丹参减轻炎性因子-炎症反应作用探讨
摘要
<正>丹参是临床上常用的活血化瘀中药之一,《本经》载:"主心腹邪气,肠鸣幽幽如走水,寒热积聚,破癥除瘕,止烦满,益气。"《别录》云:"养血,去心腹痼疾结气,腰脊强脚痹,除风邪留热。久服利人。"《本草纲目》载:"活血,通心包络,治疝痛。"随着医学科技进步,现代医学研究发现丹参的化学成分由水溶性酚酸类及脂溶性丹参酮类化合物组成,此两种化合物均有抗炎作用,在两者组成当中,丹参酮类化合物中丹参酮ⅡA(Tanshinone ⅡA,TⅡA)占丹参干重的0
引文
[1] 曹珍,温春秀,赵建成,等. 不同种质丹参的药材有效成分比较[J]. 河北农业科学,2006,10(4):20-22
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[3] 赵娜,郭治昕,赵雪,等. 丹参的化学成分与药理作用[J]. 国外医药植物药分册,2007,22(4):155-160
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[5] 王潮临. 丹参对外周血中性粒细胞和单核细胞的调整作用[J]. 广西医科大学学报,1997,14(3):9-11
[6] Shi JX,Su X,Xu J,et al. MK2 posttranscriptionally regulates TNF-α-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascularendothelial cells[J]. Am J Physiol Lung Cell Mol Physiol,2012,302(8):L793-L799
[7] Yasui K,Kobayashi N,Yamazaki T,et al. Superoxide dismutase (SOD) as a potential inhibitory mediator of inflammation via neutrophil apoptosis[J]. Free Radi Res,2005,39(7):755-762
[8] Hayden MS,Ghosh S. Signaling to NF-kappaB[J]. G-enes Dev,2004,18(18):2195-2224
[9] Ben-Neriah Y,Karin M. Inflammation meets cancer,with NF-κB as the matchmaker[J]. Nat Immunol,2011,12(8):715-723
[10] Xu M,Cao F,Liu L,et al. Tanshinone ⅡA-induced attenuation of lung injury in endotoxemic mice is associated with reduction of hypoxia-inducible factor 1α expression[J]. Am J Respir Cell Mol Biol,2011,45(5):1028-1035
[11] Jaakkola P,Mole DR,Tian YM,et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation[J]. Science,2001,292(5516):468-472
[12] Cramer T,Yamanishi Y,Clausen BE,et al. HIF-1alpha is essential for myeloid cell-mediated inflammation[J]. Cell,2003,112(5):645-657
[13] Peyssonnaux C,Cejudo-Martin P,Doedens A,et al. Cutting edge:essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis[J]. Immunol,2007,178(12):7516-7519
[14] Peyssonnaux C,Datta V,Cramer T,et al. HIF-1alpha expressionregulates the bactericidal capacity of phagocytes[J]. Clin Invest,2005,115(7):1806-1815
[15] Xu M,Cao FL,Zhang YF,et al. Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice[J]. Acta Pharmacol Sin,2015,36(2):179-187
[16] 许梅,张湘燕,冯端兴,等. 丹参水提物对急性肺损伤保护作用的实验研究[J]. 中华结核和呼吸杂志,2004,27(2):124-125
[17] 徐赤裔,金雨虹,张可静,等. 丹参抗急性肺损伤及其机制的研究[J]. 浙江医学,2012,34(10):780-782
[18] Wan LM,Tan L,Wang ZR,et al. Preventive and therapeutic effects of Danhong injection on lipopolysaccharide induced acute lung injury in mice[J]. J Ethnopharmacol,2013,149(1):352-359
[19] Agawal S,Long P,Seyedain A,et al. A central role for the nuclear factor-kappa B pathway in anti-inflammatory and pro inflammatory action of mechanical strain[J]. FASEB J,2003,17(8):899-901
[20] Zhang Y,Zhang B,Xu DQ,et al. Tanshinone IIA Attenuates Seawater Aspiration-Induced Lung Injury by Inhibiting Macrophage Migration Inhibitory Factor[J]. Biol Pharm Bull,2011,24(7):1052-1057
