两性霉素B前体脂质体的制备工艺研究
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- 英文论文题名：Study on the Preparation Technology of Amphotericin B Proliposomes
- 论文作者：庚丽丽 ; 王立华 ; 张朋美 ; 王永利
- 英文论文作者：Lili Geng ; Lihua Wang ; Pengmei Zhang ; Yongli Wang ; Institute of applied chemistry ; HeBei North University
- 年：2016
- 作者机构：河北北方学院应用化学研究所;
- 论文关键词：两性霉素B ; 前体脂质体 ; 载体沉积法 ; 低速离心法 ; 包封率
- 英文论文关键词：Amphotericin B ; proliposome ; carrier aggradation method ; low-speed centrifugation ; entrapment efficiency
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TQ460.6
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：147k
- 原文格式：D
- 会议级别：全国
摘要
目的:研究两性霉素B前体脂质体制备工艺.方法采用载体沉积法制备两性霉素B前体脂质体,以包封率为评价指标采用单因素和正交优化处方,并观察其重现性、稳定性。结果两性霉素B的最优处方工艺条件为:膜材比为1:2,载脂比为5:1,药脂比1:8.载体为甘露醇,最优处方下平均包封率为:(63.4±1.5)%.结论由最佳处方工艺条件制备的两性霉素B前体脂质体的包封率和稳定性高,重现性.
Objective: Study on preparation technology of Amphotericin B proliposomes,Methods Amphotericin B proliposomes were prepared by carrier aggradation method. A single-factor investigation and orthogonal design were used to select the optimum formulation. And the repeatability and stability were observed. Results The best prescription of Chrysophanol Proliposomes is that: the ratio of cholesterol to phospholipid is 1:2, the ratio of carrier to phospholipid is 5:1, the ratio of phospholipid to drug is 1:8. the best carrier is mannnitol, The average encapsulation efficiency of the optimal prescription is:(63.4±1.5)%. Conclusion Amphotericin B is highly entrapped into proliposomes with good reproduction and stability.
Objective: Study on preparation technology of Amphotericin B proliposomes,Methods Amphotericin B proliposomes were prepared by carrier aggradation method. A single-factor investigation and orthogonal design were used to select the optimum formulation. And the repeatability and stability were observed. Results The best prescription of Chrysophanol Proliposomes is that: the ratio of cholesterol to phospholipid is 1:2, the ratio of carrier to phospholipid is 5:1, the ratio of phospholipid to drug is 1:8. the best carrier is mannnitol, The average encapsulation efficiency of the optimal prescription is:(63.4±1.5)%. Conclusion Amphotericin B is highly entrapped into proliposomes with good reproduction and stability.
引文
[1]仲跻云,陈梁,肖斌.口服用前体脂质体研究进展[J].药学与临床研究,2012,20(01):56-59.
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[4]王立华,毛微曦,黄慧婷,等.大黄酚前体脂质体的制备及其质量评价[J].中草药,2014:45(14):2014-2017.
[5]白春清.羧基壳聚糖包覆着该仁油前体脂质体的制备、表征、稳定性及体外释放研究[D].南昌:南昌大学,2011.
[2]郑稳生,王璐璐,张宇佳.多柔比星前体脂质体制备工艺筛选及质量考察[J].中国药师,2012,15(8):1130-1134.
[3]杨鹏波,张华.脂质体的研究新进展[J].浙江中医药大学学报,2013,37(7):936-939.
[4]王立华,毛微曦,黄慧婷,等.大黄酚前体脂质体的制备及其质量评价[J].中草药,2014:45(14):2014-2017.
[5]白春清.羧基壳聚糖包覆着该仁油前体脂质体的制备、表征、稳定性及体外释放研究[D].南昌:南昌大学,2011.