工业结晶技术在维生素生产中的应用
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摘要
通过详细的文献查阅,主要从药物的晶型和粒度控制、药物制剂以及结晶工艺的选择对维生素产品质量的影响进行阐述。指明新型维生素药物晶型的研发、制剂的功能化、连续结晶技术的应用等是未来研究的方向。
Through detailed literature review,the effects of polymorphism,particle size control,preparation and crystallization process on the quality of crystalline products are discussed.The research and development of new Vitamin drug crystal,the functionalization of the preparation,and the application of continuous crystallization technology are the future research directions.
Through detailed literature review,the effects of polymorphism,particle size control,preparation and crystallization process on the quality of crystalline products are discussed.The research and development of new Vitamin drug crystal,the functionalization of the preparation,and the application of continuous crystallization technology are the future research directions.
引文
[1] 齐天骄,徐瑞娟.维生素类化合物结晶提纯法研究进展[J].现代化工,2011,31(3):33-36.
[2] Yu Z Q,Chew J W,Chow P S,et al.Recent advances in crystallization control:an industrial perspective[J].Chemical Engineering Research and Design,2007,85(7):893-905.
[3] Reddy J P,Swain D,Pedireddi V R.Polymorphism and phase transformation behavior of solid forms of 4-amino-3,5-dinitrobenzamide[J].Crystal Growth & Design,2014,14(10):5064-5071.
[4] Sarma B,Chen J,Hsi H Y,et al.Solid forms of pharmaceuticals:Polymorphs,salts and cocrystals[J].Korean Journal of Chemical Engineering,2011,28(2):315-322.
[5] Denekamp C,Meikler O,Zelner M,et al.Controlling the crystal morphology and polymorphism of 2,4-dinitroanisole[J].Crystal Growth & Design,2018,18(3):1350-1357.
[6] 张辉,马秋娟,邓声菊.药物晶型专利的新颖性探讨[J].中国新药杂志,2016,25(5):490-494.
[7] Baxter J G,Robeson C D.Crystalline Vitamin A1[J].Journal of the American Chemical Society,1942,64(10):2411-2416.
[8] Chakravarty P,Berendt R T,Munson E J,et al.Insights into the dehydration behavior of thiamine hydrochloride (Vitamin B1) hydrates:Part II[J].Journal of Pharmaceutical Sciences,2010,99(2):816-827.
[9] 熊婧,宁保明,吴建敏,等.维生素B2的晶型表征及其水分吸附特性研究[J].中国药学杂志,2015,50(16):1436-1440.
[10] Wang J R,Zhu B,Yu Q,et al.Selective crystallization of Vitamin D3 for the preparation of novel conformational polymorphs with distinctive chemical stability[J].Cryst Eng Comm,2016,18(7):1101-1104.
[11] Rane S,Ahmed K,Salunke-Gawali S,et al.Vitamin K3 family members-Part II:Single crystal X-ray structures,temperature-induced packing polymorphism,magneto-structural correlations and probable anti-oncogenic candidature[J].Journal of Molecular Structure,2008,892(1):74-83.
[12] Bouquiere J P,Finney J L,Lehmann M S,et al.High-resolution neutron study of Vitamin B12 coenzyme at 15 K:structure analysis and comparison with the structure at 279 K[J].Acta Crystallographica Section B,2010,49(1):79-89.
[13] Long S,Parkin S,Siegler M A,et al.Polymorphism and phase behaviors of 2-(phenylamino) nicotinic acid[J].Crystal Growth and Design,2008,8(11):4006-4013.
[14] GLOOR.Process for the purification of riboflavin:US,76670800B2[P].2013-03-02.
[15] Tanaka Y,Matsuoka M.Selection of solvents for organic crystal growth from solution[J].Journal of Crystal Growth,1990,99(1):1130-1133.
[16] 恒旭红.维生素C精制粒度影响因素考察[J].辽宁化工,2014,43(6):697-699.
[17] 董云军,杨星惠,张树仁,等.VC晶体粒度影响因素的生产研究[J].河北化工,1999(2):17-18.
[18] 杨小云,付丽娜,张翠利,等.药物剂型及其使用方法对药物疗效的影响[J].广东化工,2015,42(17):89,96.