[21] 徐旭东,汪国香,陈达,等. 丹参多酚酸盐在单肺通气肺损伤中保护作用的研究[J]. 中华医院感染学杂志,2014,24(3):638-641
[22] 乔永莉. 丹参多酚酸联合乌司他丁治疗急性呼吸窘迫综合征的疗效及对患者生化指标的影响[J]. 中国药师,2016,19(9):1713-1715
[23] 吴华初,洪奕. 丹参多酚酸盐辅助治疗急性呼吸窘迫综合征效果观察[J]. 白求恩医学杂志,2015,3(13):273-274
[24] 黄樱菲,薛秋平. 丹参多酚酸盐治疗急性呼吸窘迫综合征的疗效观察[J]. 现代医院,2014,14(1):56-58
[25] 谢炎燊,佟万成. IL-6、IL-8、TNF-α、CRP在慢性阻塞性肺病中的表达及与FEV1%pred相关性研究[J]. 中国实用医药,2009,4(9):95-96
[26] 郑玉兰,付文荣,曹锋生. 丹参川芎嗪对慢性阻塞性肺疾病急性加重合并呼吸衰竭患者肺功能及炎症因子的影响[J]. 中国老年学杂志,2015(24):7109-7111
[27] 王丽,张焕利,王华伟. 复方丹参对失血性休克大鼠早期炎症反应的影响[J]. 实用医药杂志,2008,25(11):1365-1367
[28] 邓柳霞,余国龙,艾旗,等. 人脐血单个核细胞静脉移植联合复方丹参滴丸对急性心肌梗死局灶炎症反应的影响[J]. 中国中西医结合杂志,2013,33(11):1532-1537
[29] 张辉,张杨,杨蓉,等. 丹参多酚酸盐对急性冠脉综合征患者炎症因子影响的相关研究[J]. 中国中西医结合杂志,2013,33(5):598-601
[30] Feng J,Li S,Chen H. Tanshinone IIA inhibits myocardial remodeling induced by pressure overload via suppressing oxidative stress and inflammation:possible role of silent information regulator[J]. Eur J Pharmacol,2016,791:632-639
[31] 张滨. 丹参注射液对2型糖尿病下肢血管病变患者炎症学指标的影响[J]. 山东医药,2011,51(9):75-76
[32] 史朝红,张近波,许国斌. 丹参注射液对急性肺损伤的疗效与安全性[J]. 中国临床药理学杂志,2013,29(7):501-502
[33] 段炼,魏毅涛. 中草药对急性肺损伤的保护机制研究进展[J]. 医学研究生学报,2016,29(5):533-537
[34] 周炜栋,杨蒙召,陈晔. 自噬在丹参酮ⅡA 减轻内毒素性急性肺损伤中的作用及相关机制研究[J]. 浙江中西医结合杂志,2016,26(6):532-535
[35] 徐文会,杨敏. 丹参注射液对急性坏死性胰腺炎大鼠肺组织ICAM-1表达的影响[J]. 中华胰腺病杂志,2016,5(16):340-342
[2] 代云桃,秦雪梅,郭小青,等. 不同产地不同品种丹参药材内在质量评价[J]. 山西医科大学学报,2006,37(7):716-719
[3] 赵娜,郭治昕,赵雪,等. 丹参的化学成分与药理作用[J]. 国外医药植物药分册,2007,22(4):155-160
[4] Chang CC,Lai JS,Tsai CS,et al. Proapoptotic and T-RAIL-sensitizing constituents isolated from Salvia militiorrhiza (Danshen)[J]. J Biosci Bioeng,2013,116(4):516-523
[5] 王潮临. 丹参对外周血中性粒细胞和单核细胞的调整作用[J]. 广西医科大学学报,1997,14(3):9-11
[6] Shi JX,Su X,Xu J,et al. MK2 posttranscriptionally regulates TNF-α-induced expression of ICAM-1 and IL-8 via tristetraprolin in human pulmonary microvascularendothelial cells[J]. Am J Physiol Lung Cell Mol Physiol,2012,302(8):L793-L799
[7] Yasui K,Kobayashi N,Yamazaki T,et al. Superoxide dismutase (SOD) as a potential inhibitory mediator of inflammation via neutrophil apoptosis[J]. Free Radi Res,2005,39(7):755-762
[8] Hayden MS,Ghosh S. Signaling to NF-kappaB[J]. G-enes Dev,2004,18(18):2195-2224
[9] Ben-Neriah Y,Karin M. Inflammation meets cancer,with NF-κB as the matchmaker[J]. Nat Immunol,2011,12(8):715-723
[10] Xu M,Cao F,Liu L,et al. Tanshinone ⅡA-induced attenuation of lung injury in endotoxemic mice is associated with reduction of hypoxia-inducible factor 1α expression[J]. Am J Respir Cell Mol Biol,2011,45(5):1028-1035
[11] Jaakkola P,Mole DR,Tian YM,et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation[J]. Science,2001,292(5516):468-472
