年轻患者重复性葡萄胎恶化为侵蚀性葡萄胎1例
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摘要
<正>1主持人杭州市妇产科医院费小阳主任医师2病例汇报人杭州市妇产科医院妇科谢中医师3.病例摘要患者谢XX,20岁,销售员,因"停经2~+月,阴道流血1 h余"于2019年2月18日入院。入院查体:宫底耻上1指,无压痛。妇检:外阴已婚未产式,阴道畅,可见少量
引文
[1] 石一复.GTD /GTN诊治进展和争议问题 [J].实用肿瘤杂志,2016,31(6):488-490.
[2] Iwase A,Sugita A,Hirokawa W,et al.Anti-Mullerianhormone as a marker of ovarian reserve following chemotherapy in patients with gestational trophoblastic neoplasia [J].Eur J Obstet Gynecol Reprod Biol,2013,167(2) :194-198.
[3] 于海林,奚美丽,鹿欣.妊娠滋养细胞疾病患者生育相关问题[J].妇产与遗传(电子版),2017,7(4):3-6.
[4] Braga A,Maesta I,Michelin OC,et al.Maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia in Brazilian women[J].GynecolOncol,2009,112(3) :568-571.
[5] Bedoschi G,Turan V,Oktay K.Utility of GnRH-agonists for fertility preservation in women with operable breast cancer:is it protective?[J].Curr Breast Cancer Rep,2013,5(4) :302-308.
[6] Del ML,Ceppi M,Poggio F,et al.Gonadotropin-releasing hormone analogues for the prevention of chemotherapy induced premature ovarian failure in cancer women:systematic review and meta-analysis of randomized trials [J].Cancer Treat Rev,2014,40(5) :675-683.
[7] Mangili G,Lorusso D,Brown J,et al.Trophoblastic disease review for diagnosis and management:a joint report from the International Society for the Study of Trophoblastic Disease,European Organisation for the Treatment of Trophoblastic Disease,and the Gynecologic Cancer InterGroup [J].Int J Gynecol Cancer,2014,24(9 Suppl3) :S 109-S 116.
[8] Akoury E,Gupta N,Bagga R,et al.Live births in women with recurrent hydatidiform mole and two NLRP7 mutations [J].Reprod Biomed Online,2015,31(1):120- 124.
[9] 沈曦,陈秋菊,匡延平.妊娠滋养细胞疾病史的不孕患者体外受精/卵胞质内单精子显微注射结局分析 [J].中华生殖与避孕杂志,2018,38(8):671-676.
[10] Williams D,Hodgetts V,Gupta J.Recurrent hydatidiform moles[J].Eur J ObstetGynecolReprodBiol,2010,150(1):3-7.
[11] 石一复主编.葡萄胎、绒毛膜癌及相关疾病 [M].北京:人民军医出版社,2006:101.
[12] 向阳主编.宋鸿钊滋养细胞肿瘤学 [M].第3版.北京:人民卫生出版社,2011:75.
[13] 石一复.对低危型GTN单一化疗的浅识 [J].中国实用妇科与产科杂志,2016,32(8):769-771.
[14] 石一复.12年来第1～4版FIGO妊娠滋养细胞疾病分期、分类及临床实践指南的演变和思考[J].国际妇产科学杂志,2013,40(3):195-197.
[15] Lee YJ,Park JY,Kim DY,et al.Comparing and evaluating the efficacy of methotrexate and actinomycin D as first-line single chemotherapy agents in low risk gestational trophoblastic disease [J].J GynecolOncol,2017,28(2):e 8.
[16] Taylor F,Grew T,Everard J,et al.The outcome of patients with low risk gestational trophoblastic neoplasia treated with single agent intramuscular methotrexate and oral folinic acid [J].Eur JCancer,2013,49(15):3184-3190.
[2] Iwase A,Sugita A,Hirokawa W,et al.Anti-Mullerianhormone as a marker of ovarian reserve following chemotherapy in patients with gestational trophoblastic neoplasia [J].Eur J Obstet Gynecol Reprod Biol,2013,167(2) :194-198.
[3] 于海林,奚美丽,鹿欣.妊娠滋养细胞疾病患者生育相关问题[J].妇产与遗传(电子版),2017,7(4):3-6.
[4] Braga A,Maesta I,Michelin OC,et al.Maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia in Brazilian women[J].GynecolOncol,2009,112(3) :568-571.
[5] Bedoschi G,Turan V,Oktay K.Utility of GnRH-agonists for fertility preservation in women with operable breast cancer:is it protective?[J].Curr Breast Cancer Rep,2013,5(4) :302-308.
[6] Del ML,Ceppi M,Poggio F,et al.Gonadotropin-releasing hormone analogues for the prevention of chemotherapy induced premature ovarian failure in cancer women:systematic review and meta-analysis of randomized trials [J].Cancer Treat Rev,2014,40(5) :675-683.
[7] Mangili G,Lorusso D,Brown J,et al.Trophoblastic disease review for diagnosis and management:a joint report from the International Society for the Study of Trophoblastic Disease,European Organisation for the Treatment of Trophoblastic Disease,and the Gynecologic Cancer InterGroup [J].Int J Gynecol Cancer,2014,24(9 Suppl3) :S 109-S 116.
[8] Akoury E,Gupta N,Bagga R,et al.Live births in women with recurrent hydatidiform mole and two NLRP7 mutations [J].Reprod Biomed Online,2015,31(1):120- 124.
[9] 沈曦,陈秋菊,匡延平.妊娠滋养细胞疾病史的不孕患者体外受精/卵胞质内单精子显微注射结局分析 [J].中华生殖与避孕杂志,2018,38(8):671-676.
[10] Williams D,Hodgetts V,Gupta J.Recurrent hydatidiform moles[J].Eur J ObstetGynecolReprodBiol,2010,150(1):3-7.
[11] 石一复主编.葡萄胎、绒毛膜癌及相关疾病 [M].北京:人民军医出版社,2006:101.
[12] 向阳主编.宋鸿钊滋养细胞肿瘤学 [M].第3版.北京:人民卫生出版社,2011:75.
[13] 石一复.对低危型GTN单一化疗的浅识 [J].中国实用妇科与产科杂志,2016,32(8):769-771.
[14] 石一复.12年来第1～4版FIGO妊娠滋养细胞疾病分期、分类及临床实践指南的演变和思考[J].国际妇产科学杂志,2013,40(3):195-197.
[15] Lee YJ,Park JY,Kim DY,et al.Comparing and evaluating the efficacy of methotrexate and actinomycin D as first-line single chemotherapy agents in low risk gestational trophoblastic disease [J].J GynecolOncol,2017,28(2):e 8.
[16] Taylor F,Grew T,Everard J,et al.The outcome of patients with low risk gestational trophoblastic neoplasia treated with single agent intramuscular methotrexate and oral folinic acid [J].Eur JCancer,2013,49(15):3184-3190.