消风散结合自血疗法对荨麻疹患者免疫失衡及相关因子水平的影响
|
摘要
目的:观察消风散结合自血疗法对荨麻疹患者免疫失衡及相关因子水平的影响。方法:选择我院2016年1月至2017年12月收治的荨麻疹患者80例,按照随机数字表法分为对照组(n=40)和观察组(n=40),对照组给予常规西药治疗,观察组给予消风散结合自血疗法治疗,比较两组治疗效果,治疗前后症状积分,T淋巴细胞亚群(CD4+、CD8+、CD4+/CD8+)水平和免疫球蛋白Ig E水平,C反应蛋白(CRP)和白细胞介素-6 (IL-6)水平。结果:(1)观察组有效率92. 50%高于对照组的72. 50%(P<0. 05);(2)治疗后,观察组风团、红疹和瘙痒积分均低于对照组(P<0. 05);(3)治疗后,观察组CD4+、CD4+/CD8+水平均高于对照组(P<0. 05),CD8+、Ig E水平均低于对照组(P<0. 05);(4)治疗后,观察组CRP、IL-6水平均明显低于对照组(P<0. 05)。结论:消风散结合自血疗法可有效调节荨麻疹患者免疫平衡,改善免疫功能和炎症因子水平。
Objective: To explore the effects of Xiaofeng Powder combined with autohemotherapy on immune imbalance and related factors for patients with urticaria. Methods: 80 cases of patients with urticaria treated in our hospital from January 2016 to December 2017 were divided into controlled group(n = 40) and observation group(n = 40). The controlled group was given conventional western medicine,and the observation group was given Xiaofeng Powder combined with autohemotherapy. The treatment effects,and the symptoms scores,levels of T lymphocyte subsets(CD4+,CD8+,CD4+/CD8+),immunoglobulin Ig E,C-reactive protein(CRP) and interleukin-6(IL-6) before and after treatment were compared between the two groups. Results:The effective rate in the observation group was higher than that in the controlled group(92. 50% vs 72. 50%)(P<0. 05). After treatment,the scores of wheal,rash and itching in the observation group were lower than those in the controlled group(P <0. 05). After treatment,the levels of CD4+and CD4+/CD8+in the observation group were higher than those in the controlled group(P<0. 05) while the levels of CD8+and Ig E were lower than those in the controlled group(P<0. 05). After treatment,the levels of CRP and IL-6in the observation group were significantly lower than those in the controlled group(P< 0. 05). Conclusions: Xiaofeng Powder combined with autohemotherapy can effectively modulate the immune balance of urticaria patients,and improve immune function and inflammatory factors level.
Objective: To explore the effects of Xiaofeng Powder combined with autohemotherapy on immune imbalance and related factors for patients with urticaria. Methods: 80 cases of patients with urticaria treated in our hospital from January 2016 to December 2017 were divided into controlled group(n = 40) and observation group(n = 40). The controlled group was given conventional western medicine,and the observation group was given Xiaofeng Powder combined with autohemotherapy. The treatment effects,and the symptoms scores,levels of T lymphocyte subsets(CD4+,CD8+,CD4+/CD8+),immunoglobulin Ig E,C-reactive protein(CRP) and interleukin-6(IL-6) before and after treatment were compared between the two groups. Results:The effective rate in the observation group was higher than that in the controlled group(92. 50% vs 72. 50%)(P<0. 05). After treatment,the scores of wheal,rash and itching in the observation group were lower than those in the controlled group(P <0. 05). After treatment,the levels of CD4+and CD4+/CD8+in the observation group were higher than those in the controlled group(P<0. 05) while the levels of CD8+and Ig E were lower than those in the controlled group(P<0. 05). After treatment,the levels of CRP and IL-6in the observation group were significantly lower than those in the controlled group(P< 0. 05). Conclusions: Xiaofeng Powder combined with autohemotherapy can effectively modulate the immune balance of urticaria patients,and improve immune function and inflammatory factors level.
