et al.Curcumin loaded mic rosponges for colon targeting in inflammatory Bowel Disease:Fabrication,Optimization,and In Vitro and Pharmacodynamic Evaluation[J].Biomed Res Int,2014(5):340701.
[25]Chaudhary A,Tiwari N,Jain V,et al.Microporous bil ayer osmotic tablet for colon-specific delivery[J].Eur JPharm Biopharm,2011,78(1):134-140.
[26]Bathool A,Gowda DV,Khan MS,et al.Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride[J].J Adv Pharm TechnolRes,2012,3(2):124-129.
[27]Tsai SW,Yu DS,Tsao SW,et al.Hyaluronan-cisplatin conjugate nanoparticles embedded in Eudragit S100-coated pectin/alginate microbeads for colon drug delivery[J].Int JNanomedicine,2013(8):2399-2407.
[28]黄健,高春生,梅兴国.新型结肠靶向给药系统[J].国外医学:药学分册,2002,29(5):306-308.
[29]朱盛山,梁文权,吕万良,等.药剂新剂型[M].北京:化学工业出版社,2003:173.
[30]张正利,张光奇,何鲜平.健脾益肠散和固本保元腹袋治疗溃疡性结肠炎22例[J].浙江中医杂志,2000,35(2):59-61.
[31]刘晓华,张钧寿,李纯球,等.中药结肠靶向给药研究[J].中成药,2001,23(12):859-862.
[2]Bai JP,Chang LL,Guo JH.Targeting of peptide and protein drugs to specific sites in the oral route[J].Critical Reviews in Therapeutic Drug Carrier Systems,1995,12(4):339-371.
[3]孙锡维,周芝芳,孙洁胤.结肠靶向给药制剂研究的新进展[J].中国现代应用药学杂志,2002,19(3):196-198.
[4]江延辉.薄膜包衣技术的应用[J].中国实用医药,2007,2(24):124-125.
[5]詹璐璐,尹东东,王杏林,等.结肠靶向给药制备技术的研究进展[J].中国新药杂志,2014,23(16):1868-1874.
[6]李小芳,曹小勇,熊婷婷.p H-酶依赖型肠康宁结肠靶向片的包衣工艺研究[J].成都中医药大学学报,2009,32(4):69-73.
[7]Shah N,Shah T,Amin A.Polysaccharides:a targeting strategy for colonic drug delivery[J].Expert Opiniion on Drug Delivery,2011,8(6):779-796.
[8]Rubinstein A,Radai R,Ezra M,et al.In vitro evaluation of calcium pectinate:a potential colonspecific drug delivery carrier[J].Pharmaceutical Research,1993,10(10):258-260.
[9]Sinha VR,Kumria R.Polysaccharides in colon-specific drug delivery[J].International Journal of Pharmaceutics,2001,224(122):19-38.
[10]Kong H,Kim H,Do H,et al.Structural effects of naromatic acyamino acid conjugates on their deconjugation in the cecal contents of rats:implication in design of a colon-specific prodrug with controlled conversion rate at the target site[J].Biopharmaceutics&Drug Disposition,2011,32(6):343-354.
[11]Udo K,Hokonohara K,Motoyama K,et al.5-fluorouracil acetic acid/beta-cyclodextrin conjugates:drug release behavior in enzymatic and rat cecal media[J].International JournalofPharmaceutics,2010,388(1-2):95-100.
[12]Sharma R,Rawal RK,Malhotra M,et al.Design,synthesis and ex-vivo release studies of colon-specific polyphosphazene-anti-cancer drug conjugates[J].Bioorg Med Chem,2014,22(3):1104-1114.
[13]FerrariPC,SouzaFM,GiorgettiL,etal.Development and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery[J].Carbohydr Polym,2013,91(1):244-252.
[14]Huang Y,Tian R,HU W,et al.A novel plug-controlled colon-specific pulsatile capsule with tablet of curcumin-loaded SMEDDS[J].Carbohydr Polym,2013,92(2):2218-2223.
[15]Xu M,Sun M,Qiao H,et al.Preparation and evaluation of colon adhesive pellets of 5-aminosalicylic acid[J].Int J Pharm,2014,468(1-2):165-171.
[16]付帮翠,张芸,郭苗苗,等.基于纳米技术的结肠靶向给药系统研究进展[J].中国药师,2012,15(5):633-636.
[17]Kshirsagar SJ,Bhalekar MR,Patel JN,et al.Preparation and characterization of nanocapsules for colon-targeted drug delivery system[J].Pharm Dev Technol,2012,17(5):607-613.
[18]Verma S,Kaul M,Saini S,et al.Solid dispersion:a strategy for solubility enhancement[J].Int J Pharm Tech,2011,3(2):1062-1099.
[19]田力,刘红宁,管咏梅,等.白头翁总皂苷结肠定位固体分散体制备[J].中成药,2015,37(12):2619-2623.
[20]严红梅,张振海,蒋艳荣,等.黄芩苷结肠定位固体分散体的制备及其体外释放度评价[J].中国中药杂志,2014,39(1):71-74.
[21]Nokhodchi A,Jelvehgari M,Siahi Mr,et al.Factors affectingthe morphology of benzoyl peroxide mic rosponges[J]Micron,2007,38(8):834-840.
[22]张林,刘秀菊,翟光喜.口服结肠靶向给药系统的研究进展[J].中国新药与临床杂志,2011,30(8):574-579.
[23]Orlum E,Araman A.Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges[J].Int J Pharm,2006,318(1-2):103-117.
[24]Sareen R,Nath K,Jain N,et al.Curcumin loaded mic rosponges for colon targeting in inflammatory Bowel Disease:Fabrication,Optimization,and In Vitro and Pharmacodynamic Evaluation[J].Biomed Res Int,2014(5):340701.
[25]Chaudhary A,Tiwari N,Jain V,et al.Microporous bil ayer osmotic tablet for colon-specific delivery[J].Eur JPharm Biopharm,2011,78(1):134-140.
[26]Bathool A,Gowda DV,Khan MS,et al.Development and evaluation of microporous osmotic tablets of diltiazem hydrochloride[J].J Adv Pharm TechnolRes,2012,3(2):124-129.
[27]Tsai SW,Yu DS,Tsao SW,et al.Hyaluronan-cisplatin conjugate nanoparticles embedded in Eudragit S100-coated pectin/alginate microbeads for colon drug delivery[J].Int JNanomedicine,2013(8):2399-2407.
[28]黄健,高春生,梅兴国.新型结肠靶向给药系统[J].国外医学:药学分册,2002,29(5):306-308.
[29]朱盛山,梁文权,吕万良,等.药剂新剂型[M].北京:化学工业出版社,2003:173.
[30]张正利,张光奇,何鲜平.健脾益肠散和固本保元腹袋治疗溃疡性结肠炎22例[J].浙江中医杂志,2000,35(2):59-61.
[31]刘晓华,张钧寿,李纯球,等.中药结肠靶向给药研究[J].中成药,2001,23(12):859-862.