中药防治奥沙利铂神经毒性的作用及机制研究进展
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摘要
奥沙利铂是第3代铂类抗肿瘤药物,具有疗效好、抗癌谱广泛等优点。但周围神经病变是其主要的剂量限制性毒性,影响患者的治疗进程和生活质量。以中医理论为指导的益气活血、温阳通络等传统中药在治疗此症上取得一定进展。从中药复方及活性成分两方面对国内外研究进展予以综述,为临床医师治疗奥沙利铂神经毒性提供依据。
Oxaliplatin is the third generation of platinum antitumor drugs, which has the advantages of good efficacy, broad anticancer spectrum and so on. However, peripheral neurotoxicity is the main dose limiting toxicity, which affects not only its clinical application but also the quality of patients' life. According to Chinese medicine theory, some progress has been made in the treatment of this disease by using the traditional herb with invigorating qi and activating blood and warming yang for removing obstruction in collaterals. This article summarizes the literatures in domestic and foreign countries from the aspects of Chinese prescription and active ingredients, which provides basis for clinicians to treat the neurotoxicity of oxaliplatin.
Oxaliplatin is the third generation of platinum antitumor drugs, which has the advantages of good efficacy, broad anticancer spectrum and so on. However, peripheral neurotoxicity is the main dose limiting toxicity, which affects not only its clinical application but also the quality of patients' life. According to Chinese medicine theory, some progress has been made in the treatment of this disease by using the traditional herb with invigorating qi and activating blood and warming yang for removing obstruction in collaterals. This article summarizes the literatures in domestic and foreign countries from the aspects of Chinese prescription and active ingredients, which provides basis for clinicians to treat the neurotoxicity of oxaliplatin.
引文
[1]杨洋.黄芪桂枝五物汤化裁防治奥沙利铂引起的外周神经毒性的临床观察[D].南京:南京中医药大学,2017.
[2]Areti A,Komirishetty P,Kumar A.Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy[J].Toxicol Appl Pharmacol,2016,322(1):97-103.
[3]顾展丞.基于铂蓄积机制探讨黄芪桂枝五物汤对奥沙利铂致周围神经病变的防治作用[D].南京:南京中医药大学,2016.
[4]Cheng X L,Huo J G,Wang D W,et al.Herbal medicine AC591 prevents qxaliplatin-induced peripheral neuropathy in animal model and cancer patients[J].Front Pharmacol,2017,8(1):1-13.
[5]胡莹.当归四逆汤防治奥沙利铂致慢性外周神经毒性实验研究[D].南京:南京中医药大学,2012.
[6]Teng R Y,Zhao Y,Feng W.Gabapentin prevents oxaliplatin-induced central sensitization in the dorsal horn neurons in rats[J].Iran J Basic Med Sci,2015,18(5):493-498.
[7]丁蓉.基于TRPs通道探讨当归四逆汤对奥沙利铂神经毒性机制的研究[D].南京:南京中医药大学,2015.
[8]Egashira N,Hirakawa S,Kawashiri T,et al.Mexiletine reverses oxaliplatin-induced neuropathic pain in rats[J].J Pharmacol Sci,2010,112(4):473-476.
[9]Descoeur J,Pereira V,Pizzoccaro A,et al.Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors[J].EMBO Mol Med,2011,3(5):266-278.
[10]Anand U,Otto W R,Anand P.Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons[J].Mol Pain,2010,6(1):1-13.
[11]Gauchan P,Andoh T,Kato A,et al.Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice[J].Neurosci Lett,2009,458(2):93-95.
[12]Mizuno K,Kono T,Suzuki Y,et al.Goshajinkigan,a traditional Japanese medicine,prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat[J].J Pharmacol Sci,2014,125(1):91-98.
[13]Kono T,Suzuki Yi,Mizuno K,et al.Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats[J].Sci Rep,2015,5(1):1-11.
[14]Deng B,Jia L Q,Pan L,et al.Wen-Luo-Tong prevents glial activation and nociceptive sensitization in a rat model of oxaliplatin-induced neuropathic pain[J].Evid-Based Compl Altern Med,2016,2016:3629489.
[15]Di Cesare M L,Pacini A,Micheli L,et al.Glial role in oxaliplatin-induced neuropathic pain[J].Exp Neurol,2014,261(1):22-23.
[16]王媛媛,邓博,段锦龙,等.温经通络散外用对奥沙利铂周围神经毒性大鼠神经保护作用的研究[J].中华中医药杂志,2015,30(8):2917-2920.
[17]魏晓晨,王慧,朱立勤,等.补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价[J].中国实验方剂学杂志,2016,22(22):186-190.
[18]方灿途,孟金成,高玉桥,等.双筋龙汤对奥沙利铂所致大鼠后根神经节及生长因子表达的影响[J].中医临床研究,2016,8(20):7-9.
[19]孟金成,方灿途,高玉桥,等.双筋龙汤预防奥沙利铂所致大鼠神经毒副作用及对大鼠外周血中CD3+、CD4+、CD8+T淋巴细胞的影响[J].时珍国医国药,2016,27(5):1068-1069.