[19] 郭桂军.关于药物剂型及给药途径的合理应用性临床分析[J].中国医药指南,2014,12(11):189-190.
[20] 张艳萍,马琳,李博.药物剂型临床使用中存在的问题[J].中外医疗,2014,33(8):197-198.
[21] 杨丽红.药物剂型临床使用中存在的问题探索[J].世界最新医学信息文摘,2017,17(39):172.
[22] 孙臣忠.视黄醇结合蛋白亲和层析提纯[J].国外医学.临床生物化学与检验学分册,2005(8):95-96.
[23] 朱银惠,马东祝,李文红,等.超滤法提纯维生素C发酵液的研究[J].中国酿造,2008(15):54-57.
[24] 杜亚威,杨文玲,刘红梅,等.离子交换树脂法提纯维生素C磷酰化反应液[J].香料香精化妆品,2007(4):12-16.
[25] 石铭,潘辉.分子蒸馏技术提纯天然维生素E的工艺分析[J].化工设计通讯,2016,42(1):185-186.
[26] 曹晓伟,魏金慧,江振西,等.L-抗坏血酸多聚磷酸酯的合成研究[J].现代化工,2009,29(S1):228-230,232.
[27] Eggers J,Kempkes M,Cornel J,et al.Monitoring size and shape during cooling crystallization of ascorbic acid[J].Chemical Engineering Science,2009,64(1):163-171.
[28] 曹晓群,程岱峰,王玉民,等.维生素K3的合成研究[J].山东化工,2003(1):3-4.
[29] 黄金钊,马延军,孙明昆,等.L-抗坏血酸-2-磷酸酯镁的合成[J].青岛海洋大学学报:自然科学版,1999(S1):221-224.
[30] 赵茜,高大维,秦贯丰.溶剂超声波协同法用于有机物系结晶快速成核[J].化工学报,1997(5):631-634.
[31] 闫序东,杨瑞金,卢蓉蓉,等.果糖结晶性能的研究[J].食品工业科技,2008(9):227-230.
[32] Zhang Dejiang,Xu Shijie,Du Shichao,et al.Progress of pharmaceutical continuous crystallization[J].Engineering,2017(3):354-364.
[33] 张国荣.连续结晶在医药工业中的应用[J].山东化工,2016,45(3):82-84.
[34] Wierzbowska B,Hutnik N,Piotrowski K,et al.Continuous mass crystallization of Vitamin C in ascorbic acid-ethanol-water system:Size-independent growth kinetic model approach[J].Crystal Growth & Design,2011,11(5):1557-1565.
[2] Yu Z Q,Chew J W,Chow P S,et al.Recent advances in crystallization control:an industrial perspective[J].Chemical Engineering Research and Design,2007,85(7):893-905.
[3] Reddy J P,Swain D,Pedireddi V R.Polymorphism and phase transformation behavior of solid forms of 4-amino-3,5-dinitrobenzamide[J].Crystal Growth & Design,2014,14(10):5064-5071.
[4] Sarma B,Chen J,Hsi H Y,et al.Solid forms of pharmaceuticals:Polymorphs,salts and cocrystals[J].Korean Journal of Chemical Engineering,2011,28(2):315-322.
[5] Denekamp C,Meikler O,Zelner M,et al.Controlling the crystal morphology and polymorphism of 2,4-dinitroanisole[J].Crystal Growth & Design,2018,18(3):1350-1357.
[6] 张辉,马秋娟,邓声菊.药物晶型专利的新颖性探讨[J].中国新药杂志,2016,25(5):490-494.
[7] Baxter J G,Robeson C D.Crystalline Vitamin A1[J].Journal of the American Chemical Society,1942,64(10):2411-2416.
[8] Chakravarty P,Berendt R T,Munson E J,et al.Insights into the dehydration behavior of thiamine hydrochloride (Vitamin B1) hydrates:Part II[J].Journal of Pharmaceutical Sciences,2010,99(2):816-827.
[9] 熊婧,宁保明,吴建敏,等.维生素B2的晶型表征及其水分吸附特性研究[J].中国药学杂志,2015,50(16):1436-1440.
