电致孔条件下苦参经皮给药的探究
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摘要
经皮给药是中医常用的给药方式,但由于皮肤角质层的屏障作用,许多药物难以透过皮肤进入机体。电致孔经皮给药是通过在皮肤加一个瞬间的电脉冲产生亲水性孔道,促进药物分子渗入皮肤而被机体吸收。经皮给药是苦参治疗疾病的常用手段。本文从苦参的药理作用、经皮给药的作用机理、电致孔的透皮机理、电致孔经皮给药的影响因素等方面对电致孔条件下苦参经皮给药进行综述。
Transdermal administration is a commonly used drug administration method in traditional Chinese medicine, but due to barrier effect of cuticle, it is difficult for many drugs to enter body through skin. Electroporous transdermal drug administration can generate hydrophilic channels through an instantaneous electric pulse to skin,which promote drug molecules penetrating into skin and be absorbed by the body. Transdermal drug administration is a common method for sophora flavescens to treat diseases. The article reviews transdermal administration of sophora flavescens under electroporous conditions from aspects of pharmacological effects of sophora flavescens, mechanism of transdermal administration, transdermal mechanism of electroporation, and influencing factors.
Transdermal administration is a commonly used drug administration method in traditional Chinese medicine, but due to barrier effect of cuticle, it is difficult for many drugs to enter body through skin. Electroporous transdermal drug administration can generate hydrophilic channels through an instantaneous electric pulse to skin,which promote drug molecules penetrating into skin and be absorbed by the body. Transdermal drug administration is a common method for sophora flavescens to treat diseases. The article reviews transdermal administration of sophora flavescens under electroporous conditions from aspects of pharmacological effects of sophora flavescens, mechanism of transdermal administration, transdermal mechanism of electroporation, and influencing factors.
引文
[1]岳奇峰,郝保华,邓周虎,等.电致孔条件下不同电学参数对青藤碱经皮给药的影响[J].中草药,2006,37(11):1639-1641.
[2]Kenji M,Tetsuya H.Effect of electric field on the enhanced skin permeation of rugsby electroporation[J].Journal ofcontrolled release,2003,90:171-179.
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[4]胡巧红,应美芳,李小芳.电穿孔技术促进甲硝唑家兔在体经皮吸收的研究[J].广东药学院学报,2006,22(2):115-120.
[5]吕建华,魏红,张振,等.苦参碱微乳经皮给药在小鼠体内分布及对兔耳增生性瘢痕预防作用的研究[J].时珍国医国药,2011,22(3):572-575.
[6]张岩,何治芬,汤湛,等.苦参碱体内外微透析回收率的研究[J].中国药学杂志,2014,49(22):2031-2035.
[7]Murthy S N.Surfactant-enhanced transderma delivery by electroporation[J].Journal of Controlled Release.2004,98:307-315.
[8]刘伟,唐金花,王亚娣.苦参的研究进展[J].时珍国医国药,2006,17(5):829-830.
[9]薛贵平,庞学书,薄爱华,等.苦参碱对免疫性肝损伤保护作用的研究[J].时珍国医国药,2007,18(6):1302.
[10]刘苏,秦晶,陆伟根,等.氧化苦参碱在大鼠体内药代动力学特征[J].中成药,2011,33(6):962-965.
[2]Kenji M,Tetsuya H.Effect of electric field on the enhanced skin permeation of rugsby electroporation[J].Journal ofcontrolled release,2003,90:171-179.
[3]徐和,戴领,沈成英,等.苦参碱凝胶剂的制备及体外释药特性考察[J].中国实验方剂学杂志,2014,20(1):8-11.
[4]胡巧红,应美芳,李小芳.电穿孔技术促进甲硝唑家兔在体经皮吸收的研究[J].广东药学院学报,2006,22(2):115-120.
[5]吕建华,魏红,张振,等.苦参碱微乳经皮给药在小鼠体内分布及对兔耳增生性瘢痕预防作用的研究[J].时珍国医国药,2011,22(3):572-575.
[6]张岩,何治芬,汤湛,等.苦参碱体内外微透析回收率的研究[J].中国药学杂志,2014,49(22):2031-2035.
[7]Murthy S N.Surfactant-enhanced transderma delivery by electroporation[J].Journal of Controlled Release.2004,98:307-315.
[8]刘伟,唐金花,王亚娣.苦参的研究进展[J].时珍国医国药,2006,17(5):829-830.
[9]薛贵平,庞学书,薄爱华,等.苦参碱对免疫性肝损伤保护作用的研究[J].时珍国医国药,2007,18(6):1302.
[10]刘苏,秦晶,陆伟根,等.氧化苦参碱在大鼠体内药代动力学特征[J].中成药,2011,33(6):962-965.