miRNA:2型糖尿病潜在的新型生物标志物
摘要
2型糖尿病(type 2 diabetes mellitus,T2DM)是一种渐进性的多因素代谢紊乱性疾病,微小核糖核酸(microRNA,miRNA)是一类小分子非编码RNA,可通过在转录后水平对其靶信使RNA翻译抑制和/或降低其稳定性来调节基因表达,miRNA具有大量的生物学和生理学功能,在T2DM的发生发展、胰岛素的生成与分泌、胰岛素抵抗和糖尿病并发症等方面起重要作用。该综述通过对T2DM相关miRNA的研究,以阐明miRNA在T2DM预防、早期预警和治疗方面具有的潜在应用前景。
引文
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[27]Wei ZT,Weng SY,Wang L,et al.Mechanism of Astragalus polysaccharides in attenuating insulin resistance in Rats with type 2 diabetes mellitus via the regulation of liver microRNA-203a-3p[J].Mol Med Rep,2018,17(1):1617-1624.
[2]Shaw JE,Sicree RA,Zimmet PZ.Global estimates of the prevalence of diabetes for 2010 and 2030[J].Diabetes Res Clin Pract,2010,87(1):4-14.
[3]Xu Y,Wang L,He J,et al.Prevalence and control of diabetes in Chinese adults[J].JAMA,2013,310(9):948-959.
[4]Honardoost M,Sarookhani MR,Arefian E,et al.Insulin resistance associated genes and miRNA[J].Appl Biochem Biotechnol,2014,174(1):63-80.
[5]Chen X,Ba Y,Ma L,et al.Characterization of microRNAs in serum:a novel class of biomarkers for diagnosis of cancer and other diseases[J].Cell Res,2008,18(10):997-1006.
[6]Al-Muhtaresh HA,Al-Kafaji G.Evaluation of two-diabetes related microRNAs suitability as earlier blood biomarkers for detecting prediabetes and type 2 diabetes mellitus[J].J Clin Med,2018,7(2):1-13.
[7]Jaeger A,Zollinger L,Saely CH,et al.Circulating microRNAs -192 and -194 are associated with the presence and incidence of diabetes mellitus[J].Sci Rep,2018,8(1):14274.
[8]Matsha TE,Kengne AP,Hector S,et al.MicroRNA profiling and their pathways in South African individuals with prediabetes and newly diagnosed type 2 diabetes mellitus[J].Oncotarget,2018,9(55):30485-30498.
[9]Liang YZ,Li JJ,Xiao HB,et al.Identification of stress-related microRNA biomarkers in type 2 diabetes mellitus:A systematic review and meta-analysis[J].J Diabetes,2018,17:1-11.
[10]Yaribeygi H,Katsiki N,Behnam B,et al.MicroRNAs and type 2 diabetes mellitus:Molecular mechanisms and the effect of antidiabetic drug treatment[J].Metabolism,2018,87:48-55.
[11]van de Bunt M,Gaulton KJ,Parts L,et al.The miRNA profile of human pancreatic islets and beta-cells and relationship to type 2 diabetes pathogenesis[J].PLoS One,2013,8(1):e55272.
[12]Miao CG,Zhang GX,Xie ZW,et al.MicroRNAs in the pathogenesis of type 2 diabetes:new research progress and future direction[J].Can J Physiol Pharmacol,2018,96(2):103-112.
[13]Dou L,Wang S,Sun L,et al.Mir-338-3p mediates Tnf-A-induced hepatic insulin resistance by targeting PP4r1 to regulate PP4 expression[J].Cell Physiol Biochem,2017,41(6):2419-2431.
[14]Kamalden TA,Macgregor-Das AM,Kannan SM,et al.Exosomal MicroRNA-15a transfer from the pancreas augments diabetic complications by inducing oxidative stress[J].Antioxid Redox Signal,2017,27(13):913-930.
[15]Wang SS,Li YQ,Liang YZ,et al.Expression of miR-18a and miR-34c in circulating monocytes associated with vulnerability to type 2 diabetes mellitus and insulin resistance[J].J Cell Mol Med,2018,21(12):3372-3380.
[16]Zampetaki A,Kiechl S,Drozdov I,et al.Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes[J].Circ Res,2010,107(6):810-817.
[17]Amr KS,Abdelmawgoud H,Ali ZY,et al.Potential value of circulating microRNA-126 and microRNA-210 as biomarkers for type 2 diabetes with coronary artery disease[J].Br J Biomed Sci,2018,75(2):82-87.
[18]Wan S,Wang J,Wang J,et al.Increased serum miR-7 is a promising biomarker for type 2 diabetes mellitus and its microvascular complications[J].Diabetes Res Clin Pract,2017,130:171-179.
[19]Roux M,Perret C,Feigerlova E,et al.Plasma levels of hsa-miR-152-3p are associated with diabetic nephropathy in patients with type 2 diabetes[J].Nephrol Dial Transplant,2018,33(12):2201-2207.
[20]Milas O,Gadalean F,Vlad A,et al.Deregulated profiles of urinary microRNAs may explain podocyte injury and proximal tubule dysfunction in normoalbuminuric patients with type 2 diabetes mellitus[J].J Investig Med,2018,66(4):747-754.
[21]Delic D,Eisele C,Schmid R,et al.Urinary exosomal miRNA signature in type II diabetic nephropathy patients[J].PLoS One,2016,11(3):e0150154.
[22]Zou HL,Wang Y,Gang Q,et al.Plasma level of miR-93 is associated with higher risk to develop type 2 diabetic retinopathy[J].Graefes Arch Clin Exp Ophthalmol,2017,255(6):1159-1166.
[23]Zhou JY,Xu B,Li L.A New role for an old drug:metformin targets microRNAs intreating diabetes and cancer[J].Drug Dev Res,2015,76(6):263-269.
[24]Flowers E,Aouizerat BE,Abbasi F,et al.Circulating microRNA-320a and microRNA-486 predict thiazolidinedione response:moving towards precision health for diabetes prevention[J].Metabolism,2015,64(9):1051-1059.
[25]Song I,Roels S,Martens GA,et al.Circulating microRNA-375 as biomarker of pancreatic beta cell death and protection of beta cell mass by cytoprotective compounds[J].PLos One,2017,12(10):e0186480.
[26]Lee IS,Park KC,Yang KJ,et al.Exenatide reverses dysregulated microRNAs in high-fat diet-induced obese mice[J].Obes Res Clin Pract,2016,10(3):315-326.
[27]Wei ZT,Weng SY,Wang L,et al.Mechanism of Astragalus polysaccharides in attenuating insulin resistance in Rats with type 2 diabetes mellitus via the regulation of liver microRNA-203a-3p[J].Mol Med Rep,2018,17(1):1617-1624.
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