[20]祝敬燕.桂龙通络方对奥沙利铂神经毒性的预防作用研究[D].济南:山东中医药大学,2002.
[21]贾志洋.芍药钩藤木耳汤防治奥沙利铂慢性周围神经毒性的临床研究[D].太原:山西中医学院,2016.
[22]节阳华,韩芸,张洪亮.张洪亮主任医师治疗奥沙利铂引起周围神经病变经验[J].光明中医,2018,33(1):28-30.
[23]郭立达.姜黄素联合奥沙利铂抗结肠癌作用及其相关机制研究[D].石家庄:河北师范大学,2012.
[24]Mansour S,Moundhri A,Al-Salam S,et al.The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats:Some behavioral,biochemical,and histopathological studies[J].J Med Toxicol,2013,9(1):25-33.
[25]Hsu B,Kin K C.Pharmacological study of tetrahydropalmatine and its analogs.A new type of central depressants[J].Arch Int Pharmacodyn Ther,1962,139(1):318-327.
[26]Guo Z G,Man Y Y,Wang X Y,et al.Levo-tetrahydropalmatine attenuates oxaliplatin-induced mechanical hyperalgesia in mice[J].Sci Rep,2014,4(1):1-4.
[27]Sun M Y,Ye Y,Xiao L,et al.Anticancer effects of ginsenoside Rg3[J].Int J Mol Med,2017,39(3):507-518.
[28]陈群伟,舒琦瑾,刘清君等.人参皂苷Rg3对大鼠奥沙利铂神经毒性的保护作用[A]//第一届青年中西医结合肿瘤学术论坛论文集[C].重庆:中国中西医结合学会肿瘤专业委员会,中国抗癌协会肿瘤传统医学专业委员会,2015.
[29]李燕,李芸霞,龚小红,等.附子灵和尼奥宁的药理研究进展[J].中药与临床,2014,5(3):56-58.
[30]Suzuki T,Miyamoto K,Yokoyama N,et al.Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain[J].J Ethnopharmacol,2016,186(1):44-52.
[31]Zhou H H,Zhang L,Zhou Q G,et al.(+)-Borneol attenuates oxaliplatin-induced neuropathic hyperalgesia in mice[J].Neuroreport,2016,27(3):160-165.
[32]Liang S,Xu C,Li G,et al.P2X receptors and modulation of pain transmission:Focus on effects of drugs and compounds used in traditional Chinese medicine[J].Neurochem Int,2010,57(7):705-712.
[33]Liang S D,Gao Y,Xu C S,et al.Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat[J].Brain Res,2004,995(2):247-252.
[34]Leng Y F,Gao X M,Wang S X,et al.Effects of tetramethylpyrazine on neuronal apoptosis in the superficial dorsal horn in a rat model of neuropathic pain[J].Am J Chin Med,2012,40(6):1229-1239.
[35]Wang Z J,Wang Q,Wang C J,et al.Tetramethylpyrazine attenuates periorbital allodynia and neuroinflammation in a model of traumatic brain injury[J].J Inflamm,2017,14(13):1-9.
[36]刘展华,吴玉生,谭开基.川芎嗪预防奥沙利铂致神经毒性反应14例[J].实用中医药杂志,2003,19(11):575.
[2]Areti A,Komirishetty P,Kumar A.Carvedilol prevents functional deficits in peripheral nerve mitochondria of rats with oxaliplatin-evoked painful peripheral neuropathy[J].Toxicol Appl Pharmacol,2016,322(1):97-103.
[3]顾展丞.基于铂蓄积机制探讨黄芪桂枝五物汤对奥沙利铂致周围神经病变的防治作用[D].南京:南京中医药大学,2016.
[4]Cheng X L,Huo J G,Wang D W,et al.Herbal medicine AC591 prevents qxaliplatin-induced peripheral neuropathy in animal model and cancer patients[J].Front Pharmacol,2017,8(1):1-13.
[5]胡莹.当归四逆汤防治奥沙利铂致慢性外周神经毒性实验研究[D].南京:南京中医药大学,2012.
[6]Teng R Y,Zhao Y,Feng W.Gabapentin prevents oxaliplatin-induced central sensitization in the dorsal horn neurons in rats[J].Iran J Basic Med Sci,2015,18(5):493-498.
[7]丁蓉.基于TRPs通道探讨当归四逆汤对奥沙利铂神经毒性机制的研究[D].南京:南京中医药大学,2015.
[8]Egashira N,Hirakawa S,Kawashiri T,et al.Mexiletine reverses oxaliplatin-induced neuropathic pain in rats[J].J Pharmacol Sci,2010,112(4):473-476.
[9]Descoeur J,Pereira V,Pizzoccaro A,et al.Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors[J].EMBO Mol Med,2011,3(5):266-278.
[10]Anand U,Otto W R,Anand P.Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons[J].Mol Pain,2010,6(1):1-13.
[11]Gauchan P,Andoh T,Kato A,et al.Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice[J].Neurosci Lett,2009,458(2):93-95.