引文
[1]谢红,蔡梅,周晓鸿.赛庚啶递减疗法联合咪唑斯汀治疗慢性荨麻疹45例的疗效及预后分析[J].实用临床医药杂志,2017,21(13):187~188
[2]张玉刚.地氯雷他定分散片依巴斯汀片联合复方甘草酸苷片治疗慢性荨麻疹的临床疗效观察[J].山西医药杂志,2015,44(18):2155~2157
[3]张婉容,郎娜.走罐配合自血穴位注射治疗慢性荨麻疹及对患者血清IL-4、Ig E的影响[J].中国针灸,2014,34(12):1185~1188
[4]林中方,何斌,熊超.枸地氯雷他定片联合匹多莫德分散片治疗慢性荨麻疹的疗效及对T细胞亚群的影响[J].实用医学杂志,2014,30(15):2490~2492
[5]石春蕊,熊潇,王敏,等.慢性自发性荨麻疹患者血清RANTES和MCP-3的水平检测及其意义[J].临床皮肤科杂志,2015,44(9):548~550
[6]刘金星.养血祛风法治疗荨麻疹的临证体会[J].中国中医急症,2015,24(6):1021~1021
[7]陈洁,姚玉芳.姚玉芳教授运用五苓散化裁治疗儿科病4则[J].浙江中医药大学学报,2015,39(11):840~842
[8]孙凤,邹经纬,孙岸,等.孙伟正治疗紫癜风经验[J].山东中医杂志,2016,35(6):544~545
[9]陈耿明,黄国强,黄亿平.自血疗法肌肉注射治疗慢性荨麻疹的疗效观察及对免疫学指标的影响[J].临床和实验医学杂志,2017,16(14):1376~1379
[10]张磊,张理涛.慢性荨麻疹患者血清金黄色葡萄球菌超抗原特异性Ig E检测及其意义[J].中国中西医结合皮肤性病学杂志,2016,15(4):201~204
[11]阳媚,吴钱红,杨红杰.穴位自血疗法治疗慢性荨麻疹及对Th1/Th2细胞因子的影响[J].针灸临床杂志,2016,32(1):5~8
[12]刘丽娟,杨晶,尚元元,等.生物共振治疗系统对慢性荨麻疹患者的疗效及血清细胞因子的影响[J].宁夏医科大学学报,2015,37(1):42~45
[2]张玉刚.地氯雷他定分散片依巴斯汀片联合复方甘草酸苷片治疗慢性荨麻疹的临床疗效观察[J].山西医药杂志,2015,44(18):2155~2157
[3]张婉容,郎娜.走罐配合自血穴位注射治疗慢性荨麻疹及对患者血清IL-4、Ig E的影响[J].中国针灸,2014,34(12):1185~1188
[4]林中方,何斌,熊超.枸地氯雷他定片联合匹多莫德分散片治疗慢性荨麻疹的疗效及对T细胞亚群的影响[J].实用医学杂志,2014,30(15):2490~2492
[5]石春蕊,熊潇,王敏,等.慢性自发性荨麻疹患者血清RANTES和MCP-3的水平检测及其意义[J].临床皮肤科杂志,2015,44(9):548~550
[6]刘金星.养血祛风法治疗荨麻疹的临证体会[J].中国中医急症,2015,24(6):1021~1021
[7]陈洁,姚玉芳.姚玉芳教授运用五苓散化裁治疗儿科病4则[J].浙江中医药大学学报,2015,39(11):840~842
[8]孙凤,邹经纬,孙岸,等.孙伟正治疗紫癜风经验[J].山东中医杂志,2016,35(6):544~545
[9]陈耿明,黄国强,黄亿平.自血疗法肌肉注射治疗慢性荨麻疹的疗效观察及对免疫学指标的影响[J].临床和实验医学杂志,2017,16(14):1376~1379
[10]张磊,张理涛.慢性荨麻疹患者血清金黄色葡萄球菌超抗原特异性Ig E检测及其意义[J].中国中西医结合皮肤性病学杂志,2016,15(4):201~204
[11]阳媚,吴钱红,杨红杰.穴位自血疗法治疗慢性荨麻疹及对Th1/Th2细胞因子的影响[J].针灸临床杂志,2016,32(1):5~8
[12]刘丽娟,杨晶,尚元元,等.生物共振治疗系统对慢性荨麻疹患者的疗效及血清细胞因子的影响[J].宁夏医科大学学报,2015,37(1):42~45