[10] Wang J R,Zhu B,Yu Q,et al.Selective crystallization of Vitamin D3 for the preparation of novel conformational polymorphs with distinctive chemical stability[J].Cryst Eng Comm,2016,18(7):1101-1104.
[11] Rane S,Ahmed K,Salunke-Gawali S,et al.Vitamin K3 family members-Part II:Single crystal X-ray structures,temperature-induced packing polymorphism,magneto-structural correlations and probable anti-oncogenic candidature[J].Journal of Molecular Structure,2008,892(1):74-83.
[12] Bouquiere J P,Finney J L,Lehmann M S,et al.High-resolution neutron study of Vitamin B12 coenzyme at 15 K:structure analysis and comparison with the structure at 279 K[J].Acta Crystallographica Section B,2010,49(1):79-89.
[13] Long S,Parkin S,Siegler M A,et al.Polymorphism and phase behaviors of 2-(phenylamino) nicotinic acid[J].Crystal Growth and Design,2008,8(11):4006-4013.
[14] GLOOR.Process for the purification of riboflavin:US,76670800B2[P].2013-03-02.
[15] Tanaka Y,Matsuoka M.Selection of solvents for organic crystal growth from solution[J].Journal of Crystal Growth,1990,99(1):1130-1133.
[16] 恒旭红.维生素C精制粒度影响因素考察[J].辽宁化工,2014,43(6):697-699.
[17] 董云军,杨星惠,张树仁,等.VC晶体粒度影响因素的生产研究[J].河北化工,1999(2):17-18.
[18] 杨小云,付丽娜,张翠利,等.药物剂型及其使用方法对药物疗效的影响[J].广东化工,2015,42(17):89,96.
[19] 郭桂军.关于药物剂型及给药途径的合理应用性临床分析[J].中国医药指南,2014,12(11):189-190.
[20] 张艳萍,马琳,李博.药物剂型临床使用中存在的问题[J].中外医疗,2014,33(8):197-198.
[21] 杨丽红.药物剂型临床使用中存在的问题探索[J].世界最新医学信息文摘,2017,17(39):172.
[22] 孙臣忠.视黄醇结合蛋白亲和层析提纯[J].国外医学.临床生物化学与检验学分册,2005(8):95-96.
[23] 朱银惠,马东祝,李文红,等.超滤法提纯维生素C发酵液的研究[J].中国酿造,2008(15):54-57.
[24] 杜亚威,杨文玲,刘红梅,等.离子交换树脂法提纯维生素C磷酰化反应液[J].香料香精化妆品,2007(4):12-16.
[25] 石铭,潘辉.分子蒸馏技术提纯天然维生素E的工艺分析[J].化工设计通讯,2016,42(1):185-186.
[26] 曹晓伟,魏金慧,江振西,等.L-抗坏血酸多聚磷酸酯的合成研究[J].现代化工,2009,29(S1):228-230,232.
[27] Eggers J,Kempkes M,Cornel J,et al.Monitoring size and shape during cooling crystallization of ascorbic acid[J].Chemical Engineering Science,2009,64(1):163-171.
[28] 曹晓群,程岱峰,王玉民,等.维生素K3的合成研究[J].山东化工,2003(1):3-4.
[29] 黄金钊,马延军,孙明昆,等.L-抗坏血酸-2-磷酸酯镁的合成[J].青岛海洋大学学报:自然科学版,1999(S1):221-224.
[30] 赵茜,高大维,秦贯丰.溶剂超声波协同法用于有机物系结晶快速成核[J].化工学报,1997(5):631-634.
[31] 闫序东,杨瑞金,卢蓉蓉,等.果糖结晶性能的研究[J].食品工业科技,2008(9):227-230.
[32] Zhang Dejiang,Xu Shijie,Du Shichao,et al.Progress of pharmaceutical continuous crystallization[J].Engineering,2017(3):354-364.
[33] 张国荣.连续结晶在医药工业中的应用[J].山东化工,2016,45(3):82-84.
[34] Wierzbowska B,Hutnik N,Piotrowski K,et al.Continuous mass crystallization of Vitamin C in ascorbic acid-ethanol-water system:Size-independent growth kinetic model approach[J].Crystal Growth & Design,2011,11(5):1557-1565.