[12]Mizuno K,Kono T,Suzuki Y,et al.Goshajinkigan,a traditional Japanese medicine,prevents oxaliplatin-induced acute peripheral neuropathy by suppressing functional alteration of TRP channels in rat[J].J Pharmacol Sci,2014,125(1):91-98.
[13]Kono T,Suzuki Yi,Mizuno K,et al.Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats[J].Sci Rep,2015,5(1):1-11.
[14]Deng B,Jia L Q,Pan L,et al.Wen-Luo-Tong prevents glial activation and nociceptive sensitization in a rat model of oxaliplatin-induced neuropathic pain[J].Evid-Based Compl Altern Med,2016,2016:3629489.
[15]Di Cesare M L,Pacini A,Micheli L,et al.Glial role in oxaliplatin-induced neuropathic pain[J].Exp Neurol,2014,261(1):22-23.
[16]王媛媛,邓博,段锦龙,等.温经通络散外用对奥沙利铂周围神经毒性大鼠神经保护作用的研究[J].中华中医药杂志,2015,30(8):2917-2920.
[17]魏晓晨,王慧,朱立勤,等.补阳还五汤预防奥沙利铂所致周围神经毒性疗效及安全性的系统评价[J].中国实验方剂学杂志,2016,22(22):186-190.
[18]方灿途,孟金成,高玉桥,等.双筋龙汤对奥沙利铂所致大鼠后根神经节及生长因子表达的影响[J].中医临床研究,2016,8(20):7-9.
[19]孟金成,方灿途,高玉桥,等.双筋龙汤预防奥沙利铂所致大鼠神经毒副作用及对大鼠外周血中CD3+、CD4+、CD8+T淋巴细胞的影响[J].时珍国医国药,2016,27(5):1068-1069.
[20]祝敬燕.桂龙通络方对奥沙利铂神经毒性的预防作用研究[D].济南:山东中医药大学,2002.
[21]贾志洋.芍药钩藤木耳汤防治奥沙利铂慢性周围神经毒性的临床研究[D].太原:山西中医学院,2016.
[22]节阳华,韩芸,张洪亮.张洪亮主任医师治疗奥沙利铂引起周围神经病变经验[J].光明中医,2018,33(1):28-30.
[23]郭立达.姜黄素联合奥沙利铂抗结肠癌作用及其相关机制研究[D].石家庄:河北师范大学,2012.
[24]Mansour S,Moundhri A,Al-Salam S,et al.The effect of curcumin on oxaliplatin and cisplatin neurotoxicity in rats:Some behavioral,biochemical,and histopathological studies[J].J Med Toxicol,2013,9(1):25-33.
[25]Hsu B,Kin K C.Pharmacological study of tetrahydropalmatine and its analogs.A new type of central depressants[J].Arch Int Pharmacodyn Ther,1962,139(1):318-327.
[26]Guo Z G,Man Y Y,Wang X Y,et al.Levo-tetrahydropalmatine attenuates oxaliplatin-induced mechanical hyperalgesia in mice[J].Sci Rep,2014,4(1):1-4.
[27]Sun M Y,Ye Y,Xiao L,et al.Anticancer effects of ginsenoside Rg3[J].Int J Mol Med,2017,39(3):507-518.
[28]陈群伟,舒琦瑾,刘清君等.人参皂苷Rg3对大鼠奥沙利铂神经毒性的保护作用[A]//第一届青年中西医结合肿瘤学术论坛论文集[C].重庆:中国中西医结合学会肿瘤专业委员会,中国抗癌协会肿瘤传统医学专业委员会,2015.
[29]李燕,李芸霞,龚小红,等.附子灵和尼奥宁的药理研究进展[J].中药与临床,2014,5(3):56-58.
[30]Suzuki T,Miyamoto K,Yokoyama N,et al.Processed aconite root and its active ingredient neoline may alleviate oxaliplatin-induced peripheral neuropathic pain[J].J Ethnopharmacol,2016,186(1):44-52.
[31]Zhou H H,Zhang L,Zhou Q G,et al.(+)-Borneol attenuates oxaliplatin-induced neuropathic hyperalgesia in mice[J].Neuroreport,2016,27(3):160-165.
[32]Liang S,Xu C,Li G,et al.P2X receptors and modulation of pain transmission:Focus on effects of drugs and compounds used in traditional Chinese medicine[J].Neurochem Int,2010,57(7):705-712.
[33]Liang S D,Gao Y,Xu C S,et al.Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat[J].Brain Res,2004,995(2):247-252.
[34]Leng Y F,Gao X M,Wang S X,et al.Effects of tetramethylpyrazine on neuronal apoptosis in the superficial dorsal horn in a rat model of neuropathic pain[J].Am J Chin Med,2012,40(6):1229-1239.
[35]Wang Z J,Wang Q,Wang C J,et al.Tetramethylpyrazine attenuates periorbital allodynia and neuroinflammation in a model of traumatic brain injury[J].J Inflamm,2017,14(13):1-9.
[36]刘展华,吴玉生,谭开基.川芎嗪预防奥沙利铂致神经毒性反应14例[J].实用中医药杂志,2003,19(11):575.