[12] Cramer T,Yamanishi Y,Clausen BE,et al. HIF-1alpha is essential for myeloid cell-mediated inflammation[J]. Cell,2003,112(5):645-657
[13] Peyssonnaux C,Cejudo-Martin P,Doedens A,et al. Cutting edge:essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis[J]. Immunol,2007,178(12):7516-7519
[14] Peyssonnaux C,Datta V,Cramer T,et al. HIF-1alpha expressionregulates the bactericidal capacity of phagocytes[J]. Clin Invest,2005,115(7):1806-1815
[15] Xu M,Cao FL,Zhang YF,et al. Tanshinone IIA therapeutically reduces LPS-induced acute lung injury by inhibiting inflammation and apoptosis in mice[J]. Acta Pharmacol Sin,2015,36(2):179-187
[16] 许梅,张湘燕,冯端兴,等. 丹参水提物对急性肺损伤保护作用的实验研究[J]. 中华结核和呼吸杂志,2004,27(2):124-125
[17] 徐赤裔,金雨虹,张可静,等. 丹参抗急性肺损伤及其机制的研究[J]. 浙江医学,2012,34(10):780-782
[18] Wan LM,Tan L,Wang ZR,et al. Preventive and therapeutic effects of Danhong injection on lipopolysaccharide induced acute lung injury in mice[J]. J Ethnopharmacol,2013,149(1):352-359
[19] Agawal S,Long P,Seyedain A,et al. A central role for the nuclear factor-kappa B pathway in anti-inflammatory and pro inflammatory action of mechanical strain[J]. FASEB J,2003,17(8):899-901
[20] Zhang Y,Zhang B,Xu DQ,et al. Tanshinone IIA Attenuates Seawater Aspiration-Induced Lung Injury by Inhibiting Macrophage Migration Inhibitory Factor[J]. Biol Pharm Bull,2011,24(7):1052-1057
[21] 徐旭东,汪国香,陈达,等. 丹参多酚酸盐在单肺通气肺损伤中保护作用的研究[J]. 中华医院感染学杂志,2014,24(3):638-641
[22] 乔永莉. 丹参多酚酸联合乌司他丁治疗急性呼吸窘迫综合征的疗效及对患者生化指标的影响[J]. 中国药师,2016,19(9):1713-1715
[23] 吴华初,洪奕. 丹参多酚酸盐辅助治疗急性呼吸窘迫综合征效果观察[J]. 白求恩医学杂志,2015,3(13):273-274
[24] 黄樱菲,薛秋平. 丹参多酚酸盐治疗急性呼吸窘迫综合征的疗效观察[J]. 现代医院,2014,14(1):56-58
[25] 谢炎燊,佟万成. IL-6、IL-8、TNF-α、CRP在慢性阻塞性肺病中的表达及与FEV1%pred相关性研究[J]. 中国实用医药,2009,4(9):95-96
[26] 郑玉兰,付文荣,曹锋生. 丹参川芎嗪对慢性阻塞性肺疾病急性加重合并呼吸衰竭患者肺功能及炎症因子的影响[J]. 中国老年学杂志,2015(24):7109-7111
[27] 王丽,张焕利,王华伟. 复方丹参对失血性休克大鼠早期炎症反应的影响[J]. 实用医药杂志,2008,25(11):1365-1367
[28] 邓柳霞,余国龙,艾旗,等. 人脐血单个核细胞静脉移植联合复方丹参滴丸对急性心肌梗死局灶炎症反应的影响[J]. 中国中西医结合杂志,2013,33(11):1532-1537
[29] 张辉,张杨,杨蓉,等. 丹参多酚酸盐对急性冠脉综合征患者炎症因子影响的相关研究[J]. 中国中西医结合杂志,2013,33(5):598-601
[30] Feng J,Li S,Chen H. Tanshinone IIA inhibits myocardial remodeling induced by pressure overload via suppressing oxidative stress and inflammation:possible role of silent information regulator[J]. Eur J Pharmacol,2016,791:632-639
[31] 张滨. 丹参注射液对2型糖尿病下肢血管病变患者炎症学指标的影响[J]. 山东医药,2011,51(9):75-76
[32] 史朝红,张近波,许国斌. 丹参注射液对急性肺损伤的疗效与安全性[J]. 中国临床药理学杂志,2013,29(7):501-502
[33] 段炼,魏毅涛. 中草药对急性肺损伤的保护机制研究进展[J]. 医学研究生学报,2016,29(5):533-537
[34] 周炜栋,杨蒙召,陈晔. 自噬在丹参酮ⅡA 减轻内毒素性急性肺损伤中的作用及相关机制研究[J]. 浙江中西医结合杂志,2016,26(6):532-535
[35] 徐文会,杨敏. 丹参注射液对急性坏死性胰腺炎大鼠肺组织ICAM-1表达的影响[J]. 中华胰腺病杂志,2016,5(16):340-342